Acide lithospermique

==Nom de la substance==
Acide lithospermique
==Famille moléculaire==
* Polyphénol : Dihydrobenzofurane
* Formé de trois molécules d’acide caféique, proche de l’acide rosmarinique (autre dérivé caféique)
==Source végétale==
* Lithospermum officinale, Lithospermum ruderale surtout Gestur Johnsona, S.G. Sunderwirtha, H. Gibian1, a, A.W. Coultera, F.X. Gassner. Lithospermum ruderale: Partial characterization of the principal polyphenol isolated from the roots. Phytochemistry, Volume 2, Issue 2, June 1963, Pages 145-150, Salvia miltiorrhiza, Lycopus europeus
==Propriétés==
* Propriétés antihormonales (antigonadotrope, antithyréotrope, antiprolactine) William E. Findley, Barry R. Jacobs. The antigonadotropic activity of Lithospermum ruderale I. The lack of steroid-like activity at the receptor level. Contraception 1980, Volume 21, Issue 2, Pages 199-205, inhibition de la LH par inhibition de l'activité de son releasing factor William E. Findley. The antigonadotropic activity of Lithospermum ruderale II. The inhibition of LRF-induced gonadotropin release. Contraception 1981, Volume 23, Issue 2, Pages 157-162, surtout par ses produits d'oxydation Findley WE, Hollstein U, Besch PK. Effect of purified lithospermic acid and its oxidation product on luteinizing hormone release in vitro. Biol Reprod. 1985 Sep;33(2):309-15.
* Diminution de la fertilité Farnsworth NR, Bingel AS, Cordell GA, Crane FA, Fong HH. Potential value of plants as sources of new antifertility agents I. J Pharm Sci. 1975 Apr;64(4):535-98. PMID 167146, Farnsworth NR, Bingel AS, Cordell GA, Crane FA, Fong HS. Potential value of plants as sources of new antifertility agents II. J Pharm Sci. 1975 May;64(5):717-54. PMID 1151641
* Effet favorable sur le fonctionnement rénal, diminution de l’urémie, augmentation de la vitesse de filtration glomérulaire, de l’excrétion d’urée et de créatinine, effet hypouricémiant par inhibition de la xanthine oxydase Liu X, Chen R, Shang Y, Jiao B, Huang C. Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats. Chem Biol Interact. 2008 Nov 25;176(2-3):137-42. doi: 10.1016/j.cbi.2008.07.003. PMID 18694741., Liu X, Chen R, Shang Y, Jiao B, Huang C. Superoxide radicals scavenging and xanthine oxidase inhibitory activity of magnesium lithospermate B from Salvia miltiorrhiza. J Enzyme Inhib Med Chem. 2009 Jun;24(3):663-8. doi: 10.1080/14756360802323829. PMID 18686136.
* Hypotenseur par effet vasodilatateur Katsuo Kamata, Mariko Noguchi, Masahiro Nagai. Hypotensive effects of lithospermic acid B isolated from the extract of Salviae miltiorrhizae Radix in the rat. General Pharmacology: The Vascular System, Volume 25, Issue 1, January 1994, Pages 69-73 et inhibiteur de l'angiotensine Dae Gill Kang, Hyuncheol Oh, Hun Taeg Chung, Ho Sub Lee. Inhibition of angiotensin converting enzyme by lithospermic acid B isolated from radix Salviae miltiorrhiza Bunge. Phytotherapy Research, Volume 17, Issue 8, pages 917–920, September 2003
* Inhibe la migration et la prolifération des cellules musculaires lisses vasculaires de l'aorte thoracique du rat, potentialités thérapeutiques dans la prévention de l'athérosclérose, la resténose après angioplastie et l'hyperplasie néointimale Chen L, Wang WY, Wang YP. Inhibitory effects of lithospermic acid on proliferation and migration of rat vascular smooth muscle cells. Acta Pharmacol Sin. 2009 Sep;30(9):1245-52. doi: 10.1038/aps.2009.122. PMID 19701233; PMCID: PMC4007173., Hur KY, Seo HJ, Kang ES, Kim SH, Song S, Kim EH, Lim S, Choi C, Heo JH, Hwang KC, Ahn CW, Cha BS, Jung M, Lee HC. Therapeutic effect of magnesium lithospermate B on neointimal formation after balloon-induced vascular injury. Eur J Pharmacol. 2008 May 31;586(1-3):226-33. doi: 10.1016/j.ejphar.2008.02.072. PMID 18387604.
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
Catégorie:Principes actifs