2010 US Open – Men's Singles

Juan Martín del Potro was the defending champion, but chose not to compete this year, after a wrist operation in May and only starting to practice again in August.

Rafael Nadal defeated Novak Djokovic 6–4, 5–7, 6–4, 6–2 to win his first US Open title. It was his ninth career major and Nadal completed the Career Golden Slam with the win. Nadal became the first player since Rod Laver in 1969 to win the French Open, Wimbledon, and the US Open all in the same calendar year. 
Seeds

 Rafael Nadal (Champion)
 Roger Federer (Semifinals)
 Novak Djokovic (Final)
 Andy Murray (Third Round)
 Robin Söderling (Quarterfinals)
 Nikolay Davydenko (Second Round)
 Tomáš Berdych (First Round)
 Fernando Verdasco (Quarterfinals)
 Andy Roddick (Second Round)
 David Ferrer (Fourth Round)
 Marin Čilić (Second Round)
 Mikhail Youzhny (Semifinals)
 Jürgen Melzer (Fourth Round)
 Nicolás Almagro (Third Round)
 Ivan Ljubičić (First Round)
 Marcos Baghdatis (First Round)

<li> Gaël Monfils (Quarterfinals)
<li> John Isner (Third Round)
<li> Mardy Fish (Fourth Round)
<li> Sam Querrey (Fourth Round)
<li> Albert Montañés (Fourth Round)
<li> Juan Carlos Ferrero (Third Round)
<li> Feliciano López (Fourth Round)
<li> Ernests Gulbis (First Round)
<li> Stanislas Wawrinka (Quarterfinals)
<li> Thomaz Bellucci (Second Round)
<li> Fernando González (First Round, retired due to a knee injury)
<li> Radek Štěpánek (First Round)
<li> Philipp Kohlschreiber (Second Round)
<li> Juan Mónaco (First Round)
<li> David Nalbandian (Third Round)
<li> Lleyton Hewitt (First Round)
<li> Michael Llodra (Third Round)

Main draw

Finals

Top Half
Section 1

Section 2

Section 3

Section 4

Bottom Half
Section 5

Section 6

Section 7

Section 8

Qualifying draw

  Ričardas Berankis
  Rik de Voest
  Ivan Dodig
  Marc Gicquel
  Andreas Haider-Maurer
  Ryan Harrison
  Robert Kendrick
  Martin Kližan
  Dušan Lojda
  Adrian Mannarino
  Kei Nishikori
  Benoît Paire
  Peter Polansky
  Milos Raonic
  Lukáš Rosol
  Júlio Silva
Other websites
 Official site of US Open

Men's Singles