Dirk Schübeler

Dirk Schübeler is a German researcher, Director of the Friedrich Miescher Institute for Biomedical Research (FMI) and professor at the University of Basel. He is an expert in gene regulation.
==Education and career==
Dirk Schübeler obtained his PhD from the Technical University in Braunschweig, Germany working in the Helmholtz Center for Infectious Research in the group of Jürgen Bode. He then did postdoctoral studies at the Fred Hutchinson Cancer Research Center in Seattle, USA, working with Mark Groudine. Schübeler joined the Friedrich Miescher Institute of Biomedical Research (FMI) in 2003 as a junior group leader, in 2008 he was appointed senior group leader, and in 2011 he became adjunct professor at the University of Basel. In April 2020 he was appointed Director of the FMI.Interview Dirk Schübeler in bz Basel bz. May 25, 2020
Schübeler serves on the editorial board of several scientific journals including EMBO Journal and Molecular Systems Biology. He is a member of the Scientific Advisory Boards of the Research Institute of Molecular Pathology (IMP), Vienna, Austria, the Wellcome-MRC Cambridge Stem Cell Institute(CSCI), Cambridge, UK and the Excellence Centre of Integrative Biological Signaling Studies (CIBBS), Freiburg, Germany.
==Research==
Schübeler’s research focuses on understanding how chromatin states are generated and how they contribute to the regulation of transcription and replication. Together with his research group, Schübeler has pioneered approaches to measure DNA methylationMichael Weber, Jonathan J Davies, David Wittig, Edward J Oakeley, Michael Haase, Wan L Lam & Dirk Schübeler (2005) Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nature Genetics 39:457-466Michael B. Stadler*, Rabih Murr*, Lukas Burger, Robert Ivanek, Florian Lienert, Anne Schöler, Erik van Nimwegen, Christiane Wirbelauer, Edward J. Oakeley, Dimos Gaidatzis, Vijay K. Tiwari & Dirk Schübeler (2011) DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature 480, 490-495, histone modifications and DNA replication at the level of the genomeSchübeler D, Lorincz MC, Groudine M (2001) Targeting silence – the use of site-specific recombination to introduce in vitro methylated DNA into the genome Science STKE 83: PL1, and combining these with functional assays such as genome editingKrebs AR, Dessus-Babus S, Burger L, Schübeler D (2014) High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions. Elife. 3:e04094. The Schübeler group has identified recruitment mechanism for readers and writers of DNA methylation towards a better understanding of the information flow that generates and reads a chromatinized genomeBaubec T, Colombo DF, Wirbelauer C, Schmidt J, Burger L, Krebs AR, Akalin A, Schübeler D (2015) Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation. Nature 520:243-8Baubec T, Ivanek R, Lienert F, Schübeler D (2013) Methylation-dependent and -independent genomic targeting principles of the MBD protein family. Cell. 153:480-492. More recently, the group has aimed to define how transcription factors can bind and modify chromatinDomcke S*, Bardet AF*, Ginno P, Hartl D, Burger L, Schübeler D (2015) Competition between DNA methylation and transcription factors determines binding of NRF1. Nature 528:575-9Barisic D, Stadler MB, Iurlaro M, Schübeler D (2019) Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors. Nature 569:136-140.
==Awards and honors==
1995-1998: Graduate Fellowship, Foundation of the German Chemical Industry
1997: Thesis award, GBF Förderpreis
1998-2000: Postdoctoral Fellowship, Deutsche Forschungsgemeinschaft
2000-2002: Postdoctoral Fellowship, Rett Syndrome Research Foundation
2006: EMBO Young Investigator Award
2006: Election to the Epigenome Network of Excellence 
2007: Friedrich Miescher Prize, Swiss Society for Biochemistry
2008: European_Research_Council Starting Grant
2009: Election to EMBO
2011: Novartis VIVA Leading Scientist Award
2012: Election to Academia Europaea 
2014: ESCI Award for Excellence in Basic/Translational Research
2015: ERC Advanced Grant
2020: ERC Advanced Grant
== References ==
==External links==
* The Schübeler lab website 
* Schübeler research group 
* Friedrich Miescher Institute of Biomedical Research (FMI)
Category:Living people
Category:Members of the European Molecular Biology Organization
Category:Members of Academia Europaea