Total complement activity

Golle timmuɗe (TCA) ko jarribooji keewɗi baɗɗiiɗi e golle njuɓɓudi timmundi e nder neɗɗo.

 Testeeji 
Teskuyaaji timmuɗiC4 (C)FB (A)C3CH50Sarɗiiji·↓↓↓PSG, C3 NeF AA↓·↓·HAE, C4D···↓TCPD↓·/↓↓↓SLE↑↑↑↑f

Teskuyaaji keewɗi ina mbaawi huutoreede ngam fooɗtude TCA, kono ɓurɗo huutoreede e dow ko teskuyaaji CH50..  Fooyre woɗnde ina waɗi ƴeewndo liposome (LIA),  feere tiitoonde tuuba gooto,method.e feere ƴiiƴam-plaquemethod.

 CH50 Laawol ngol 
Fooyre ndee tuugii ko e mbaawka serum neɗɗo ngam ustude ƴiiƴam baali, ɓuuɓɗam, ɓuuɓɗam, ɓuuɓɗam (IgG rabbit).  Serum neɗɗo oo ina ɓuuɓnee haa 50% e ƴiiƴam baali ɗii ɓuuɓtoo.  Ɗum winndaa ko e CH50.

CH50 ina ƴeewtoo laawol timmungol kiiɗɗo, ɗum noon ina ɗaɓɓi geɗe C1-C9 gollotooɗe.

 CH50 Firo 
So tawii neɗɗo ina jogii geɗe ballitooje ŋakkeende walla ŋakkeende golle, ndeen e fuɗɗoode ɗe ina usta mbaawka limtude eritrosit.  Ko ɗum waɗi kala dillugol e serum maɓɓe ina ɓeyda bonnude ngool gollal, ɗum firti ko dillugol les ngol ina foti yettaade ngam heɓde 50% e mbaawka.  E ko feewti heen, kala neɗɗo mo tolnooji komplement walla golle mum ɓeydii, ina jogori jogaade CH50 toowɗo nde tawnoo ɓeydagol dillugol ina foti yettaade 50% e maande lyse.

Ustagol CH50 ina waawi yiyeede e cirrhosis walla hepatitis[6] sabu ŋakkeende peewnugol komplement e nder heeñere.  Ina waawi kadi yiyeede e lupus erythematosus systemique sabu ɓeydagol huutoraade geɗe ballitooje sabu patoloji ngonka autoimmune.  Ina ustoo e sahaa njiyaagu (kono wonduɓe e ñawu nguu ina njogii nafoore no feewi hakkunde njiyaagu).[7]

Ɓeydagol teddeendi CH50 firti ko timmugol mum en ina heewi golle so renndinaama e no woorunoo, ɗum ina waawi yiyeede e kanseer walla e kolitis ulceratif[citation needed].

Neɗɗo ina waawi firtude nafoore CH50 wondude e nafoore faktoruuji timmuɗi neɗɗo ngam wallitde anndude etioloji.  Yeru, so tawii e neɗɗo ina jogii teddeendi C3/C4 no woorunoo kono CH50 ina usta, ɗuum ina waawi hollitde ŋakkeende laawol timmungol tawa so neɗɗo ina jogii teddeendi C3 e CH50 tokosiri ina waawi hollitde ngonka autoimmune ko wayi no lupus erythematosus systemique.

Anndugol hemolitik laawol goɗngol ("AH50") ina waawi huutoreede e jokkondire ngam hollitde so tawii won ŋakkeende laawol timmungol (CH50 e AH50 fof ina famɗi), ŋakkeende laawol kiiɗɗo (CH50 ina famɗi, AH50 ina woodi) walla ŋakkeende laawol goɗngol (AH50 ina famɗi, CH50 ina famɗi).

 Tuugnorgal