Tramadol

Tramadol, dem sell under de brand name Tramal among odas, be an opioid pain medication den a serotonin–norepinephrine reuptake inhibitor (SNRI) dem use to treat moderate to severe pain. Wen dem take am by mouth insyd an immediate-release formulation, de onset of pain relief usually dey begin within an hour. E sanso be available by injection. E be available in combination plus paracetamol (acetaminophen).

As e be typical of opioids, common side effects dey include constipation, itchiness, den nausea. Serious side effects fi include hallucinations, seizures, increased risk of serotonin syndrome, decreased alertness, den drug addiction. A change insyd dosage fi be recommended insyd those plus kidney anaa liver problems. Dem no dey recommend am insyd those wey be at risk of suicide anaa insyd those wey dey preg. While e no be recommended insyd women wey dey breastfeed, those wey take a single dose for no generally stop breastfeeding. Tramadol be converted insyd de liver to O-desmethyltramadol (desmetramadol), an opioid plus a stronger affinity for de μ-opioid receptor.

Tramadol be patented insyd 1972 wey na dem launch am under de brand name Tramal insyd 1977 by de West German pharmaceutical company Grünenthal GmbH. Insyd de mid-1990s, na dem approve am insyd de United Kingdom den de United States. E be available as a generic medication wey na dem market am under chaw brand names worldwide. Insyd 2023, na e be de 36th most commonly prescribed medication insyd de United States, plus more dan 16million prescriptions.

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Category:5-HT2C antagonists
Category:Analgesics
Category:Cyclohexanols
Category:Dimethylamino compounds
Category:Euphoriants
Category:Experimental antidepressants
Category:German inventions
Category:Mu-opioid receptor agonists
Category:Muscarinic antagonists
Category:Nicotinic antagonists
Category:NMDA receptor antagonists
Category:Opioids
Category:3-Methoxyphenyl compounds
Category:Racemic mixtures
Category:Serotonin–norepinephrine reuptake inhibitors
Category:Translated from MDWiki