Ankylosing spondylitis

Ankylosing spondylitis (AS) be a type of arthritis from de disease spectrum of axial spondyloarthritis. De term dey cam from de Greek ankylos wey dey mean crooked, curved anaa rounded, spondylos dey mean vertebra, den -itis wey dey mean inflammation. E be characterized by long-term inflammation of de joints of de spine, typically wer de spine join de pelvis. Lower back pain be a hallmark, buh eye den gastrointestinal problems den arthritis of oda joints sanso fi occur. Joint mobility insyd de affected areas often dey worsen over time, though de progression of symptoms dey vary significantly.

Dem dey believe ankylosing spondylitis to involve a combination of genetic den environmental factors. More dan 90% of people affected insyd de UK get a specific human leukocyte antigen dem know as de HLA-B27 antigen, though de genetic correlation dey vary across populations (e.g., 70% of AS patients per insyd Turkey be HLA-B27 positive). De underlying mechanism dem believe e be autoimmune anaa autoinflammatory. Diagnosis be based on symptoms plus support from medical imaging den blood tests. AS be a type of seronegative spondyloarthropathy, wey dey mean say tests dey show no presence of rheumatoid factor (RF) antibodies.

Der currently be no cure give AS. Treatments fi include medication, physical therapy, den surgery. Medication therapy dey focus on relieving de pain den oda symptoms of AS, as well as stopping disease progression by counteracting long-term inflammatory processes. Commonly used medications dey include NSAIDs, TNF inhibitors, IL-17 antagonists, den DMARDs. Glucocorticoid injections often be used for acute den localized flare-ups.

About 0.1% to 0.8% of de population be affected, plus onset typically dey occur insyd young adults. While men den women equally be affected plus AS, women be more likely to experience inflammation rather dan fusion.

 References 

 External links 

 Questions and Answers about Ankylosing Spondylitis - US National Institute of Arthritis and Musculoskeletal and Skin Diseases


Category:Arthritis
Category:Autoimmune diseases
Category:Rheumatology
Category:Diseases dem name after discoverers
Category:Translated from MDWiki