Josef T. Vitkouski

Josef T. Vitkouski (nome orijinal Joseph T. Witkowski) (*1943-†2008) ia es un cimiste american https://www.legacy.com/us/obituaries/dfw/name/joseph-witkowski-obituary?id=15294539. Inventor 20 patenta a rexersa cancerosa.

 Lias
Mercedes Fuertes, Joseph T. Witkowski, David G. Streeter, and Roland K. 1974 Robins Synthesis and enzymic activity of 1,2,4-triazole-3-carboxamide 6'-deoxyhomoribonucleoside-6'-phosphonic acid and related compounds J. Med. Chem 17( 6): 642–645

Pickering MV, Witkowski JT, Robins RK.1976  Synthesis of 1-(4-thio-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide. J Med Chem. 1 19(6):841-2. doi: 10.1021/jm00228a022

Sidwell RW, Allen LB, Khare GP, et al.1973 Effect of 1-beta-D-ribofuranosyl1-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on herpes and vaccinia keratitis and encephalitis in laboratory animals.Antimicrob Agents Chemother. 3(2): 242-246

Srivastava PC, Pickering MV, Allen LB, Streeter DG, Campbell MT, Witkowski JT, Sidwell RW, Robins RK.1977 Synthesis and antiviral activity of certain thiazole C-nucleosides. J Med Chem.  20(2):256-62

Streeter DG, Witkowski JT, Khare GP, Sidwell RW, Bauer RJ, Robins RK, Simon LN. 1973 Mechanism of action of 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.  Proc Natl Acad Sci U S A. 70(4):1174-8 PMC

Huffman JH, Sidwell RW, Khare GP, Witkowski JT, Allen LB, Robins RK. In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses. Antimicrob Agents Chemother. 1973;3(2):235-241

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