Tellimagrandin

==Nom de la substance==
Tellimagrandin, tellimagrandine I et II
==Famille moléculaire==
* Tanins hydrolysables (ellagitanins monomères)
==Source végétale==
* Reine des prés Filipendula ulmaria, noix Juglans regia (pellicule de la noix), églantier Rosa canina , eucalyptus Hou AJ, Liu YZ, Yang H, Lin ZW, Sun HD. Hydrolyzable tannins and related polyphenols from Eucalyptus globulus. J Asian Nat Prod Res. 2000;2(3):205-12. PMID 11256694, giroflier Kim HJ, Lee JS, Woo ER, Kim MK, Yang BS, Yu YG, Park H, Lee YS. Isolation of virus-cell fusion inhibitory components from Eugenia caryophyllata. Planta Med. 2001 Apr;67(3):277-9. PMID 11345703, Poincianella pluviosa Bueno FG, Panizzon GP, Mello EV, Lechtenberg M, Petereit F, de Mello JC, Hensel A. Hydrolyzable tannins from hydroalcoholic extract from Poincianella pluviosa stem bark and its wound-healing properties: phytochemical investigations and influence on in vitro cell physiology of human keratinocytes and dermal fibroblasts. Fitoterapia. 2014 Dec;99:252-60. doi: 10.1016/j.fitote.2014.10.007. PMID 25454458, Geum japonicum, Tellima grandiflora (Saxifragaceae) Ruth Niemetz, Gerhard Schilling, Georg G Gross. Biosynthesis of the dimeric ellagitannin, cornusiin E, in Tellima grandiflora. Phytochemistry, Volume 64, Issue 1, 2003, Pages 109-114, https://doi.org/10.1016/S0031-9422(03)00280-2.
==Propriétés==
* Cytotoxique sur différents cancers par affaiblissement de la fonction mitochondriale et induction de l'apoptose Le V, Esposito D, Grace MH, Ha D, Pham A, Bortolazzo A, Bevens Z, Kim J, Okuda R, Komarnytsky S, Lila MA, White JB. Cytotoxic effects of ellagitannins isolated from walnuts in human cancer cells. Nutr Cancer. 2014;66(8):1304-14. doi: 10.1080/01635581.2014.956246. PMID 25264855, antitumoral sur cellules de cancer du col Yi ZC, Liu YZ, Li HX, Yin Y, Zhuang FY, Fan YB, Wang Z. Tellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro. Cancer Lett. 2006 Oct 8;242(1):77-87. PMID 16338066 et de cellules leucémiques Yi Z, Wang Z, Li H, Liu M. Inhibitory effect of tellimagrandin I on chemically induced differentiation of human leukemia K562 cells. Toxicol Lett. 2004 Mar 1;147(2):109-19. PMID 14757314, activité antitumorale et induction d’interleukine-1 (IL-1 bêta) Miyamoto K, Murayama T, Nomura M, Hatano T, Yoshida T, Furukawa T, Koshiura R, Okuda T. Antitumor activity and interleukin-1 induction by tannins. Anticancer Res. 1993 Jan-Feb;13(1):37-42. PMID 8476228
* Hypotriglycéridémiant Shimoda H, Tanaka J, Kikuchi M, Fukuda T, Ito H, Hatano T, Yoshida T. Effect of polyphenol-rich extract from walnut on diet-induced hypertriglyceridemia in mice via enhancement of fatty acid oxidation in the liver. J Agric Food Chem. 2009 Mar 11;57(5):1786-92. doi: 10.1021/jf803441c. PMID 19256553
* Hépatoprotecteur Shimoda H, Tanaka J, Kikuchi M, Fukuda T, Ito H, Hatano T, Yoshida T. Walnut polyphenols prevent liver damage induced by carbon tetrachloride and d-galactosamine: hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut. J Agric Food Chem. 2008 Jun 25;56(12):4444-9. doi: 10.1021/jf8002174. PMID 18494495
* Restaure l'efficacité de l'oxacilline Hatano T, Kusuda M, Inada K, Ogawa TO, Shiota S, Tsuchiya T, Yoshida T. Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus. Phytochemistry. 2005 Sep;66(17):2047-55. PMID 16153408, et des bêta-lactamines Shiota S, Shimizu M, Sugiyama J, Morita Y, Mizushima T, Tsuchiya T. Mechanisms of action of corilagin and tellimagrandin I that remarkably potentiate the activity of beta-lactams against methicillin-resistant Staphylococcus aureus. Microbiol Immunol. 2004;48(1):67-73. PMID 14734860, Shiota S, Shimizu M, Mizusima T, Ito H, Hatano T, Yoshida T, Tsuchiya T. Restoration of effectiveness of beta-lactams on methicillin-resistant Staphylococcus aureus by tellimagrandin I from rose red. FEMS Microbiol Lett. 2000 Apr 15;185(2):135-8. PMID 10754237 vis-à-vis de Staphylococcus aureus résistant à la méthicilline (MRSA)
==Effet thérapeutique==
* Hyperlipidémie 
==Effets indésirables==
==Bibliographie==
* Yi ZC, Liu YZ, Li HX, Wang Z. Chebulinic acid and tellimagrandin I inhibit DNA strand breaks by hydroquinone/Cu(II) and H(2)O(2)/Cu(II), but potentiate DNA strand breaks by H(2)O(2)/Fe(II). Toxicol In Vitro. 2009 Jun;23(4):667-73. doi: 10.1016/j.tiv.2009.03.009. PMID 19328845
Catégorie:principes actifs