Myelofibrosis

Primary myelofibrosis is a relatively rare bone marrow / blood cancer. It is currently classified as a myeloproliferative neoplasm.

Signs and symptoms
Symptoms include:

Abdominal fullness related to an enlarged spleen (splenomegaly).
Bone pain
Bruising and easy bleeding due to inadequate numbers of platelets
Cachexia (loss of appetite, weight loss, and fatigue)
Enlargement of both the liver and spleen
Fatigue
Gout and high uric acid levels
Increased susceptibility to infection, such as pneumonia 
Pallor and shortness of breath due to anemia
In rarer cases, a raised red blood cell volume 
 Cutaneous myelofibrosis is a rare skin condition characterized by dermal and subcutaneous nodules.

References

Category:Cancer