Frontotemporal dementia

Frontotemporal dementia (FTD), dem sanso call frontotemporal degeneration disease anaa frontotemporal neurocognitive disorder, dey encompass several types of dementia wey dey involve de progressive degeneration of de brain ein frontal den temporal lobes. Men den women appear to be equally affected. FTD generally dey present as a behavioral anaa language disorder plus gradual onset. Signs den symptoms tend to appear insyd mid adulthood, typically between de ages of 45 den 65, although e fi affect people younger anaa older dan dis. As of 2017 der be no cure anaa approved symptomatic treatment give FTD, although na dem prescribe sam off-label drugs den behavioral methods.

Na dem first describe features of FTD by Arnold Pick between 1892 den 1906. Na dem coin de name Pick's disease insyd 1922, buh na dem reserve am for de behavioral variant of FTD, insyd wich characteristic Pick bodies den Pick cells be present. Na dem first describe dese by Alois Alzheimer insyd 1911. Common signs den symptoms dey include significant changes insyd social den personal behavior, disinhibition, apathy, blunting den dysregulation of emotions, den deficits insyd both expressive den receptive language.

Each FTD subtype relatively be rare. FTDs mostly be early onset syndromes dem link to frontotemporal lobar degeneration (FTLD), wich be characterized by progressive neuronal loss predominantly wey dey involve de frontal anaa temporal lobes, den a typical loss of more dan 70% of spindle neurons, while oda neuron types remain intact. De three main subtypes anaa variant syndromes be a behavioral variant (bvFTD) dem previously know as Pick's disease, den two variants of primary progressive aphasia (PPA): semantic (svPPA) den nonfluent (nfvPPA). Two rare distinct subtypes of FTD be neuronal intermediate filament inclusion disease (NIFID) den basophilic inclusion body disease (BIBD). Oda related disorders dey include corticobasal syndrome (CBS anaa CBD), den FTD plus amyotrophic lateral sclerosis (ALS).

 Notable cases 
People wey na dem be diagnosed as having FTD (dem often refer to as Pick's disease in cases of de behavioral variant) dey include:

 John Berry (1963–2016), American hardcore punk musician den founding member of de Beastie Boys
 Clancy Blair (1960–2024), American developmental psychologist den professor
 Don Cardwell (1935–2008), Major League Baseball pitcher
 Charmian Carr (1942–2016), wey play Liesl, from de Sound of Music, dem born Charmian Anne Farnon

 Jerry Corbetta (1947–2016), frontman, organist den keyboardist of American psychedelic rock band Sugarloaf
 Ted Darling (1935–1996), Buffalo Sabres television announcer

 Robert W. Floyd (1936–2001), computer scientist
 Lee Holloway (born 1982), computer scientist, co-founder of Cloudflare
 Colleen Howe (1933–2009), sports agent den ice hockey team manager, dem know as "Mrs. Hockey"

 Kazi Nazrul Islam (1899–1976) national poet of Bangladesh
 Terry Jones (1942–2020), Welsh comedian (Monty Python) den director
 Ralph Klein (1942–2013), former premier of Alberta, Canada

 Kevin Moore (1958–2013), English footballer
 Ernie Moss (1949–2021), English footballer
 Nic Potter (1951–2013), British bassist for Van der Graaf Generator
 Christina Ramberg (1946–1995), American painter wey associate plus de Chicago Imagists

 David Rumelhart (1942–2011), American cognitive psychologist
 Sir Nicholas Wall (1945–2017), English judge
 Bruce Willis (born 1955), American actor
 Mark Wirtz (1943–2020), pop musician, composer den producer
 Curtis Hanson (1945–2016), American film director, screenwriter, den producer

 References 

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External links

 Patient group

Category:Cognitive disorders
Category:Dementia
Category:Frontal lobe
Category:Temporal lobe
de:Frontotemporale Demenz
Category:Translated from MDWiki