Netrina 1

Netrina-1 es un proteina incodate in humanes per le gen NTN1 sul chromosoma 17.

Netrina es parte de un familia de laminina-relative proteinas secretate. Se pensa que netrina-1 es implicate in axon guidantia (principalemente de axones commissural in le tubo neural) e cellular migration durante embryogenese.  Mutationes e perta de expression del gene suggere un implication in cancerogenese.

Pathologia
Un mutation del gene NTN1 serea responsabile del .Méneret A, Franz EA, Trouillard O  Mutations in the netrin-1 gene cause congenital mirror movements, J Clin Invest, 2017;127:3923-3936

Le rata urinari de netrina serea un marcator precoce del insufficientia renal acute.Ramesh G, Krawczeski CD, Woo JG, Wang Y, Devarajan P, Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery, Clin J Am Soc Nephrol, 2010;5:395–401

Durante un hepatite acute, netrina serea superexprimite et sustenerea le inflammation.

Scopo therapeutic
Le anticorpore NP137 de Netris Pharma bloca netrina-1 e inhibi in consequentia le epithelial ad mesenchymal transition implicate in tumor initiation, progression, metastases e resistentia al tractamentos.

Categoria:Proteina
Categoria:Medicamento