CXCL1

CXCL1（）是一小分子的细胞因子属于CXC趋化因子家族Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.。又被称作生长调节致癌基因α (Growth-regulated oncogene alpha, GROα)Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198化学式为：C337H572O103N102S5。 趋化因子CXCL1是由巨噬细胞，中性粒细胞和上皮细胞表达的Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.Becker S, Quay J, Koren HS, Haskill JS.	Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.。趋化因子CXCL1对中性粒细胞有细胞趋化作用。CXCL1结合到趋化因子受体CXCR2上而起细胞趋化作用Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244。人类的CXCL1与许多CXC类的趋化因子基因相邻聚集在第四染色体上Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.。CXCL1的主要作用包括新血管形成、炎症反应、伤口愈合和肿瘤形成。

 参见 
CXCR2
趋化因子

 参考文献 

Category:细胞因子