CYP1A2

Cytochroma P450 CYP1A2  (Numerus EC: 1.14.14.1) est haemoproteinum et pars gregis Cytochroma P450 ideo in metabolismo Coffeini (Coffeum, Thea, Cola, Mate, Paullinia cupana/Guaraná, energy drink) et oestrogenorum interest. 

Expressio geni CYP1A2 brassicis et tabaco et medicamento Omeprazoli (inductores) aucta est. 

Cuminum et Curcuma et Hypericum Perforatum et Malum paradisi et antibioticum Ciprofloxacini (inhibitores) haemoproteinum CYP1A2 inhibent. 

Fieri potest ut functio aucta CYP1A2 periculo aucto cancri mammae praesitHong CC, Tang BK, Rao V, Agarwal S, Martin L, Tritchler M, Yaffe M, Boyd NF (2004). Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study. Breast Cancer Res 6: 7, pp. 338–351 http://download.springer.com/static/pdf/139/art%253A10.1186%252Fbcr797.pdf?originUrl=http%3A%2F%2Fbreast-cancer-research.biomedcentral.com%2Farticle%2F10.1186%2Fbcr797&token2=exp=1482277547~acl=%2Fstatic%2Fpdf%2F139%2Fart%25253A10.1186%25252Fbcr797.pdf*~hmac=088fe1b55e95e49a9e798c6dbb6af0466e5327eec218fba5763fe045d52662ae

 Locus 
 Reticulum endoplasmaticum

 Pharmaca ad CYP1A2 relata 
Multa antidepressiva substratum cytochromatis 1A2 sunt. Inhibitores ut ciprofloxacinum (antibioticum) effectus substratorum augere possunt.

 Pharmaca relata ad CYP1A2Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric PublishingPreskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc..|-
! Substrati !! InhibitoresInhibitor cum subtratorum effectibus fortioribus !! InductoresInductor cum subtratorum effectibus minoribus
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 Substantiae antidepressivae
 Antidepressiva tricyclica 
 Amitriptylinum
 Clomipraminum
 Imipraminum
 Antidepressiva tetracyclica
 MirtazapinumMetabolismus CYP1A2 lentior quam CYP2D6
 Agomelatinum
 Antipsychotica
 Clozapinum
 Olanzapinum
 Haloperidolum
 Coffeinum 
 Ropivacainum
 Theophyllinum
 Zolmitriptanum
 Melatoninum
 Tamoxifenum
 Erlotinibum
 Cyclobenzaprinum
 Oestradiolum
 Fluvoxaminum
 Mexiletinum
 Naproxenum
 Ondansetronum
 Phenacetinum
 Paracetamolum
 Propranololum
 Riluzolum
 Tacrinum
 Tizanidinum
 Verapamilum
 VarfarinumAnglice: Warfarin, WARF = Wisconsin Alumni Research Foundation; -arin: ex Coumarin derivatur
 Zileutonum 
 Naphthalinum 
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 Psychopharmaca
 Fluvoxaminum Perazinum
 Cimetidinum
 Antibiotica
 Ciprofloxacinum (forte)
 Norfloxacinum
 Isoniazidum
 Amiodaronum
 Enoxacinum'''
 Hypericum perforatum
 Interferonum
 Cuminum cyminumhomines cum effectibus variis cytochromati CYP1A2 
 Aethinyl-oestradiolum Carbamezepinum
 Phenytoinum
 Tabacum
 Omeprazolum
 Brassicarum diversae
 Brassica oleracea: 
Cauliculus Bruxellanus
 Var. botrytis
 Var. italica
 Lopanivirum-Ritonavirum
 Ritonavirum
 Modafinilum

 Notae 

 Nexus externi  

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