Acetylornithine transaminase

Acetylornithine transaminase (EC 2.6.1.11) is an enzyme that catalyzes the reaction:

This reaction plays a crucial role in the urea cycle and amino acid metabolism by transferring nitrogenous groups. The enzyme belongs to the family of transferases, specifically the transaminases. It requires the cofactor pyridoxal phosphate to function.

 Reaction 
The enzyme's substrates are N2-acetyl-L-ornithine and 2-oxoglutarate, and its products are N-acetyl-L-glutamate 5-semialdehyde and L-glutamate.

 Alternative Names 
Several alternative names are used for acetylornithine transaminase, including:
 Acetylornithine delta-transaminase
 ACOAT
 Acetylornithine 5-aminotransferase
 N-acetylornithine-delta-transaminase
 Succinylornithine aminotransferase

 Structural Information 
As of 2007, six structures have been solved for this enzyme class, with PDB accession codes: 1VEF, 1WKG, 1WKH, 2E54, 2EH6, and 2ORD.

 References 

Category:Enzymes