Alcool de patchouly

==Nom de la substance==
Alcool de patchouly, patchoulol, alcool de patchouli
==Famille moléculaire==
* Sesquiterpénol
==Source végétale==
* Patchouly Pogostemon cablin
==Propriétés==
* Immunostimulant (protection vis-à-vis du virus grippal) Li YC, Peng SZ, Chen HM, Zhang FX, Xu PP, Xie JH, He JJ, Chen JN, Lai XP, Su ZR. Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice. Int Immunopharmacol. 2012 Jan;12(1):294-301. doi: 10.1016/j.intimp.2011.12.007. PMID 22193241, Liao, J. B., Wu, D. W., Peng, S. Z., Xie, J. H., Li, Y. C., Su, J. Y., ... & Su, Z. R. (2013). Immunomodulatory potential of patchouli alcohol isolated from Pogostemon cablin (Blanco) Benth (Lamiaceae) in mice. Tropical Journal of Pharmaceutical Research, 12(4), 559-565.
* Activité antibactérienne, inhibe les bactéries Gram-négatives et Gram-positives, ainsi que certaines bactéries résistantes comme Staphylococcus aureus résistant à la méthicilline (SARM) Wan F, Peng F, Xiong L, Chen JP, Peng C, Dai M. In Vitro and In Vivo Antibacterial Activity of Patchouli Alcohol from Pogostemon cablin. Chin J Integr Med. 2021 Feb;27(2):125-130. doi: 10.1007/s11655-016-2452-y. PMID 27080999.
* Anti-inflammatoire Jeong JB, Shin YK, Lee SH. Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells. Food Chem Toxicol. 2013 May;55:229-33. doi: 10.1016/j.fct.2012.12.062. PMID 23348408, Li YC, Xian YF, Ip SP, Su ZR, Su JY, He JJ, Xie QF, Lai XP, Lin ZX. Anti-inflammatory activity of patchouli alcohol isolated from Pogostemonis Herba in animal models. Fitoterapia. 2011 Dec;82(8):1295-301. doi: 10.1016/j.fitote.2011.09.003. PMID 21958968, Xian, Y. F., Li, Y. C., Ip, S. P., Lin, Z. X., Lai, X. P., & Su, Z. R. (2011). Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264. 7 macrophages. Experimental and Therapeutic Medicine, 2(3), 545-550.
* Inducteur d’apoptose de cellules de cancer colorectal humain Jeong JB, Choi J, Lou Z, Jiang X, Lee SH. Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells. Int Immunopharmacol. 2013 Jun;16(2):184-90. doi: 10.1016/j.intimp.2013.04.006. PMID 23602914
* Neuroprotecteur Abd Rashed, A., Abd Rahman, A. Z., & Rathi, D. N. G. (2021). Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review. Molecules, 26(4), 1107., Wei, L. L., Chen, Y., Yu, Q. Y., Wang, Y., & Liu, G. (2018). Patchouli alcohol protects against ischemia/reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice. Brain research, 1682, 61-70.
* Protège le poumon des lésions aiguës induites par les lipopolysaccharides chez la souris Su Z, Liao J, Liu Y, Liang Y, Chen H, Chen X, Lai X, Feng X, Wu D, Zheng Y, Zhang X, Li Y. Protective effects of patchouli alcohol isolated from Pogostemon cablin on lipopolysaccharide-induced acute lung injury in mice. Exp Ther Med. 2016 Feb;11(2):674-682. doi: 10.3892/etm.2015.2918. PMID 26893665; PMCID: PMC4733951
* Anti-athéroscléreux Wang, H. T., Wang, Z. Z., Wang, Z. C., Wang, S. M., Cai, X. J., Su, G. H., & Yuan, Z. Y. (2016). Patchouli alcohol attenuates experimental atherosclerosis via inhibiting macrophage infiltration and its inflammatory responses. Biomedicine & Pharmacotherapy, 83, 930-935.
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
Catégorie:principes actifs