oeg/software_benchmark_v2 huggingface dataset:
Concerning the numerical stability of Algorithm 5 we notice that various suggestions have been made in the literature to calculate solutions of Riccati equations in a numerically reliable way (see e.g. Laub (1979, 1991), Paige and van Loan (1981), van Dooren (1981), Mehrmann (1991) and Abou-Kandil and Bertrand (1986) for a more general survey on various types of Riccati equations).
• PROJECT_NAME_model.txt: text file containing the structural and reduced form of the dynamic system; • inputPROJECT_NAME.m: binary MATLAB file containing (processed) input to the project; • PROJECT_NAME_validation.txt: text file containing all the information about the various stages of model validation; • PROJECT_NAME_output.txt: text file containing all the output produced; and • outputPROJECT_NAME.m: binary MATLAB file containing all the project's output.
Further, many successful commercial ICT standards started out by securing a temporary bundling or at least a licensing cooperation with one of the major players in a tied subsector: Microsoft's success in the 1980s came after (and as a direct consequence of) its alliance with IBM in the 1970s; one of the first strategic actions of Sun's deployment of Java in 1995 was a licensing agreement with Microsoft (Garud et al. 2002); the three successful mobile operating systems (Android iOS Windows Mobile were established by major vendors of other (tied) standards, the Google search engine (in combination with other Google online services) in case of Android and PC operating systems in case of Apple's iOS and Microsoft's Windows Mobile
Thus, starting from a feasible solution, we solve for g 1 using g (−1) as data in the first firm's optimization problem (where g (−1) means all firms' generation capacities except for firm 1's), then solve for 17 Recall that any LCP can be written as the problem of finding a vector x ∈ n such that x = q + M · y, x T · y = 0, x ≥ 0, and y ≥ 0, where M ∈ n×n , q ∈ n , and y ∈ n .
where υ ij represents the technical efficiency of the ith farmer; Z 1 denotes years of farming experience of the ith farmers; Z 2 denotes years of formal education; Z 3 is a dummy variable scored 1 if farmer belongs to farmers' association and zero otherwise; Z 4 is a dummy variable scored 1 if farmer uses improved cassava cutting and zero otherwise; Z 5 is a dummy variable scored 1 if farmer has access to markets and zero otherwise; Z 6 is a dummy variable scored 1 if farmer uses mechanized cassava-processing technology and zero otherwise; Z 7 is dummy variable score 1 if farmer has access to credit and zero otherwise, Z 8 is a dummy variable scored 1 if farmer has off-farm income and zero otherwise; Z 9 is a dummy variable scored 1 if farmer sells cassava to processors and zero otherwise and Z 10 is a dummy variable scored 1 if farmer plants cassava as a sole crop and zero otherwise.
To verify this, I carried out a simple Monte Carlo experiment generating Y by (2a) and (2b), one X variable drawn from a uniform distribution on the interval [Á1,1], r 0 a 0 b 0 u 0 l 0 0:25; s 2 00.01, N060, and a spatial weights matrix W corresponding to the corners of the seams in a soccer ball (in Matlab known as the Bucky Ball).
Here we use the best and weighted average parameter sets in bootstrap to calculate individuals' welfare without discretizing them, and then we calculate Theil's first and second indices and generalized entropy index with γ ¼ −1/2 using R package "ineq." Here we use generalized entropy index with γ ¼ −1/2 because the metric entropy measure we use is the same entropy metric with γ ¼ −1/2.
(JEL C91, D80, D83) (Levitt and List 2007) Kahneman and Tversky (1979, 265) (Battalio, Kagel, and Jiranyakul 1990; Harrison 2006; Holt and Laury 2002, 2005) (Beattie and Loomes 1997; Kühberger, Schulte-Mecklenbeck, and Perner 2002; Wiseman and Levin 1996) Taylor (2013) cognitive ability tend to make choices exhibiting hypothetical bias.
Mouselab is a method of processtracing used by psychologists for nearly three decades, and economists more recently, because it is lower-cost alternative to eye-tracking and provides analogous measures (Costa-Gomes and Crawford 2006; Costa-Gomes, Crawford, and Broseta 2001; Gabaix et al. 2006; Johnson et al. 2002; Payne, Bettman, and Johnson 1988; Reutskaja et al. 2011).
PanelWhiz currently has more than 300 users and currently supports international datasets such as the German SOEP, the British BHPS (or its successor, the UK Understanding Society study), the American PSID and Current Population Survey-National Bureau of Economic Research, the American Survey of Income and Program Participation, the South African National Income Dynamics Study, in addition to the HILDA Survey, MABEL, LSAC, LSIC and CASiE.
To cite just two authoritative observers, Donald Knuth, author of The Art of Computer Programming and inventor of TeX has stated that "I don't think I would have been able to create TeX if the present [patent] climate had existed in the 1970s," while erstwhile entrepreneur Bill Gates has opined that "If people had understood how patents would be granted when most of today's ideas were invented and had taken out patents, the industry would be at a complete standstill today."
Similarly, using (1): z t+1 =ẑ t+1,t + Gη t+1 + 0 (y t+1 −ŷ t+1,t ), wherê z t+1,t = K + 0ŷt+1,t + L−1 l=0 l z t−l , (C3) and using (12): r t+1 =r t+1,t + B 0 (y t+1 −ŷ t+1,t ) + B 1 (z t+1 −ẑ t+1,t ) + e t+1 , wherê r t+1,t = α + B 0ŷ t+1,t + B 1ẑ t+1,t + L l=2 B l z t+2−l .
13 Obviously, it is even harder to solve the cross-border anticommons tragedy at the international level resulting from fragmented sovereignty, as Adam Smith observed in 1776 in The Wealth of Nations: "The navigation of the Danube is of very little use to the different states of Bavaria, Austria and Hungary, in comparison of what it would be if any of them possessed the whole of its course till it falls into the Black Sea"(Smith 1789: book 1, chapter 3, paragraph 8; Buchanan and Yoon 2000; Heller 2008: 182, 183).
Ellison (2013, p. 68) describes his data as follows: "The dataset includes citation records of almost all faculty at the top 50 economics departments in the 1995 NRC ranking. Faculty lists were taken from the departmental websites in the fall of 2011. Citation data for each economist were collected from Google Scholar Economists were classified into one or more of 15 subfields primarily by mapping keywords appearing in descriptions of research interests on departmental or individual websites. Slightly less than one-half of economists are classified as working in a single field."
We use the following statistics in testing the goodness of fit: Chi square (c²) (Bollen 1989); normed fit index (NFI) (Bentler, Bonett 1980); comparative fit index (CFI) (Bentler 1990); root mean square residual (RMR) (Hu, Bentler 1995); and root mean square error of approximation (RMSEA) (Browne, Cudeck 1993).
However, RMSEA (0.88 > 0.08) demonstrates a poor fit of the proposed model for our data (Jöreskog, Sörbom 1989) -besides there are three insignificant paths: Social Role → Attitude (pvalue = 0.281 > 0.05), Materialism → Attitude (pvalue = 0.218 > 0.05), and Falsity → Attitude (pvalue = 0.176 > 0.05).
In this regard, we notice that c² value is insignificant (c²/ df = 1.076, pvalue > 5%), the normed fit index is higher than 0.9 (NFI = 0.982), the comparative fit index is higher than 90% (CFI = 0.999), the root mean square residual is less than 0.05 (RMR = 0.032), and the root mean square error of approximation is less than 0.08 (RMSEA = 0.020) (Jöreskog, Sörbom 1989; Hu, Bentler 1995; Bentler 1992; MacCallum et al. 1996).
Negotiations are consequently being conducted by means of the electronic media, starting with simple phone calls, through the videoconferences, online chatting, with the use of software negotiation support system (NSS), ending with the electronic negotiation system (ENS) -a software that employs Internet technologies and is deployed on the web for the purpose of facilitating, organizing, supporting and/or automating activities undertaken by the negotiators and/or the third party (Kersten and Lai 2007).
The average Q-scores and column scores (the fraction of entirely correctly columns) in manually defined core blocks are reported in Table 2. For Q-score measurement of alignment quality, the Wilcoxon signed rank tests show thatMUMMALS with best-performing models (HMM_3_3_1 or HMM_1_3_1) is statistically better than other programs, albeit MUMMALS does not have the highest average Q-score.
While HMM_1_1_0, used mainly as a control, has the same model structure as the one in ProbCons the other four models (HMM_1_1_1, HMM_1_3_1, HMM_3_1_1 and HMM_3_3_1) incorporate more match states, which take into account residue substitution differences in unaligned regions and aligned core blocks, as well as local structural differences in aligned core blocks.
Briefly, bone marrow was isolated and collected in a single cell suspension at a concentration of 100 ϫ 10 6 cells/ml in sterile cell sort media, containing sterile 1ϫ Hank's balanced salt solution without phenol red, 2% heat-inactivated fetal bovine serum, 10 mmol ⅐ l Ϫ1 ⅐ ml Ϫ1 HEPES buffer, and 30 l/ml gentamicin (Gibco, Grand Island, NY).
Sorted FCs (purity was Ն95%) were incubated with Fc receptor block (anti-CD16/CD32) before staining with lineage-specific markers: anti-CD11 FITC, CD11b APC, CD14 FITC, NK1.1 FITC, DX5 FITC, B220 PerCP, Gr-1 APC, and CD19 APC, as previously described (4).
ECs were plated in 24-well plates, with 25 ϫ 10 3 cells/well in EC medium with supplements for 24 h and then cultured in EC medium without supplements but containing 0.5% fetal bovine serum (starvation medium) for an additional 24 h (basal control) or stimulated with either VEGF-A (20 ng/ml; Peprotech, London, U.K.) in starvation medium or MSCconditioned medium (supernatant from 24-h MSC cultures in starvation medium).
Islets of Langerhans (10,000 -30,000 islet equivalents) were incubated within 2-5 days after isolation with 0.5 ϫ 10 6 CT orange-labeled ECs (EC islets) or with 0.25 ϫ 10 6 CT green-labeled MSCs in combination with 0.25 ϫ 10 6 CT orange-labeled ECs (EC-MSC islets) in a total volume of 500 l.
Total DNA (Picogreen; Invitrogen), interleukin (IL)-8, IL-6 (R&D Systems, Oxford, U.K.), monocyte chemotactic protein-1 (MCP-1) (Serotec, Oxford, U.K.), tissue factor (TF) (Imubind; American Diagnostica, Stamford, CT), and insulin (Mercodia) contents were measured on a Gyrolab workstation (Gyros, Uppsala, Sweden), and the values were divided with total DNA.
Composite and control islets were fixed in 4% paraformaldehyde for 30 min, washed in PBS, and incubated in 20% sucrose/PBS overnight at 4°C, then embedded in optimal cutting temperature medium (Tissue Tech; Sakura Finetek, Zoeterwoude, Netherlands), frozen, cryosectioned, and permeabilized in 0.3% Triton X-100/PBS for 15 min.
Stocks of Discosoma species-derived red fluorescent (DsRed)-expressing lentiviral vectors (Lv-DsRed) were produced by cotransfection of three plasmids, the viral core packaging construct pCMVdeltaR8.74, the VSV-G envelope protein vector pMDG.2, and the transfer vector pRRLsinPPThCMV-MCS-wpre containing DsRed cDNA (a gift of W.T. Hendriks), into human embryonic kidney 293T cells as previously described (19,20).
In the present work, MS analysis revealed that SuSy1 from the nodules of M. truncatula is also phosphorylated at Ser11, the same residue identified as phosphorylated in soybean and homologous to Ser15 in maize SuSy1 (VHS 11 LKER; spectra can be found in ProMEX database http://promex.mpimp-golm.mpg.de/home.shtml).
The structure was solved by molecular replacement with Phaser (McCoy, 2007) using ADP-bound yeast Hsp90-N (PDB code: 1AMW) and the solution structure of human Sgt1-CS domain (PDB code: 1RL1) as search models, built using COOT (Emsley and Cowtan, 2004), and refined with CNS in PHENIX (Adams et al, 2002), using NCS restraints.
Tissue ROS levels were measured by the conversion of nonfluorescent 2Ј, 7Ј-dichlorofluorescein-diacetate (DCFDA) to the highly fluorescent 2Ј, 7Ј-dichlorofluorescein (DCF) in the presence of esterases and ROS (26) (for details, see the supplementary methods available in an online appendix at http://dx.doi.org/10.2337/db08-0079).
For microarray analysis, samples were further purifi ed with Trizol (Invitrogen), followed by use of the RNeasy Mini kit (QIAGEN) according to the manufacturer ' s protocols. Biotin-labeled cRNA was synthesized using the High Yield RNA transcript labeling kit (BioArray; Enzo Biochem, Inc.) and hybridized to human genome U133A and U133B microarray chips according to the manufacturer ' s instructions (Aff ymetrix).
Genes were judged to be significantly up-regulated if the expression levels for a least one corresponding probe set (as determined by Entrez Gene identifi ers) satisfi ed the following three criteria: (1) a p-value of ≤ 0.05 from the right-tailed paired Student ' s t test on the log of the stimulated and control expression levels; (2) a geometric mean fold change of ≥ 1.7; and (3) at most, one of the calls for the stimulated expression levels failed to be present. Custom software written in the Interactive Data Language (IDL ITT Visual Information Solutions, Boulder, CO) was used to conduct this analysis. The data discussed in this publication have been deposited in the National Center for Biotechnology Information ' s Gene Expression Omnibus and are accessible through the GEO Series accession no.
The fi nal Ramachandran statistics were as follows: DM1 TCR, 92.5% (most favored region) and 98.6% (allowed region); HLA-B*4402 EENL , 97.6% (most favored region) and 100% (allowed region); HLA-B*4403 EENL , 97.9% (most favored region) and 99.5% (allowed region); HLA-B*4405 EENL , 97.1% (most favored region) and 99.2% (allowed region); and DM1 TCR -HLA-B*4405 EENL , 86.3% (most favored region) and 97.5% (allowed region).
CD8 + T cells from 4 -8-wk-old Tcra Ϫ / Ϫ × P14 TCR transgenic (Taconic), C57BL/6J WT, or Tbx21 Ϫ / Ϫ (The Jackson Laboratory) mice were purifi ed ( > 95% purity) by negative selection (Invitrogen) from pooled spleen and lymph node cells.
Although a fraction of the KO DP cells silenced CD4 expression after activation, the ratio of SP/DP cells in each enriched population remained constant thereafter, and we did not observe any major diff erences between these two populations throughout the culture period, indicating that in terms of eff ector CTL diff erentiation and under our culture conditions, Runx3 Ϫ / Ϫ CD8 + T cells that also coexpress CD4 are indistinguishable from those that do not.
CD4 ϩ T-cells were plated on membrane inserts (8-m pore size) in serum-free RPMI 1640, and cell migration was assayed using Transwell chambers (Corning), in the presence or absence of purified porcine kidney DPP-IV (32.1 units/mg; 100 mU/ml final concentration; provided by Dr. Hans-Ulrich Demuth, Probiodrug, Halle, Germany) (28) Ϯ DPP-IV inhibitor (100 mol/l).
Probing of the membranes was performed with antibodies to phosphop38 mitogen-activated protein kinase (MAPK) (threonine-180/tyrosine-182), p38 MAPK, phospho-p42/44 MAPK (threonine-202/tyrosine-204), p42/44 MAPK, phospho-stress-activated protein kinase/Jun NH 2 -terminal kinase (SAPK/JNK) (threonine-183/tyrosine-185), phospho-protein kinase B (PKB) (serine-473), phospho-PKB (threonine-308), PKB, and ␤-actin (Cell Signaling Technology, Beverly, MA).
The pre-sequence amphipathicity influences the targeting of MITS1 At present, the biological function of MITS1 remains unknown, but publicly available databases (NCBI and TAIR)indicate MITS1 as a putative actin-binding protein, with an 'actinin-type actin-binding domain signature 1' that is similar to a region involved in the actin-binding activity of the chloroplastic actin-binding protein, CHUP1 (Oikawa et al., 2003).
Although stability of the a-helix is important for maintenance of mitochondrial import (Hammen et al., 1996; Heard and Weiner, 1998), in vivo mutagenesis analysis of a plant presequence from the b-subunit of the F 1 -ATPsynthase from Nicotiana plumbaginifolia showed that the N-terminal helical structure of the pre-sequence is necessary but not sufficient for efficient mitochondrial import, and that its hydrophobic residues play an essential role in in vivo mitochondrial targeting (Duby et al., 2001).
The microcarriers were washed once in 50 ml washing solution and three times in 50 mL ddH 2 O and directly added to a poly(fluoro acrylate) PCR-bag (Welch Fluorocarbon, Dover, NH; 100 Â 100 mm; thickness: 50 mm) containing 10 ml PCR reagent [ddH 2 O containing: 1 M betaine; 5% DMSO; 1 Â PCR buffer; 0.1 mM BaCl 2 ; 0.2 mM of each dNTPs; 0.2 mM primer M13F (-21); 0.2 mM primer GA 9 ; 700 U Taq polymerase; Genscript, Piscataway, NJ].
All gas bubbles were removed, the PCR-bag was air-tightly sealed, and cycled on a custom-built flat-screen thermocycler that consisted of a chamber flanked by aluminum plates which contained channels for water circulation for temperature control (32 cycles; 90 s at 968C; 180 s at 558C) exerted by two waterbaths (Huber Polystat CC3; set to 968C and 568C, respectively).
For determination of the relative motilities (relative molecular weight [M r ]), marker polypeptides were also electrophoresed with protein samples, in a non contiguous lane to avoid contaminations, and blotted to nitrocellulose, namely: rabbit muscle phosphorylase b (97.4 kDa), bovine serum albumin (66.2 kDa), hen egg-white albumin (45 kDa), bovine carbonic anhydrase (31 kDa), soybean trypsin inhibitor (21.5 kDa), and hen egg white lysozyme (14.4 kDa) (Bio-Rad Laboratories, Richmond, CA).
T cell populations secreting both IFN- and IL-10 are found in both mouse and man (Trinchieri, 2007; O'Garra and Vieira, 2007; Haringer et al., 2009) and have been implicated in regulating the immune response to persistent infections with intracellular pathogens (Trinchieri, 2001; Anderson et al., 2007; Jankovic et al., 2007).
For DC co-stimulatory molecule staining, splenic DCs were cultured either alone or with an equal number of CD4 + T cells from naive or peptide-treated mice in the presence of 100 µg/ml of Ac1-9[4K] and, where indicated, with 10 µg/ml of anti-IL-10R (clone 1B1.3a) or isotype control (BD) antibody.
Reference sequence, which was downloaded from Los Alamos HIV Sequence Database (Los Alamos National Laboratory, Los Alamos, NM, USA), was used to identify the subtype of obtained sequence; Genetic distance between sequences was assessed using the software MEGA 3.1 Kimura 2-parameter (Center for Evolutionary Functional Geromics The Biodesign Institute, Tempe, AZ, USA), 12 and phylogenetic tree was reestablished with neighbor-joining method.
Web-based user interfaces, such as the Biology Workbench (Subramaniam, 1998), PISE (Letondal, 2001), wEMBOSS (Sarachu and Colet, 2005), Galaxy (Giardine et al., 2005), GenePattern (Reich et al., 2006), MOWServ (Navas-Delgado et al., 2006), the New Generation Biology Workbench (Rifaieh et al., 2007), BioManager (Cattley and Arthur, 2007) and BioExtract (Lushbough et al., 2008), simplify the access to powerful computer resources by providing a familiar graphical-based environment for inexperienced users and by saving them from installing software on their own computer.
In contrast with these tools which focus on the execution of programs, and where the users can often interactively chain analyses, GBrowse MOBY (Wilkinson, 2006) and Seahawk (Gordon and Sensen, 2007b) propose data-centric solutions where the user can explore a set of BioMOBY (Wilkinson, 2004) services to analyse a set of given data, with edition, navigation and visualization components which fully exploit the composite nature of BioMOBY objects.
A number of tools facilitates the publication and management of BioMOBY services, such as MoSeS (http:// biomoby.open-bio.org/CVS_CONTENT/moby-live/Java/docs/ Moses-generators.html) and the BioMOBY dashboard (http:// biomoby.open-bio.org/CVS_CONTENT/moby-live/Java/docs/ Dashboard.html).
Receptor Binding Assay-Freshly thawed plasma membrane preparations from transiently transfected HEK293 cells expressing GLP-1R (20 g protein/well) were pulled through a 25-gauge needle three times and diluted in assay buffer (50 mM HEPES, 5 mM MgCl 2 , 5 mM EGTA, 0.005 volume % Tween 20, pH 7.4).
Some experiments were conducted on a spinning disc confocal microscope (CARV; BD) consisting of an inverted microscope (TE2000; Nikon) with a 60× 1.4 NA Plan-Apochromat oil lens and a 60× 1.2 NA Plan-Apochromat water lens, the CARV spinning disc head, and a camera (ORCA-ER; Hamamatsu), controlled by MetaMorph software (MDS Analytical Technologies).
Among EMTB-3G-expressing anucleate cytoplasts, we scored all cases in which either no furrows or discrete furrows formed (omitting cases in which the cytoplast strangled itself into the shape of a balloon animal, which we took to be a sign of poor health) as follows: for each centrosome pair in focus, we measured, at the time corresponding to anaphase, the distance between centrosomes and divided by the distance from the midpoint between them to the cell surface.
PCR products were formed in a reaction volume of 15 μL that contained 30 ng of template DNA, 0.5 units of AmpliTaq Gold Taq polymerase (Applied Biosystems, Foster City, CA), 1.5 μL of MgCl2-free 10× buffer (Applied Biosystems), 0.9 μL of 25 mmol/L MgCl2, 0.5 μL of each specific primer 5'-AAGGCTCAGCTGAACCTGGTT-3' and 5'-CTGCT-GAAACAAATGAAACCC-3' for CTLA4 +49A/G and 0.75 μL of deoxyribonucleoside triphosphates (2.5 mmol/L of each deoxyribonucleoside triphosphate).
Glu-fibrinopeptide B (Glu-fib) was used as an internal standard for mass calibration at 1 pmol µl −1 in 90% acetonitrile containing 0.1% formic acid.Abbreviations CID, collision-induced dissociation; ER, endoplasmic reticulum; ES, electrospray; GC-MS gas chromatography-mass spectrometry; GPI, glycosylphosphatidylinositol; GPI-AP, glycosylphosphatidylinositol anchored protein; HF hydrogen fluoride; MS, mass spectrometry; MS/MS, tandem mass spectrometry; PMAAs, partially methylated alditol acetates; sVSG, soluble variant surface glycoprotein; T. brucei, Trypanosoma brucei.
The samples were mixed with loading buffer (95% formamide, 25 mM EDTA and 5 mg/ml blue dextran) and denatured for 2 min at 90 C. The samples were loaded onto a 12% polyacrylamide gel (25 Â 25 Â 0.03 cm) [20 ml 12% polyacrylamide/7 M urea with 100 ml 10% ammonium persulphate (Sigma Aldrich) and 10 ml 100% TEMED (Fluka)] and separated for 1 h at 20 W. The gels were exposed to a Phosphoimaging screen (Science Imaging Scandinavia IP-MS2325) for $1 h before analysis on a Phosphoimager using the Image Reader and Image Process software.
After washing with Tween-containing PBS, the sample was treated with 10 ml of DAPI (4 0 ,6-diamidino-2-phenylindole dihydrochloride, 10 mg/ml) for 1 min for staining DNA, and covered with one drop of mountain medium (1 mg/ml p-phenylenediamine and 90% glycerol in PBS, pH 9.0).
PET images were reconstructed in GE Advance using a 128 ϫ 128 matrix with a 30-cm field of view (FOV) in three-dimensional (3D) mode and Filtered Back Projection (FBP) reconstruction, in Siemens HRϩ using 128 ϫ 128 matrix with zoom two (28.8 cm FOV) in 3D mode and FBP reconstruction and in PET-CT using 128 ϫ 128 matrix with 35 cm FOV in 3D mode and Iterative Ordered Subset Expectation Maximization (OSEM) reconstruction (VUEPoint).
For mtDNA quantification, the quantitative real-time (q)PCR reactions were done with 25 ng total DNA used as template and normalizing the mt-Cytb gene amplification level (primer sequences: 5 0 -GCTTTCCACTTCATCT TACCATTTA-3 0 and 5 0 -TGTTGGGTTGTTTGATCC TG-3 0 ) against the nuclear b-actin gene (primer sequences: 5 0 -GGAAAAGAGCCTCAGGGCAT-3 0 and 5 0 -GAAGA GCTATGAGCTGCCTGA-3 0 ).
Given the dramatic pace of expansion in experimental and bioinformatics data pertaining to TA systems in the last 10 years and the likely impending avalanche triggered by next-generation sequencing-facilitated prokaryoticand metagenomic-sequencing projects, we have created aPostgreSQL database of Type 2 TA systems, known as TADB (http://bioinfo-mml.sjtu.edu.cn/TADB/), that provides for ready access, analysis, manipulation and exploitation of this invaluable biological information.