MK-2048

MK-2048系第二代整合酶抑制剂，是抗病毒药品，用于对抗HIV感染。其较前代整合酶抑制剂药物拉替拉韦英文：raltegravir，又称MK-0518。商品名为“Isentress”。的优点是，该药物对HIV整合酶的有效抑制时间长达4倍。MK-2048作为暴露前阻断药物（PrEP）的实用性正在研究当中。Keith Alcorn. Ralvetgravir shows potential for use as PrEP drug  AIDSmap.com. 28 April 2009. Accessed 8 Nov 2009.

MK-2048由默克藥廠开发。Mark Mascolini. Merck Offers Unique Perspective on Second-Generation Integrase Inhibitor.   10th International Workshop on Clinical Pharmacology of HIV Therapy, April 15–17, 2009, Amsterdam.  Accessed 8 Nov 2009.

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参考

Category:整合酶抑制剂
Category:试验药物