Sublingual administration

Sublingual administration (abbreviated as SL), from the Latin word for "under the tongue", refers to a pharmacological method of drug delivery where substances are absorbed into the bloodstream through tissues located under the tongue. This route is often preferred for its rapid absorption and avoiding the first-pass metabolism in the liver, making it a faster and more effective method for certain drugs.

 Principle 
When a substance is placed beneath the tongue, it comes into contact with the mucous membranes and diffuses into the blood via the numerous capillaries present in the area. This method bypasses the gastrointestinal tract and the liver's first-pass metabolism, allowing for more direct entry into systemic circulation. This is especially useful for drugs that might be degraded by stomach acids or enzymes if taken orally.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206068https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950356

 Forms 
 Sublingual tablets
 Sublingual strips
 Multi-purpose tabletshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234198
 Sublingual dropshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950356
 Sublingual sprays
 Lozenges
 Effervescent buccal or sublingual tablets

 Advantages 
 Faster onset of action compared to oral administration
 Avoids degradation by stomach acids and digestive enzymes
 Bypasses first-pass metabolism in the liver

 References 

Category:Pharmacology
Category:Drug delivery devices
Category:Routes of administration