Mgbanwe nke transcriptome

Transcriptome instabiliti bụ ihe jikọrọ ya na genome,  akparamagwa pre-mRNA splicing-related  nke ụfọdụ ọrịa kansa. N'ozuzu, pre-mRNA splicing na-agbanwe n'ọtụtụ mkpụrụ ndụ kansa.   Maka ụdị ọrịa kansa ụfọdụ, dị ka na colorectal na prostate, e gosipụtara na ọnụọgụ njehie splicing ọ bụla dịgasị iche iche n'etiti ọrịa kansa ọ bụla, ihe a na-akpọ Transcriptome instabiliti   Mgbanwe nke transcriptome na-emetụta n'ụzọ dị ịrịba ama na mbelata ngosipụta nke mkpụrụ ndụ ihe nketa splicing factor. Mgbanwe nke DNMT3ADNMT3A aka na mmepe nke malignancies hematologic, na  ahịrị mkpụrụ ndụ a wughariri DNMT 3A-c

na-egosipụta transcriptome instabiliti ma e jiri ya tụnyere isogenic waidtaip kauntapati .