Ihepatitis B

Ihepatitis B sifo lesisulelanako lesibangelwa ligciwane lehepatitis B (i-HBV) lesitsikameta sibindzi. Ingabangela kokubili kusuleleka ngesifo kakhulu nangendlela lengalapheki. Bantfu labanyenti ababi netimphawu nabasuleleka kwekucala. Labanye bavele bagule bacale kuhlanta, babe nesikhumba lesiluphuti, bative bakhatsele, umchamo lomnyama nekulunywa sisu."Hepatitis B  Fact sheet N°204". who.int. July 2014. Retrieved 4 November 2014. Letimphawu tivamise kuba khona emaviki lambalwa kantsi akukavami kwekutsi lokusuleleka kwekucala kubangele kufa.Raphael Rubin; David S. Strayer (2008). Rubin's Pathology : clinicopathologic foundations of medicine ; [includes access to online text, cases, images, and audio review questions!] (5th ed.). Philadelphia [u.a.]: Wolters Kluwer/Lippincott Williams & Wilkins. p. 638. ISBN 9780781795166. Kungatsatsa emalanga lange-30 kuya ku-180 kutsi timphawu ticale. Kulabo labasulelekako ngaleso sikhatsi sekubelekwa labangu-90% baba nesifo lesingalapheki sehepatitis B ngalesikhatsi labangaphansi kwa-10% walabo labasulelekile baba nalesifo nabaneminyaka lesihlanu."Hepatitis B FAQs for the Public — Transmission". U.S. Centers for Disease Control and Prevention (CDC). Retrieved 2011-11-29. Labanyenti balabo labanalesifo lesingasalapheki ababi netimphawu; noma kunjalo, icirrhosis nemdlavuza wesibidzi kungahle kucale kube khona.Chang MH (June 2007). "Hepatitis B virus infection". Semin Fetal Neonatal Med. 12 (3): 160–167. doi:10.1016/j.siny.2007.01.013. PMID 17336170. Lokucakeka kuyaye kubangele kufa kwalabangu-15 kuya ku-25% walabo labanesifo lesingalapheki. 

Leligciwane lindluliselwa ngekusuleleka ngengati noma lokuliketjezi lokunalesifo lokuvela emtimbeni. Kusuleleka ngalesikhatsi kubelekwa noma kutsintsana nalabanye bantfu ngalesikhatsi basebancane yindlela lejwayeleke kakhulu lapho khona ihepatitis B itfolakala etindzaweni lapho khona lesifo sijwayelekile. Etindzaweni lapho lesifo singakavami khona kusetjentiswa kwetidzakamiva ngekutijova nekuya emacansini ngito tindlela letijwayelekile tekundlulisa lesifo. Letinye tintfo letiyingoti tifaka ekhatsi: kusebenta kutemphilo, kufakelwa ingati, idayalisisi, kuhlala nemuntfu losulelekile, kuya etindzaweni lapho lesifo sisiningi khona, nekuhlala esikhungweni. Kwenta ithathu nekuhlatjwa ngetinalitsi emtimbeni bekuholela kumazinga laphakeme ekugula ngeminyaka yabo 1980; noma kunjalo, loku akusavamanga ngenca yekuhlantwa kwetintfo lesekwentiwe ncono.Thomas HC (2013). Viral Hepatitis (4th ed.). Hoboken: Wiley. p. 83. ISBN 9781118637302. Ligciwane lehepatitis B angeke lasatjalaliswa ngekuchebulana, kusebentisa titja tinye, kucabuzana, kugonana, kukhwehlela, kutsimula, noma kumunyisa. Lokusuleleka kungatfolwa ngemuva kwemalanga lange-30 kuya ku-60 ngemuva kwekusuleleka. Kuhlolelwa lesifo kwenteka ngekuhlola ingati kute kutfolakale tincenye talesifo nemasotja lalwisana naleligciwane. Ngulesinye salamagciwane lasihlanu latiwako ehepatitis: A, B, C, D, na E. 

Lokusuleleka bekuvikeleka ngekugoma kusukela nga-1982.Pungpapong S, Kim WR, Poterucha JJ (2007). "Natural History of Hepatitis B Virus Infection: an Update for Clinicians". Mayo Clinic Proceedings. 82 (8): 967–975. doi:10.4065/82.8.967. PMID 17673066. Kugoma kuyanconywa yiNhlangano Yetemphilo Mhlabawonkhe ngelilanga lekucala uma kukhonakala. Emadosi mabili noma matsatfu ayadzingeka ngekuhamba kwesikhatsi kute kusebenteke ngalokuphelele. Lomjovo usebenta ngalokulinganiselwa ku-95% ngaleso sikhatsi. Emave lalinganiselwa ku-180 aniketa lomjovo njengencenye yetinhlelo tavelonkhe kusukela nga-2006.Williams R (2006). "Global challenges in liver disease". Hepatology. 44 (3): 521–526. doi:10.1002/hep.21347. PMID 16941687. Kuyanconywa futsi kutsi ingati yonkhe ihlolelwe ihepatitis B ngembi kwekuyindlulisela kulomunye nekutsi kusetjentiswe emajazi emkhwenyane kuvikela kusuleleka. Ngalesikhatsi sekucala kusuleleka, kunakekela kucondziswe kuletimphawu umuntfu lanato.  Kulabo lababa nesifo lesingalapheki imitsi yekulwisana naleligciwane lefana ne tenofovir noma interferon ingahle ibe lusito, noma kunjalo lemitsi iyabita. Kufakelwa sibindzi lesisha ngalesinye sikhatsi kuyentiwa uma une cirrhosis. 

Incenye yebantfu balokutsatfu emhlabeni bake basuleleka ekuphileni kwabo, kufaka ekhatsi tigidzi leti-240 kuya kutigidzi leti-350 webantfu lebasulelekile ngesifo lesingasalapheki.Schilsky ML (2013). "Hepatitis B "360"". Transplantation Proceedings. 45 (3): 982–985. doi:10.1016/j.transproceed.2013.02.099. PMID 23622604. Bantfu labangetulu kwa-750,000 babulawa yi-hepatitis B njalo ngemnyaka. Lesifo nyalo sivamise e-East Asia nase sub-Saharan Africa lapho khona bantfu labadzala labasemkhatsini wa-5 na 10% banetifo letingalapheki. Emazinga ase Europe nase North America angaphansi nga-1%. Bekuvamise kwatiwa nge-serum hepatitis.Barker LF, Shulman NR, Murray R, Hirschman RJ, Ratner F, Diefenbach WC, Geller HM (1996). "Transmission of serum hepatitis. 1970". Journal of the American Medical Association. 276 (10): 841–844. doi:10.1001/jama.276.10.841. PMID 8769597. Lucwaningo lubuke ekwakheni kudla lokunemutsi we-HBV.Thomas, Bruce (2002). Production of Therapeutic Proteins in Plants. p. 4. ISBN 9781601072542. Retrieved 25 November 2014. Lesifo singaba nemtselela kuletinye timfene futsi.Plotkin, [edited by] Stanley A.; Orenstein,, Walter A.; Offit, Paul A. (2013). Vaccines (6th. ed.). [Edinburgh]: Elsevier/Saunders. p. 208. ISBN 9781455700905. 

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