Cannabidiol

Cannabidiol (CBD) be a phytocannabinoid, one of 113 cannabinoids dem identify insyd Cannabis, along plus tetrahydrocannabinol (THC), wey e dey account for up to 40% of de plant ein extract. Medically, e be an anticonvulsant dem use take treat multiple forms of epilepsy."Epidiolex – cannabidiol solution". DailyMed. August 26, 2020. Archived from the original on February 25, 2021. Retrieved September 11, 2020. Na dem discover am insyd 1940 den, as of 2024 clinical research for CBD included studies wey relate to de treatment of anxiety, addiction, psychosis, movement disorders, den pain, buh der be insufficient high-quality evidence dat CBD be effective for dese conditions. Dem dey sell CBD as an herbal dietary supplement wey dem promote am plus yet unproven claims of particular therapeutic effects.

Dem fi take cannabidiol internally insyd chaw ways, wey dey include by inhaling cannabis smoke anaa vapor, dey swallow am by mouth, den thru use of an aerosol spray into de cheek. E fi be supplied as CBD oil wey dey contain CBD per as de active ingredient (wey dey exclude THC anaa terpenes), CBD-dominant hemp extract oil, capsules, dried cannabis, anaa prescription liquid solution. CBD no get de same psychoactivity as Tetrahydrocannabinol (THC), wey e fi modulate de psychoactive effects of THC for de body top if both be present. Conversion of CBD to THC fi occur wen CBD be heated to temperatures between 250–300 °C, potentially wey dey lead to ein partial transformation into THC.

 Chemistry 
At room temperature, cannabidiol be a colorless crystalline solid. Insyd strongly basic media den de presence of air, e be oxidized to cannabinodiol (CBND) den a quinone wey be called HU-331. Under acidic conditions e dey cyclize to THC, wich sanso dey occur during pyrolysis, den during smoking. Na de synthesis of cannabidiol be accomplished by chaw research groups.

 Overview 
CategoryCompoundDescriptionAnalog4'-Fluorocannabidiolfluorinated cannabidiol derivative of CBDAnalogCannabidibutol (CBDB)an analogue to tetrahydrocannabutol (THCB)AnalogCannabidiol diacetatea semi-synthetic derivative of CBDAnalogCannabidiol dimethyl ether (CBDD)an analog of CBDAnalogH4-CBDa structural analog of CBDAnalogHU-320a structural analog of CBDAnalogKLS-13019a structural analog of CBDHomologue8,9-Dihydrocannabidiol (H2CBD)synthetic derivative of CBDHomologueCannabidiorcol (CBD-C1)a homologue of CBDHomologueCannabidiphorol (CBDP)de heptyl-homologue of CBDHomologueCannabidivarin (CBDV)a homologue of CBDHomologueCBD-DMHsynthetic homologue of CBDHomologueΔ-6-Cannabidiola positional isomer of CBDIsomerAbnormal cannabidiola synthetic regioisomer of CBDMetabolite7-Hydroxycannabidiol (7-OH-CBD)an active metabolite of CBDPrecursorCannabidiolic acid (CBDA)precursor to CBD

Biosynthesis
class=skin-invert-image|upright=1.3|thumb|Cannabidiol den THC biosynthesis

Cannabis dey produce CBD thru de same metabolic pathway as THC, til de next to last step, wer CBDA synthase dey perform catalysis instead of THCA synthase.

Isomerism
class=skin-invert-image|center|250px|Cannabidiol numbering

Cannabidiol's 7 double bond isomers den dema 30 stereoisomers Formal numbering  Terpenoid numbering  Number of stereoisomers  Natural occurrence Convention on Psychotropic Substances Schedule  Structure Short name  Chiral centers  Full name  Short name  Chiral centers Δ-Cannabidiol  1 den 3  2-(6-isopropenyl-3-methyl-5-cyclohexen-1-yl)-5-pentyl-1,3-benzenediol  Δ-Cannabidiol  1 den 3  4  No  Unscheduled 150px Δ-Cannabidiol  1, 3 den 6  2-(6-isopropenyl-3-methyl-4-cyclohexen-1-yl)-5-pentyl-1,3-benzenediol  Δ-Cannabidiol  1, 3 den 4  8  No  Unscheduled 150px Δ-Cannabidiol  1 den 6  2-(6-isopropenyl-3-methyl-3-cyclohexen-1-yl)-5-pentyl-1,3-benzenediol  Δ-Cannabidiol  3 den 4  4  Yes  Unscheduled 150px Δ-Cannabidiol  1 den 6  2-(6-isopropenyl-3-methylenecyclohex-1-yl)-5-pentyl-1,3-benzenediol  Δ-Cannabidiol  3 den 4  4  No  Unscheduled 150pxΔ-Cannabidiol1 den 62-(6-isopropenyl-3-methyl-2-cyclohexen-1-yl)-5-pentyl-1,3-benzenediolΔ-Cannabidiol3 den 44YesUnscheduled150px Δ-Cannabidiol  3 den 6  2-(6-isopropenyl-3-methyl-1-cyclohexen-1-yl)-5-pentyl-1,3-benzenediol  Δ-Cannabidiol  1 den 4  4  No  Unscheduled 150px Δ-Cannabidiol  3  2-(6-isopropenyl-3-methyl-6-cyclohexen-1-yl)-5-pentyl-1,3-benzenediol  Δ-Cannabidiol 1  2  No  Unscheduled 150px

Pyrolysis
Insyd de typical operating temperature range of e-cigarettes (250–400 °C (482–752 °F)), 25–52% of CBD be transformed into oda chemical substances: Δ9-THC, Δ8-THC, cannabinol den cannabichromene as predominant pyrolysates. From a chemical point of view, CBD insyd e-cigarettes fi be considered a precursor of THC.

Synthetic derivatives
Numerous synthetic derivatives of CBD be known, wey na dem be researched for generally similar applications as CBD einself.
 References 

 External links 

 CBD: What Does the Science Say?

 Dunning B (May 18, 2021). "Skeptoid #780: CBD for Everything: Cannabidiol is sold as an additive to just about every kind of product you can imagine. Why?". Skeptoid. Retrieved May 21, 2022.

Category:5-HT1A agonists
Category:Analgesics
Category:Anti-inflammatory agents
Category:Anticonvulsants
Category:Cyclohexenes
Category:CYP2D6 inhibitors
Category:CYP3A4 inhibitors
Category:Drugs plus unknown mechanisms of action
Category:Endocannabinoid reuptake inhibitors
Category:Experimental anxiolytics
Category:Natural phenols
Category:Opioid receptor negative allosteric modulators
Category:Orphan drugs
Category:Phytocannabinoids
Category:Resorcinols
Category:Transient receptor potential channel modulators
Category:Translated from MDWiki