Ageing

Ageing or aging is the many changes that happen in an individual over time. In living things, ageing includes most physical and psychological changes which happen after adulthood.

Senescence is the biological process which leads to ageing.Medawar P.B. & J.S. 1983. Aristotle to Zoos: a philosophical dictionary of biology. Harvard University Press, p58.  There have been many attempts to answer the question: why do animals (especially humans) age?Comfort, Alex 1956. Ageing: the biology of senescence. London: Routledge & Kegan Paul.

In one way, ageing begins at birth, because cell division and growth is fastest then, and gradually slows down as time goes on.

In another way, ageing starts when the likelihood of death increases. Actuarial tables show the likelihood of death at each stage of life. These tables are used by insurance companies to assess the rates of insurance on life policies and pensions. It turns out that we are least likely to die when we are adolescents and young adults. The reason suggested by biologists (such as Peter Medawar and George C. Williams) is that this is the time most significant for reproduction, or was in mankind's past.Williams G.C. 1957. Pleiotropy, natural selection and senescence. Evolution 11, 398411. The assumption is that the peak age of reproduction in mankind's history was lower than today.Medawar P.B. 1952. An unsolved problem of biology. An inaugural lecture delivered at University College London, 6 December, 1951. London: H.K. Lewis. A gene can be expressed at various stages of life. Any allele of a gene which interfered with reproduction would have less chance of passing on to the next generation. The number of such genes in the population would automatically be reduced. Thus natural selection would virtually eliminate any inherited effect which reduced fertility.

However, later in life, inherited defects would have little or no effect on the population as a whole. In fact, during life our cells collect damage to their DNA which is random, but causes us to become gradually less fit as we age. And we have some cell types which never, or rarely, divide during adult life. Muscle cells and most neurons never divide in adult life. Obviously, they collect damage, and not just to the DNA. Also, we inherit various genetic conditions which have effect later in life, like Huntington's chorea. The twin effects of delayed heredity and buildup of damage is what makes us age. Protists do not age: they divide, and the next generation is just as good as the last.McGowan, Christopher. [1994] 1999. Diatoms to dinosaurs: the size and scale of living things. London: Penguin, p69.  Why do even our dividing cells collect damage? The answer to that question is not known, but may be connected to a cell division phenomenon.

 An article 
Ageing is not a popular topic in general publication. One recent work is worth noting. It goes over the ground well.Lawton, Graham (editor). Ageing: the secrets to a long and healthy life. New Scientist Essential Guide #18. London 2023.

Related pages
Apoptosis
Gerontology
Hayflick limit
Death
Old age
Supercentenarian

 References 


Category:Biology
Category:Gerontology