Taxifoline

==Nom de la substance==
Taxifoline, dihydroquercétine
==Famille moléculaire==
Flavonoïde (flavanone)
==Source végétale==
* Bois de mélèze Larix sibirica Ledeb, Larix dahurica Turcz. ex Trautv., chardon-Marie, pin sylvestre Pinus sylvestris, cannelle de Magellan Drymis winteri
** La production de taxifoline est plus importante dans les populations de pins des régions plus chaudes P Lebreton, C Laracine-Pittet, C Bayet, J Lauranson. Variabilité polyphénolique et systématique du pin sylvestre Pinus sylvestris L. Ann. For. Sci. 47 (1990) 117-130
==Propriétés==
* Anti-oxydant
* Anti-inflammatoire
* Hypotenseur
* Diminue la synthèse hépatique de lipides, diminue l’Apo-B, augmente l’Apo-A1, inhibe l’activité de l’HMG-CoA reductase (de 47 ± 7%) Theriault, A., Q. Wang, S. C. Van Iderstine, B. Chen, A. A. Franke, and K. Adeli. Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid. J. Lipid Res. 2000. 41: 1969–1979, Casaschi A, Rubio BK, Maiyoh GK, Theriault AG. Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion. Atherosclerosis. 2004 Oct;176(2):247-53. PMID 15380446
* Améliore la récupération de l'activité des enzymes mitochondriales dans les muscles squelettiques de la souris âgée G. E. Bronnikov, T. P. Kulagina, A. V. Aripovsky. Dietary supplementation of old mice with flavonoid dihydroquercetin causes recovery of the mitochondrial enzyme activities in skeletal muscles. Biochemistry (Mscow) supplemental series A: membrane and cell biology. Biomedical and life sciences. Volume 3, Number 4, 453-458
* Hépatoprotecteur par effet anti-oxydant Teselkin Yu O., Dihydroquercetin as a mean of antioxidative defence in rats with tetrachloromethane hepatitis, Phytotherapy Research, 2000 May, 14(3) : 495-502. PMID 10815007
* Protection vis-à-vis de l'irradiation Teselkin Yu. O, Babenkova I. V, Tjukavkina N. A. Influence of dihydroquercetin on the lipid peroxidation of mice during post-radiation period. Phytotherapy research, 1998, vol. 12, n° 7, pp. 517-519 
* Chimio-prévention par activité sur les enzymes de phase 2 et la quinone reductase Lee SB, Cha KH, Selenge D, Solongo A, Nho CW. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID 17541156
* Neuroprotecteur Dok-Go H, Lee KH, Kim HJ, Lee EH, Lee J, Song YS, Lee YH, Jin C, Lee YS, Cho J. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res. 2003 Mar 7;965(1-2):130-6. PMID 12591129, Wang YH, Wang WY, Chang CC, Liou KT, Sung YJ, Liao JF, Chen CF, Chang S, Hou YC, Chou YC, Shen YC. Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation. J Biomed Sci. 2006 Jan;13(1):127-41. PMID 16283433
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
* Patrick Trouillas, Philippe Marsal, Didier Siri, Roberto Lazzaroni, Jean-Luc Duroux. A DFT study of the reactivity of OH groups in quercetin and taxifolin antioxidants: The specificity of the 3-OH site. Food Chemistry, Volume 97, Issue 4, August 2006, Pages 679–688 
Catégorie:principes actifs