Pseudokinase

Pseudokinases bụ ụdị na_ezughi dịka katalist nke pseudoenzyme na-enweghị ihe ọ bụla  nke protin kinases nke a na-anọchite anya na kinomes niile gafee alaeze nke ndụ. Pseudokinases nwere ma ọrụ fisiolojikal (ihe ngosi transdokshon ) na  ọrụ pathophysiological.

 Akụkọ ihe mere eme 
E chepụtara okwu pseudokinase n'afọ puku abụọ na abụọ . E mechara kewaa ha n'ime 'Klaasị' dị iche iche.Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM (December 2009). "Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation". Science. 326 (5960): 1707–11. Bibcode:2009Sci...326.1707Z. doi:10.1126/science.1178377. PMC 3518268. PMID 19892943. A na-ahụ ọtụtụ ezinụlọ nwere pseudokinase na kinome mmadụ, gụnyere Tribbles pseudokinases, nke dị na intafeesi n'etiti kinase na ubiquitin E3 ligase signaling.  

Pseudokinases nke mmadụ (na ụmụnne ha pseudophosphatase) na-emetụta ọrịa dịgasị iche iche,   nke mere ka ha bụrụ ndị ọgwụ na ndị na-egbochi ọrịa.    Pseudokinases mejupụtara ngwakọta evolushọn nke ukariotik protin kinase (ePK) na protein pseudoenzyme na-abụghị ePK (dịka, FAM20A, nke na-ejikọta ATP  ma bụrụ pseudokinase n'ihi glutamate echekwara na glutamine swap na alpha-C helix.  FAM20A na-emetụta Ọrịa periodontal, ma na-arụ ọrụ iji chịkwaa ọrụ katalik nke FAM20C, casein kinase dị mkpa nke na-achịkwa phosphorylation nke protin na ngwaọrụ Golgi nke a kara aka maka ịgbapụta  dị ka protein mmiri ara ehi casein. 

Nnyocha zuru oke nke evolushọn na-akwado na pseudokinases na-agbakọta n'ime ọtụtụ ndị okpuru ezinaụlọ a na-ahụkwa ndị a na kinome nke ihe ndị dị ndụ gafee alaeze nke ndụ, gụnyere prokaryotes, archaea na usoro ọmụmụ niile eukaryotic nwere proteome; nchọcho a nwere ike ịchọ na ProKino (http://vulcan.cs.edu/prokino/about/browser).