Α1-B-糖蛋白

α1-B-糖蛋白（）是一种功能未知的血浆糖蛋白，分子量为54.3 kDa，由A1BG 基因编码"Entrez Gene: Alpha-1-B glycoprotein". ，和免疫球蛋白超家族成员的可变区序列有着一定相似性。胰管腺癌患者的胰液中会出现A1BG过表达Tian M, Cui YZ, Song GH, Zong MJ, Zhou XY, Chen Y, Han JX (2008). 。

 同源体 

 直系同源 
如下表所示，α-1-B糖蛋白在如下动物中都是保守的，很可能在所有哺乳动物中都具有一定的保守性"NCBI Blast results for A1BG protein sequence" . 。
 拉丁文学名 通用名 与人类分化的时间（百万年前）"Time Tree" .  NCBI蛋白质编码 与人类的序列相似性   蛋白序列长度 基因名 Homo sapiens"alpha-1-B glycoprotein [Homo sapiens]" .  人类 --  NP_570602  100%  495  A1BG Pan troglodytes"PREDICTED: alpha-1B-glycoprotein isoform 4 [Pan troglodytes]" .  黑猩猩 6.2  XP_001146669  97.0%  501  PREDICTED: Alpha-1B-glycoprotein isoform 4 Pan Paniscus"PREDICTED: alpha-1B-glycoprotein [Pan paniscus]" .  倭黑猩猩 6.3  XP_003816677  97.0%  499  A1BG Gorilla gorilla gorilla "PREDICTED: alpha-1B-glycoprotein" .  大猩猩 8.8  XP_004061652  95.0%  275  PREDICTED: alpha-1B-glycoprotein Pongo Abelii"Send to:  PREDICTED: alpha-1B-glycoprotein isoform 1 [Pongo abelii]" .  蘇門達臘猩猩 15.7  XP_002829953  95.0%  495  alpha-1B-glycoprotein isoform 1 Macaca mulatta"hypothetical protein EGK_11172, partial [Macaca mulatta]" .  普通獼猴 29.0  XM_001101821  88.0%  351  hypothetical protein EGK_11172, partial Callithrix jacchus"PREDICTED: alpha-1B-glycoprotein [Callithrix jacchus]" .  普通狨 42.6  XP_002762619  83.0%  500  A1BG Mus musculus "alpha-1B-glycoprotein precursor [Mus musculus]" .  小家鼠 91.0  NP_001074536  44.0%  512  alpha-1B-glycoprotein precursor Felis catus"PREDICTED: alpha-1B-glycoprotein [Felis catus]" .  猫 94.2  XP_003997399  62.0%  481  PREDICTED: alpha-1B-glycoprotein Equus caballus"PREDICTED: alpha-1B-glycoprotein-like" .  马 97.4  XP_001495344  58.0%  568  PREDICTED: alpha-1B-glycoprotein-like Loxodonta africana "PREDICTED: alpha-1B-glycoprotein-like [Loxodonta africana]" .  非洲象 104.7  XP_003406722   61.0%  520  PREDICTED: alpha-1B-glycoprotein-like

 旁系同源 
目前并未发现α-1-B糖蛋白的旁系同源体"A1BG Gene" . 。

 同源结构域 
An initial NCBI Blast alignment of alpha-1B glycoprotein illustrates that the protein is mainly composed of three immunoglobulin domains."NCBI conserved domain search" . There is a large segment of amino acids from position 297 to 400 that is not shown to be an immunoglobulin domain.  However, a NCBI BLAST alignment of just the amino acids from 297-400 does illustrate that the latter sequence is indeed a fourth immunoglobulin domain."NCBI Blast: Protein Sequence" . Ultimately, alpha-1B glycoprotein seems to be primarily composed of four immunoglobulin domains.

 参考文献 

Category:人类蛋白质