Trimethoprim-Sulfamethoxazole (Bactrim DS)

==General information==
Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.Trimethoprim-Sulfamethoxazole (Bactrim DS) package insertTrimethoprim-Sulfamethoxazole (Bactrim DS) package insert (locally hosted backup)
Route: PO, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, or the prescribing information. 
==Patient drug information==
*Trimethoprim-Sulfamethoxazole (Bactrim DS) patient drug information (UpToDate)Trimethoprim-Sulfamethoxazole (Bactrim DS) patient drug information (UpToDate)
==Also known as==
*Generic names: cotrimazole, cotrimoxazole, co-trimoxazole, SMX / TMP, SMZ ( CO ), SMZ-TMP, SMZ-TMP DS, TMP-SMX, TMS
*Brand names:
Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms
Abacin 	Abactrim 	Abatrim 	Abditri 	Abetrim 	Actrim 	Aditrim 	Adrenol
Adtrim 	Aksotran 	Albrotran 	Albutrim 	Alcorim-F 	Alcot 	Allibac 	Altrim
Amazole 	Amoxazol 	Amtran 	Amtril 	Andoprim 	Anitrim 	Anprim 	Antibac
Antrim 	Antrimox 	Apcetrim 	APO-Bactotrim	APO Sulfatrim 	Apotrinelax 	Aptrim 	Aratran
Ascotran 	Aspen 	Assepium 	Atomexin 	Avlotrin 	B.S. 	BAC-Sulfitrin 	Bacfar
Bacidal 	Bacin 	Bacitran 	Bacmetrin 	Bacoprim 	Bacotrin 	Bacprotin 	Bacris
Bacsulfaprin 	Bacsultrim 	Bactar 	Bactazol 	Bactekod 	Bactelan 	Bacteracin 	Bacterial
Bacteric 	Bacteriof.klebs PN	Bacterol 	Bacticel 	Bactide 	Bactifor 	Bactigram 	Bactille-TS
Bactipront 	Bactiseptol 	Bactiver 	Bactoprim 	Bactoreduct 	Bactosain 	Bactostab 	Bactramin
Bactricid 	Bactricida 	Bactricin 	Bactrilac 	Bactrim 	Bactrimel 	Bactrin 	Bactrisan
Bactrium DS 	Bactrizole 	Bactron 	Bactronil 	Bactropin 	Bacxal 	Baczin 	Baczole
Baklinger 	Baktar 	Bakton 	Baktrisid DS 	Balkatrin 	Balkatrine 	Bantizol 	Basatin
Baserin 	Batrox 	Baxolex 	Belfactrin 	Bencole 	Benectrin 	Berlocid 	Bestofens
Bethaprim 	Bibakrim 	Bicotrim 	Bimatrim 	Bioprim 	Biosulten 	Biotran 	Biotrim
Biotrin 	Biprim 	Biseptin 	Biseptol 	Biseptrim 	Bismoral 	Bisultrim 	Bitrim
Blexon 	Boschtrim 	Brifeseptol 	Broncoflam 	Brongenit 	BS 	Canprim 	Caretran
Centrim 	Chemitrim 	Chemix 	Chemizol 	Chemoprim 	Chemotran 	Chemotrim 	Chemotrin
Chemozole 	Chromo-Z 	Cidaprim 	Cipaprim 	Ciplin 	Citrim 	Cladon 	Clinitran
Clonea 	Clotrizol 	CO-Sultrin 	CO-Tasian 	CO-Traisole 480 	CO-Trim-Tablinen	CO-Trimazole 	CO-Trimed
CO-Trimoxa 	CO-Trimoxazol 	Cobact 	Cobal ST 	Cocydal 	Cofatrim 	Colitran 	Colizole
Colotrim 	Comax 	Comazole 	Combact 	Combi-Methoxan 	Comixco 	Comox 	Comoxol
Contrimoxazole	Coprim 	Coprime 	Cosat 	Cosig 	Costazole 	Cosulf 	Cotoram
Cotran 	Cotrazen 	Cotrexel 	Cotri 	Cotribase 	Cotribene 	Cotribid 	Cotril
Cotrilin 	Cotrim 	Cotrimax 	Cotrimaxazol 	Cotrimaxazole 	Cotrimel 	Cotrimhexal 	Cotrimol
Cotrimox 	Cotrimoxazol 	Cotrimoxin 	Cotrimstada 	Cotripharm 	Cotrisul 	Cotrixyl-L 	Cotrizol
Cotrizole 	Cots 	Cozol 	Cozole 	Creptrim 	Curaprim 	Daiphen 	Decatrim
Deotrim 	Dertrin 	Dhatrin 	Dino-BAC 	Diseptyl 	Doctrim 	Dosatran 	Drilozole
Drossul 	Droxol 	Drylin 	Dubac 	Dumotrim 	Duobact 	Duobiocin 	Duoctrin
DUO Septol 	Duratrimet 	Dutran 	Dvaseptol 	Dynaprim 	Ectaprim 	Ectrin 	Editrim
Eduprim 	Eliprim 	Eroprim 	Erotrim 	Erphatrim 	Esbesul 	Escoprim 	Espectrin
Espectroprima 	Ethitrim 	Eurotrim 	Eusaprim 	Eutrim 	Exazol 	Fabubac 	Fakzol
Falprim 	Fameprim 	Fectrim 	Fedimed 	Fisat 	Flatran 	Flocot 	Forcrim
Forteprim 	Gamactrin 	Gatrima 	Genoctrin 	Genoxzole 	Gentrim 	Genzaprim 	Getrim
Globaxol 	Gobens Trim 	Graprima 	Groseptol 	Gunametrim 	Hatrix 	Helveprim 	Herixina
Hexaprim 	Hicot 	Hufacid 	Huma-Trimel 	Ibtrim 	Imcotran 	Imexim 	Inatrim
Infatrim 	Infectran 	Infectrim 	Infectrin 	Infesin 	Intrafort 	Introcin 	Irgagen
Isoprim 	Isotrim 	Japtrim 	Jasotrim 	Jenamoxazol 	Jestrim 	Justeprim 	K.B.famate
Kaftrim 	Kathrex 	Katrim 	Kaytran 	Kemocid 	Kemoprim 	Kentricid 	Kepinol
Kindoprim 	KO-Kure 	Kombina 	Kotazol 	Kotrimoksazol 	Krobactrol 	L-Trim 	Lacreozole
Lagatrim 	Lapikot 	Laratrim 	Larprim 	Lastrim 	Leotrim 	Leprim 	Lescot
Letus 	Lictora 	Lifactrin 	Lifzol 	Lisaprin 	Litrim 	Lobact 	Longasal
Lupectrin 	Lusaprim 	Lykaprim 	M-Moxa 	M-Trim 	Macprim 	Macromed 	Mactran
Madroxin 	Maktrim 	Martiprim 	Maxaprim 	Maxiprim 	Maxitrin 	Maxol 	Maxtrim
Maxzol 	Mazatrim 	Mebryn 	Medcotrim 	Mediprim 	Meditran 	Meditrim 	Medtrim
Megabroncoflam	Megaset 	Megatrim 	Meprim 	Meprotrin 	Methoprim 	Methotrin 	Metoprim
Metoprin 	Metoxiprim 	Metrim 	Metxaprim 	Mexaprim 	Mexazole 	Mezenol 	Micinovo
Micogyl 	Microbid 	Microcetim 	Microdyn 	Microsupos Amigdalar	Microtrim 	Mikotrim 	Mikrosid
Miratrim 	Moly 	Mortin 	Moxadden 	Moxalas 	Moxatrim 	Moxzole 	Mukadryl
Myctrim 	Naftran 	Napatrim 	Navatrim 	Necorzole 	Neoset 	Neotrim 	Netocur
Neuroprim 	Nicotrim 	Nilium 	Nodilon 	Nopil 	Norisep 	Nortrim 	Nortrime
Notrim 	Notrime 	Novactil 	Novidrine 	Novotrimel 	Novotrimox 	Novotrim Plus 	Novozole
Nucotrim 	Nufaprim 	Nuruzole 	Octil-S 	Octran 	Octrim 	Oecotrim 	Okatrim
Omegtrim 	Omnatrim 	Omsat 	Onetrim 	Oradin 	Orbak 	Orgastran 	Oribact
Ormoprim 	Ostrin Forte 	Otrim 	Ottoprim 	Oxaprim 	Pakzole 	Pantrim 	Patrim
Pehatrim 	Penetrin 	Pentrin 	Penzole 	Pharmatrim 	Pharmazol 	Phartex 	Pisatrina
Plurisul 	Polibatrin 	Politrim 	Polytran 	Pribac 	Primadex 	Primasul 	Primasulf
Primatrim 	Primavon 	Primazol 	Primazole 	Primotren 	Primox 	Primsulfon 	Primzole
Protrin 	Pulkrin 	Purbac 	Qiftrim 	Qiftrin 	Quimio-PED 	Quisulyn 	Rancotrim
Rasat 	Raseptol 	Ratrim 	Regtin 	Rematrim 	Renatrim 	Resprim 	Retrim
Rexaprim 	Ribatrim 	Rimazole 	Rimezone 	Rivoprim 	Rizol 	Rolprim 	Roubac
Roxtrim 	Roytrin 	Salgatran 	Saltrim 	Sanprima 	Saptrim 	Satrim 	Sbpa Trimeth Smeth
Scribcin 	Seematrim 	Seftrim 	Selectrin 	Semozol 	Sepiran 	Sepmax 	Septabid
Septazol 	Septazole 	Septerin 	Septinix 	Septiolan 	Septocid R + 	Septoprin 	Septra
Septran 	Septrin-S 	Septrin Paediatric	Servitrim 	Sigaprim 	Sigatrim 	Silpin 	Siltran
Sinatrim 	Sinersul 	Sinotrim 	Sisoprim 	Sistrim 	Sitrim 	Skytrin 	Smartrim
Soltrim 	Soptrim 	Sosetran 	Spectrem 	Spectrim 	Stan 	Stopan 	Strim
Suftrex 	Sulbacta 	Sulfagrand 	Sulfamer 	Sulfamet 	Sulfamethoprim 	Sulfametoxazol	Sulfaprim
Sulfarim 	Sulfatalpin 	Sulfaton 	Sulfatrim 	Sulfatropim 	Sulfawal-T 	Sulfinam 	Sulfoid Trimetho
Sulfometh 	Sulfonamide 	Sulfort 	Sulfotrim 	Sulfotrimin 	Sulftran 	Sulgotri 	Sulotrim
Sulphaprim 	Sulphathoprim 	Sulphatran 	Sulphatrim 	Sulphax 	Sulphytrim Forte	Sulprim 	Sulprimed
Sultase 	Sulthrim 	Sultiprim 	Sultorim 	Sultra 	Sultrex 	Sultrim 	Sultrima
Sultrimmix 	Sultrivon-F 	Sultropim 	Sumetoprim 	Sumetrolim 	Sumetrolin 	Sumitran 	Suntrim
Supim 	Supracombin 	Suprasulf 	Suprex 	Supribac 	Suprim 	Suprimass 	Suprin
Suptrex 	Suptrim 	Sutaprim 	Sutrim 	Sutrisan 	Suxprim 	Syltrifil 	Synac
Synastat 	Synbac 	Synco-Smzt 	Syndal 	Synermed 	Synerzole 	Synetra 	Synotrim
Syntoprim 	System 	Tabrol 	Tagremin 	Teof 	Terasulf 	Terbosulfa 	Teutrin
Theraprim 	Therasept 	Theratrim 	Thoprim 	Thriazol 	Torrid 	Tprim 	Trelibec
Trib 	Tricban 	Tricomox 	Tricot 	Trifides 	Triforam 	Trihexal 	Trim
Trima 	Trimaxazole 	Trimel 	Trimephar 	Trimeran 	Trimerazin 	Trimeril 	Trimesol
Trimesul 	Trimesulf 	Trimeta 	Trimethox 	Trimetoger 	Trimetop Duplo 	Trimetotal 	Trimetox
Trimetrin 	Trimetsol 	Trimexasol 	Trimexazol 	Trimexazole 	Trimexole-F 	Trimezol 	Trimezole
Trimfasul 	Trimidar M 	Triminex 	Trimocom 	Trimoks 	Trimosul 	Trimosulfa 	Trimoxavin
Trimoxazol 	Trimoxazole-BC 	Trimoxin 	Trimoxis 	Trimoxsul 	Trimozol 	Trimsul 	Trimzol
Triphimox 	Tripur 	Trisep 	Trisfides 	Trisolak Forte 	Trisolvat 	Trisul 	Trisulcom
Trisulfa 	Trisulfose 	Trisuprim 	Trisural 	Tritenk 	Tritosul 	Trixazol 	Trixzol
Trizole 	Tryseptolum 	Tytrim 	U-Prin 	Ulfaprim 	Ultrasept 	Ultrazole 	Ultrim
Unitran 	Uprina 	Urethrax 	Urodown 	Uroplus DS 	Urtium 	Utrin 	Versatrim
Virin 	Weiditrin 	Wiatrim 	Wiltran 	Wypal 	X-Trim 	XA-Zole 	Xazotrim
Xepaprim 	Xerazole 	Xeroprim 	Yekaprim 	Zactron 	Zamboprim 	Zantran 	Zaxol
Zecatrim 	Zeptra 	Zerrprim 	Zolebid 	Zolmed 	Zoltrijem 	Zoltrim 	Zultrop
==References==
Category:Drugs
Category:Combination drugs
Category:Oral medications
Category:Intravenous medications
Category:Antimetabolites
Category:Antifolates
Category:Antibacterials
Category:PCP prophylaxis
Category:FDA approved in 1973