Aziz Rodan Sarohan

Aziz Rodan Sarohan (born 1978, Turkey) is a Turkish physician specializing in obstetrics and gynecology, with a focus on reproductive medicine and translational research. He is known for proposing the Endogenous Retinoic Acid Theory (TERA) and the concept of Retinoic Acid Depletion Syndrome (RADS), theoretical frameworks concerning retinoid signaling and immune system dysregulation, particularly in relation to inflammatory diseases and COVID-19.

 Early life and education 

Sarohan received his medical degree from Gazi University Faculty of Medicine in 2000. He completed his residency in obstetrics and gynecology at Abant İzzet Baysal University Faculty of Medicine (Düzce campus) in 2008.

 Medical and academic career 

In addition to his clinical work in reproductive medicine, Sarohan has conducted research on immunology, retinoid metabolism, and inflammatory disease mechanisms. He introduced the Endogenous Retinoic Acid Theory (TERA), proposing that disruption of retinoic acid metabolism may contribute to immune dysregulation and severe inflammatory responses.

He further proposed Retinoic Acid Depletion Syndrome (RADS), describing depletion of endogenous retinoic acid stores under conditions of excessive immune activation.

 Research on COVID-19 

During the COVID-19 pandemic, Sarohan published hypothesis-driven and clinical studies linking retinoid signaling disorders to disease severity. His clinical investigations into serum retinol levels in hospitalized COVID-19 patients were published in Clinical Nutrition Open Science.

These studies examined the association between vitamin A depletion and inflammatory markers in severe COVID-19 cases.

 Clinical focus 

Sarohan’s clinical practice centers on infertility, recurrent implantation failure, recurrent pregnancy loss, endometriosis, and immune-related reproductive disorders.

 References