Guillain–Barré syndrome

Guillain–Barré syndrome (GBS) be a rapid-onset muscle weakness wey be caused by de immune system wey dey damage de peripheral nervous system. Typically, both sides of de body be involved, den de initial symptoms be changes in sensation anaa pain often insyd de back along plus muscle weakness, wey dey begin insyd de feet den hands, often dey spread to de arms den upper body. De symptoms fi develop over hours to a few weeks. During de acute phase, de disorder fi be life-threatening, plus about 15% of people dey develop respiratory muscle weakness wey dey require mechanical ventilation. Sam be affected by changes insyd de function of de autonomic nervous system, wich fi lead to dangerous abnormalities in heart rate den blood pressure.

Although de cause be unknown, de underlying mechanism dey involve an autoimmune disorder insyd wich de body ein immune system mistakenly dey attack de peripheral nerves den dey damage dema myelin insulation. Sam time dis immune dysfunction be triggered by an infection anaa, less commonly, by surgery, den by vaccination. De diagnosis be usually based on de signs den symptoms thru de exclusion of alternative causes wey be supported by tests such as nerve conduction studies den examination of de cerebrospinal fluid. Der be chaw subtypes based on de areas of weakness, results of nerve conduction studies, den de presence of certain antibodies. Dem classify am as an acute polyneuropathy.

Insyd those plus severe weakness, prompt treatment plus intravenous immunoglobulins anaa plasmapheresis, togeda plus supportive care, dey lead to good recovery insyd de majority of cases. Recovery fi take weeks to years, plus about a third dey get sam permanent weakness. Globally, death dey occur in approximately 7.5% of patients. Guillain–Barré syndrome be rare, at 1 anaa 2 cases per 100,000 people every year.

Na dem name de syndrome after de French neurologists Georges Guillain den Jean Alexandre Barré, wey, togeda plus French physician André Strohl, describe de condition insyd 1916.

 References 

 External links 

 Information on GBS from UK Charity GAIN (Guillain–Barré and Associated Inflammatory Neuropathies)
 Information on GBS from NGO GBS/CIDP Foundation International
 Information on GBS from NGO EPODIN (European Patient Organization for Disimmune & Inflammatory Neuropathies)

Category:1976 health disasters
Category:Autoimmune diseases
Category:Cytomegalovirus-associated diseases
Category:Medical triads
Category:Myelin disorders
Category:Peripheral nervous system disorders
Category:Rare syndromes
Category:Syndromes wey dey affect de nervous system
Category:Diseases dem name after discoverers
Category:Translated from MDWiki