Mkpụrụ ndụ endothelial jikọtara ya na akpụ

Mkpụrụ ndụ endothelial jikọtara akpụ ma ọ bụ mkpụrụ ndụ endot helial (TECs) na-ezo aka na mkpụrụ ndụ ndị dị n'akụkụ Akwara ọbara jikọtara akpụ nke na-achịkwa ịgafe nke ihe oriri n'ime anụ ahụ gbara ya gburugburu . N'ime ụdị ọrịa kansa dị iche iche, a chọpụtala na akwara ọbara ndị metụtara akpụ dị iche iche na akwara jini nkịtị na ọdịdị, ngosipụta mkpụrụ ndụ ihe nketa, na ọrụ n'ụzọ na-akwalite ọganihu ọrịa kansa. E nwere mmasị dị ịrịba ama n'ịmepụta ọgwụgwọ ọrịa kansa nke na-eji ihe ndị a na-adịghị mma nke endothelium jikọtara ya na akpụ iji bibie akpụ.[3]

 Ọdịdị na-adịghị mma 
A na-edepụta mkpụrụ ndụ endotilial nke akpụ (TECs) iji gosipụta njirimara ọdịdị na-adịghị mma dị ka akụkụ na-adịghị ike na projekshon saitoplasmic na-adịghị adị.Dudley, Andrew C. (2012-03-01). "Tumor Endothelial Cells". Cold Spring Harbor Perspectives in Medicine. 2 (3): a006536. doi:10.1101/cshperspect.a006536. ISSN 2157-1422. PMC 3282494. PMID 22393533. N'ime akwara ọbara nkịtị, a maara na mkpụrụ ndụ endotilial na-emepụta otu ngongo na-ejikọta ọnụ na-enweghị mkpuchi, mana TECs na-emepụta otu ngongo na-enweghị nhazi na njikọ, na-agbakarị ma na-agbasa gafee lumen iji kpuchie ndị agbata obi ha. Na mgbakwunye na nke a, TECs na-egosi akara dị iche iche nke na-ekewapụ ha n'ụzọ doro anya na mkpụrụ ndụ endotilial. A na-akọwa karị akpu endotilium  dị ka mozaic n'ihi ngosipụta ya na-adịghị mma nke akara mkpụrụ ndụ endotilial ọdịnala (CD31 na CD105),  na-akwado ịdị adị nke oghere na-adịghị n'etiti mkpụrụ ndụ endotilial. [3] Na ọkwa anaghị ahụ anya , karịa ịhụ obere oghere mmetụta mkpụrụ ndụ n'etiti TECs dị nso, akọwaala oghere dị ukwuu na mgbidi nke akpụ akwara ọbara[1]

A na-akọwa ọtụtụ akpụ site na ngosipụta dị elu nke vascular endothelial growth factor (VEGF), nke bụ vasodilator siri ike. E gosipụtara na VEGF na-akpali ntolite na isi alaka na mkpụrụ ndụ endothelial, na-eduga na otu ngongo endotheliel nwere nkwarụ. Nnyocha na-akwado na mkpakọ nke akwara akpụ site na mkpụrụ ndụ akpụ gbara ya gburugburu na-ebute nrụgide na mgbanwe na ọbara. A tụwo aro na mgbanwe ndị a na-agafe agafe na-akpata ngosipụta na-adịghị mma nke ihe ndị na-eme ka ọdịdị endothelial, nha, na ọdịiche dị iche iche.

A na-ejikarị perisaiti s na-akwado ya na-agba obere ọwa ọbara 

gburugburu nke na-enyere aka na nkwụsi ike nke arịa. Mfu nke ihe na-eto eto pericyte (PDGFB) na onye na-anabata ya na mkpụrụ ndụ endothelial bụ mgbanwe nke ọkwa nke nwere ike ịkọwa maka mfu a na-adịghị mma na nkwado perisaiti  Ọnụ ọgụgụ dị ala nke pericytes gbara endothelium metụtara akpụ ahụ gburugburu ejikọtara ya na ọgba aghara nke akwara ọbara na leakiness.