Hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM, anaa HOCM wen obstructive) be a condition insyd wich muscle tissues of de heart cam be thickened widout an obvious cause. De parts of de heart wey be most commonly affected be de interventricular septum den de ventricles. Dis dey result in de heart be less able to pump blood effectively wey sanso fi cause electrical conduction problems. Specifically affected be de bundle branches wey dey conduct impulses thru de interventricular septum den into de Purkinje fibers, as dese be responsible for de depolarization of contractile cells of both ventricles.

People wey get hypertrophic cardiomyopathy fi get a range of symptoms. People fi be asymptomatic, anaa dem fi get fatigue, leg swelling, den shortness of breath. E sanso fi result in chest pain anaa fainting. Symptoms fi be worse wen de person be dehydrated. Complications fi include heart failure, an irregular heartbeat, den sudden cardiac death.

Hypertrophic cardiomyopathy most commonly be inherited insyd an autosomal dominant pattern. E often be secof mutations insyd certain genes wey be involved plus making heart muscle proteins. Oda inherited causes of left ventricular hypertrophy dey include Fabry disease den Friedreich's ataxia. Oda considerations for causes of enlarged heart be athlete's heart den hypertension (high blood pressure). Making de diagnosis of hypertrophic cardiomyopathy often dey involve a family history anaa pedigree, an electrocardiogram, echocardiogram, den stress testing. Genetic testing be recommended for affected people den dema family members. Hypertrophic cardiomyopathy fi be distinguished from oda inherited causes of cardiomyopathy by ein autosomal dominant pattern, whereas Fabry disease be X-linked, wey Friedreich's ataxia be inherited insyd an autosomal recessive pattern.

Treatment dey depend on symptoms den oda risk factors. Medications fi include beta blockers, verapamil anaa disopyramide. An implantable cardiac defibrillator fi be recommended insyd those plus certain types of irregular heartbeat. Surgery, insyd de form of a septal myectomy anaa heart transplant, dem fi do insyd those wey no dey improve plus oda measures. Plus treatment, de risk of death from de disease be less dan one percent per year.

Hypertrophic cardiomyopathy dey affect up to one insyd 500 people. People of all ages may be affected. Na de first modern description of de disease be by Donald Teare insyd 1958.
References

 External links 

  GeneReviews/NIH/NCBI/UW entry on Familial Hypertrophic Cardiomyopathy Overview
 National Heart, Blood, and Lung Institute Cardiomyopathy Page

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Category:Autosomal dominant disorders
Category:Cardiogenetic disorders
Category:Cardiomyopathy
Category:Cat diseases
Category:Cytoskeletal defects
Category:Sports medicine
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