Prodelphinidines

==Nom de la substance==
Prodelphinidines
==Famille moléculaire==
Proanthocyanidines, polymères de flavonoïdes
* Les deux groupes majeurs de proanthocyanidines sont les procyanidines et les prodelphinidines
** Les monomères constitutifs des procyanidines sont la catéchine et l’épicatéchine
** Les monomères constitutifs des prodelphinidines sont la gallocatéchine et l’épigallocatéchine
==Source végétale==
* Feuilles de cassis, grenade, feuilles de thé vert, Myrica rubra
==Propriétés==
* Anti-inflammatoires Hou DX, Luo D, Tanigawa S, Hashimoto F, Uto T, Masuzaki S, Fujii M, Sakata Y. Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Biochem Pharmacol. 2007 Sep 1;74(5):742-51. PMID 17658484, Kuo PL, Hsu YL, Lin TC, Lin CC. The antiproliferative activity of prodelphinidin B-2 3'-O-gallate from green tea leaf is through cell cycle arrest and Fas-mediated apoptotic pathway in A549 cells. Food Chem Toxicol. 2005 Feb;43(2):315-23. PMID 15621344
* Anti-oxydants Tawaha K, Sadi R, Qa'dan F, Matalka KZ, Nahrstedt A. A bioactive prodelphinidin from Mangifera indica leaf extract. Z Naturforsch C. 2010 May-Jun;65(5-6):322-6. PMID 20653233
* Antiviraux (Herpes virus) Cheng HY, Lin TC, Ishimaru K, Yang CM, Wang KC, Lin CC. In vitro antiviral activity of prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra. Planta Med. 2003 Oct;69(10):953-6. PMID 14648402, Cheng HY, Lin CC, Lin TC. Antiviral properties of prodelphinidin B-2 3'-O-gallate from green tea leaf. Antivir Chem Chemother. 2002 Jul;13(4):223-9. PMID 12495210
* Inducteurs d'apoptose Kuo PL, Hsu YL, Lin TC, Lin LT, Lin CC. Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra via Fas-mediated pathway. J Pharm Pharmacol. 2004 Nov;56(11):1399-406. PMID 15525446, Kuo PL, Hsu YL, Lin TC, Lin CC. Prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra inhibits proliferation of A549 carcinoma cells via blocking cell cycle progression and inducing apoptosis. Eur J Pharmacol. 2004 Oct 6;501(1-3):41-8. PMID 15464061
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
* Masquelier J, Dumon MC, Dumas J. Stabilisation du collagène par les oligomères procyanidoliques. Acta Therapeutica, (1981) 7 : 101-105.
* Andriambeloson Emile, Stoclet Jean Claude, Andriantsitohaina Ramaroson. Mechanism of Endothelial Nitric Oxide-Dependent Vasorelaxation Induced by Wine Polyphenols in Rat Thoracic Aorta. Journal of Cardiovascular Pharmacology, February 1999 - Volume 33 - Issue 2 - pp 248-254
* M. Diebolt, L. Germain, F. A. Auger and R. Andriantsitohaina. Mechanism of potentiation by polyphenols of contraction in human vein-engineered media. Am J Physiol Heart Circ Physiol 288:H2918-H2924, 2005. Texte intégral
* Aoun M, Michel F, Fouret G, Casas F, Jullien M, Wrutniak-Cabello C, Ramos J, Cristol JP, Coudray C, Carbonneau MA, Feillet-Coudray C. A polyphenol extract modifies quantity but not quality of liver fatty acid content in high-fat-high-sucrose diet-fed rats: possible implication of the sirtuin pathway. Br J Nutr. 2010 Dec;104(12):1760-70. PMID 20673376
* Andreas Danne, Frank Petereit and Adolf Nahrstedt. Flavan-3-ols, prodelphinidins and further polyphenols from Cistus salvifolius. Phytochemistry, Volume 37, Issue 2, 1994, Pages 533–538
Catégorie:principes actifs