Sildenafil

Sildenafil, dem sell under de brand name Viagra among odas, be a medication dem use to treat erectile dysfunction den pulmonary arterial hypertension. E sanso sam times be used off-label for de treatment of certain symptoms insyd secondary Raynaud's phenomenon. E be unclear if e be effective for treating sexual dysfunction insyd females. Dem fi take am orally (dem swallow by mouth), intravenously (injection into a vein), anaa thru de sublingual route (dem dissolve under de tongue). Onset wen dem take am orally be typically within twenty minutes den dey last for about two hours.

Common side effects dey include headaches, heartburn, den flushed skin. Caution be advised insyd those plus cardiovascular disease. Rare buh serious side effects dey include vision problems, hearing loss, den prolonged erection (priapism) wey fi lead to damage to de penis. Sildenafil for no be taken by people on nitric oxide donors such as nitroglycerin, as dis fi result in a serious drop in blood pressure.

Sildenafil dey act by blocking phosphodiesterase 5 (PDE5), an enzyme wey dey promote breakdown of cGMP, wich dey regulate blood flow insyd de penis. E dey require sexual arousal to work, den no dey by einself cause anaa increase sexual arousal. E sanso dey result in dilation of de blood vessels insyd de lungs.

Na Pfizer originally discover de medication insyd 1989 while dem dey look for a treatment give angina. Na dem approve am for medical use insyd de United States den insyd de European Union insyd 1998. Insyd 2023, na e be de 151st most commonly prescribed medication insyd de United States, plus more dan 3million prescriptions. E be available as a generic medication. Insyd de United Kingdom, e be available as a pharmacy medicine.

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Category:Erectile dysfunction drugs
Category:Lactams
Category:HERG blocker
Category:PDE5 inhibitors
Category:Drugs wey Pfizer develop
Category:Phenol ethers
Category:4-Methylpiperazin-1-yl compounds
Category:Products dem introduce insyd 1998
Category:Pyrazolopyrimidines
Category:Ethoxy compounds
Category:Translated from MDWiki