1-氧杂-4,7-二氮杂环壬烷

1-氧杂-4,7-二氮杂环壬烷是一种有机化合物，化学式为C6H14N2O。它可由N,N'-二(4-甲苯磺酰基)乙二胺二钠和二乙二醇二(4-甲苯磺酸)酯在干燥的DMF中于110 °C反应，再在乙酸、48%氢溴酸和苯酚的混合溶液中回流制得。Ana S. Fernandes, et al. Macrocyclic copper(II) complexes: Superoxide scavenging activity, structural studies and cytotoxicity evaluation. Journal of Inorganic Biochemistry, 2007. 101 (5): 849-858. .它和卤代烷基化合物（如溴乙基氨二乙酸二叔丁酯、2-溴-1-(4-羟甲基-1-哌啶基)乙酮等）反应，可以得到4,7-二(取代烷基)-1-氧杂-4,7-二氮杂环壬烷。New 9- or 10-Dentate Luminescent Lanthanide Chelates. Bioconjugate Chem. 2008, 19, 5, 1105–1111. Botar, Richard; Garda, Zoltan; Fodor, Tamas; Kalman, Ferenc, Krisztian; Nagy, Viktoria; Tircso, Gyula; Toth, Imre. Triazacyclononane derivatives and their use as ligands in Mn(II)-based MRI contrast agents. 2017. HU2015000563 A2.

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Category:胺
Category:醚