X-linked intellectual disability

X-linked intellectual disability dey refer to medical disorders wey be associated plus X-linked recessive inheritance wey result in intellectual disability.

As plus chaw X-linked disorders, males be more heavily affected dan females. Females plus one affected X chromosome den one normal X chromosome tend to get milder symptoms.

Unlike chaw oda types of intellectual disability, de genetics of dese conditions relatively be well understood. Na dem estimate der be ~200 genes involved insyd dis syndrome; of dese ~na 100 be identified. Chaw of dese genes be found on de short 'p' arm of de chromosome, den duplications at Xp11.2 be associated plus de syndromic form of de condition.

X-linked intellectual disability dey account for ~16% of all cases of intellectual disability insyd males.

 Syndromes 
Several X-linked syndromes dey include intellectual disability as part of de presentation. Dese include:

 Coffin–Lowry syndrome
 DDX3X syndrome
 MASA syndrome
 MECP2 duplication syndrome
 Mental retardation den microcephaly plus pontine den cerebellar hypoplasia
 X-linked alpha thalassemia mental retardation syndrome

 References 

Category:Intellectual disability
Category:X-linked recessive disorders