nyuuzyou/wikis huggingface dataset:
Zolbetuximab (Vyloy)

==Mechanism of action==
From the NCI Drug Dictionary: A chimeric immunoglobulin G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, zolbetuximab specifically targets and binds to CLDN18.2 expressed on tumor cells. This may kill CLDN18.2-expressing tumor cells by antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), and inhibit cell proliferation.
==Diseases for which it is established==
*Gastric cancer
*Gastroesophageal junction adenocarcinoma
==History of changes in FDA indication==
*2024-10-18: Approved with fluoropyrimidine- and platinum-containing chemotherapy, for the first-line treatment of adults with locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumors are CLDN18.2 positive, as determined by an FDA-approved test. (Based on GLOWgastric & SPOTLIGHT)
==Also known as==
*Code names: GC-182, IMAB-362
*Generic name: zolbetuximab-clzb
*Brand name: Vyloy
Category:Drugs
Category:Intravenous medications
Category:Protein expression-specific medications
Category:Anti-CLDN18.2 antibodies
Category:Gastric cancer medications
Category:FDA approved in 2024
Zuberitamab (Anruixi)

==General information==
Class/mechanism: Anti-CD20 monoclonal antibody.
==Diseases for which it is used==
*Diffuse large B-cell lymphoma
==History of changes in NMPA indication==
*2023-09-13: Initial approval for the treatment of CD20-positive diffuse large B-cell lymphoma (DLBCL). (Based on Li et al. 2024)
==Also known as==
*Code name: HS-006
*Brand name: Anruixi
Category:Drugs
Category:Intravenous medications
Category:Protein expression-specific medications
Category:Anti-CD20 antibodies
Category:Diffuse large B-cell lymphoma medications
Category:NMPA approved in 2023
Category:Stub
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Obnoxion | BirdSim | Queen of Tarts | D.Angus | Reflux | Sm0t | AveraDiane‎ | GRANDNumberofMULTIPLES‎ | Scorptatious‎ | WanderingVagabond‎ | R.A.E.L.‎ | Yellow Yam Scam‎ | Saber‎ | Lacquer Head‎ | The Riddler | Toasty | TheMightyMonarch‎ | 2Spoopy | Sparklemilhouse‎ | Golly | Red | Strewth | Atsimuel | Ahavayeshana‎ | Meltychocolate‎ | Buster kitten‎ | Dollarpennypincher‎ | Venus | Megahertz | Coster | Ferls
2Spoopy

Because of the no contact we have with him, my brother and I are stuck. Our father has every right to go pay his respects to his own dad. If we show up at the funeral, knowing he'll be there, it voids our no contact agreement, and he can do whatever the fuck he wants.
I know all of our family is going to be talking shit about both of us for not being there, because hell, we've heard just a FEW of the lies he's been telling different people about why he went to jail that night. In one story, he blamed my fiance for hitting him and he went to a bar to cool off. Thing is, my fiancé was at his own house TEN hours away. He was the one that dropped fucking everything the night it went down and got his ass to my dad's house to help me and my brother move out. I couldn't even believe my ears when someone told me that's what they heard.
Some people have looked up the police reports and realized how full of shit he is. Some people... haven't.
I will never know, but I am fairly sure that my granddad went to his grave believing at least one of my dad's lies. I want too much of a coward to even talk to him after my dad's arrest, because I didn't want my granddad saying something about it to my dad and it starting something really bad really fast.
I'm pissed at my father. Why couldn't it have been him who died? My granddad was a much better father to me than him, even with all the flaws he did have.
I'm mostly pissed at myself for being too afraid to talk to my granddad and only talked to him through my grandma.
I know he was living on borrowed time. He was a heavy smoker who had gone through multiple heart surgeries in the last decade and just kept on smoking. He could be a real son-of-a-bitch sometimes; my dad had to learn it from somewhere. But it doesn't stop how I feel. He loved us, and we loved him.
I need a goddamn drink. 
==May 24th, 2015==
It's been 5 months since it all went down, and I thought it would stop being like this. I almost lost my little brother twice in December, once by his own hand, once by our father's. Held him down after I caught him searching the closet for a gun to turn on himself after a really bad round of verbal abuse from our father. In return, he put himself in the path of alcoholic dear old dad, soon after, to protect me. Had to fight off my dad to get his hands from my brother's neck. Cops were called for the first time. It should have happened a long time ago.
I got him and myself the fuck out of dodge and to a safe place with our mom. He's thriving now. I know there's nothing to be afraid of. If our father makes a peep for a year to him, he's going back in the slammer for a lot longer.
But when it gets quiet, I shake to the point of almost being sick. I'm still so scared I'll lose what family I have left.
I've been through PTSD before. I worked though it. I just thought I was stronger than this to go through it a second time. And I'm angry at myself for it.
This has been really fucking therapeutic. Thanks. 
Category:Fag
Ahavayeshana

My hair cutter died within the past five years due to a car accident. That alone was difficult enough for me to handle, because I'd been visiting her since I was fourteen years old. Even though she's ten years older than me, we developed a close bond as I grew older. She helped me through a lot of difficult times as a teenager, because she'd been through similar issues and could relate.
She finally announced she was going to divorce her husband, which came as an absolute shock, because she was regularly attending church and trying to be a devout Christian. She regularly participated in charities, too; she did a lot of good for the town. Looking back I should have realized the signs were screaming nothing was right in her life, and she was trying to put on a good act. Perhaps she was trying to convince herself? I honestly don't know.
Not long after she filed for separation, she started dating another man. She showed me a couple of pictures of him on her phone. She drastically lost weight due to stress, picked up smoking after having quit for a decade, and started talking about psychics. She would have been hard pressed to even acknowledge knowing a psychic, considering she was trying to be a loyal Christian. Generally speaking her behavior became more erratic (not because of the psychic, mind you)--She became more forgetful and nervous. Obviously she was under a lot of stress and wasn't having a good relationship with her young daughters.
While I was in the psychiatric ward, two hours away, someone came in for a couple of days. He looked oddly familiar and I couldn't put my finger on it; it had been several months since I'd seen her, let alone his pictures. When I found out his name, I asked him if he was dating -----? He became suspicious and asked me why? I apologized for freaking him and explained how I knew her. He must have decided he could trust me, because he opened up a little bit to me. I'm not going to go into details, but we got along very well.
After I left I didn't get to talk to her again. I found out six months later she passed away in an accident. That in itself wasn't what was so hard to cope with--It sucks; I was upset. I am hoping she finally found peace at last if there truly is an afterlife. She moved with her boyfriend and didn't really notify any of us where she was going; it wasn't even that that upset me. She probably just had to do it.
I started snooping around FaceBook one evening and found out her husband was remarried immediately after her passing. This is what upset me: Was he having an affair behind her back and tried to make her feel guilty so he wouldn't have to deal with it? I mean the marriage was within a few months; she'd barely just announced her divorce seven or eight months earlier. Did he really find a new love of his life that quick? Or was there something else going on?
Category:Fag
Atsimuel

I'm not really comfortable with this, but shit, since my mental health team are either incompetent or apathetic (and that's not just my opinion, the local NHS Trust has terrible independent review scores when it comes to mental health) I literally don't have any other option.
Basically, I'm fucked. In the past six years since everything started I've only gotten worse, and it's gotten to the point that I can barely leave the house. I'm 23 now, and it just feels like my life is being eaten away. I've pretty much exhausted every kind of therapy and nothing's worked, and I've lost count of how many different medications I've been put on. I've dropped out of like four different colleges in the past six years. I managed to last about a year and a half at work, which was a fucking miracle, but that couldn't last either - it was probably nearly two years ago that I quit.
I could talk about what I've been diagnosed with, but to cut a long story short, the problem is simply that I hate myself. Like, really, really hate myself. I hate most aspects of my personality and I completely despise how ugly I am, and I how I come across to people. I have a pretty bad self harm problem, so my arm's pretty fucked up and scarred. I've made a massive effort to change all those things, but i can throw as many different affectations up as I want, people can still sense the same dweeby sub-social shithead I was when I was at school . Maybe. I don't know. I just want to be someone else. I have nothing to show for my life. My cousin, who's the same age, is getting married in a few months. That's going to be fun for me. Except, of course, I don't think I'm going to be able to stay alive that long anyway, so swings and roundabouts I guess.
You know, I'm gonna stop here. It's all just a tangled ball of shit and I could write a whole wall of text about my problems, and no-one wants to see all my dirty laundry. Besides, I'm starting to sound like when the Sluthaters raided minus all the rampant axe-crazy misogyny.
TL;DR, my avatar has never seemed so appropriate.
Category:Fag
AveraDiane

I am having a life crisis, especially since I graduated college last year.
First off, I feel worthless about my degree. I have a bachelor's degree in history with a minor in gender studies. I keep trying to be positive over everything, but it's disheartening to hear about how I have a useless major and I am destined to have a job that doesn't pay well. Don't get me wrong, I love history (especially learning about women's role), but I do hope I can get a museum job or some federal job so I can have some use for it.
Secondly, I don't have a license. I had my permit since I was 18 (or 19). I know how to drive, but I failed the driving test (I was close, but the stupid snow piles in March and a sudden burst of anxiety got to me). I need to go again, but I am terrified I will fail again. 
Category:Fag
Buster kitten

So I'm scheduled for a revision on the eye surgery I had last fall. A metal surgical staple was left behind, and this was just recently discovered when I flipped out during an unsuccessful MRI. It felt like my eye was going to boil out of my skull, which was horrible. So I'm not exactly pleased about this; metal in the eye socket is an absolute contraindication against MRIs, and the team who originally did my eye surgery was - or should have been - aware that I have scans on the regular.
Between that, and needing to travel out of town on short notice to help my sister get ready for a job interview (she's physically disabled), things have been kind of stressful around here. At least my little brother was in the area to take me to my eye appointment. He also brought me along to hang out with one of his former classmates, which was nice of him and plenty fun.
Right now, though, my partner is hosting a couple of his international colleagues in our house. This is great, but also kind of stressful, since I wasn't able to get everything fixed up before their visit as much as I'd hoped. The night before they arrived, my partner surprised me with tickets to a regional theater production for our wedding anniversary. I enjoyed the play and don't want to seem ungracious, but I really could've used more help getting ready for houseguests.
Things have been worse, but I still wish they were better. I just feel like I should be making more progress, but I'm being plagued by all these little setbacks and inconveniences and it gets old in a hurry. And then I feel petty for complaining at all - but I'm just so tired and feel so lost all the time.
Category:Fag
Coster

Well, haha, here I am once again. It's just like it was before, only this time I also have to focus on bringing up my failing class grade as well as this. I want to rip my goddamn head off. I told myself I didn't want to feel this way again, that I didn't want to be this way again, but look where I fucking am, back at square one.
Am I overreacting? Is this just my insecure paranoid bullshit creeping up on me? I'm hoping it'll all be better soon, but the last time I tried that I ended up in an almost eight month depression before I even began to feel better.
I want school to be over. I want to work more, because I'm good at what I do and it makes me money. I'm gonna try to get my driver's license over the summer, maybe save up for a car if I can get enough hours.
I miss home. Is it weird to say I miss my sister's dog a lot? I watched that dog grow up from a tiny puppy to a mini horse. I remember when I went home for Christmas last year and how just excited she was when I got there. She had no idea I'd be coming back because I had been gone for so long and she didn't know why. She practically danced off the walls. I know she misses me - my sister told me before that she occasionally perks her head up and rushes to the door when she hears my old school bus go by, because she thinks I'll be coming home.
 
Category:Fag
D.Angus

I sometimes feel useless, and that I'm not even trying to get better.. I had to move back to my boyfriends parents house with him, after living almost 8 months on our own with other roommates. I'm looking for work and not finding any that fits my needs, but I keep having this feeling that I should throw away my new life and just move back to my crowded aunts and go back to working my old job.. Which I think would depress me even more.. 
Category:Fag
Dollarpennypincher

Think my insomnia's back. I fucking hate having to deal with this and waking up with muscle pain like I have for the past few weeks now. Doesn't help that I already feel very uncertain about the future and don't always know what direction I'm heading. I also still get really jealous checking up on what I people I knew from my high school days are doing now compared to what I've done and regret a few decisions I made in the past to this day.
It's all because even after all this time, I still have to deal with my inner insecurities, worrying too much about shit that doesn't matter in the long run, and how I'm such a self-deprecating person. It also terrified me when I overheard people at my college talk about how they knew this accounting major who did really well who ended up working as an Uber taxi driver and how the only way you can really get a job now is through getting internships before you graduate. Still want to make my career goals a reality and I feel more motivated than ever to keep going and see what happens but some days I really feel like saying "fuck it" and giving up, like there's this voice in my head telling me that it's not worth it and I'll never be as good as other people at what I want to do, etc.
So yeah, it's a combination of a bunch of stuff that's been gradually building up more and more overtime and wasn't sure if I should have even bothered to let any of it out here.
Category:Fag
GRANDNumberofMULTIPLES

I fell asleep driving in 2011. This was just a few weeks after one of my really good friends fell asleep driving, went airborne off the freeway, and managed to miss every single tree on the hillside on his way down. I fell asleep just a block from my house and almost crashed into a wooden light pole. Jerked the wheel away before my car could connect with the pole and only smashed the glass out of my sideview mirror which conveniently remained attached to the car.
The body was not damaged but my struts and shocks were fucked up. I also ripped a hole clean through the sidewall of a tire. Exhausted as I was I couldn't sleep and ended up going out to a movie with another of my friends. I called him on the verge of tears saying that whenever I closed my eyes all I saw was that wooden light pole heading right for me.
Ended up trading in the remains of that car (200K miles and it needed more maintenance in its last year than it ever needed in its whole life) for my new car in 2013. It was really nice getting off the train and getting to my car and not having to worry if it was going to start or not.
==Jun 24, 2015==
I left an abusive relationship (emotional and physical) and thought I was ~so strong~ for not going to therapy. It was like I thought going was some indication that he won. I'm going now (six years after I got my freedom) and while there is a lot that I managed to process there's a lot that I never unpacked. I think it would be a good idea.
Still working through finding and developing nondestructive coping mechanisms for manic/mixed episodes. (:_(
==May 14th, 2015==
There's few people outside my close family that can pick out when I'm really manic. Luckily I don't get to that position at the frequency I used to but it almost makes the times that I am that much weirder. Half of me is terrified and the other half is WAHHAHAHA AWESOME :biggrin:. There's something especially frustrating (yet secretly I'll tell you can be great) with the territory that is rapid cycling. But I'm not here to bore or whatever, I'm just here to bitch.
I made it to 20 before getting the diagnosis but I always knew something was off.
For better or for worse, my boss is able to pinpoint when this shit goes down. I'm lucky enough to be in a role where I can usually take care of business but I still worry. I wasn't as bad as I was yesterday and I think part of it has to do with not getting the hanky panky for 2 weeks while the biopsy heals, waiting for said biopsy results, and having my dad (who I love dearly and never actually separated with my mom) move back in.
tl;dr I need a shut up brain
Category:Fag
Golly

Having a drunkversation with my mom about all manner of things before fixating on just how much she wants to leave my dad is not my idea of an enjoyable evening. She's told me this ~4 years ago, and has occasionally brought it up ever since. Tonight being one of those occasions. And in light of the past few weeks, it's definitely been one of the more convincing ones.I try to be brave, of course. I'm 22 and my brother is entering college this year. I'm not a 10 year old who doesn't understand the logistics behind failed relationships. I understand why she feels the way she does, too. I've asked her if she would consider staying with dad if he fixed everything after going to some kind of magical rehab program, and she said yes. So there's that.
But it still hurts more than I would like it to.
Does anyone here know how to deal with this? I feel like I'm faced with two options: distraction or excessive feels. I don't want to wallow in self pity, but I don't want to bottle anything up that could manifest itself as something ugly later on.
==May 27th, 2015==
So yeah. Same old I guess? Dad's been drinking again. I leave for 2 months, and my family convinces me they have shit on lockdown. Dad will go to rehab/be kicked out/learn the consequences of his actions. Nope. I came back less than three weeks ago and he's gotten drunk twice with very little effort to improve himself. He's Connor if Connor had a drinking problem and managed to reproduce. In fact, since Connor has no desire to drink, he may even be better than my dad. Congratulations, Connor [insert final Evangelion scene here]. Tonight was the second time he got too drunk to function since my return.
Until now, Dad, for lack of anything better to do, has been available to drive me around and pay for my voice lessons. Before leaving, I was beginning to see how ridiculous this was. Ironically, I have a license, but have always been very anxious about driving. Partly because anxiety, but fuck psychological excuses. It's inexperience and the fact that I haven't worn glasses regularly until nearly a year ago. Can't really drive confidently if you can't see clearly lol. My license has a vision impairment mention, so it's really just been up to me, but I've been too chicken shit to just up and do it.
Tomorrow I'm going to call the local driving school for my first refresher's driver's lesson and we'll take it from there. The money I've earned cashiering over the past few months, paired with my savings, will be enough to buy me lessons and a hopefully tolerable first car. I can't have a weak and hurtful man have this level of control over my life anymore. I wish I had a more positive reason to invoke this strong desire to take action for myself, but I guess any motivation is better than none?
Wish me luck, Kiwis.
Category:Fag
Lacquer Head

jesus fuck man, being an alcoholic isn't fun. I used to be drunk every single day for almost 3 years and would spend hundreds of dollars a week. Recently I started quitting and I didn't have a drink for 8 weeks but I'm starting to relapse. I think I may go full blown alcoholic again and i'm not sure how to stop it. I can't get high because of my job so that isn't an option, I don't have any friends because I just moved here and alcohol is really cheap. Not sure what to do
Category:Fag
Megahertz

My closest friend is starting to show some ED warning signs.
It sounds selfish of me but I wish she would stop telling me about how many calories she ate that day or about how whenever she looks in the mirror she wants to "rip off anything that jiggles" (she's 118 lbs. She is of a healthy, borderline underweight but she doesn't exercise, hence the jiggle), or how she "wants to lose 10 lbs" or how guilty she feels about eating a burger. I wish it would stop. I hate hearing it. But I'm really the only person she can confide this sort of stuff to.
The topic of wanting to obsessively lose weight to unhealthy levels is a very uncomfortable topic for me.
I used to be really underweight in high school, because I never ate due to medicinal side effects. I could see all my bones and I felt disgusting, and none of my clothes fit right. I felt like shit constantly because I had no energy, and ever since I gained the weight back I am terrified of being underweight again. so seeing my best friend spouting all this bullshit about how nobody will love her if she isn't a fucking rail makes me angry and I'm sick of hearing it. I don't want her to desire something that I already went through and hated. I keep telling her that what she's thinking is wrong, that she's over analyzing everything, but she never listens. The voice of self-image is always louder, and I can't make her love herself. She's already thin.Why doesn't she see that?
When will girls understand that if they're already skinny, softness is fucking normal? When you bend over and see rolls, that's your fucking skin. not some gigantic patch of subcutaneous fat. It frustrates me to no end and now somebody whom I love has bought into it.
We go to different universities, so she is out of my reach if I want to put her in ED counseling or some shit. I don't even know if I have the right to intervene or not. (Her parents are out of the picture.) I don't know what to do. I just want her to love herself, but the environment in which she grew up permanently screwed with that.
Category:Fag