Huntington's disease

Huntington's disease (HD), dem sanso know am as Huntington's chorea, be an incurable neurodegenerative disease wey mostly dem inherit. E typically dey present as a triad of progressive psychiatric, cognitive, den motor symptoms. De earliest symptoms be often subtle problems plus mood anaa mental/psychiatric abilities, wich dey precede de motor symptoms give chaw people.Dayalu P, Albin RL (February 2015). "Huntington disease: pathogenesis and treatment". Neurologic Clinics. 33 (1): 101–114. doi:10.1016/j.ncl.2014.09.003. PMID 25432725. De definitive physical symptoms, wey dey include a general lack of coordination den an unsteady gait, eventually dey follow. Over time, de basal ganglia region of de brain gradually cam be damaged. De disease be primarily characterized by a distinctive hyperkinetic movement disorder dem know am as chorea. Chorea classically dey present as uncoordinated, involuntary, "dance-like" body movements wey cam be more apparent as de disease advances. Physical abilities gradually worsen til coordinated movement cam turn difficult wey de person be unable to talk. Mental abilities generally dey decline into dementia, depression, apathy, den impulsivity at times.Frank S (January 2014). "Treatment of Huntington's disease". Neurotherapeutics. 11 (1): 153–160. doi:10.1007/s13311-013-0244-z. PMC 3899480. PMID 24366610. De specific symptoms dey vary somewat between people. Symptoms usually dey begin between 30 den 50 years of age, wey fi start for any age buh be usually seen around de age of 40. De disease fi develop earlier for each successive generation insyd. About eight percent of cases start before de age of 20 years, wey ebe known as juvenile HD, wich typically dey present plus de slow movement symptoms of Parkinson's disease rather dan those of chorea.
References

External links

 HOPES project Archived 27 August 2020 at the Wayback Machine – Stanford University's HD information project
 HDBuzz – HD research news written by scientists in plain language
 HD Drug Works – news about current treatments and planned trials


Category:Autosomal dominant disorders
Category:Disorders wey dey cause seizures
Category:Diseases dem name after discoverers
Category:Extrapyramidal den movement disorders
Category:Genetic diseases den disorders
Category:Trinucleotide repeat disorders
Category:Translated from MDWiki