莽草酸脱氢酶

莽草酸脱氢酶（，EC 1.1.1.25 ）化学式为：C1334H2102O398N352S10，是一种以NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：

莽草酸 + NADP+  3-脱氢莽草酸 + NADH + H+

上述反应中的NADP+不能以NAD+替代。莽草酸脱氢酶主要参与苯丙氨酸、酪氨酸和色氨酸的生物合成过程——莽草酸途径。在较高等的生物细胞中，这种酶与3-脱氢奎尼酸脱水酶一同构成一种多酶复合物。

功能
Shikimate dehydrogenase is an enzyme that catalyzes one step of the shikimate pathway. This pathway is found in bacteria, plants, fungi, algae, and parasites and is responsible for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan) from the metabolism of carbohydrates. In contrast, animals and humans lack this pathway hence products of this biosynthetic route are essential amino acids that must be obtained through an animal's diet.

There are seven enzymes that play a role in this pathway. Shikimate dehydrogenase (also known as 3-dehydroshikimate dehydrogenase) is the fourth step of the seven step process. This step converts 3-dehydroshikimate to shikimate as well as reduces NADP+ to NADPH.

异名
由于莽草酸脱氢酶催化一个可逆的氧化还原反应，且对于莽草酸碳原子编号顺序不同，所以除了它的系统名：shikimate:NADP+ 3-oxidoreductase 莽草酸：NADP+ 3-氧化还原酶之外，还存在多个异名：

 dehydroshikimic reductase 脱氢莽草酸还原酶
 shikimate oxidoreductase 莽草酸氧化还原酶
 shikimate:NADP+ oxidoreductase 莽草酸：NADP+ 氧化还原酶
 5-dehydroshikimate reductase 5-脱氢莽草酸还原酶
 shikimate 5-dehydrogenase 莽草酸 5-脱氢酶
 5-dehydroshikimic reductase 5-脱氢莽草酸还原酶
 DHS reductase DHS还原酶
 shikimate:NADP+ 5-oxidoreductase 莽草酸：NADP+ 5-氧化还原酶
 AroE。

 参考文献 

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Category:EC 1.1.1
Category:NADH依赖性酶
Category:已知结构的酶