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The 2021 Pakistan Super League (also known as PSL 6 or for sponsorship reasons HBL PSL 2021) was the sixth season of the Pakistan Super League, a franchise Twenty20 cricket league established by the Pakistan Cricket Board (PCB) in 2015. It was initially scheduled to be the second season held entirely in Pakistan in February and March 2021, after the previous seasons were held elsewhere due to the security situation there.

On 4 March 2021, the PCB suspended the tournament with 14 of the scheduled 30 group matches having been played after multiple cases of COVID-19 were recorded. In March, the PCB proposed to reschedule the remaining fixtures for June 2021 with all matches to be held in Karachi, however, on 4 May, all the teams asked the PCB to move to the United Arab Emirates (UAE) because of a surge in COVID-19 cases in Pakistan.

On 20 May 2021, approval was granted to play the remaining matches of the PSL 6 in Abu Dhabi and the tournament restarted on 9 June. On 24 June 2021, Multan Sultans beat Peshawar Zalmi in the final, by 47 runs to win their first title.

 League stage 

 Fixtures 
The PCB confirmed the fixtures for the tournament on 8 January 2021. The tournament was initially scheduled to take place in February and March.

 Playoffs