Sésamine

==Nom de la substance==
Sésamine
==Famille moléculaire==
Lignane
==Source végétale==
* Graines de sésame (Sesamum indicum), éleuthérocoque (Acanthopanax senticosus)
==Propriétés==
* Anti-inflammatoire
* Anti-allergique
* Anti-hypertenseur Matsumura Y, Kita S, Morimoto S, Akimoto K, Furuya M, Oka N, Tanaka T. Antihypertensive effect of sesamin. I. Protection against deoxycorticosterone acetate-salt-induced hypertension and cardiovascular hypertrophy. Biol Pharm Bull. 1995 Jul;18(7):1016-9. PMID 7581242, Kita S, Matsumura Y, Morimoto S, Akimoto K, Furuya M, Oka N, Tanaka T. Antihypertensive effect of sesamin. II. Protection against two-kidney, one-clip renal hypertension and cardiovascular hypertrophy. Biol Pharm Bull. 1995 Sep;18(9):1283-5. PMID 8845824, Matsumura Y, Kita S, Tanida Y, Taguchi Y, Morimoto S, Akimoto K, Tanaka T. Antihypertensive effect of sesamin. III. Protection against development and maintenance of hypertension in stroke-prone spontaneously hypertensive rats. Biol Pharm Bull. 1998 May;21(5):469-73. PMID 9635502, Nakano D, Itoh C, Takaoka M, Kiso Y, Tanaka T, Matsumura Y. Antihypertensive effect of sesamin. IV. Inhibition of vascular superoxide production by sesamin. Biol Pharm Bull. 2002 Sep;25(9):1247-9. PMID 12230131
* Neuro-protecteur
* Hépato-protecteur Akimoto K, Kitagawa Y, Akamatsu T, Hirose N, Sugano M, Shimizu S, Yamada H. Protective Effects of Sesamin against Liver Damage Caused by Alcohol or Carbon Tetrachloride in Rodents. Annals of Nutrition and Metabolism 1993, Vol. 37, No. 4, pp 218–224 
* Hypocholestérolémiant Hirose N, Inoue T, Nishihara K, Sugano M, Akimoto K, Shimizu S, Yamada H. Inhibition of cholesterol absorption and synthesis in rats by sesamin. J Lipid Res. 1991 Apr;32(4):629-38. PMID 1856608, effet potentialisé par l'alpha-tocophérol Nakabayashi A, Kitagawa Y, Suwa Y, Akimoto K, Asami S, Shimizu S, Hirose N, Sugano M, Yamada H. alpha-Tocopherol enhances the hypocholesterolemic action of sesamin in rats. Int J Vitam Nutr Res. 1995;65(3):162-8. PMID 8829994
* Inducteur d'apoptose dans le cancer de l'estomac Hibasami Hiroshige, Fujikawa Takahiko, Takeda Hidekatsu, Nishibe Sansei, Satoh Takashi, Fujisawa Toshiro, Nakashima Kunio. Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells. Oncology reports, 2000, vol. 7, no6, pp. 1213-1216, préventif du cancer du sein Hirose N, Doi F, Ueki T, Akazawa K, Chijiiwa K, Sugano M, Akimoto K, Shimizu S, Yamada H. Suppressive effect of sesamin against 7,12-dimethylbenz[a]-anthracene induced rat mammary carcinogenesis. Anticancer Res. 1992 Jul-Aug;12(4):1259-65. PMID 1386971, inhibiteur de la delta-5-désaturase dans la synthèse des acides gras poly-insaturés Sakayu Shimizu, Kengo Akimoto, Yoshifumi Shinmen, Hiroshi Kawashima, Michihiro SuganoetHideaki Yamada. Sesamin is a potent and specific inhibitor of Δ5 desaturase in polyunsaturated fatty acid biosynthesis. Lipids, Volume 26, Number 7 (1991), 512-516
* Stimule la synthèse des protéoglycanes par les chondrocytes, réduit l'inflammation Warunee Srisuthtayanont, Dumnoensun Pruksakorn, Prachya Kongtawelert and Peraphan Pothacharoen. Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes. BMC Complementary and Alternative Medicine 2017, 17:286 | Published on: 31 May 2017texte intégral
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
* Kong X, Ma M, Zhang Y, Weng M, Gong W, Guo L, Zhang J, Wang G, Su Q, Quan Z, Yang J. Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma. BMC Complementary and Alternative Medicine 2014, 14:254 (19 July 2014) Abstract texte intégral
Catégorie:principes actifs