Michael Z. Lin

Michael Z. Lin (an haife shi a shekara ta alif  1973) a Taipei, a ƙasar Taiwan) ɗan Taiwan-Ba-Amurke masanin ilimin halittu ne kuma injiniyan halittu. Shi mataimakin Farfesa ne na Neurobiology da Bioengineering a Jami'ar Stanford. An fi saninsa da aikin injiniyanci na gani da ido da sunadarai masu sinadarai.

 Ilimi da aiki 
Lin ya kammala karatu daga Jami'ar Harvard a 1994 tare da digiri a cikin ilimin kimiyyar halittu summa cum laude."Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu. Daga baya ya horar da shi a matsayin dalibi na PhD yana nazarin fassarar siginar neuronal tare da Michael E. Greenberg a Makarantar Kiwon Lafiya ta Harvard, ya kammala karatunsa a 2002,"Chemistry Tree - Michael Z. Lin". academictree.org. kuma ya sami MD a UCLA a 2004. "Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu. Daga nan Lin ya yi bincike na gaba da digiri tare da Chemistry Nobel Prize Laureate Roger Y. Tsien a UCSD."Chemistry Tree - Michael Z. Lin". academictree.org. Tun 2009, ya kasance memba na baiwa a Makarantar Magunguna ta Jami'ar Stanford.

 Bincike 
A lokacin horo na postdoctoral tare da Roger Y. Tsin, Lin ya haɓaka ingantattun sunadaran sunadaran jaShaner, N. C.; Lin, M. Z.; McKeown, M. R.; Steinbach, P. A.; Hazelwood, K. L.; Davidson, M. W.; Tsien, R. Y. (2008). "Improving the photostability of bright monomeric orange and red fluorescent proteins". Nature Methods. 5 (6): 545–51. doi:10.1038/nmeth.1209. PMC 2853173. PMID 18454154  da channelrhodopsins, Lin, J. Y.; Lin, M. Z.; Steinbach, P.; Tsien, R. Y. (2009). "Characterization of engineered channelrhodopsin variants with improved properties and kinetics". Biophysical Journal. 96 (5): 1803–14. Bibcode:2009BpJ....96.1803L. doi:10.1016/j.bpj.2008.11.034. PMC 2717302. PMID 19254539 kuma ya fara yin amfani da magungunan miyagun ƙwayoyi don gyare-gyaren furotin a cikin hanyar lakabin furotin TimeSTAMP. Rukunin Lin a Jami'ar Stanford sun ƙera sunadaran sunadaran tare da sabbin ayyuka don optogenetics, chemogenetics, da ilimin halitta na roba. Fitattun abubuwan ƙirƙira sun haɗa da:

 Red fluorescent da sunadaran bioluminescent Chu, J.; Oh, Y.; Sens, A.; Ataie, N.; Dana, H.; MacKlin, J. J.; Laviv, T.; Welf, E. S.; Dean, K. M.; Zhang, F.; Kim, B. B.; Tang, C. T.; Hu, M.; Baird, M. A.; Davidson, M. W.; Kay, M. A.; Fiolka, R.; Yasuda, R.; Kim, D. S.; Ng, H. L.; Lin, M. Z. (2016). "A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo". Nature Biotechnology. 34 (7): 760–7. doi:10.1038/nbt.3550. PMC 4942401. PMID 27240196 Gitig, Diana (9 November 2016). "Watching a cell cycle". Ars Technica
 Sunadaran da za'a iya canzawa ta gani ta amfani da ingin ingin sunadaran furotin mai kyalli "Phosphorylation at the Flick of a Switch". The Scientist Magazine Zhou, XX; Fan, LZ; Li, P; Shen, K; Lin, MZ (24 February 2017). "Optical control of cell signaling by single-chain photoswitchable kinases". Science. 355 (6327): 836–842. Bibcode:2017Sci...355..836Z. doi:10.1126/science.aah3605. PMC 5589340. PMID 28232577Zhou, XX; Fan, LZ; Li, P; Shen, K; Lin, MZ (24 February 2017). "Optical control of cell signaling by single-chain photoswitchable kinases". Science. 355 (6327): 836–842. Bibcode:2017Sci...355..836Z. doi:10.1126/science.aah3605. PMC 5589340. PMID 28232577
 Iyali mai nuna alamar wutar lantarki ta asali ta ASAP Vogt, Nina (January 2020). "RAMPing up voltage indicator imaging". Nature Methods. 17 (1): 25. doi:10.1038/s41592-019-0720-4. PMID 31907465. S2CID 209897141 Villette, V; Chavarha, M; Dimov, IK; Bradley, J; Pradhan, L; Mathieu, B; Evans, SW; Chamberland, S; Shi, D; Yang, R; Kim, BB; Ayon, A; Jalil, A; St-Pierre, F; Schnitzer, MJ; Bi, G; Toth, K; Ding, J; Dieudonné, S; Lin, MZ (12 December 2019). "Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice". Cell. 179 (7): 1590–1608.e23. doi:10.1016/j.cell.2019.11.004. PMC 6941988. PMID 31835034
 Sarrafa sinadarai na bayanin furotin ta hanyar ƙwayoyin cuta na RNA Chung, H. K.; Jacobs, C. L.; Huo, Y.; Yang, J.; Krumm, S. A.; Plemper, R. K.; Tsien, R. Y.; Lin, M. Z. (2015). "Tunable and reversible drug control of protein production via a self-excising degron". Nature Chemical Biology. 11 (9): 713–20. doi:10.1038/nchembio.1869. PMC 4543534. PMID 26214256 Jacobs, C. L.; Badiee, R. K.; Lin, M. Z. (2018). "StaPLs: Versatile genetically encoded modules for engineering drug-inducible proteins". Nature Methods. 15 (7): 523–526. doi:10.1038/s41592-018-0041-z. PMC 6456726. PMID 29967496
 Sunadaran roba waɗanda ke sake dawo da siginar cutar kansa zuwa kunnawar warkewa Jacobs, C. L.; Badiee, R. K.; Lin, M. Z. (2018). "StaPLs: Versatile genetically encoded modules for engineering drug-inducible proteins". Nature Methods. 15 (7): 523–526. doi:10.1038/s41592-018-0041-z. PMC 6456726. PMID 29967496 Chung, HK; Zou, X; Bajar, BT; Brand, VR; Huo, Y; Alcudia, JF; Ferrell JE, Jr; Lin, MZ (3 May 2019). "A compact synthetic pathway rewires cancer signaling to therapeutic effector release". Science. 364 (6439): eaat6982. doi:10.1126/science.aat6982. PMC 7053279. PMID 31048459
 SARS-CoV-2 protease inhibitors dangane da gyara HCV protease inhibitors Westberg, Michael; Su, Yichi; Zou, Xinzhi; Ning, Lin; Hurst, Brett; Tarbet, Bart; Lin, Michael Z. (2020-09-16). "Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases". bioRxiv: 2020.09.15.275891. doi:10.1101/2020.09.15.275891. S2CID 221823586

 Kyaututtuka da karramawa 

 Kudin hannun jari Burroughs Wellcome Fund Kyauta a Kimiyyar Kiwon Lafiya (2007) "2011-2007 Awardees | Burroughs Wellcome Fund". www.bwfund.org
 Kyautar Majagaba ta Cibiyar Kiwon Lafiya ta Ƙasa (2013)
 Masanin Gidauniyar Rita Allen (2016) "Michael Lin". Rita Allen Foundation.
 Ƙungiyar Hoto Kwayoyin Halitta ta Duniya Roger Tsien Awardee don Ƙwarewa a Ilimin Sinadarai (2019) "World Molecular Imaging Society Announces Early Stage Awardees for 2019". World Molecular Imaging Society. 12 September 2019.

 Manazarta 

Category:Haifaffun 1973
Category:Rayayyun mutane
Category:Mutanan Anurka
Category:Maza
Category:Masana Ilimin Hallitu