Crohn's disease

Crohn's disease be a type of inflammatory bowel disease (IBD) wey fi affect any segment of de gastrointestinal tract. Symptoms often dey include abdominal pain, diarrhea, fever, abdominal distension, den weight loss. Complications outsyd of de gastrointestinal tract fi include anemia, skin rashes, arthritis, inflammation of de eye, den fatigue. De skin rashes fi be secof infections, as well as pyoderma gangrenosum anaa erythema nodosum. Bowel obstruction fi occur as a complication of chronic inflammation, den those plus de disease be at greater risk of colon cancer den small bowel cancer.

Although de precise causes of Crohn's disease (CD) be unknown, dem dey believe e be caused by a combination of environmental, immune, den bacterial factors in genetically susceptible individuals. E dey result insyd a chronic inflammatory disorder, insyd wich de body ein immune system dey defend de gastrointestinal tract, possibly dey target microbial antigens. While Crohn's be an immune-related disease, e no dey seem to be an autoimmune disease (de immune system no be triggered by de body einself). De exact underlying immune problem no be clear; however, e fi be an immunodeficiency state.

About half of de overall risk be related to genetics, plus more dan 70 genes be involved. Tobacco smokers be three times as likely make dem develop Crohn's disease as non-smokers. Crohn's disease be often be triggered after a gastroenteritis episode. Oda conditions plus similar symptoms dey include irritable bowel syndrome den Behçet's disease.

Crohn's disease dey affect about 3.2 per 1,000 people insyd Europe den North America; e be less common insyd Asia den Africa. E historically be more common insyd de developed world. Rates, however, dey increase, particularly insyd de developing world, since de 1970s. Inflammatory bowel disease wey result insyd 47,400 deaths insyd 2015, den those plus Crohn's disease get a slightly reduced life expectancy. Onset of Crohn's disease tend e dey start insyd adolescence den young adulthood, though e fi occur for any age. Males den females be affected roughly equally.

 Name controversy 
Na dem name de disease after gastroenterologist Burrill Bernard Crohn, wey insyd 1932, togeda plus Leon Ginzburg (1898–1988) den Gordon D. Oppenheimer (1900–1974) for Mount Sinai Hospital insyd New York, describe a series of people plus inflammation of de terminal ileum of de small intestine, de area wey be most commonly affected by de illness. De decision make dem name de disease after Crohn remain controversial. While Crohn, insyd ein memoir, dey describe ein original investigation of de disease, Ginzburg provide strong evidence of how na he den Oppenheimer be de first make dem study de disease.

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Category:Abdominal pain
Category:Articles wey dey contain video clips
Category:Autoimmune diseases
Category:Crohn's disease
Category:Inflammations
Category:Membrane transport protein disorders
Category:Noninfective enteritis den colitis
Category:Steroid-responsive inflammatory conditions
Category:Diseases dem name after discoverers
Category:Translated from MDWiki