Down syndrome

Down syndrome anaa Down's syndrome, dem sanso know am as trisomy 21, be a genetic disorder wey be caused by de presence of all anaa part of a third copy of chromosome 21. E be usually associated plus developmental delays, mild to moderate intellectual disability, den characteristic physical features.

De parents of de affected individual be usually genetically normal. De incidence of de syndrome dey increase plus de age of de mommie, from less dan 0.1% for 20-year-old mommies to 3% for those of age 45. E be believed make e occur by chance, plus no known behavioral activity anaa environmental factor wey dey change de probability. Usually, babies get 23 chromosomes from each parent for a total of 46, whereas insyd Down syndrome, a third 21st chromosome be attached. De extra chromosome be provided for conception as de egg den sperm combine. Insyd 1–2% of cases, de additional chromosome be added insyd de embryo stage wey e dey impact per sam of de cells insyd de body; dis be known as Mosaic Down syndrome. Translocation Down syndrome be anoda rare type. Down syndrome fi be identified during pregnancy by prenatal screening, wey be followed by diagnostic testing, anaa after birth by direct observation den genetic testing. Since de introduction of screening, Down syndrome pregnancies be often aborted (rates wey dey vary from 50 to 85% wey dey depend on maternal age, gestational age, den maternal race/ethnicity).

Signs den symptoms
upright=1.2|thumb|A boy from Somalia plus Down syndrome 
Those plus Down syndrome nearly always get physical den intellectual disabilities. As adults, dema mental abilities be typically similar to those of an 8- anaa 9-year-old. For de same time, dema emotional den social awareness be very high. Dem fi get poor immune function den generally reach developmental milestones for a later age. Dem get an increased risk of a number of health concerns, such as congenital heart defect, epilepsy, leukemia, den thyroid diseases.

CharacteristicsPercentageCharacteristicsPercentageMental impairment 99%Abnormal teeth 60%Stunted growth 90%Slanted eyes 60%Umbilical hernia 90%Shortened hands 60% Increased skin on back of neck 80%Short neck 60%Low muscle tone 80%Obstructive sleep apnea 60%Narrow roof of mouth 76%Bent fifth finger tip 57%Flat head 75%Brushfield spots insyd de iris 56%Flexible ligaments 75%Single transverse palmar crease 53%Proportionally large tongue 75%Protruding tongue 47%Abnormal outer ears 70%Congenital heart disease 40%Flattened nose 68%Strabismus ≈35%Separation of first and second toes 68%Undescended testicles 20%
Insyd popular culture
thumb | Chris Burke, an actor plus Down syndrome, born insyd 1965

Individuals
Jamie Brewer be an American actress den model. She best be known for ein roles insyd de FX horror anthology television series American Horror Story.
Sofía Jirau be a Puerto Rican model plus Down syndrome, wey dey work plus designers den media outlets such as Vogue Mexico, People, den Hola!.
Chris Nikic be de first person plus Down syndrome make he fini an Ironman Triathlon. Na dem award am de Jimmy V Award for Perseverance for de 2021 ESPY Awards.
Grace Strobel be an American model den de first person plus Down Syndrome make she represent an American skin-care brand. Na she first join Obagi insyd 2020, wey she continue be an Ambassador give de brand as of 2022.

Television den film
Life Goes On be an American drama television series wey be aired for American Broadcasting Company (ABC) from September 12, 1989, to May 23, 1993.Life Goes On (TV Series 1989–1993) - IMDb, retrieved 2023-04-01 De show dey center for de Thatcher family wey dey live insyd suburban Chicago: Drew, ein wifey Libby, den dema children Paige, Rebecca den Charles. Charles, dem call Corky for de show top wey be portrayed by Chris Burke, na he be de first major character on a television series plus Down syndrome.
Struck by Lightning, an Australian film by Jerzy Domaradzki wey dey star Garry McDonald, be a comedy-drama wey dey depict de efforts by a newly appointed physical education teacher make dem introduce soccer to a specialized school give youths plus Down syndrome.
Champions (2023) be a film wey dey star four main actors plus Down syndrome: Madison Tevlin, Kevin Iannucci, Matthew Von Der Ahe den James Day Keith.Champions (2023) - IMDb, retrieved 2023-04-01 E be an American sports comedy film wey be directed by Bobby Farrelly insyd ein solo directorial debut, from a screenplay wey Mark Rizzo wrep. 
Born This Way be an American reality television series wey be produced by Bunim/Murray Productions wey dey feature seven adults plus Down syndrome wey dem work hard make dem achieve goals den overcome obstacles. Na de show receive a Television Academy Honor insyd 2016.
The Peanut Butter Falcon be a 2019 American comedy-drama film wey Tyler Nilson den Michael Schwartz wrep den direct, insyd dema directorial film debut, den dey star Zack Gottsagen, Shia LaBeouf, Dakota Johnson den John Hawkes.The Peanut Butter Falcon (2019) - IMDb, retrieved 2023-04-01 De plot dey follow a young man plus Down syndrome wey escape from an assisted living facility, so say he go follow ein dream of make he be a wrestler, wey he befriend a wayward fisherman on de run. As de two men form a rapid bond, a social worker attempt make dem track dem.

Music
De Devo song "Mongoloid" be about sam bro plus Down syndrome.
De Amateur Transplants song "Your Baby" be about a fetus plus Down syndrome.

Toys
Insyd 2023, na Mattel release a Barbie doll plus characteristics of a person wey get Down syndrome as a way make dem promote diversity.
 References 

 Read further 




 External links 

 Down's syndrome by the UK National Health Service


Category:Autosomal trisomies
Category:Genetic syndromes
Category:Syndromes plus intellectual disability
Category:Syndromes wey dey affect de gastrointestinal tract
Category:Syndromes wey dey affect de heart
Category:Syndromes wey dey affect de nervous system
Category:Syndromes plus craniofacial abnormalities
Category:Syndromic autism
Category:Diseases dem name after discoverers
Category:Translated from MDWiki