Valproate

Valproate (VPA) da valproic acid, sodium valproate, da valproate semisodium siffofin magunguna ne da farko da ake amfani da su don magance farfadiya da cututtuka na bipolar da kuma hana ciwon kai. Suna da amfani don rigakafin faɗuwar da cuta a cikin waɗanda ba su da faɗuwar rashi, faɗuwar ɓangarori, da faɗuwar gaba ɗaya. Ana iya ba su ta hanyar jini ko ta baki, kuma nau'ikan kwamfutar hannu suna wanzu a cikin tsari mai tsayi da gajere.

Illolin valproate na yau da kullun sun haɗa da tashin zuciya, amai, bacci, da bushewar baki. Mummunan illa na iya haɗawa da gazawar hanta, don haka ana ba da shawarar saka idanu akai-akai na gwajin aikin hanta. Sauran manyan haɗari sun haɗa da pancreatitis da ƙara haɗarin kashe kai. An san Valproate yana haifar da mummunar rashin daidaituwa a cikin jarirai idan an sha a lokacin daukar ciki, kuma saboda haka ba a ba da shawarar ba ga matan da suka kai shekarun haihuwa waɗanda ke da migraines.

Ba a san takamaiman tsarin aikin Valproate ba. Hanyoyin da aka tsara sun haɗa da rinjayar matakan GABA, toshe tashoshin sodium mai ƙarfin lantarki, da hana histone deacetylases. Valproic acid fatty acid ne mai guntun sarka (SCFA) wanda aka yi daga valeric acid.

An fara yin Valproate a cikin 1881 kuma ya fara amfani da magani a cikin 1962. Yana cikin Jerin Mahimman Magunguna na Hukumar Lafiya ta Duniya. Ana samunsa azaman magani na gama-gari. Jimlar farashin a cikin ƙasashe masu tasowa kusan dalar Amurka 0.40 kowace rana kamar na 2015. A Amurka, kuɗin da ake kashewa yana kusan dalar Amurka 1.30 a kowace rana kamar na 2019. Ana sayar da shi a ƙarƙashin alamun alamun Depakote, da sauransu. A cikin 2017, shi ne na 126th mafi yawan magunguna a Amurka, tare da magunguna fiye da miliyan biyar.

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