CYP3A4

Cytochroma P450 CYP3A4  (Numerus EC: 1.14.13.97) est haemoproteinum et pars gregis Cytochroma P450 ideo in metabolismo xenobioticorum interest. CYP3A4 maxime omnium cytochromatum iecoris humani exprimatur. 

 Locus 
 In reticulis endoplasmaticis cellularum intestini iecorisque.

 Pharmaca ad CYP3A4 relata 
Multa chemotherapeutica, analgetica, cardiaca, psychopharmaca substratum cytochromatis 3A4 sunt. Inhibitores ut proteasis inhibitores (SCDI!) effectus substratorum augere possunt.

 Pharmaca relata ad CYP3A4Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric PublishingPreskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc..|-
! Substrati !! InhibitoresInhibitor cum subtratorum effectibus fortioribus !! InductoresInductor cum subtratorum effectibus minoribus
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 Antiarrhythmica
 Amiodaronum (classis III)
 Substantiae beta-receptoriae inhibendae
 Bisoprololum 
 Propranololum
 Calcii canalium inhibitores
 Amlodipinum
 Diltiazemum
 Felodipinum
 Lercanidipinum
 Nifedipinum'''
 Nisoldipinum
 Nitrendipinum
 Verapamilum
 Immunosuppressiva
 Cyclosporinum
 Tacrolimus
 Sirolimus
 Chemotherapeutica
 Anastrozolum
 Cyclophosphamidum
 Docetaxelum
 Doxorubicinum
 Erlotinibum
 Etoposidum
 Gefitinibum
 Ifosfamidum
 Imatinibum
 Irinotecanum
 Paclitaxelum
 Sorafenibum
 Sunitinibum
 Tamoxifenum
 Temsirolimus
 Teniposidum
 Venurafenibum
 Vinblastinum
 Vincristinum
 Vindesinum
 Antibiotica
 Macrolida
 Clarithromycinum
 Erythromycinum
 Antidepressiva
 Tricyclica
 Amitriptylinum
 Clomipraminum
 Imipraminum
 Citalopramum
 Venlafaxinum
 Sertralinum
 Antipsychotica
 Cariprazinum
 Quetiapinum
 Risperidonum
 Haloperidolum
 Benzodiazepina
 Alprazolamum
 Diazepamum
 Midazolamum
 Triazolamum
 Alfentanilum
 Statina
 Simvastatinum 
 Atorvastatinum
 Lovastatinum
 Sildenafilum
 Hormonta
 Oestradiolum
 Oestradiolovaleratum
 Aethinyloestradiolum
 Laevonorgestrelum
 Vitaminum D
 Anticoagulantes 
 Apixabanum Apixabanum et Rivaroxabanum / P-gp et inductores fortes CYP3A4 Apixabani interactionum effectus 
 Rivaroxabanum 

 Notae 

 Nexus externi  

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