Dupuytren's contracture

Dupuytren's contracture (dem sanso call Dupuytren's disease, Morbus Dupuytren, Palmar fibromatosis den historically as Viking disease anaa Celtic hand) be a condition insyd wich one anaa more fingers cam permanently be bent insyd a flexed position. Dem name am after Guillaume Dupuytren, wey na first describe de underlying mechanism of action, wey be followed by de first successful operation insyd 1831 den publication of de results insyd The Lancet insyd 1834. E usually dey begin as small, hard nodules just under de skin of de palm, then dey worsen over time til de fingers no longer fi be fully straightened. While typically no be painful, sam aching anaa itching, anaa pain, fi be present. De ring finger follow by de little and middle fingers be most commonly affected. E fi affect one anaa both hands. De condition fi interfere plus activities such as preparing chow, writing, putting de hand insyd a tight pocket, putting on gloves, anaa shaking hands.

Der be no single cause for Dupuytren's contracture, buh der be chaw risk factors wey be associated plus an increased risk of developing am. De cause be unknown buh fi get a genetic component. Risk factors dey include family history, alcoholism, smoking, thyroid problems, liver disease, diabetes, previous hand trauma, den epilepsy. De underlying mechanism dey involve de formation of abnormal connective tissue within de palmar fascia. Diagnosis usually dey base on physical examination. Insyd sam cases imaging fi be indicated.

Insyd 2020, na de World Health Organization reclassify Dupuytren's (dem term palmar-type fibromatosis) as a specific type of tumor insyd de category of intermediate (locally aggressive) fibroblastic den myofibroblastic tumors.

Initial treatment be typically plus cortisone dem inject into de affected area, occupational therapy, den physical therapy. Among those wey worsen, clostridial collagenase injections anaa surgery fi be tried. Radiation therapy fi be used to treat dis condition. Na de Royal College of Radiologists (RCR) Faculty of Clinical Oncology conclude say radiotherapy be effective insyd early stage disease wich na progress within de last 6 to 12 months. De condition fi recur at sam time after treatment; e then sanso fi be treated. E be easier to treat wen de amount of finger bending be more mild.

Na dem once believe say Dupuytren's most often occur insyd white males over de age of 50 wey na dem think to be rare among Asians den Africans. E sam times be called "Viking disease," since na e often be recorded among those of Nordic descent. Insyd Norway, na about 30% of men over 60 years old get de condition, while insyd de United States about 5% of people be affected at sam point insyd time. Insyd de United Kingdom, na about 20% of people over 65 get sam form of de disease.

More recent den wider studies dey show de highest prevalence insyd Africa (17 percent) den Asia (15 percent).

Notable cases
 Chelsea Handler (born 1975), American comedian, actress den writerDana Leigh Smith: Hand Trouble? It Might Be THIS, womenshealthmag.com,  May 8, 2013
 Tim Herron (born 1970), American golfer
 Prince Joachim of Denmark (born 1969)
 Joanne Harris (born 1964), British authorNew Treatment Straightens Bent Fingers without Surgery , springgroup.org
 Tommy Lee (born 1962), American drummer
 Ally McCoist (born 1962), Scottish footballer
 Jonathan Agnew (born 1960), English cricketerJonathan Agnew: How my Viking ancestry nearly cost me my hands, telegraph.co.uk, 27 July 2017
 John Elway (born 1960), American football player
 Nanci Griffith (1953–2021),  American singer, guitarist, den songwriter
 Bill Murray (born 1950), American actor den comedian Dupuytren Disease and the Dupuytren Research Group , dupuytrens.org
 Bill Nighy (born 1949), British actor
 Mitt Romney (born 1947), American politician
 Misha Dichter (born 1945), American pianist
 José Feliciano (born 1945), Puerto Rican musician, singer den composerJoe Bosso: José Feliciano on the Enduring Ecstasies of Guitar Playing, guitarplayer.com, May 8, 2020
 Bill Frindall (1939–2009), English cricket player den statistician, wey na dem amputate a fingerJonathan Agnew, Aggers' Ashes (London, 2011), page 103
 David McCallum (1933–2023), Scottish/British actor den musicianDavid McCallum, imdb.com
 Paul Newman (1925–2008), American actor den film director"Local MD Will Speak on Crippling Hand Disease Which Affects Many Seniors," Sun-Sentinel, July 15, 2014
 Margaret Thatcher (1925–2013), Prime Minister of de United Kingdom
 Ronald Reagan (1911–2004), American President den actorDrug Approved to Treat Hand-Crippling Syndrome, Delthia Ricks, Chicago Tribune, March 17, 2010.
 Andrew Wyeth (1917–2009), American visual artist
 Frank Sinatra (1915–1998), American singer, actor, den producer
 Samuel Beckett (1906–1989), Irish novelist, poet and playwright
 Max Planck (1858–1947), German theoretical physicist den Nobel Prize laureate
 Dave Mustaine (born 1961), American guitarist

 References 

 External links 

Category:Disorders of fascia
Category:Rare diseases
Category:Soft tissue disorders
Category:Translated from MDWiki