Helicobacter pylori

Helicobacter pylori, dem previously know as Campylobacter pylori, be a gram-negative, flagellated, helical bacterium. Mutants fi get a rod anaa curved rod shape wey dey exhibit less virulence. Na dem think ein helical body (from wich de genus name Helicobacter dey derive) e evolve to penetrate de mucous lining of de stomach, wey ein flagella help, den thereby establish infection. While na chaw earlier reports of an association between bacteria den de ulcers exist, such as de works of John Lykoudis, na e be insyd 1983 per wen na dem formally describe de bacterium for de first time insyd de English-language Western literature as de causal agent of gastric ulcers by Australian physician-scientists Barry Marshall den Robin Warren. Insyd 2005, na dem award de pair de Nobel Prize insyd Physiology anaa Medicine for dema discovery.

Infection of de stomach plus H. pylori no dey necessarily cause illness: over half of de global population be infected, buh chaw individuals be asymptomatic. Persistent colonization plus more virulent strains fi induce a number of gastric den non-gastric disorders. Gastric disorders secof infection dey begin plus gastritis, anaa inflammation of de stomach lining. Wen infection be persistent, de prolonged inflammation go cam be chronic gastritis. Initially, dis go be non-atrophic gastritis, buh de damage cause to de stomach lining fi bring about de development of atrophic gastritis den ulcers within de stomach einself anaa de duodenum (de nearest part of de intestine). At dis stage, de risk of developing gastric cancer be high. However, de development of a duodenal ulcer dey confer a comparatively lower risk of cancer. Helicobacter pylori be class 1 carcinogenic bacteria, den potential cancers dey include gastric MALT lymphoma den gastric cancer. Infection plus H. pylori be responsible for an estimated 89% of all gastric cancers wey be linked to de development of 5.5% of all cases cancers worldwide. H. pylori be de bacterium per dem know to cause cancer.

Extragastric complications wey be linked to H. pylori dey include anemia secof either iron deficiency anaa vitamin B12 deficiency, diabetes mellitus, cardiovascular illness, den certain neurological disorders. An inverse association sanso been claimed plus H. pylori get a positive protective effect against asthma, esophageal cancer, inflammatory bowel disease (wey dey include gastroesophageal reflux disease den Crohn's disease), den odas.

Some studies dey suggest say H. pylori dey play an important role insyd de natural stomach ecology by e dey influence de type of bacteria wey colonize de gastrointestinal tract. Oda studies dey suggest say non-pathogenic strains of H. pylori fi beneficially normalize stomach acid secretion, den regulate appetite.

Insyd 2023, na dem estimate say about two-thirds of de world ein population be infected plus H. pylori, e be more common insyd developing countries. Na de prevalence decline insyd chaw countries secof eradication treatments plus antibiotics den proton-pump inhibitors, den plus increased standards of living. 

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Category:Bacteria dem describe insyd 1989
Category:Conditions dem diagnose by stool test
Category:Infectious causes of cancer
Category:Pathogenic bacteria
Category:Translated from MDWiki