Screen Actors Guild Award untuk Penampilan Luar Biasa oleh Aktor Wanita dalam Serial Komedi

Screen Actors Guild Award untuk Penampilan Luar Biasa oleh Aktor Wanita dalam Serial Komedi adalah penghargaan yang diberikan oleh SAG-AFTRA untuk menghormati pencapaian akting wanita terbaik dalam serial komedi. Aktris berhak menerima penghargaan ini, baik mereka tampil sebagai pemeran utama maupun pendukung dalam program mereka masing-masing.

Julia Louis-Dreyfus memegang rekor untuk kemenangan terbanyak (5) dan nominasi (12). Dia menang dua kali karena memerankan Elaine Benes dalam Seinfeld (1996, 1997) dan tiga kali atas peran Selina Meyer dalam Veep (2013, 2016, 2017). Tina Fey telah menang empat kali atas peran Liz Lemon dalam 30 Rock. Aktris yang menerima tujuh nominasi termasuk Edie Falco, Tina Fey dan Megan Mullally.

 Pemenang dan nominasi 
jmpl|130px|Helen Hunt menang atas Mad About You (1994)
jmpl|130px|Christine Baranski menang atas Cybill (1995)
jmpl|130px|Tracey Ullman menang atas Tracey Takes On... (1998)
jmpl|130px|Lisa Kudrow menang atas peran Phoebe Buffay dalam Friends (1999)
jmpl|130px|Sarah Jessica Parker menang atasSex and the City (2000)
jmpl|130px|Megan Mullally menang tiga kali atas Will & Grace (2001–2003)
jmpl|130px|Teri Hatcher menang atas Desperate Housewives (2004)
jmpl|130px|Felicity Huffman menang atas Desperate Housewives (2005)
jmpl|130px|America Ferrera menang atas Ugly Betty (2006)
jmpl|130px|Tina Fey menang empat kali atas peran Liz Lemon di 30 Rock (2007–2009, 2012)
jmpl|130px|Betty White menang dua kali atas Hot in Cleveland (2010, 2011)
jmpl|130px|Julia Louis-Dreyfus menang lima kali, dua kali atas Elaine Benes di Seinfeld (1996, 1997), dan tiga kali atas Selina Meyer di Veep (2013, 2016–2017)
jmpl|130px|Uzo Aduba menang dua kali atas Orange is the New Black (2014–2015)
jmpl|130px|Rachel Brosnahan menang atas The Marvelous Mrs. Maisel (2018)
jmpl|130px|Phoebe Waller-Bridge menang atas Fleabag (2019)
jmpl|130px|Catherine O'Hara menang atas Schitt's Creek (2020) dan The Studio (2025)
jmpl|130px|Jean Smart menang tiga kali atas Hacks (2021–2022; 2024)
jmpl|130px|Ayo Edebiri menang atas The Bear (2023)
1990-an
 Tahun Aktris Film Peran 1994
(ke-1)  Helen Hunt Mad About You Jamie Buchman Roseanne Barr Roseanne Roseanne Conner Candice Bergen Murphy Brown Murphy Brown Ellen DeGeneres Ellen Ellen Morgan Julia Louis-Dreyfus Seinfeld Elaine Benes 1995
(ke-2)  Christine Baranski Cybill Maryann Thorpe Candice Bergen Murphy Brown Murphy Brown Helen Hunt Mad About You Jamie Buchman Lisa Kudrow Friends Phoebe Buffay Julia Louis-Dreyfus Seinfeld Elaine Benes 1996
(ke-3)  Julia Louis-Dreyfus Seinfeld Elaine Benes Christine Baranski Cybill Maryann Thorpe Ellen DeGeneres Ellen Ellen Morgan Helen Hunt Mad About You Jamie Buchman Kristen Johnston 3rd Rock from the Sun Sally Solomon 1997
(ke-4)  Julia Louis-Dreyfus Seinfeld Elaine Benes Kirstie Alley Veronica's Closet Veronica Chase Ellen DeGeneres Ellen Ellen Morgan Calista Flockhart Ally McBeal Ally McBeal Helen Hunt Mad About You Jamie Buchman 1998
(ke-5)  Tracey Ullman Tracey Takes On... Various Characters Calista Flockhart Ally McBeal Ally McBeal Lisa Kudrow Friends Phoebe Buffay Julia Louis-Dreyfus Seinfeld Elaine Benes Amy Pietz Caroline in the City Annie Spadaro 1999
(ke-6)  Lisa Kudrow Friends Phoebe Buffay Calista FlockhartAlly McBeal Ally McBeal Lucy Liu Ling Woo Sarah Jessica Parker Sex and the City Carrie Bradshaw Tracey Ullman Tracey Takes On... Berbagai Karakter

2000-an
 Tahun Aktris Film Peran 2000
(ke-7)  Sarah Jessica Parker Sex and the City Carrie Bradshaw Calista Flockhart Ally McBeal Ally McBeal Jane Kaczmarek Malcolm in the Middle Lois Debra MessingWill & Grace Grace Adler Megan Mullally Karen Walker 2001
(ke-8)  Megan Mullally Will & Grace Karen Walker Jennifer Aniston Friends Rachel Green Kim Cattrall Sex and the City Samantha Jones Patricia Heaton Everybody Loves Raymond Debra Barone Sarah Jessica Parker Sex and the City Carrie Bradshaw 2002
(ke-9)  Megan Mullally Will & Grace Karen Walker Jennifer Aniston Friends Rachel Green Kim Cattrall Sex and the City Samantha Jones Patricia Heaton Everybody Loves Raymond Debra Barone Jane Kaczmarek Malcolm in the Middle Lois 2003
(ke-10)  Megan Mullally Will & Grace Karen Walker Patricia Heaton Everybody Loves Raymond Debra Barone Lisa Kudrow Friends Phoebe Buffay Debra Messing Will & Grace Grace Adler Doris Roberts Everybody Loves Raymond Marie Barone 2004
(ke-11)  Teri Hatcher Desperate Housewives Susan Mayer Patricia Heaton Everybody Loves Raymond Debra Barone Megan Mullally Will & Grace Karen Walker Sarah Jessica Parker Sex and the City Carrie Bradshaw Doris Roberts Everybody Loves Raymond Marie Barone 2005
(ke-12)  Felicity Huffman Desperate Housewives Lynette Scavo Candice Bergen Boston Legal Shirley Schmidt Patricia Heaton Everybody Loves Raymond Debra Barone Megan Mullally Will & Grace Karen Walker Mary-Louise Parker Weeds Nancy Botwin 2006
(ke-13)  America Ferrera Ugly Betty Betty Suarez Felicity Huffman Desperate Housewives Lynette Scavo Julia Louis-Dreyfus The New Adventures of Old Christine Christine Campbell Megan Mullally Will & Grace Karen Walker Mary-Louise Parker Weeds Nancy Botwin Jaime Pressly My Name Is Earl Joy Turner 2007
(ke-14)  Tina Fey 30 Rock Liz Lemon Christina Applegate Samantha Who? Samantha Newly America Ferrera Ugly Betty Betty Suarez Mary-Louise Parker Weeds Nancy Botwin Vanessa Williams Ugly Betty Wilhelmina Slater 2008
(ke-15)  Tina Fey 30 Rock Liz Lemon Christina Applegate Samantha Who? Samantha Newly America Ferrera Ugly Betty Betty Suarez Mary-Louise Parker Weeds Nancy Botwin Tracey Ullman Tracey Ullman's State of the Union Various Characters 2009
(ke-16)  Tina Fey 30 Rock Liz Lemon Christina Applegate Samantha Who? Samantha Newly Toni Collette The United States of Tara Tara Gregson Edie Falco Nurse Jackie Jackie Peyton Julia Louis-Dreyfus The New Adventures of Old Christine Christine Campbell

2010-an
 Tahun Aktris Film Peran 2010
(ke-17)  Betty White Hot in Cleveland Elka Ostrovsky Edie Falco Nurse Jackie Jackie Peyton Tina Fey 30 Rock Liz Lemon Jane Lynch Glee Sue Sylvester Sofía Vergara Modern Family Gloria Delgado-Pritchett 2011
(ke-18)  Betty White Hot in Cleveland Elka Ostrovsky Julie Bowen Modern Family Claire Dunphy Edie Falco Nurse Jackie Jackie Peyton Tina Fey 30 Rock Liz Lemon Sofía Vergara Modern Family Gloria Delgado-Pritchett 2012
(ke-19)  Tina Fey 30 Rock Liz Lemon Edie Falco Nurse Jackie Jackie Peyton Amy Poehler Parks and Recreation Leslie Knope Sofía Vergara Modern Family Gloria Delgado-Pritchett Betty White Hot in Cleveland Elka Ostrovsky 2013
(ke-20)  Julia Louis-Dreyfus Veep Selina Meyer Mayim Bialik The Big Bang Theory Amy Farrah Fowler Julie Bowen Modern Family Claire Dunphy Edie Falco Nurse Jackie Jackie Peyton Tina Fey 30 Rock Liz Lemon 2014
(ke-21)  Uzo Aduba Orange Is the New Black Suzanne "Crazy Eyes" Warren Julie Bowen Modern Family Claire Dunphy Edie Falco Nurse Jackie Jackie Peyton Julia Louis-Dreyfus Veep Selina Meyer Amy Poehler Parks and Recreation Leslie Knope 2015
(ke-22)  Uzo Aduba Orange Is the New Black Suzanne "Crazy Eyes" Warren Edie Falco Nurse Jackie Jackie Peyton Ellie Kemper Unbreakable Kimmy Schmidt Kimmy Schmidt Julia Louis-Dreyfus Veep Selina Meyer Amy Poehler Parks and Recreation Leslie Knope 2016
(ke-23)  Julia Louis-Dreyfus Veep Selina Meyer Uzo Aduba Orange Is the New Black Suzanne "Crazy Eyes" Warren Jane Fonda Grace and Frankie Grace Hanson Ellie Kemper Unbreakable Kimmy Schmidt Kimmy Schmidt Lily Tomlin Grace and Frankie Frankie Bergstein 2017
(ke-24)  Julia Louis-Dreyfus Veep Selina Meyer Uzo Aduba Orange Is the New Black Suzanne "Crazy Eyes" Warren Alison Brie GLOW Ruth Wilder Jane Fonda Grace and Frankie Grace Hanson Lily Tomlin Frankie Bergstein 2018
(ke-25)  Rachel Brosnahan The Marvelous Mrs. Maisel Miriam "Midge" Maisel Alex Borstein The Marvelous Mrs. Maisel Susie Myerson Alison Brie GLOW Ruth Wilder Jane Fonda Grace and Frankie Grace Hanson Lily Tomlin Frankie Bergstein 2019
(ke-26)  Phoebe Waller-Bridge Fleabag Fleabag Christina Applegate Dead to Me Jen Harding Alex Borstein The Marvelous Mrs. Maisel Susie Myerson Rachel Brosnahan Miriam "Midge" Maisel Catherine O'Hara Schitt's Creek Moira Rose

2020-an
 Tahun Aktris Film Peran 2020
(ke-27)  Catherine O'Hara Schitt's Creek Moira Rose Christina Applegate Dead to Me Jen Harding Linda Cardellini Judy Hale Kaley Cuoco The Flight Attendant Cassie Bowden Annie Murphy Schitt's Creek Alexis Rose 2021
(ke-28)  Jean Smart Hacks Deborah Vance Elle Fanning The Great Catherine the Great Sandra Oh The Chair Ji-Yoon Kim Juno Temple Ted Lasso Keeley Jones Hannah Waddingham Rebecca Welton 2022
(ke-29) Jean Smart Hacks Deborah Vance Christina Applegate Dead to Me Jen Harding Rachel Brosnahan  The Marvelous Mrs. Maisel Miriam "Midge" Maisel Quinta Brunson Abbott Elementary Janine Teagues Jenna Ortega  Wednesday Wednesday Addams 2023
(ke-30) Ayo Edebiri The Bear Sydney Adamu Alex Borstein The Marvelous Mrs. Maisel Susie Myerson Rachel Brosnahan  Miriam "Midge" Maisel Quinta Brunson Abbott Elementary Janine Teagues Hannah Waddingham Ted Lasso Rebecca Welton 2024
(ke-31) Jean Smart Hacks Deborah Vance Kristen Bell Nobody Wants This Joanne Quinta Brunson Abbott Elementary Janine Teagues Liza Colón-ZayasThe Bear Tina Marrero Ayo Edebiri Sydney Adamu 2025
(ke-32) Catherine O'HaraThe Studio Patty Leigh Kathryn Hahn The Studio Maya Mason Jenna Ortega  Wednesday Wednesday Addams Jean Smart  Hacks Deborah Vance Kristen Wiig  Palm Royale Maxine Simmons

Superlatif
 Superlative Aktris - Serial Drama Aktris - Serial Komedi Keseluruhan Aktris dengan penghargaan terbanyak Julianna Margulies 4 Julia Louis-Dreyfus 5 Julia Louis-Dreyfus 5 Aktris dengan nominasi terbanyak Julianna Margulies 9 Julia Louis-Dreyfus 12 Edie Falco 14 Aktris dengan nominasi terbanyak  tanpa pernah menang Kyra Sedgwick 7 Edie Falco 7 Kyra Sedgwick 7 Program televisi dengan kemenangan terbanyak The Crown 4 30 Rock 4 30 Rock / The Crown 4 Program televisi dengan nominasi terbanyak The Sopranos 12 Will & Grace 9 The Sopranos 12
Aktor dengan banyak penghargaan

 5 kemenangan 
 Julia Louis-Dreyfus

 4 kemenangan
 Tina Fey

 3 kemenangan
 Megan Mullally
 Jean Smart

 2 kemenangan
 Uzo Aduba
 Catherine O'Hara
 Betty White

Serial dengan banyak penghargaan

 4 kemenangan
 30 Rock (NBC)

 3 kemenangan
 Hacks (HBO Max)
 Veep (HBO)
 Will & Grace (NBC)

 2 kemenangan
 Desperate Housewives (ABC)
 Hot in Cleveland (TV Land)
 Orange Is the New Black (Netflix)
 Seinfeld (NBC)

Aktor dengan banyak nominasi

 12 nominasi
 Julia Louis-Dreyfus

 7 nominasi
 Edie Falco
 Tina Fey
 Megan Mullally

 6 nominasi
 Christina Applegate

 5 nominasi
 Patricia Heaton

 4 nominasi
 Uzo Aduba
 Rachel Brosnahan
 Calista Flockhart
 Helen Hunt
 Lisa Kudrow
 Mary-Louise Parker
 Sarah Jessica Parker
 Jean Smart

 3 nominasi
 Candice Bergen
 Alex Borstein
 Julie Bowen
 Quinta Brunson
 Ellen DeGeneres
 America Ferrera
 Jane Fonda
 Catherine O'Hara
 Amy Poehler
 Lily Tomlin
 Tracey Ullman
 Sofía Vergara
 Betty White

 2 nominasi
 Jennifer Aniston
 Christine Baranski
 Alison Brie
 Kim Cattrall
 Ayo Edebiri
 Felicity Huffman
 Jane Kaczmarek
 Ellie Kemper
 Debra Messing
 Jenna Ortega
 Doris Roberts
 Hannah Waddingham

Seri dengan banyak nominasi

 9 nominasi
 Will & Grace (NBC)

 7 nominasi
 30 Rock (NBC)
 Everybody Loves Raymond (CBS)
 The Marvelous Mrs. Maisel (Amazon)
 Nurse Jackie (Showtime)

 6 nominasi
 Grace and Frankie (Netflix)
 Modern Family (ABC)
 Sex and the City (HBO)

 5 nominasi
 Ally McBeal (Fox)
 Friends (NBC)
 Seinfeld (NBC)
 Veep (HBO)

 4 nominasi
 Dead to Me (Netflix)
 Hacks (HBO Max)
 Mad About You (NBC)
 Orange Is the New Black (Netflix)
 Ugly Betty (ABC)
 Weeds (Showtime)

 3 nominasi
 Abbott Elementary (ABC)
 The Bear (FX)
 Desperate Housewives (ABC)
 Ellen (ABC)
 Hot in Cleveland (TV Land)
 Parks and Recreation (NBC)
 Samantha Who? (ABC)
 Schitt's Creek (PopTV)
 Ted Lasso (Apple TV)

 2 nominasi
 Cybill (CBS)
 GLOW (Netflix)
 Malcolm in the Middle (Fox)
 Murphy Brown (CBS)
 The New Adventures of Old Christine (CBS)
 The Studio (Apple TV)
 Tracey Takes On... (HBO)
 Unbreakable Kimmy Schmidt (Netflix)
 Wednesday (Netflix)