Lutéine

==Nom de la substance==
Lutéine
==Famille moléculaire==
Caroténoïde de type xanthophylle non provitaminique A
==Source végétale==
Épinard, chou vert, légumes jaunes (maïs, carotte) ou à feuilles vertes (épinards, oseille) et des fleurs comestibles telles que la rose d'Inde (Tagetes erecta)
==Propriétés==
* Antioxydant, chimio-prévention du cancer Frederick Khachik, Gary R. Beecher, J. Cecil Smith Jr. Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer. Journal of Cellular Biochemistry, Volume 59, Issue Supplement 22, pages 236–246, 1995, Rong Tsao, Mingchen Wang, Zeyuan Deng. Lutein: Separation, Antioxidant Activity, and Potential Health Benefits. A.C.S. symposium series, 2007, 956, 352-372, protège contre les dommages de l'ADN et l'instabilité chromosomique induits par le cisplatine Serpeloni, J.M., Grotto, D., Mercadante, A.Z. et al. Lutein improves antioxidant defense in vivo and protects against DNA damage and chromosome instability induced by cisplatin. Arch Toxicol 84, 811–822 (2010). https://doi.org/10.1007/s00204-010-0576-y
* Réduction de la dégénérescence maculaire liée à l'âge Richer S, Stiles W, Statkute L, Pulido J, Frankowski J, Rudy D, Pei K, Tsipursky M, Nyland J. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr;75(4):216-30. PMID 15117055, protection oculaire Bernstein, P. S., Li, B., Vachali, P. P., Gorusupudi, A., Shyam, R., Henriksen, B. S., & Nolan, J. M. (2016). Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Progress in retinal and eye research, 50, 34–66. https://doi.org/10.1016/j.preteyeres.2015.10.003 PMID 26541886 , les bénéfices sur la DMLA seraient démontrés à partir de 6 mg/j de lutéine, sachant que (la consommation moyenne est de 2 mg/j) Ranard, K. M., Jeon, S., Mohn, E. S., Griffiths, J. C., Johnson, E. J., & Erdman, J. W., Jr (2017). Dietary guidance for lutein: consideration for intake recommendations is scientifically supported. European journal of nutrition, 56(Suppl 3), 37–42. https://doi.org/10.1007/s00394-017-1580-2 PMID 29149368
* Les revues de grande envergure seraient peu significatives Bartlett HE, Eperjesi F. Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial. Eur J Clin Nutr. 2007 Sep;61(9):1121-7. PMID 17268417, Evans JR, Henshaw K. Antioxidant vitamin and mineral supplementation for preventing age-related macular degeneration. Cochrane Database Syst Rev. 2000;(2):CD000253. PMID 10796707, Rehak M, Fric E, Wiedemann P. Lutein and antioxidants in the prevention of age-related macular degeneration. Ophthalmologe. 2008 Jan;105(1):37-8, 40-5.PMID 18075744
* Protection face aux radiations photoniques à onde courte pénétrant dans la rétine, quand elle est associée à la zéaxanthine Hammond, B. R., Fletcher, L. M., Roos, F., Wittwer, J., & Schalch, W. (2014). A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on photostress recovery, glare disability, and chromatic contrast. Investigative ophthalmology & visual science, 55(12), 8583–8589. https://doi.org/10.1167/iovs.14-15573 PMID 25468896
* Synergie avec le lycopène
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
* Meike Trieschmann, Stephen Beatty, John M. Nolan, Hans Werner Hense, Britta Heimes, Ulrike Austermann, Manfred Fobker, Daniel Pauleikhoff. Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: The LUNA study. Experimental Eye Research, Volume 84, Issue 4, April 2007, Pages 718-728
* Olaf Sommerburg, Jan E E Keunen, Alan C Bird, Frederik J G M van Kuijk. Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br J Ophthalmol 1998;82:907-910 doi:10.1136/bjo.82.8.907
* Judy D. Ribaya-Mercado, Jeffrey B. Blumberg. Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention. J Am Coll Nutr December 2004 vol. 23 no. suppl 6
Catégorie:principes actifs