3-丁炔-1-醇

3-丁炔-1-醇是一种有机化合物，化学式为C4H6O，它是合成天然产物的重要中间体。Yu, Xiao-Chun; Gu, Haining; Xu Wei-Ming. A practical synthesis of 3-butyn-1-ol. Organic Preparations and Procedures International (2006), 38(5), 467-469. 

合成与反应
3-丁炔-1-醇可由乙炔在液氨中和锂反应，再和环氧乙烷反应制得；或通过4-氯-2,3-二氢呋喃在四氢呋喃中和钠反应得到。它也可由乙炔和乙基溴化镁反应，再和环氧乙烷反应制得。

它和4-氟碘苯在三乙胺存在下、碘化亚铜和二氯化二(三苯基膦)钯催化下反应，可以得到4-(4-氟苯基)-3-丁炔-1-醇。Sooriyaarachchi, Sanjeewani; Chofor, Rene; Risseeuw, Martijn D. P.; Bergfors, Terese; Pouyez, Jenny; Dowd, Cynthia S.; Maes, Louis ; Wouters, Johan; Jones, T. Alwyn; Van Calenbergh, Serge; Mowbray, Sherry L. Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with β-Arylpropyl Analogues of Fosmidomycin. ChemMedChem. 2016. 11 (18): 2024-2036. .
参考文献

Category:炔醇