Splenomegaly

Splenomegaly is the enlargement of the spleen. It frequently occurs in asscociation with hematological cancers. 
Causes
Acute myeloid leukemia
Malaria
Chronic lymphocytic leukemia
Autoimmune hemolytic anemia
Polycythemia vera
Chronic myeloid leukemia
Myelofibrosis
Typhoid fever
Infectious mononucleosis
Cirrhosis, often as a result of Portal hypertension.

References

Category:Diseases and disorders of the cardiovascular system