Sertralinum

Sertralinum est substantia psychoanaleptica, antidepressiva et inhibitor reabsorptionis serotonini selectivus. Quae ad conturbationem obsessionem-compulsionem et phobias curandas adhibetur. 

 Historia 
Anno 1978 chemicus Willard Welsh societatis Pfizer mixturam Sertralini et enantiomerium eius fecitWillard M. Welch (1995). Discovery and preclinical development of the serotonin reuptake inhibitor sertraline. Advances in Medicinal Chemistry 3: 113-148JJ Li (2009). Triumph of the heart. The Story of Statins. Oxford University Press. Pag. 135. 
Intra unum mensem Welsh enantiomeres inactivos removit, ut Sertralinum primus inhibitor reabsorptionis Serotonini selectivus purus fuerit. 
Anno 1991 Sertralinum in mercatum introductum est. 

 Natura Sertralini 
 Natura chemica 
Sertralinum est naphtylaminum cuius structura chemica (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-aminum et massa molaris 306.229 g/mol est. Codex ATC est N06AB06.

 Natura pharmacologica 
 Pharmacodynamica 
Sertralinum imprimis inhibitor reabsorptionis serotonini affinitate sui notate cum transportatro serotonini (SERT) est, Ki = 2.0 habenshttp://www.abcam.com/Sertraline-hydrochloride-ab141068.pdf.
Novem mg/die sufficit ut transportatrorum dimidium serotonini impediaturMeyer JH, Wilson AA, Sagrati S, Hussey D, Carella A, Potter WZ, Ginovart N, Spencer EP, Cheok A, Houle S (2004). Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am J Psych 161 (5): 826–35.

 Pharmacocinetica 
Tempus semivitae biologicum  est circa 25 horae.Fons. Sertralinum substratum cytochromatum, imprimis CYP2B6, minor CYP3A4 et CYP2C19, est. Excretio est per urinas.

 Usus Sertralini 
 Toxicitas 
Dosis letalis Shinkei Seishin Yakuri (1997). Neuropsychopharmacology. Bd. 19, S. 395 2800-7000 mg/kg homini (mus: 336) est.

 Effectus usu 
 Reactiones adversae 

 Hyponatraemia


 Depressio
 Pharmacologia

 Notae 

Categoria:Antidepressiva