Though they dig into Sheol, there my hand will take them; and though they climb up to heaven, there I will bring them down.
The ancients conceived of Sheol as under the surface of the earth, so digging into Sheol meant hiding in the ground. Neither would hiding in the forests and caves of Mt. Carmel, one of the highest elevations in Israel, or trying to conceal oneself on the floor of the sea be effective. The Lord would seek the guilty out and command His agents to execute them, even if that agent had to be a serpent in the sea (cf. Amos 5:19; Job 26:12-13; Psalms 74:13-14; Psalms 89:9-10; Isaiah 27:1; Isaiah 51:9-10). Note the chiastic structure in these verses going from down to up and back down, signifying all places.