10-甲氧基喜树碱

10-甲氧基喜树碱是一种有机化合物，分子式C21H18N2O5，是常见的喜树碱衍生物，具有抗肿瘤活性Luo, P., He, Q., He, X., Hu, Y., Lu, W., Cheng, Y., & Yang, B. (2006). Potent antitumor activity of 10-methoxy-9-nitrocamptothecin. Molecular cancer therapeutics, 5(4), 962-968. 。它可由10-羟基喜树碱和重氮甲烷在甲醇-二氧六环（1:1）中反应得到Synthesis of new cytotoxic E-ring modified camptothecins. Tetrahedron Letters. 2010. .。它在碘化亚铜-三乙胺催化下和氧气反应，可以得到5-羟基的衍生物Xungui He,Heyong Gao,Wei Lu & Junchao Cai. New Method for the Synthesis of 5‐Hydroxycamptothecin Derivatives. Synthetic Communications, 2004. .。


参考文献

拓展阅读
 M Gao; K D. Miller; G W. Sledge; Q-H Zheng. Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers. Bioorganic & Medicinal Chemistry Letters. 2005. 15 (17). .

Category:生物碱
Category:Δ-内酯
Category:甲氧基化合物