Diphenhydramine

Diphenhydramine, dem sell under de brand name Benadryl among odas, be an antihistamine den sedative. Although dem generally consider am sedating, diphenhydramine fi cause paradoxical central nervous system stimulation insyd sam individuals, particularly at higher doses. Dis fi manifest as agitation, anxiety, anaa restlessness rather dan sedation. E be a first-generation H1-antihistamine wey e dey work by blocking certain effects of histamine, wich dey produce ein antihistamine den sedative effects. Diphenhydramine sanso be a potent anticholinergic. Dem mainly dey use am to treat allergies, insomnia, den symptoms of de common cold. E sanso be less commonly used for tremors insyd parkinsonism, den nausea. Dem dey take am by mouth, injected into a vein, injected into a muscle, anaa applied to de skin. Maximal effect typically be around two hours after a dose, wey effects fi last for up to seven hours.

Common side effects dey include sleepiness, poor coordination, den an upset stomach. Der be no clear risk of harm wen dem use during pregnancy; however, ein use during breastfeeding no be recommended.

Na e be developed by George Rieveschl wey dem put into commercial use insyd 1946. E be available as a generic medication. Insyd 2023, na e be de 294th most commonly prescribed medication insyd de United States, plus more dan 700,000 prescriptions.

Ein sedative den deliriant effects lead to sam cases of recreational use.

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