CCL1

CCL1（）是一小分子的细胞因子属于CC趋化因子家族，是由活化的T细胞分泌的糖蛋白Miller MD, Krangel MS. The human cytokine I-309 is a monocyte chemoattractant. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2950-4.。CCL1与细胞表面的趋化因子受体CCR8结合Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B. Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem. 1997 Jul 11;272(28):17251-4.。CCL1对单核细胞，自然杀伤细胞，未成熟的B细胞和树突状细胞有细胞趋化作用。人类的CCL1基因与许多CC趋化因子的基因相邻聚集在第17染色体上Miller MD, Wilson SD, Dorf ME, Seuanez HN, O'Brien SJ, Krangel MS. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. J Immunol. 1990 Oct 15;145(8):2737-44..

 参见 
 趋化因子
 CCR8

 参考文献 

 外部链接 
 Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.

Category:细胞因子
Category:免疫学