Capsule (farumasi)

Mugukora imiti, encapsulation mugikonoshwa gisanzwe kizwi nka capsule, kibemerera, kurugero, gufatwa kumanwa cyangwa gukoreshwa nkibitekerezo . Ubwoko bubiri bwingenzi bwa capsules ni:

 Capsules ikomeye, irimo ibintu byumye, ifu cyangwa pellet ntoya yakozwe na eg inzira yo gukuramo cyangwa spheronisation . Ibi bikozwe mu bice bibiri: “diameter” ntoya ya diameter yuzuye hanyuma igashyirwaho kashe ukoresheje “cap” nini ya diameter.
 Capsules yoroshye-ikoreshwa cyane cyane mumavuta no mubintu bikora bishonga cyangwa bihagarikwa mumavuta.

Ibyo byiciro byombi bya capsules bikozwe mubisubizo byamazi ya gelline, nka proteine y'inyamanswa (cyane cyane gelatine ) cyangwa polysaccharide y'ibimera cyangwa ibiyikomokaho (nka karrageenans nuburyo bwahinduwe bwa krahisi na selile ). Ibindi bikoresho bishobora kongerwaho mubisubizo bya gelling harimo plasitike nka glycerine cyangwa sorbitol kugirango bigabanye ubukana bwa capsule.

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 Igice kimwe cya gel encapsulation ("capsules yoroshye") 
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Mu 1833,Bakoresheje ibyuma kubikorwa byabo, bakuzuza capsules kugiti cyabo hamwe nigitonyanga cyimiti. Nyuma yaho, uburyo bwateguwe bwakoresheje amasahani hamwe nu mifuka kugirango bakore capsules. Nubwo ibigo bimwe bigikoresha ubu buryo, ibikoresho ntibigikora mubucuruzi. Ibikoresho byose bigezweho byoroshye-gel ikoresha itandukaniro ryibikorwa byakozwe na RP Scherer muri 1933. Agashya ke yakoresheje kuzunguruka kugirango atange capsules. Baca baruzuzwa no gukubitwa . Ubu buryo bwari umusaruro mwinshi, uhoraho, kandi ugabanya imyanda.

Softgels ishobora kuba uburyo bwiza bwo gutanga imiti yo mu kanwa, cyane imiti idashonga,.Ibikoresho byamazi biragoye kubishyira mubindi bikoresho byose bya dosiye nka tablet. Softgels nayo ikwiranye cyane nibiyobyabwenge bikomeye (urugero, aho ikinini ari <100 )

mu 1847.  Capsules ikozwe mubice bibiri. Capsules itangwa nkibice bifunze uruganda rukora imiti.capsule yuzuyemo ifu cyangwa pellet nyinshi zisanzwe zakozwe mugikorwa cyo gusohora no guterana.

Capsile igizwe na gelatine ikozwe muri kolagen yuruhu rwinyamaswa cyangwa amagufwa. 

Indabo za capsule zatangiwe mu 1987,  zakozwe muri selile, ibintu bigize ibimera. Ibintu nyamukuru bigize capsules zikomoka ku bimera ni hydroxypropyl methyl selulose . Mu kinyejana cya 21. 

Capsule yuzuza uburemere ni ikintu cyingenzi muri ensapsulation hamwe nuburyo butandukanye bwo kuzuza uburemere,kimwe no kugenzura uburemere kumurongo, kugirango ubuziranenge bwibicuruzwa. 
Ingano Umubumbe (mL) [A] Uburebure bufunze (mm) [A] Diameter yo hanze (mm) [A] 5 0.13 11.1 4.91 4 0.20 14.3 5.31 3 0.27 15.9 5.82 2 0.37 18 6.35 1 0.48 19.4 6.91 0 0.67 21.7 7.65 0E 0.7 23.1 7.65 00 0.95 23.3 8.53 000 1.36 26.14 9.91 13 3.2 30 15.3 12 5 40.5 15.3 12el 7.5 57 15.5 11 10 47.5 20.9 10 18 64 23.4 7 24 78 23.4 Su07 28 88.5 23.4
Umuti urashobora kuba mumutwe wa capsule, umubiri wa capsule cyangwa mumubiri ndetse numutwe wa capsule. Umuntu arashobora gushira imiti irenze imwe muri capsule shell matrix. Umuti urashobora kuba muburyo bwasheshwe kandi bwahagaritswe muri capsule shell matrix. Rero, umuntu arashobora gukora ubwoko butandukanye bwo gutandukana muri "capsules yashizwemo ibiyobyabwenge". Igipimo cyo kurekura ibiyobyabwenge kirashobora gutandukana ukurikije uburyo ibiyobyabwenge byinjijwe muri capsule shell matrix hamwe nibiyobyabwenge. Joshi, H.N., Tara Innovations LLC, 2014. Physically/molecularly distributed and/or chemically bound medicaments in empty, hard capsule shells. U.S. Patent 8,728,521. Joshi, H.N., 2018. Physically dispersed, molecularly dissolved and/or chemically bound drugs in an empty, hard capsule shell composition. U.S. Patent 9,884,024.

 Reba