nyuuzyou/wikis huggingface dataset:
Example orders for Docetaxel (Taxotere) in prostate cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Docetaxel (Taxotere)==
Published regimens and references can be found on the prostate cancer page.
===Example order set #1===
*Docetaxel (Taxotere) 75 mg/m2 IV over 60 minutes once on day 1; use non-DEHP (paclitaxel) tubing
*Optional: Prednisone (Sterapred) 5 mg PO twice per day on days 1 to 21
21-day cycles
====Supportive therapy====
*Dexamethasone (Decadron) 8 mg PO given twice, the evening before and morning of chemotherapy
*Dexamethasone (Decadron) 12 mg PO once; 30 minutes prior to chemotherapy
*Diphenhydramine (Benadryl) 25 to 50 mg IV once; 30 minutes prior to chemotherapy
*Famotidine (Pepcid) 20 mg IV over 15 minutes once; 30 minutes prior to chemotherapy
Hydration:
*Normal saline IV continuous infusion at 5 mL/H
*Normal saline 25 to 50 mL IV prn flush before and after chemotherapy
Nursing:
*Patients without central lines: insert peripheral IV before therapy. Flush peripheral IV with 10 mL 0.9% normal saline after each day's dose of chemotherapy. Remove peripheral IV when therapy is complete. 
*Patients with central lines: access the central venous access device before therapy. Flush central line according to institutional guidelines after each day's dose of chemotherapy. Deaccess device when therapy is complete.
===Example order set #2===
*Docetaxel (Taxotere) 75 mg/m2 IV over 60 minutes once on day 1; use non-DEHP (paclitaxel) tubing
**Due to toxicity, later dose reduced to Docetaxel (Taxotere) 60 mg/m2 IV over 60 minutes once on day 1
21-day cycles
====Supportive therapy====
*Dexamethasone (Decadron) 10 mg IV once; 30 minutes prior to chemotherapy
*Prochlorperazine (Compazine) 10 mg PO once, prior to chemotherapy
*Due to severe neutropenia, used: Pegfilgrastim (Neulasta) 6 mg SC once on day 2, 24 hours after completion of chemotherapy
Hydration:
*Normal saline IV continuous infusion at 5 mL/H
*Normal saline 25 to 50 mL IV prn flush before and after chemotherapy
Nursing:
*Patients without central lines: insert peripheral IV before therapy. Flush peripheral IV with 10 mL 0.9% normal saline after each day's dose of chemotherapy. Remove peripheral IV when therapy is complete. 
*Patients with central lines: access the central venous access device before therapy. Flush central line according to institutional guidelines after each day's dose of chemotherapy. Deaccess device when therapy is complete.
Category:Example chemotherapy order sets
Example orders for FLOX in colon cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==FLOX==
FLOX: Fluorouracil, Leucovorin, OXaliplatin
Published regimens and references may be found on the colon cancer page.
===Example regimen #1===
*Fluorouracil (5-FU) 500 mg/m2 IV bolus on days 1, 8, 15, 22, 29, 36, to be given last, 1 hour after start of leucovorin
*Leucovorin (Folinic acid) 500 mg/m2 IV over 2 hours on days 1, 8, 15, 22, 29, 36, given concurrently with oxaliplatin on days when oxaliplatin is given
**Mixed in 250 mL D5W.
*Oxaliplatin (Eloxatin) 85 mg/m2 IV over 2 hours on days 1, 15, 29, given concurrently with leucovorin
**Mixed in 500 mL D5W, and only infuse through D5W line.
8-week cycles x 3 cycles
====Supportive therapy====
*Ondansetron (Zofran) 8 mg IV on days 1, 15, 29; 30 minutes prior to oxaliplatin
*Dexamethasone (Decadron) 10 mg IV on days 1, 15, 29; 30 minutes prior to oxaliplatin
*Ondansetron (Zofran) 8 mg IV prn breakthrough nausea
*Calcium gluconate 1 g & magnesium sulfate 1 g (admixed together) IV, given over 30 minutes, to start prior to oxaliplatin to decrease likelihood of neuropathy
*Calcium gluconate 1 g & magnesium sulfate 1 g (admixed together) IV, given over 30 minutes, to start after oxaliplatin infusion is complete to decrease likelihood of neuropathy
*Calcium and magnesium no longer recommended to reduce risk of oxaliplatin-induced neuropathy: Charles L. Loprinzi, Rui Qin, Shaker R. Dakhil, Louis Fehrenbacher, Philip J. Stella, Pamela J. Atherton, Drew K. Seisler, Rubina Qamar, Grant Carlton Lewis, Axel Grothey. Phase III randomized, placebo (PL)-controlled, double-blind study of intravenous calcium/magnesium (CaMg) to prevent oxaliplatin-induced sensory neurotoxicity (sNT), N08CB: An alliance for clinical trials in oncology study. 2013 ASCO Annual Meeting abstract 3501. link to abstract
Hydration:
*500 ml D5W at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml D5W.
Monitoring:
*Hold if ANC less than 1000 or platelets less than 100 and notify physician.
Comments:
*Rather than administer drugs in the order of: 1) Oxaliplatin (Eloxatin), 2) Leucovorin (Folinic acid), 3) Fluorouracil (5-FU), my institution administers oxaliplatin and leucovorin concurrently and then 5-FU last.
Category:Example chemotherapy order sets
Example orders for FOLFIRI in colon cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==FOLFIRI==
FOLFIRI: FOLinic acid, Fluorouracil, IRInotecan
Original references may be found at FOLFIRI
===Example regimen #1===
*Leucovorin (Folinic acid) 400 mg/m2 IV over 2 hours on day 1, given during irinotecan infusion
*Fluorouracil (5-FU) 400 mg/m2 IV bolus over 10-15 minutes on day 1, given after irinotecan and leucovorin
*Fluorouracil (5-FU) 1200 mg/m2/day IV continuous infusion over 46 hours on days 1 to 2, given last after bolus 5-FU 
*Irinotecan (Camptosar) 180 mg/m2 IV over 90 minutes on day 1, given first together with leucovorin
14-day cycles
====Supportive therapy====
*Ondansetron (Zofran) 8 mg IV 30 minutes prior to chemotherapy 
*Dexamethasone (Decadron) 10 mg IV 30 minutes prior to chemotherapy 
*Lorazepam (Ativan) 0.5-1 mg IV or PO prn nausea/anxiety
*Atropine 0.4 mg IV prn diaphoresis, visual changes, abdominal cramping, or diarrhea during or after irinotecan infusion 
Monitoring:
*Hold if ANC less than 1000 or platelets less than 100 and notify physician. 
Outpatient medications:
*Loperamide (Imodium) 4 mg PO x1 for each day's first episode of diarrhea; 2 mg PO prn each loose stool thereafter, up to a maximum of 16 mg per day
Category:Example chemotherapy order sets
Example orders for Goserelin (Zoladex) in prostate cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Goserelin (Zoladex)==
Published regimens and references can be found on the prostate cancer page.
===Example order set #1 (once every 12 weeks)===
*Goserelin (Zoladex) 10.8 mg SC once every 12 weeks
===Example order set #2 (once every 4 weeks)===
*Goserelin (Zoladex) 3.6 mg SC once every 4 weeks
Category:Example chemotherapy order sets
Example orders for High-dose Methotrexate (MTX) & Ifosfamide in lymphoma

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==High-dose Methotrexate (MTX) & Ifosfamide==
Original references may be found at High-dose Methotrexate (MTX) & Ifosfamide
===Example regimen #1===
*Methotrexate (MTX) 4000 mg/m2 IV over 4 hours on day 1
**Do not start methotrexate until urine pH is at least 8 or higher. Admix with sodium bicarbonate.
*Sodium bicarbonate 25 mEq IV once on day 1, admix with methotrexate
*Ifosfamide (Ifex) 2000 mg/m2 IV over 3 hours on days 3-5
*Mesna (Mesnex) 500 mg/m2 IV every 3 hours x 4 doses per day on days 3-5 with ifosfamide
**Times for mesna in relation to start of ifosfamide; Dose 1 of mesna is at time at 0, dose 2 is 3 hours after start of ifosfamide, dose 3: 6 hours after start of ifosfamide, dose 4: 9 hours post ifosfamide. 
*Leucovorin (Folinic acid) 50 mg IV every 6 hours, starting on day 2
**To begin 24 hours after the start of day 1's methotrexate infusion and continue for at least 8 doses. Discuss changes such as potential transition to PO leucovorin with MD according to MTX levels. 
====Supportive therapy====
*Ondansetron (Zofran) 8 mg IV on days 1 to 5; 30 minutes prior to chemotherapy
*Dexamethasone (Decadron) 8 mg IV twice per day on days 1 to 5
*Ondansetron (Zofran) 4-8 mg IV every 8 hours prn nausea
*Prochlorperazine (Compazine) 10 mg PO every 6 hours prn nausea 
Hydration:
*150 mEq sodium bicarbonate in 1000 mL D5W, continuous at 125 mL/H, start on day 1 hours before methotrexate infusion for urine alkalinization. Continue fluids unless discussed otherwise with MD.
Monitoring:
*Check methotrexate levels 24, 48, and 72 hours after completion of methotrexate infusion.
*Check urine pH every 4 hours and notify physician if urine pH less than 8
Clinical scenario & comments:
*54 year-old gentleman with stage IV diffuse large B-cell lymphoma with extranodal disease (primary testicular lymphoma), with progression after 6 cycles of R-CHOP. He only received treatment with high-dose methotrexate & ifosfamide for one cycle; treatment was complicated by acute kidney injury, with subsequent improvement back to baseline. This was followed with R-ICE therapy, with disease remission achieved and subsequent allogeneic stem cell transplant.
Category:Example chemotherapy order sets
Example orders for Ipilimumab (Yervoy) in melanoma

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Ipilimumab (Yervoy)==
Original references may be found at Ipilimumab (Yervoy)
===Example regimen #1===
*Ipilimumab (Yervoy) 3 mg/kg IV on days 1, 22, 43, 64
** Infuse via non-pyrogenic, low-protein-binding in-line filter. Requires a post infusion flush with NS or D5 after each infusion 
12-week course
====Supportive therapy====
*In case of hypersensitivity reaction, contact MD first, and then may use:
**Hydrocortisone (Cortef) 100 mg IV push
**Diphenhydramine (Benadryl) 50 mg IV push (only give if >6 hours from last dose)
**Famotidine (Pepcid) 20 mg IV over 15 minutes
**Epinephrine (EpiPen) 0.3 mg IM
Hydration:
*500 ml NS at KVO rate. Use as running IV for chemotherapy infusion. Give up to 500 ml NS.
Monitoring:
*Prior to first dose, check hepatitis B & C, HIV, and pregnancy status, if appropriate
*Prior to each dose, check: CBC with differential, absolute lymphocyte count, platelets, sodium, potassium, chloride, bicarbonate, BUN, creatinine, glucose, calcium, alkaline phosphatase, SGOT (AST), SGPT (ALT), total bilirubin, direct bilirubin, albumin, total protein, LDH, uric acid, amylase, lipase, TSH, Free T4
*Vital signs should be checked every 15 minutes x 1 hour after the first dose of ipilimumab 
Clinical scenario & comments:
*65 year-old lady with locally advanced, recurrent melanoma after prior surgical resection. No previous systemic therapy had been used. My institution includes all 4 doses of ipilimumab to be given over the 12-week course in a single order set.
Category:Example chemotherapy order sets
Example orders for Irinotecan (Camptosar) in colon cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Irinotecan (Camptosar)==
Original references may be found at Irinotecan (Camptosar)
===Example regimen #1===
*Irinotecan (Camptosar) 350 mg/m2 IV over 90 minutes on day 1
21-day cycles
====Supportive therapy====
*Ondansetron (Zofran) 8 mg IV 30 minutes prior to chemotherapy
*Dexamethasone (Decadron) 10 mg IV 30 minutes prior to chemotherapy
*Atropine 0.4 mg IV prn diaphoresis, visual changes, abdominal cramping, or diarrhea during or after irinotecan
Hydration:
*500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.
Monitoring:
*Dose reduction of Irinotecan (Camptosar) to 300 mg/m2 IV over 90 minutes on day 1 is recommended for patients over 70 years old or with prior pelvic radiation. 
*Hold for significant diarrhea, ANC less than 1000, or platelets less than 100, and notify physician.
Outpatient medications:
*Loperamide (Imodium) 4 mg PO x1 for each day's first episode of diarrhea; 2 mg PO prn each loose stool thereafter, up to a maximum of 16 mg per day
Comments:
*In contrast to the original regimen, my institution does not specifically mandate that patients with ECOG performance status 2 or higher should have a dose reduction of irinotecan.
Category:Example chemotherapy order sets
Example orders for Leuprolide (Lupron) in prostate cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Leuprolide (Lupron)==
Published regimens and references can be found on the prostate cancer page.
===Example order set #1 (once every 4 weeks)===
*Leuprolide (Lupron) 1-month depot 7.5 mg IM once every 4 weeks
===Example order set #2 (once every 12 weeks)===
*Leuprolide (Lupron) 3-month depot 22.5 mg IM once every 12 weeks
===Example order set #3 (once every 16 weeks)===
*Leuprolide (Lupron) 4-month depot 30 mg IM once every 16 weeks
Category:Example chemotherapy order sets
Example orders for Mitoxantrone (Novantrone) in prostate cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Mitoxantrone (Novantrone)==
Published regimens and references can be found on the prostate cancer page.
===Example order set #1===
*Mitoxantrone (Novantrone) 12 mg/m2 IV over 15 minutes once on day 1
*Optional: Prednisone (Sterapred) 10 mg PO once per day on days 1 to 21
21-day cycles
====Supportive therapy====
*Prochlorperazine (Compazine) 10 mg PO once; 30 minutes prior to chemotherapy
Hydration:
*Normal saline IV continuous infusion at 5 mL/H
*Normal saline 25 to 50 mL IV prn flush before and after chemotherapy
Monitoring/precautions:
*For mitoxantrone, be aware of the risk of potentially life-threatening treatment-related cardiotoxicity. Risk of cardiac toxicity is increased for patients with: ongoing or history of cardiovascular disease, previous or ongoing radiation therapy to the mediastinal/pericardial area, prior therapy with other anthracyclines or anthracenediones, or concurrent use of other cardiotoxic drugs. It is suggested that all patients undergo monitoring of cardiac function during therapy.
Nursing:
*Patients without central lines: insert peripheral IV before therapy. Flush peripheral IV with 10 mL 0.9% normal saline after each day's dose of chemotherapy. Remove peripheral IV when therapy is complete. 
*Patients with central lines: access the central venous access device before therapy. Flush central line according to institutional guidelines after each day's dose of chemotherapy. Deaccess device when therapy is complete.
Category:Example chemotherapy order sets
Example orders for Paclitaxel, nanoparticle albumin-bound & Bevacizumab in breast cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Paclitaxel, nanoparticle albumin-bound & Bevacizumab==
Published regimens and references can be found on the breast cancer page.
===Example order set #1===
*Paclitaxel, nanoparticle albumin-bound (Abraxane) 125 mg/m2 IV once per day on days 1, 8, 15
*Bevacizumab (Avastin) 10 mg/kg IV once per day on days 1 & 15
28-day cycles
====Supportive therapy====
*Ondansetron (Zofran) 8 mg PO once; 30 minutes prior to chemotherapy
*Optional: Prochlorperazine (Compazine) 10 mg PO once prn nausea prior to chemotherapy
Hydration:
*Normal saline IV continuous infusion at 5 mL/H
*Normal saline 25 to 50 mL IV prn flush before and after chemotherapy
Nursing:
*Patients without central lines: insert peripheral IV before therapy. Flush peripheral IV with 10 mL 0.9% normal saline after each day's dose of chemotherapy. Remove peripheral IV when therapy is complete. 
*Patients with central lines: access the central venous access device before therapy. Flush central line according to institutional guidelines after each day's dose of chemotherapy. Deaccess device when therapy is complete.
Category:Example chemotherapy order sets
Example orders for Paclitaxel, nanoparticle albumin-bound (Abraxane) in breast cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Paclitaxel, nanoparticle albumin-bound (Abraxane)==
Published regimens and references can be found on the breast cancer page.
===Example order set #1===
*Paclitaxel, nanoparticle albumin-bound (Abraxane) 100 mg/m2 IV once per day on days 1, 8, 15
28-day cycles
====Supportive therapy====
*Dexamethasone (Decadron) 12 mg PO once; 30 minutes prior to chemotherapy
*Ondansetron (Zofran) 8 mg PO once; 30 minutes prior to chemotherapy
*Optional: Prochlorperazine (Compazine) 10 mg PO once prn nausea prior to chemotherapy
Hydration:
*Normal saline IV continuous infusion at 5 mL/H
*Normal saline 25 to 50 mL IV prn flush before and after chemotherapy
Nursing:
*Patients without central lines: insert peripheral IV before therapy. Flush peripheral IV with 10 mL 0.9% normal saline after each day's dose of chemotherapy. Remove peripheral IV when therapy is complete. 
*Patients with central lines: access the central venous access device before therapy. Flush central line according to institutional guidelines after each day's dose of chemotherapy. Deaccess device when therapy is complete.
Category:Example chemotherapy order sets
Example orders for Paclitaxel (Taxol) in melanoma

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Paclitaxel (Taxol)==
Published regimens and references can be found on the melanoma page.
===Example order set #1===
*Paclitaxel (Taxol) 80 mg/m2 IV over 60 minutes once per day on days 1, 8, 15; use non-DEHP (paclitaxel) tubing
28-day cycles
====Supportive therapy====
*Dexamethasone (Decadron) 10 mg IV once; 30 minutes prior to chemotherapy
*Diphenhydramine (Benadryl) 25 to 50 mg (50 mg for first dose of paclitaxel; may be reduced to 25 mg for subsequent doses if tolerated) IV once 30 to 60 minutes prior to chemotherapy
*Famotidine (Pepcid) 20 mg IV over 15 minutes once; 30 minutes prior to chemotherapy
Hydration:
*Normal saline IV continuous infusion at 5 mL/H
*Normal saline 25 to 50 mL IV prn flush before and after chemotherapy
Nursing:
*Patients without central lines: insert peripheral IV before therapy. Flush peripheral IV with 10 mL 0.9% normal saline after each day's dose of chemotherapy. Remove peripheral IV when therapy is complete. 
*Patients with central lines: access the central venous access device before therapy. Flush central line according to institutional guidelines after each day's dose of chemotherapy. Deaccess device when therapy is complete.
Category:Example chemotherapy order sets
Example orders for Panitumumab (Vectibix) in colon cancer

Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
==Panitumumab (Vectibix)==
Original references may be found at Panitumumab (Vectibix)
===Example regimen #1===
*Panitumumab (Vectibix) 6 mg/kg IV over 60 minutes on day 1
**Use 0.22 micron non-DEHP/paclitaxel tubing.
14-day cycles
Hydration:
*500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.
Monitoring:
*Hold if ANC less than 1000 or platelets less than 100 and notify physician.
*Check magnesium prior to each dose of panitumumab
Category:Example chemotherapy order sets