So they sent the ark of God to Ekron. It happened, as the ark of God came to Ekron, that the Ekronites cried out, saying, They have brought about the ark of the God of Israel to us, to kill us and our people.
The Hebrew word translated "broke out" occurs only here in the Old Testament (1 Samuel 5:9). The Septuagint translators interpreted it accurately as "groin." These tumors were apparently most prominent in the groin area, hence the English translation "hemorrhoids." Tumors in the groin are a symptom of bubonic plague. Since the Philistines associated mice with this plague (1 Samuel 6:4-5), and mice carry bubonic plague, it seems clear that the hand of Yahweh sent this particular affliction on them.