Thuyanol

==﻿Nom de la substance==
Thuyanol, thujanol, 4-thujanol, thuyanol-4, thujanol-4
* cis-thuyanol-4, cis-4-thuyanol = cis-sabinène hydrate, hydrate de cis-sabinène, (Z)-sabinène hydrate, (Z)-hydrate de sabinène
* trans-thuyanol-4, trans-4-thuyanol = trans-sabinène hydrate, hydrate de trans-sabinène, (E)-sabinène hydrate, (E)-hydrate de sabinène
==Famille moléculaire==
Alcool monoterpénique bicyclique
==Source végétale==
* Huile essentielle de marjolaine, sarriette, serpolet, thym ct thuyanol (= thym à thuyanol), Pituranthos tortuosus
==Propriétés==
* Effet anti-infectieux Schmidt E, Wanner J, Hiiferl M, Jirovetz L, Buchbauer G, Gochev V, Girova T, Stoyanova A, Geissler M. Chemical composition, olfactory analysis and antibacterial activity of Thymus vulgaris chemotypes geraniol, 4-thujanol/terpinen-4-ol, thymol and linalool cultivated in southern France. Nat Prod Commun. 2012 Aug;7(8):1095-8. PMID 22978238
* Présenté comme immunostimulant (stimulerait la production des Ig A), inducteur d'apoptose (?) Krifa M, El Mekdad H, Bentouati N, Pizzi A, Ghedira K, Hammami M, El Meshri SE, Chekir-Ghedira L. Immunomodulatory and anticancer effects of Pituranthos tortuosus essential oil. Tumour Biol. 2015 Jul;36(7):5165-70. doi: 10.1007/s13277-015-3170-3. PMID 25663463
* Protège de la toxicité rénale et hépatique de l'acétate de plomb Ibrahim M. El-Ashmawy, Abeer F. El-Nahas, Osama M. Salama. Protective Effect of Volatile Oil, Alcoholic and Aqueous Extracts of Origanum majorana on Lead Acetate Toxicity in Mice. Basic & Clinical Pharmacology & Toxicology, Volume 97, Issue 4, pages 238–243, October 2005. , et de la toxicité de certains médicaments anticancéreux Kocaman AY, Istifli ES, Büyükleyla M, Rencüzogullari E, Topaktaş M. In vitro evaluation of the protective effects of 4-thujanol against mitomycin-C and cyclophosphamide-induced genotoxic damage in human peripheral lymphocytes. Toxicol Ind Health. 2013 Feb;29(1):23-37. PMID 22323477
* Antioxydant, diminue la peroxydation des lipides, l'hydrate de sabinène agit sur la prévention de la formation de peroxyde pendant le stockage des huiles alimentaires Quiroga PR, Asensio CM, Nepote V. Antioxidant effects of the monoterpenes carvacrol, thymol and sabinene hydrate on chemical and sensory stability of roasted sunflower seeds. J Sci Food Agric. 2015 Feb;95(3):471-9. doi: 10.1002/jsfa.6744. PMID 24841286
==Effet thérapeutique==
==Effets indésirables==
* Non cytotoxique ni génotoxique Kocaman AY, Rencüzoğulları E, Topaktaş M, Istifli ES, Büyükleyla M. The effects of 4-thujanol on chromosome aberrations, sister chromatid exchanges and micronucleus in human peripheral blood lymphocytes. Cytotechnology. 2011 Oct;63(5):493-502. PMID 21735266, mais une autre étude signale que le 4-thujanol a un effet clastogène significatif, donc génotoxique Kocaman AY, Rencüzoğulları E, Topaktaş M, Istifli ES, Büyükleyla M. The effects of 4-thujanol on chromosome aberrations, sister chromatid exchanges and micronucleus in human peripheral blood lymphocytes. Cytotechnology. 2011 Oct;63(5):493-502. doi: 10.1007/s10616-011-9372-7. PMID 21735266; PMCID: PMC3176937.
==Bibliographie==
* Bhatia SP, Letizia CS, Api AM. Fragrance material review on 4-thujanol. Food Chem Toxicol. 2008 Nov;46 Suppl 11:S295-6. PMID 18640194
* Johannes Novak, Christina Bitsch, Jan Langbehn, Friedrich Pank, Melpo Skoula, Yiota Gotsiou, Chlodwig M. Franz. Ratios of cis- and trans-Sabinene Hydrate in Origanum majorana L. and Origanum microphyllum (Bentham) Vogel. Biochemical Systematics and Ecology, Volume 28, Issue 7, August 2000, Pages 697-704
* Thompson JD, Chalchat JC, Michet A, Linhart YB, Ehlers B. Qualitative and quantitative variation in monoterpene co-occurrence and composition in the essential oil of Thymus vulgaris chemotypes. J Chem Ecol. 2003 Apr;29(4):859-80. PMID 12775148
Catégorie:Principes actifs