Paracetamol

Paracetamol, anaa acetaminophen, be a non-opioid analgesic den antipyretic agent dem use to treat fever den mild to moderate pain. E be a widely available over-the-counter drug dem sell under chaw brand names, wey dey include Tylenol den Panadol.

Paracetamol dey relief pain insyd both acute mild migraine den episodic tension headache. At a standard dose, paracetamol slightly dey reduce fever, though e be inferior to ibuprofen in dat respect den de benefits of ein use give fever be unclear, particularly insyd de context of fever of viral origins. De aspirin/paracetamol/caffeine combination sanso dey help plus both conditions wen de pain be mild wey na e be recommended as a first-line treatment give dem. Paracetamol be effective for pain after wisdom tooth extraction, buh e be less effective dan ibuprofen. De combination of paracetamol den ibuprofen dey provide greater analgesic efficacy dan either drug alone. De pain relief paracetamol dey provide insyd osteoarthritis be small den clinically insignificant. Evidence wey dey support ein use insyd low back pain, cancer pain, den neuropathic pain be insufficient. Paracetamol be de first-line treatment give pain den fever insyd pregnancy; na dem no establish causal association plus neurodevelopmental disorders, while untreated pain den fever fi harm de mommie den fetus.

In de short term, paracetamol be safe den effective wen na dem use as directed. Short term adverse effects be uncommon den similar to ibuprofen. Paracetamol be typically safer dan nonsteroidal anti-inflammatory drugs (NSAIDs) for long-term use. Dem sanso often dey use paracetamol insyd patients wey no fi tolerate NSAIDs like ibuprofen. Chronic consumption of paracetamol fi result insyd a drop in hemoglobin level, wey dey indicate possible gastrointestinal bleeding, den abnormal liver function tests. De recommended maximum daily dose give an adult be three to four grams. Higher doses fi lead to toxicity, wey dey include liver failure. Paracetamol poisoning be de foremost cause of acute liver failure insyd de Western world, den dey account for most drug overdoses insyd de United States, de United Kingdom, Australia, den New Zealand.

Na dem first make paracetamol insyd 1878 by Harmon Northrop Morse anaa possibly insyd 1852 by Charles Frédéric Gerhardt. E be de most commonly used medication for pain den fever insyd both de United States den Europe. E dey on de World Health Organization's List of Essential Medicines. Paracetamol be available as a generic medication, plus brand names wey dey include Tylenol den Panadol among odas. Insyd 2023, na e be de 112th most commonly prescribed medication insyd de United States, plus more dan 5million prescriptions. 

 References 

External links

Category:Acetanilides
Category:Analgesics
Category:Antipyretics
Category:Dermatoxins
Category:Drugs plus unknown mechanisms of action
Category:Endocannabinoid reuptake inhibitors
Category:Fatty acid amide hydrolase inhibitors
Category:Haleon
Category:Hepatotoxins
Category:Drugs wey Novartis develop
Category:Pesticides
Category:4-Hydroxyphenyl compounds
Category:World Health Organization essential medicines
Category:Over-the-counter drugs insyd de United States
Category:Translated from MDWiki