Adinazolam

Category:Drugboxes which contain changes to watched fields
Adinazolam (nke a na-ere n'okpuru aha Deracyn) bụ ihe na-eme ka obi dị jụụ nke klas triazolobenzodiazepine (TBZD), nke bụ benzodiazepines (BZDs) jikọtara ya na mgbanaka triazole. Ọ nwere ihe na-eme ka nchegbu kwụsị, ihe na-egbochi nkụchi, ihe na'egbochi ịda mbà n'obi. Adinazolam bụ nke Jackson B. Hester mepụtara, onye isi oche n'ime ndị na eme Ihe ya ahazi na-achọ ịkwalite ihe ndị na-egbochi ịda mbà n'obi nke alprazolam, nke ọ mepụtara. Adinazolam enwetụbeghị nkwado FDA ma ọ dịghị mgbe a kwadoro ya n'ahịa ọha na eze; Otú ọ dị, a na-ere ya dị ka ọgwụ mmepụta.

Ịṅụbiga ọgwụ ókè nwere ike ịgụnye adịghị ike nke uru ahụ, ataxia, dysarthria na ọkachasị n'ime ụmụaka hụrụ ndị ọzọ ụra mbụ Nile nwere obi ụtọ, yana mbelata mmeghachi omume, mgbagwoju anya na coma nwere ike ịpụta n'ọnọdụ ndị siri ike karị.

Nnyocha mmadụ na-eji mmetụta uche na ikike mmetọ nke adinazolam (30 mg na 50 mg) na diazepam, lorazepam na placebo gosipụtara ndị na eme ka anyị si nọrọ na nche megide na adinazoham na-akpata "ụbụrụ na ahụ" na "obi ọjọọ" kachasị.

 Pharmacodynamics na pharmacokinetics 
Adinazolam na-ejikọta na ụdị benzodiazepine nke na-emekọrịta ihe na ndị na-anabata GABA dị ka agonist iji mepụta mmetụta mgbochi.

 Metabolism 
A kọrọ na Adinazolam nwere metabolites na-arụ ọrụ na mbipụta August 1984 nke The Journal of Pharmacy and Pharmacology. Isi metabolite bụ N-desmethyladinazolam. NDMAD nwere ihe dị ka okpukpu iri abụọ na ise dị elu maka ndị na-anabata benzodiazepine ma e jiri ya tụnyere onye bu ya ụzọ, na-akọwa mmetụta dị ka benzodiazepin mgbe a nwesịrị ọgwụ. Ọtụtụ N-dealkylations na-eduga n'iwepụ dimethylaminomethyl n'akụkụ, na-edughachi na ọdịiche dị na ike ya. Abụọ ndị ọzọ metabolites bụ alpha-hydroxyalprazolam na estazolam. Na mbipụta August 1986 nke otu akwụkwọ akụkọ ahụ, Sethy, Francis na Day kọrọ na proadifen gbochiri mmepụta nke N-desmethyladinazolam.

 Hụkwa 

 Benzodiazepine
 Alprazolam
 Fluadinazolam
 GL-II-73

 Ntụaka