Naloxone

Naloxone, dem sell under de brand name Narcan among odas, be an opioid antagonist, a medication dem use to reverse anaa reduce de effects of opioids. For example, dem dey use am to restore breathing after an opioid overdose. Effects dey begin within two minutes wen dem give intravenously, five minutes wen dem inject into a muscle, den ten minutes as a nasal spray. Naloxone blocks the effects of opioids for 30 to 90 minutes.

Administration to opioid-dependent individuals fi cause symptoms of opioid withdrawal, wey dey include restlessness, agitation, nausea, vomiting, a fast heart rate, den sweating. To prevent dis, dem fi give small doses every few minutes til dem reach de desired effect. Insyd those plus previous heart disease anaa wey dey take medications wey negatively dey affect de heart, na further heart problems occur. Der be limited data on naloxone ein safety during pregnancy. Naloxone be a non-selective den competitive opioid receptor antagonist. E dey reverse de depression of de central nervous system den respiratory system wey be caused by opioids.

Na dem patent naloxone insyd 1961 wey dem approve am for opioid overdose insyd de United States insyd 1971.  E dey on de World Health Organization's List of Essential Medicines.

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