May the God of peace himself sanctify you completely. May your whole spirit, soul, and body be preserved blameless at the coming of our Lord Jesus Christ.
sanctify you wholly: The setting apart for divine service can never be half-hearted or partial. We must be sanctified through and through or not at all. It should also be noted that sanctification is not the accomplishment of a moment but a process that will continue throughout life. There is a sense in which the Thessalonians are already sanctified (saints, 3:13), but it is Paul’s prayer that sanctification "might extend to the whole man in every part" (Hogg and Vine 203).