阿拉泊韦

阿拉泊韦（INN：Alisporivir；开发代号：Debio 025、DEB025或UNIL-025）是一种亲环蛋白抑制剂。它是环孢素衍生物。

它抑制亲环蛋白A。阿拉泊韦不具有免疫抑制作用。

正在研究它在丙型肝炎治疗中的潜在用途。Flisiak R, Horban A, Gallay P, et al. The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus. Hepatology. 2008;47(3):817-826. doi:10.1002/hep.22131Flisiak R, Feinman SV, Jablkowski M, et al. The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naïve hepatitis C patients. Hepatology. 2009;49(5):1460-1468. doi:10.1002/hep.22835Buti M, Flisiak R, Kao JH, et al. Alisporivir with peginterferon/ribavirin in patients with chronic hepatitis C genotype 1 infection who failed to respond to or relapsed after prior interferon-based therapy: FUNDAMENTAL, a Phase II trial. J Viral Hepat. 2015;22(7):596-606. doi:10.1111/jvh.12360Pawlotsky JM, Flisiak R, Sarin SK, et al. Alisporivir plus ribavirin, interferon free or in combination with pegylated interferon, for hepatitis C virus genotype 2 or 3 infection. Hepatology. 2015;62(4):1013-1023. doi:10.1002/hep.27960Zeuzem S, Flisiak R, Vierling JM, et al. Randomised clinical trial: alisporivir combined with peginterferon and ribavirin in treatment-naïve patients with chronic HCV genotype 1 infection (ESSENTIAL II). Aliment Pharmacol Ther. 2015;42(7):829-844. doi:10.1111/apt.13342它还被研究用以治疗杜氏肌营养不良症，并可能具有治疗阿尔茨海默病的潜力。

自2010年2月以来，阿拉泊韦在日本的开发和销售由Debiopharm进行，而诺华则负责世界其他地区开发和销售（由Debiopharm授予许可）。

 参考资料 

Category:抗病毒药物
Category:肽
Category:罕用药