Tasirin barasa na dogon lokaci akan kwakwalwa

Tasirin barasa na dogon lokaci akan kwakwalwa ya ƙunshi nau'ikan tasirin, bambanta ta hanyar sha, shekaru, kwayoyin halitta, da sauran abubuwan kiwon lafiya. Daga cikin gabobin da yawa da barasa ke shafar, kwakwalwa tana da rauni musamman. Yawan shan giya yana haifar da lalacewar kwakwalwar barasa, tare da barasa yana aiki a matsayin neurotoxin kai tsaye zuwa kwayoyin jijiyoyi,  yayin da ƙananan matakan shan barasa na iya haifar da raguwa a cikin ƙwayar kwakwalwa, ƙarar ƙwayar launin toka na yanki, da ƙananan kwayoyin halitta. Abincin barasa mai ƙarancin-zuwa matsakaici yana iya haɗawa da wasu fa'idodin fahimi ko neuroprotection a cikin tsofaffi. Abubuwan zamantakewa da tunani na iya ba da ƙananan tasirin kariya. Dangantaka gaba ɗaya tsakanin amfani da barasa da lafiyar kwakwalwa yana da rikitarwa, yana nuna ma'auni tsakanin tasirin neurotoxic barasa da tasirin daidaitawa.

 Rabewa 
Sakamakon jijiyoyi na amfani da barasa na dogon lokaci ana iya rarraba su cikin sakamako masu cutarwa (misali, atrophy na kwakwalwa, raguwar fahimi, lalata), yuwuwar tasirin tsaka tsaki, kuma, a iyakanceccen yanayi, ƙananan tasirin kariya masu alaƙa da ƙarancin-zuwa matsakaiciyar amfani. Ana rarraba bayyanar cututtuka masu tsanani a ƙarƙashin lalacewar kwakwalwar da ke da alaka da barasa (ARBD), ciki har da yanayi kamar ciwon Wernicke-Korsakoff da kuma ciwon barasa. 
Yawan shan barasa yana da alaƙa da tartsatsi da ƙananan raunuka na kwakwalwa, musamman lalacewa ga yankunan kwakwalwa ciki har da lobe na gaba,  tsarin limbic, da cerebellum,  tare da atrophy na kwakwalwa mai yaduwa, ko raguwar kwakwalwa da lalacewa ta hanyar neuron . Ana iya ganin wannan lalacewa akan sikanin neuroimaging.  Barasa yana canza duka tsari da aikin kwakwalwa a sakamakon tasirin neurotoxic kai tsaye na barasa ko cirewar barasa. Ƙara yawan shan barasa yana haɗuwa da lalacewa ga yankunan kwakwalwa ciki har da lobe na gaba,  tsarin limbic, da cerebellum,  tare da yaduwa atrophy na cerebral, ko raguwar kwakwalwa da lalacewa ta hanyar neuron degeneration . Lalacewar lobe na gaba ya zama mafi shahara kamar shekarun barasa kuma yana iya haifar da ƙarancin aikin neuropsychological a cikin yankuna kamar warware matsala, kyakkyawan hukunci, da halayen jagoranci.  Rashin aikin sarrafa motsin rai yana haifar da lalacewa ga tsarin limbic. Wannan na iya haifar da matsala ga fahimtar yanayin fuska da kuma "fassara abubuwan motsin rai marasa fa'ida". 

Mummunan rikice-rikice sun haɗa da lalacewar kwakwalwa da ba za a iya jurewa ba, rashin lafiyar tabin hankali (misali, damuwa, damuwa), da ƙara haɗarin wasu yanayi na jijiyoyi, kamar cutar Alzheimer.

 Manazarta