CYP2C8

Cytochroma P450 CYP2C8  (Numerus EC: 1.14.14.1) est haemoproteinum oxidoreductasisque et pars gregis cytochromatum P450. 

 Natura structuraque biochemica 
Cytochroma P450 CYP2C8 abunde in iecore reperiuntur. CYP2C8 est et polypeptidum et haemoproteinum, quod ex 476 acidis aminicis constitutum est. Plus quam 100 medicamenta substrata nota sunt. Nonnullae substantiae etiam, ut Gemfibrozilum vel Clopidogrelum, gravissime CYP2C8 inhibere possunt.

 Genetica 
Nomen geni cytochromatis est CYP2C8 locus cuius geneticus in chromosomate 10 humano locatus est (cytogeneticus: 10q23.33 / coordinatae genomicae: chr10:96,796,884-96,829,159)[https://web.archive.org/web/20170528092617/http://www.rcsb.org/pdb/gene/CYP2C8 PDB proteinorum collegium datis (Protein Data Bank). Varia allela descripta sunt (CYP2C8*2, CYP2C8*3, CYP2C8*4, CYP2C8*5). Plus quam 20 singularis nucleotidi polymorphismorum (SNP) notae sunt:
 Polymorphismi CYP2C8 Polyphormismus  Locusnucleotidi  Nota CYP2C8*2  I269F  CYP2C8*3  R139K  K399R  G416A  A1196G  CYP2C8*4  I264M  CYP2C8*5  T130N  E154D  N193K  K249R  L390S  P404A  H411L 

 Pharmaca ad CYP2C8 relata 
Adhuc solum Rifampicinum inductor notum est.
 Pharmaca relata ad CYP2C8Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric PublishingPreskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc..|-
! Substrati !! InhibitoresInhibitor cum subtratorum effectibus fortioribus !! InductoresInductor cum subtratorum effectibus minoribus
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 Chemotherapeutica contra malariam
 Amodiaquinum
 Chloroquinum
 Antidiabetica
 Repaglinidum
 Rosiglitazonum
 Analgetica
 Diclophenac
 Ibuprofenum
 Buprenorphinum
 Inhibitor CSE
 Cerivastatinum
 Dasabuvirum
 Enzalutamidum
 Loperamidum
 Montelukastum
 Paclitaxelum Sorafenibum
 Torasemidum
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 Antibiotica
 Cotrimoxazolum
 Trimethoprimum
 Clopidogrelum (forte)
 Deferasiroxum
 Gemfibrozilum''' (forte)
 Leflunomidum
 Montelukastum
 Teriflunomidum
 Lapatinibum
 Quercetinum Antibiotica
 Rifampicinum

 Notae 

 Nexus externi 
 Descriptio genetica CYP2C8: https://web.archive.org/web/20200928164956/https://ghr.nlm.nih.gov/gene/CYP2C8

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