Nesfatin-1

Nesfatin-1 shine neuropeptide wanda aka samar a cikin hypothalamus na dabbobi masu shayarwa . Yana shiga cikin ka'idar ajiyar yunwa da mai.  Ƙara nesfatin-1 a cikin hypothalamus yana taimakawa wajen rage yunwa, 'jin dadi', da yiwuwar asarar kitsen jiki da nauyi.

An gudanar da nazarin tasirin tasirin nesfatin-1 a cikin berayen inda abubuwan da aka sarrafa nesfatin-1 suka ci ƙasa da ƙasa, sun yi amfani da kitsen da aka adana da yawa kuma sun zama masu aiki. Nesfatin-1-induced hana ciyarwa na iya zama tsaka-tsaki ta hanyar hana ƙwayoyin cuta na orexigenic .  Bugu da ƙari, sunadaran suna motsa ƙwayar insulin daga ƙwayoyin beta na pancreatic na berayen da berayen. 

 Biochemistry 
Nesfatin-1 shine polypeptide da aka sanya a cikin yankin N-terminal na precursor protein, Nucleobindin-2 ( NUCB2 ). Recombinant ɗan adam Nesfatin-1 furotin ne mai nauyin  tara da dugo bakwai 9.7 kDa mai ɗauke da ragowar amino acid tamanin da biyu 82.  Nesfatin-1 yana bayyana a cikin hypothalamus, a wasu sassan kwakwalwa, da kuma a cikin tsibiran pancreatic, kwayoyin endocrin na ciki da adipocytes .

Nesfatin / NUCB2 an bayyana shi a cikin nau'i-nau'i masu sarrafa abinci kamar su paraventricular nucleus (PVN), arcuate nucleus (ARC), supraoptic nucleus (SON) na hypothalamus, yanki na hypothalamic na gefe (LHA), da zona incerta a cikin berayen. An kuma sami Nesfatin-1 immunoreactivity a cikin ƙananan ƙwayoyin kwakwalwa irin su tsakiya na sashin jiki (NTS) da Dorsal nucleus na jijiyar vagus .

 Manazarta