CYP2B6

Cytochroma P450 CYP2B6  (Numerus EC: 1.14.14.1) est enzymum et haemoproteinum et pars gregis Cytochroma P450 ideo in metabolismo medicamenti chemotherapiae, ut cyclophosphamidi sive ifosfamidi, interest. Circiter centesimae quinque reactionum catabolicarum medicamentorum cum cytochromate CYP2B6 patent. Variationes multae geneticae descriptae sunt.

 Genetica 
 Phaenotypicae variantia 
Locus geni geneticus CYP2B6 in chromosomate 19 (19q13.2) situs est. Polymorphismus geneticus cum plus quam centum variationibus magnum momentum habet

 Pharmaca ad CYP2B6 relata 

 Pharmaca relata ad CYP2B6Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric PublishingPreskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc..|-
! Substrati !! InhibitoresInhibitor cum subtratorum effectibus fortioribus !! InductoresInductor cum subtratorum effectibus minoribus
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 Acidum valproicum
 Bupropionum
 Cyclophosphamidum
 Efavirenzum
 Ifosfamidum
 Ketaminum
 Methadonum
 Methoxetaminum
 Nevirapinum
 Pethidinum
 Propofolum
 Selegelinum
 Sertralinum
 Sorafenibum
 Tamoxifenum
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 Aethinyloestradiolum
 Chlorpyrifosum
 Clopidogrelum
 Clotrimazolum
 Curcuminum
 Fluoxetinum
 Fluvoxaminum
 Itraconazolum
 Ketoconazolum
 Memantinum
 Orphenadrinum''' (forte)
 Paroxetinum
 Raloxifenum
 Sertralinum
 Thiotepa
 Ticlopidinum 
 Carbamazepinum
 Phenobarbitalum
 Phenytoinum
 Rifampicinum
 Efavirenzum

 Notae 

 Nexus externi 
 Descriptio cytochromatis CYP2B6.

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