Creutzfeldt–Jakob disease

Creutzfeldt–Jakob disease (CJD) be an incurable, invariably fatal, neurodegenerative disease wey dey belong to de transmissible spongiform encephalopathy (TSE) group. Early symptoms dey include memory problems, behavioral changes, poor coordination, visual disturbances den auditory disturbances. Later symptoms dey include dementia, involuntary movements, blindness, deafness, weakness, den coma. About 70% of sufferers dey die within a year of diagnosis. Na Walther Spielmeyer introduce de name "Creutzfeldt–Jakob disease" insyd 1922, after de German neurologists Hans Gerhard Creutzfeldt den Alfons Maria Jakob.

CJD be caused by a prion, an infectious abnormal folding of a protein. Infectious prions be misfolded proteins wey fi cause normally folded proteins make e sanso cam be misfolded. About 85% of cases of CJD dey occur for unknown reasons, while about 7.5% of cases be inherited insyd an autosomal dominant manner. Exposure to brain anaa spinal tissue from an infected person sanso fi result in spread. Der be no evidence say sporadic CJD fi spread among people via normal contact anaa blood transfusions, although dis be possible insyd variant Creutzfeldt–Jakob disease. Diagnosis dey involve ruling out oda potential causes. An electroencephalogram, spinal tap, anaa magnetic resonance imaging fi support de diagnosis. Anoda diagnosis technique be de real-time quaking-induced conversion assay, wich fi detect de disease insyd early stages.

Der be no specific treatment give CJD. Dem fi use opioids to help plus pain, while clonazepam anaa sodium valproate fi help plus involuntary movements. CJD dey affect about one person per million people per year. Onset be typically around 60 years of age. Na dem first describe de condition insyd 1920. E be classified as a type of transmissible spongiform encephalopathy. Inherited CJD dey account for about 10% of prion disease cases. Sporadic CJD be different from bovine spongiform encephalopathy (mad cow disease) den variant Creutzfeldt–Jakob disease (vCJD).

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Category:Transmissible spongiform encephalopathies
Category:Neurodegenerative disorders
Category:Dementia
Category:Rare infectious diseases
Category:Diseases dem name after discoverers
Category:Rare diseases
Category:1920 insyd biology
Category:Translated from MDWiki