Granulovacuolar degeneration

Degeneraasiyoŋ granulovakuolar ko feeñde e nder neeruuji ɓuuɓɗi ɗi ngalaa no mbayi, ɗi keewi ndiyam (vacuoles) ina njogii ɓuuɓri poroteyiin denndaandi. Granulovacuoles ɓuri heewde feeñde ko e neronuuji piramidaaji hippokampus. Ɗe ina tawee e mawɓe ɓe ngalaa dementia, kono ina ɓeydoo heewde e ñawu Alzheimer e tauopathies goɗɗe. E nder ñawu Alzheimer, granulovacuoles ina ɓeydoo heewde e nokkuuji ngaandi ceertuɗi, tee keeweendi mum en ina jokkondiri e tolno tauopati, patoloji plaque Abeta, e anjiyopati amiloid cerebral. Annduɓe immunohistochimique kollitii wonde ƴiiƴam nder ɓalndu ina waɗi poroteyiinuuji keewɗi, ina heen poroteyiin tubulin tau, TDP-43 e goɗɗi. Hay so tawii granulovakuoles e nafoore mum en e golle ina pamɗi haa jooni, ɗe nanndiraama e vakuoles otofaaji

Degeneraasiyoŋ granulovakuolar (kuɗol ina hollita ɓuuɓri wootiri) e nder sitoplasma neeruuji piramidaaji e nder mbaydi hippokampal neɗɗo mo ñawu Alzheimer. Hematoksilin e mbaydi eosin. Barme njuuteendi = 20 mikroo (0,02mm).

 Tuugnorgal Although granulovacuoles and their functional significance are still poorly understood, they have been compared to autophagic vacuoles