who killed both the Lord Jesus and their own prophets, and drove us out, and didn't please God, and are contrary to all men;
Killed the Lord Jesus ... The New Testament account of the opposition to Jesus that culminated in his heartless crucifixion lies behind these brief words.  There was no extenuation of guilt in those who through deceit, suborned testimony, mob violence and bitter hatred contrived through intimidation and political pressure the crucifixion of the Lord of glory. Terrible as that was, however, it was not the last straw.  The straw that broke the camel's back, as far as God's dealings with Israel were concerned, took place right there in Thessalonica, where they forbade that the gospel of God be preached to Gentiles.  That did it!  That "filled up" the measure of their sins, and judgment soon fell.