Receptorium glutamati

Receptorium glutamati est receptorium neurotransmissoris synapsium neuroni locatum atque acido glutamico (glutamato)Basis coniugata acidi glutamici. neurotransmissore excitatorio cerebri primo stimulatumhttp://www.bristol.ac.uk/synaptic/receptors/ Receptoria Glutamati, Universitas Bristolii]  . 
Haec receptoria in receptoria ionotropica, ipsa canalibus cationium servantia, et metabotropica, cum proteino G alteras canales modificantia, dividuntur. 
Receptoriorum ionotropicorum glutamati tres familiae notae sunt: receptoria AMPA, receptoria kainati, receptoria NMDA. 
Receptoria glutamati metabotropica quoque in tres greges (I-II-III) dividuntur. 

In stimulando glutamato aliisque stimulis aptis neuroni receptoria Glutamati portantes, quibus grave pondus communicationis inter neuronos et formationis memoriae et eventuum discendi et ordinationis habet, neuronos postsynapticos excitant. 

Et partes excitotoxicitatis centrales receptoriorum glutamati et praevalentia ipsorum in systemate nervoso centrali cum morbis neurodegenerativis attribuuntur, nihilo setius autem attribuere suspiciuntur. 
Autoanticorpora contra receptoria eadem pluribus morbis coniuncta sunt veluti singulae formae morbi comitialis, Lupi erythematodis, ictuum. 

 Species  
 Species  Nomen  AgonistisAgonistis = αγωνιστής 
   ionotropicae  Receptoria NMDA  NMDA 
   Receptoria Kainati  Kainatum
   Receptoria AMPA  AMPA
   metabotropicae  mGluR  L-AP4, ACPD, L-QAOhashi H, Maruyama T, Higashi-Matsumoto H, Nomoto T, Nishimura S, Takeuchi (2002). A novel binding assay for metabotropic glutamate receptors using [3H] L-quisqualic acid and recombinant receptors. Z Naturforsch [C] 57 (3–4): 348–55

 Ionotropicae 
Subunitates Receptoriorum ionotropicorum glutamati cum genis suis:

 Familia receptoriorum Subunitas 
(nomenclatura prior) Genum Chromosoma(humanum) AMPA GluA1 (GluR1) GRIA1 5q33 GluA2 (GluR2) GRIA2 4q32-33 GluA3 (GluR3) GRIA3 Xq25-26 GluA4 (GluR4) GRIA4 11q22-23 Kainatum GluK1 (GluR5) GRIK1 21q21.1-22.1 GluK2 (GluR6) GRIK2 6q16.3-q21 GluK3 (GluR7) GRIK3 1p34-33 GluK4 (KA-1) GRIK4 11q22.3 GluK5 (KA-2) GRIK5 19q13.2 NMDA GluN1(NR1) GRIN1 9q34.3 GluN2A (NR2A) GRIN2A 16p13.2 GluN2B (NR2B) GRIN2B 12p12 GluN2C (NR2C) GRIN2C 17q24-25 GluN2D (NR2D) GRIN2D 19q13.1qter GluN3A (NR3A) GRIN3A 9q31.1 GluN3B (NR3B) GRIN3B 19p13.3

 Metabotropicae 
Mammalium receptoria metabotropica glutamati mGluR# nominantur, tres greges sunt:

 Grex Receptorium Genum Chromosoma(humanum) Effectus 1 mGluR1  GRM1 6q24 Incrementum Ca2+ in cytoplasmate. mGluR5  GRM5 11q14.3 Liberatio K+ ex cellula canalibus ionticis K+  2 mGluR2  GRM2 3p21.2 Inhibitio adenylyl cyclasis, decrementum cAMP mGluR3  GRM3 7q21.1-q21.2 3 mGluR4  GRM4 6p21.3 Incrementum canalum ionticorum Ca2+, cum influxu Ca2+ intra cellulam mGluR6  GRM6 5q35 mGluR7  GRM7 3p26-p25 mGluR8  GRM8 7q31.3-q32.1

 Notae 


 Psychopharmacologia
 Transportator glutamati

G
Categoria:Systema glutamatergicum (glutamatum)
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Categoria:Receptoria glutamati