Daf-2

DAF-2是秀麗隱桿線蟲（Caenorhabditis elegans）的一个基因，编码的蛋白与人胰岛素样生长因子1受体（IGF-1R）同源。DAF-2是第一个发现的与老化速率有关的代謝途徑基因Keyton, C. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. 。DAF-2也与生殖发育的调控，氧化应激的应对，温度耐受，缺氧以及对细菌病原体的抵抗有关Minaxi S Gami and Catherine A Wolkow (2006). 。辛西娅·凯尼恩（Cynthia Kenyon）获得的DAF-2突变体线虫寿命为普通线虫的两倍Jennie B. Dorman, Bella Albinder, Terry Shroyer & Cynthia Kenyon, "The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans," Genetics, volume 141, number 4, pages 1399-1406 (1995); and Javier Apfeld & Cynthia Kenyon, "Cell non-autonomy of C. elegans daf-2 function in the regulation of diapause and lifespan," Cell, v. 95, n.2, pp.199-210 (1998).。

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Category:秀丽隐杆线虫基因
Category:动物蛋白