2010 US Open – Women's Singles

Kim Clijsters was the defending champion, and successfully defended her 2009 title, after she won 6–2, 6–1, against Vera Zvonareva in the final.

Seeds

 Caroline Wozniacki (Semifinals)
 Kim Clijsters (Champion)
 Venus Williams (Semifinals)
 Jelena Janković (Third Round)
 Samantha Stosur (Quarterfinals)
 Francesca Schiavone (Quarterfinals)
 Vera Zvonareva (Final)
 Li Na (First Round)
 Agnieszka Radwańska (Second Round)
 Victoria Azarenka (Second Round, retired due to concussion)
 Svetlana Kuznetsova (Fourth Round)
 Elena Dementieva (Fourth Round)
 Marion Bartoli (Second Round)
 Maria Sharapova (Fourth Round)
 Yanina Wickmayer (Fourth Round)
 Shahar Pe'er (Fourth Round)

<li> Nadia Petrova (First Round)
<li> Aravane Rezaï (Second Round)
<li> Flavia Pennetta (Third Round)
<li> Anastasia Pavlyuchenkova (Fourth Round)
<li> Zheng Jie (Second Round)
<li> María José Martínez Sánchez (Second Round)
<li> Maria Kirilenko (Third Round)
<li> Daniela Hantuchová (Third Round)
<li> Alexandra Dulgheru (Third Round)
<li> Lucie Šafářová (First Round)
<li> Petra Kvitová (Third Round)
<li> Alisa Kleybanova (Second Round)
<li> Alona Bondarenko (Third Round)
<li> Yaroslava Shvedova (First Round)
<li> Kaia Kanepi (Quarterfinals)
<li> Tsvetana Pironkova (Second Round)

Main draw

Finals

Top Half
Section 1

Section 2

Section 3

Section 4

Bottom Half
Section 5

Section 6

Section 7

Section 8

Qualifying draw

  Akgul Amanmuradova
  Maria Elena Camerin
  Lourdes Domínguez Lino
  Irina Falconi
  Zuzana Kučová
  Michelle Larcher de Brito
  Nuria Llagostera Vives
  Mirjana Lučić
  Rebecca Marino
  Mandy Minella
  Sania Mirza
  Monica Niculescu
  Zuzana Ondrášková
  Tamira Paszek
  Sally Peers
  Olga Savchuk
Other websites
 Official site of US Open

Women's Singles