Dextromethorphan

Dextromethorphan, dem sell am under de brand name Robitussin among odas, be a cough suppressant dem use insyd chaw cough den cold medicines. Insyd 2022, na de US Food and Drug Administration (FDA) approve de combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant insyd people plus major depressive disorder.

E dey insyd de morphinan class of medications plus dissociative den stimulant properties (at lower doses). Dextromethorphan no get a significant affinity for de mu-opioid receptor activity typical of morphinan compounds den exert ein therapeutic effects thru chaw oda receptors. Insyd ein pure form, dextromethorphan dey occur as a white powder.

When exceeding dosages dem approve, dextromethorphan dey act as a dissociative hallucinogen. E get multiple mechanisms of action, wey dey include actions as a nonselective Serotonin–norepinephrine reuptake inhibitor den a sigma-1 receptor agonist. Dextromethorphan den ein major metabolite dextrorphan sanso block de NMDA receptor at high doses, wey dey produce effects similar to those of oda dissociative anesthetics such as ketamine, nitrous oxide, den phencyclidine.

Na dem patent am insyd 1949 wey na dem approve am for medical use insyd 1953. Insyd 2023, na de combination plus promethazine be de 252nd most commonly prescribed medication insyd de United States, plus more dan 1million prescriptions; wey na de combination plus brompheniramine den pseudoephedrine be de 281st most commonly prescribed medication insyd de United States, plus more dan 700,000 prescriptions.

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Category:Antitussives
Category:Enantiopure drugs
Category:Dissociative drugs
Category:Methoxy compounds
Category:Morphinans
Category:Mu-opioid receptor agonists
Category:Nicotinic antagonists
Category:NMDA receptor antagonists
Category:Over-the-counter drugs insyd de United States
Category:Phenol ethers
Category:Prodrugs
Category:Serotonin–norepinephrine reuptake inhibitors
Category:Sigma agonists
Category:Translated from MDWiki