SLC2A9

SLC2A9 furotin ne wanda a cikin ɗan adam ke ɓoye ta hanyar SLC2A9 gene.Phay JE, Hussain HB, Moley JF (Aug 2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)". Genomics. 66 (2): 217–20. doi:10.1006/geno.2000.6195. PMID 10860667."SLC2A9 solute carrier family 2 member 9 [ Homo sapiens (human) ]"Manolescu AR, Augustin R, Moley K, Cheeseman C (Aug 2007). "A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity". Mol Membr Biol. 24 (5–6): 455–63. doi:10.1080/09687680701298143. PMID 17710649. S2CID 35331716.

Wannan kwayar halitta ta ƙunshi memba na dangin SLC2A mai sauƙi na jigilar glucose. Membobin wannan dangi suna taka muhimmiyar rawa wajen kiyaye glucose homeostasis. Ƙwararren furotin na iya taka rawa a cikin ci gaba da rayuwa na chondrocytes a cikin matrix na guringuntsi. An gano bambance-bambancen kwafi guda biyu waɗanda ke ɓoye nau'ikan isoform daban-daban don wannan kwayar halitta."SLC2A9 solute carrier family 2 member 9 [ Homo sapiens (human) ]"

Hakanan an gano SLC2A9 kwanan nan don jigilar uric acid, kuma bambance-bambancen kwayoyin halitta na jigilar kayayyaki an danganta su da haɓaka haɗarin haɓakar cututtukan hyperuricemia, gout da cutar Alzheimer.Vitart V, Rudan I, Hayward C, et al. (2008). "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout". Nature Genetics. 40 (4): 437–42. doi:10.1038/ng.106. PMID 18327257. S2CID 6720464.Döring A, Gieger C, Mehta D, et al. (2008). "SLC2A9 influences uric acid concentrations with pronounced sex-specific effects". Nature Genetics. 40 (4): 430–6. doi:10.1038/ng.107. PMID 18327256. S2CID 29751482.Hollingworth P, Sweet R, Sims R, et al. (2012). "Genome-wide association study of Alzheimer's disease with psychotic symptoms". Molecular Psychiatry. 17 (12): 1316–1327. doi:10.1038/mp.2011.125. PMC 3272435. PMID 22005930.

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Rukuni:Lafiya