Ro 5-3663

Ro 5-3663是一种有机化合物，化学式为C10H10N2O，其化学名为1,3-二氢-5-甲基-2H-1,4-苯二氮䓬-2-酮。它可以2'-氨基苯乙酮和N-叔丁氧羰基甘氨酸（或N-芴甲氧羰基甘氨酸Kwan-Young Jung; Steven Fletcher. Fine-tuning the chemo- and regioselective alkylation of 1,4-benzodiazepines: further applications of the Mitsunobu reaction. MedChemComm, 2012. .）为原料反应制得。Romain Siegrist, Davide Pozzi, Gaël Jacob, Caterina Torrisi, Kilian Colas, Bertrand Braibant, Jacques Mawet, Thomas Pfeifer, Ruben de Kanter, Catherine Roch, Melanie Kessler, Richard Moon, Olivier Corminboeuf, Olivier Bezençon. Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers. Journal of Medicinal Chemistry (2016), 59 (23), 10661-10675. .它和苯甲醇（或异丙醇）、三丁基膦、DIAD在三氯甲烷中反应，可以得到1-苄基-Ro 5-3663或1-异丙基-Ro 5-3663。

参考文献

Category:甲基化合物