Leucovorin (Folinic acid)

==General information==
Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of Fluorouracil (5-FU) by inhibiting thymidylate synthase.Leucovorin (Folinic acid) package insertLeucovorin (Folinic acid) package insert (locally hosted backup)
Route: PO, IM, IV
Extravasation: no information 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information. 
==Diseases for which it is established (work in progress)==
Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)
*Colorectal cancer
**Colon cancer‎
**Rectal cancer
*Hepatocellular carcinoma
==Diseases for which it is used==
Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)
*Anal cancer
*Cervical cancer ‎ 
*Cholangiocarcinoma
*Esophageal cancer ‎ 
**Esophageal adenocarcinoma
*Gallbladder cancer
*Gastric cancer ‎ ‎ 
*Pancreatic cancer ‎ ‎ 
==Diseases for which it was used==
Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)
*Breast cancer
==Patient drug information==
*Leucovorin (Folinic acid) package insert
*Leucovorin (Folinic acid) patient drug information (Chemocare)Leucovorin (Folinic acid) patient drug information (Chemocare)
*Leucovorin (Folinic acid) patient drug information (UpToDate)Leucovorin (Folinic acid) patient drug information (UpToDate)
==History of changes in FDA indication==
* 1952-06-20: Initial FDA approval
* Uncertain date: Indicated for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. (Based on O'Connell 1989 & Poon et al. 1989)
==Also known as==
*Generic names: calcium folinate, citrovorum factor, folinate calcium, folinato de calcio, folinic acid, leucovorin calcium, LV, sodium folinate
*Brand names:
Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms
Antrex 	Asovorin 	Biovorin 	Buateron 	Calcifolin	Calciumfolin	Calciumfolinat	Calcium Folinato
Calcium Folint	Calcium Leucovorn	Calcivoran 	Calc Leucovorn	Calfolex 	Calfolin 	Calinat 	Cehafolin
Citofolin 	Claro 	Cromatonbic Folinico 	Dalisol 	Degalin 	Divifolin 	Durofolin 	Ecofol
Elvefocal 	Emovis 	Erbanfol 	Estroquin 	Fastovorin	Fauldleuco 	Fayining 	Fedolen
Ferbon 	Folaren 	Folaxin 	Foliben 	Foli Cell 	Folidan 	Folidar 	Foliment
Folinac 	Folinato 	Folinfabra 	Folinoral 	Folinoxan 	Folinvit 	Foliplus 	Folmigor
Ifavor 	Isovorin 	Kalciumfolinat Perivita	Kalsiumfolinat	Kunyrin 	Lederfolat 	Lederfolin 	Lederfoline
Ledervorin 	Legifol 	Leucocalcin 	Leuconolver 	Leucosar 	Leucovorina 	Leucovorine 	Leukovorin
Lovorin 	Medicofolin 	Medifolin 	Medsavorina 	Neofolin 	Nyrin 	O Folin 	Osfolate
Osfolato 	Perfolate 	Prefolic 	Prevax 	Recovorin 	Reotan 	Rescuvolin 	Resfolin
Ribofolin 	Rontafor 	Sanifolin 	Tecnovorin 	Tonofolin 	Veravorin 	Vorina 	Wellcovorin
Zyofolin 	Zytofolin 	 	 	 	 	 	
==References==
Category:Drugs
Category:Intramuscular medications
Category:Intravenous medications
Category:Oral medications
Category:Chemotherapy protective agents
Category:Folic acid analog
Category:Anal cancer medications
Category:Cervical cancer medications
Category:Cholangiocarcinoma medications
Category:Colorectal cancer medications
Category:Colon cancer medications
Category:Esophageal adenocarcinoma medications
Category:Esophageal cancer medications
Category:Gallbladder cancer medications
Category:Gastric cancer medications
Category:Hepatocellular carcinoma medications
Category:Pancreatic cancer medications 
Category:Rectal cancer medications
Category:Breast cancer medications (historic)
Category:FDA approved in 1952
Category:WHO Essential Cancer Medicine