Achmatowicz reaction

Achmatowicz Reaction jẹ́ ìṣètò organic èyí tí furan ma a ń yípadà sí dihydropyran. Ní àtẹ̀jáde Osman Achmatowicz Jr. àkọ́kọ́ ní ọdún 1971 Synthesis of methyl 2,3-dideoxy--alk-2-enopyranosides from furan compounds : A general approach to the total synthesis of monosaccharides Tetrahedron, Volume 27, Issue 10, 1971, Pages 1973-1996 O. Achmatowicz, P. Bukowski, B. Szechner, Z. Zwierzchowska and A. Zamojski doi:10.1016/S0040-4020(01)98229-8 furfuryl alcohol dàpapọ̀ ṣiṣẹ́ pẹ̀lú bromine ní methanol sí  2,5-dimethoxy-2,5-dihydrofuran  tí ó tún ara ṣàjọ sí dihydropyran pẹ̀lú àdàpọ̀ sulfuric acid. Àwọn ìgbésẹ̀ ìdàpapọ̀ ṣiṣẹ́ míràn, ìdáàbòbò alcohol pẹ̀lú methyl orthoformate àti boron trifluoride) àti ìmúkù  ketone pẹ̀lú sodium borohydride ṣe ìmújáde èyí tí a lè ṣètò  monosaccharides lati inú rẹ̀. 
 600x600px|The Achmatowicz reaction
Wọ́n ti lo ìlànà Achmatowitz lati ṣètò àwọn molecule tó lágbára fún àpẹẹrẹ bí tidesoxoprosophylline,Asymmetric total synthesis of (+)-desoxoprosophylline Tetrahedron Letters, Volume 39, Issue 50, 10 December 1998, Pages 9227-9228 Cui-Fen Yang, Yi-Ming Xu, Li-Xin Liao and Wei-Shan Zhou doi:10.1016/S0040-4039(98)02129-7 Pyrenophorin Efficient Conditions for Conversion of 2-Substituted Furans into 4-Oxygenated 2-Enoic Acids and Its Application to Synthesis of (+)-Aspicilin, (+)-Patulolide A, and (−)-Pyrenophorin  Kobayashi, Y.; Nakano, M.; Kumar, G. B.; Kishihara, K. J. Org.  àti Bao Gong Teng A.Organometallic Enantiomeric Scaffolding: Organometallic Chirons.  Láìpẹ́ yìí wọ́n lòó fún ìmú ìlọsíwájú bá ìṣètò kẹ́míkà.A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorially 
Martin D. Burke, Eric M. Berger, and Stuart L. Schreiber J. Am. Chem. Reagents: NBS, PPTS, for macrobeads see: solid-phase synthesis
 600x600px|Achmatowicz Burke 2006
àti ní enantiomeric scaffolding.Practical, Scalable, High-Throughput Approaches to 3-Pyranyl and 3-Pyridinyl Organometallic Enantiomeric Scaffolds Using the Achmatowicz Reaction Thomas C. Coombs, Maurice D. Lee, IV, Heilam Wong, Matthew Armstrong, Bo Cheng, Wenyong Chen, Alessandro F. Moretto, and Lanny S. Liebeskind J. Org. Reagents: benzyl chloroformate protects amine as Cbz group, Achmatowitz reaction with m-CPBA, complexation with a molybdenum compound, Cp is cyclopentadienyl
 600x600px|Achmatowicz Reaction Coombs 2008

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