Curcumine

==﻿Nom de la substance==
Curcumine
==Famille moléculaire==
* Pigment polyphénolique (curcuminoïde) de couleur jaune (colorant alimentaire E100)
==Source végétale==
Curcuma, Temoe-Lawaq
==Propriétés==
* Hypocholestérolémiant
* Anti-inflammatoire, activateur du facteur de transcription nucléaire PPAR-γ qui joue un rôle dans certains processus inflammatoires Mazidi M, Karimi E, Meydani M, Ghayour-Mobarhan M, Ferns GA. Potential effects of curcumin on peroxisome proliferator-activated receptor-γ in vitro and in vivo. World J Methodol. 2016 Mar 26;6(1):112-7. doi: 10.5662/wjm.v6.i1.112. eCollection 2016 Mar 26. PMID 27019802, Siddiqui AM, Cui X, Wu R, Dong W, Zhou M, Hu M, Simms HH, Wang P. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med. 2006 Jul;34(7):1874-82. PMID 16715036, activité démontrée sur des modèles d’inflammation aigue et chronique, arthrites, granulomes Ammon HP, Safayhi H, Mack T, Sabieraj J. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol 1993 Mar; 38(2-3): 113-9., différentes molécules impliquées dans l’inflammation sont inhibées par la curcumine : phospholipase, lipoxygénase, cyclooxygénase 2, leucotriènes, thromboxane, prostaglandines, NO, collagénase, élastase, hyaluronidase, monocyte chemoattractant protein-1 (MCP-1), interferon-inducible protein, tumor necrosis factor (TNF), interleukine-12 (IL-12) Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 Feb;9(1):161-8. PMID 12676044, Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets. 2011 Mar 1;12(3):332-47. PMID 20955148, Shehzad A, Rehman G, Lee YS. Curcumin in inflammatory diseases. Biofactors. 2013 Jan-Feb;39(1):69-77. doi: 10.1002/biof.1066. PMID 23281076, McCubrey JA, Lertpiriyapong K, Steelman LS, Abrams SL, Yang LV, Murata RM, Rosalen PL, Scalisi A, Neri LM, Cocco L, Ratti S, Martelli AM, Laidler P, Dulińska-Litewka J, Rakus D, Gizak A, Lombardi P, Nicoletti F, Candido S, Libra M, Montalto G, Cervello M. Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging (Albany NY). 2017 Jun 12;9(6):1477-1536. doi: 10.18632/aging.101250. PMID 28611316, avec une grande sécurité d'emploi
* Hépatoprotecteur, prévient la cytotoxicité hépatocytaire induite par le tétrachlorure de carbone Lee H, Kim S, Lee G, Choi M, Jung H, Kim Y, Kwon H, Chae H. Turmeric extract and its active compound, curcumin, protect against chronic CCl-induced liver damage by enhancing antioxidation. BMC Complementary and Alternative Medicine 2016, 16:316 (26 August 2016). Abstract texte intégral et le paracétamol Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta. 2007 Jun;1770(6):989-96.PMID 17383825, Soliman MM, Nassan MA, Ismail TA. Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats. BMC Complementary and Alternative Medicine 2014, 14:457 (29 November 2014) Abstract texte intégral, le cisplatine Palipoch S, Punsawad C, Koomhin P, Suwannalert P. Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress. BMC Complementary and Alternative Medicine 2014, 14:111 (28 March 2014) Abstract texte intégral, préventif vis-à-vis de la cirrhose et de la fibrose hépatique Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundamental & Clinical Pharmacology 2008 Aug;22(4):417-27. PMID 18705752, inhibe le processus de fibrose hépatique induit par le tétrachlorure de carbone chez le rat Yao Q, Xu B, Wang J, Liu H, Zhang S, Tu C. Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. BMC Complementary and Alternative Medicine 2012, 12:156 (16 September 2012) Abstract Provisional PDF
* Anti-oxydant Kolodziejczyk J, Olas B, Saluk-Juszczak J, Wachowicz B. Antioxidative properties of curcumin in the protection of blood platelets against oxidative stress in vitro. Platelets. 2011;22(4):270-6. PMID 21303217, Sreejayan N, Rao MN. Free radical scavenging activity of curcuminoids. Arzneimittelforschung. 1996 Feb;46(2):169-71. PMID 8720307
* Intérêt dans les maladies auto-immunes Bright JJ. Curcumin and autoimmune disease. Adv Exp Med Biol. 2007;595:425-51. PMID 17569223
* Protection vis-à-vis de l'inflammation intestinale Zhang X, Wu J, Ye B, Wang Q, Xie X, Shen H. Protective effect of curcumin on TNBS-induced intestinal inflammation is mediated through the JAK/STAT pathway. BMC Complementary and Alternative Medicine 2016, 16:299 (20 August 2016) Abstract texte intégral
* Inhibe la production d’interleukine et de TNF, chimioprotecteur, inhibe la promotion tumorale Huang MT, Smart RC, Wong CQ, Conney AH. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1988 Nov 1;48(21):5941-6. PMID 3139287, Nakamura Y, Murakami A, Ohigashi H. Search for Naturally-occurring Antioxidative Chemopreventors on the Basis of the Involvement of Leukocyte-derived Reactive Oxygen Species in Carcinogenesis. Asian Pac J Cancer Prev. 2000;1(2):115-120. PMID 12718677, favorise l’apoptose des cellules cancéreuses, anti-néoangiogénique, bloque la production de COX-2 par les cellules cancéreuses
* Inducteur d'apoptose dans certaines cellules leucémiques humaines Yang C, Chang C, Lee H, Chi C, Pan J, Yang W. Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways. BMC Complementary and Alternative Medicine 2012, 12:22 (24 March 2012) Abstract texte intégral
* Potentialise les effets de la gemcitabine dans le cancer du pancréas Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res. 2007 Apr 15;67(8):3853-61. PMID 17440100
* Association synergique avec le docetaxel dans le cancer du poumon non à petites cellules Yin H, Guo R, Xu Y, Zheng Y, Hou Z, Dai X, Zhang Z, Zheng D, Xu H. Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer. Acta Biochim Biophys Sin (Shanghai). 2012 Feb;44(2):147-53. doi: 10.1093/abbs/gmr106. PMID 22126905 et dans le cancer de la prostate Banerjee S, Singh SK, Chowdhury I, Lillard JW Jr, Singh R. Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer. Front Biosci (Elite Ed). 2017 Mar 1;9:235-245. PMID 28199187
* Inhibition du développement des cancers de peau Limtrakul P, Lipigorngoson S, Namwong O, Apisariyakul A, Dunn FW. Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett 1997 Jun 24; 116(2): 197-203. PMID 9215864, de l'œsophage Almanaa TN, Geusz ME, Jamasbi RJ. Effects of curcumin on stem-like cells in human esophageal squamous carcinoma cell lines. BMC Complementary and Alternative Medicine 2012, 12:195 (24 October 2012) Abstract texte intégral
* La curcumine inhibe la croissance du cancer de la prostate in vivo, induit l'apoptose des cellules LNCaP in vitro et joue un rôle dans la régulation épigénétique des cellules cancéreuses de la prostate Zhao, W., Zhou, X., Qi, G., & Guo, Y. (2018). Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation. Journal of biochemical and molecular toxicology, 32(5), e22049. https://doi.org/10.1002/jbt.22049. PMID 29485738
* La curcumine agit comme modulateur épigénétique (inhibition des ADN méthyltransférases, régulation des modifications des histones par les histones acétyltransférases et histones désacétylases, régulation des microARN, action en tant qu'agent de liaison à l'ADN et interaction avec les facteurs de transcription). Ces mécanismes sont interconnectés et jouent un rôle vital dans la progression tumorale. La curcumine peut également agir comme régulateur épigénétique dans les troubles neurologiques, l'inflammation et le diabète. La curcumine est un puissant inhibiteur du protéasome qui augmente le niveau de p-53 et induit l'apoptose par l'activation de la caspase Hassan, F. U., Rehman, M. S., Khan, M. S., Ali, M. A., Javed, A., Nawaz, A., & Yang, C. (2019). Curcumin as an Alternative Epigenetic Modulator: Mechanism of Action and Potential Effects. Frontiers in genetics, 10, 514. https://doi.org/10.3389/fgene.2019.00514. PMID 31214247
* Antidiabétique El-Bahr SM. Curcumin regulates gene expression of insulin like growth factor, B-cell CLL/lymphoma 2 and antioxidant enzymes in streptozotocin induced diabetic rats. BMC Complementary and Alternative Medicine 2013, 13:368 (24 December 2013) Abstract texte intégral
* Anti-Alzheimer : bloquerait l’accumulation de protéine bêta-amyloïde et détruirait les plaques existantes, améliore le comportement, la qualité de vie et la longévité sur modèles animaux Wang X, Kim J, Lee S, Kim Y, Jung M, Kwon H, Ahn Y. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models. BMC Complementary and Alternative Medicine 2014, 14:88 (5 March 2014) Abstract texte intégral, Shrikant Mishra, Kalpana Palanivelu. The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Ann Indian Acad Neurol. 2008 Jan-Mar; 11(1): 13–19. texte intégral, avec d'autres métabolites secondaires végétaux tels que catéchines et proanthocyanidines du thé vert, curcumine du curcuma, extraits enrichis en bacosides du Brahmi (Bacopa monnieri), glycosides de flavones du Ginkgo biloba, acides gras poly-insaturés oméga-3 Apetz N, Munch G, Govindaraghavan S, Gyengesi E. Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease--a translational perspective. CNS Neurol Disord Drug Targets. 2014;13(7):1175-91. PMID 25230232
* Neuroprotection dans la maladie de Parkinson Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, Dexter DT. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res. 2005 Oct;39(10):1119-25. PMID 16298737, Yang S, Zhang D, Yang Z, Hu X, Qian S, Liu J, Wilson B, Block M, Hong JS. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem Res. 2008 Oct;33(10):2044-53. doi: 10.1007/s11064-008-9675-z. PMID 18368483, Liu Z, Yu Y, Li X, Ross CA, Smith WW. Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism. Pharmacol Res. 2011 May;63(5):439-44. doi: 10.1016/j.phrs.2011.01.004. PMID 21237271, Wang MS, Boddapati S, Emadi S, Sierks MR. Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. BMC Neurosci. 2010 Apr 30;11:57. doi: 10.1186/1471-2202-11-57. PMID 20433710 texte intégral, Harish G, Venkateshappa C, Mythri RB, Dubey SK, Mishra K, Singh N, Vali S, Bharath MM. Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson's disease. Bioorg Med Chem. 2010 Apr 1;18(7):2631-8. doi: 10.1016/j.bmc.2010.02.029. PMID 20227282, Jagatha B, Mythri RB, Vali S, Bharath MM. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free Radic Biol Med. 2008 Mar 1;44(5):907-17. doi: 10.1016/j.freeradbiomed.2007.11.011. PMID 18166164, Ortiz-Ortiz MA, Morán JM, Ruiz-Mesa LM, Niso-Santano M, Bravo-SanPedro JM, Gómez-Sánchez R, González-Polo RA, Fuentes JM. Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells. Neurosci Lett. 2010 Jan 4;468(2):120-4. doi: 10.1016/j.neulet.2009.10.081. PMID 19879924, pourrait réduire l'accumulation de l'α-synucléine A53T (régulation de la signalisation mTOR/p70S6K) par induction d'autophagie Jiang TF, Zhang YJ, Zhou HY, Wang HM, Tian LP, Liu J, Ding JQ, Chen SD. Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy. J Neuroimmune Pharmacol. 2013 Mar;8(1):356-69. doi: 10.1007/s11481-012-9431-7. PMID 23325107, inhibe l'agrégation de l'alpha-synucléine Marchiani A, Mammi S, Siligardi G, Hussain R, Tessari I, Bubacco L, Delogu G, Fabbri D, Dettori MA, Sanna D, Dedola S, Serra PA, Ruzza P. Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties. Amino Acids. 2013 Aug;45(2):327-38. doi: 10.1007/s00726-013-1503-3. PMID 23645386, Singh PK, Kotia V, Ghosh D, Mohite GM, Kumar A, Maji SK. Curcumin modulates α-synuclein aggregation and toxicity. ACS Chem Neurosci. 2013 Mar 20;4(3):393-407. doi: 10.1021/cn3001203. PMID 23509976 , Pandey N, Strider J, Nolan WC, Yan SX, Galvin JE. Curcumin inhibits aggregation of alpha-synuclein. Acta Neuropathol. 2008 Apr;115(4):479-89. doi: 10.1007/s00401-007-0332-4. PMID 18189141, protection mitochondriale Mythri RB, Jagatha B, Pradhan N, Andersen J, Bharath MM. Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria? Antioxid Redox Signal. 2007 Mar;9(3):399-408. PMID 17184173, Mythri RB, Harish G, Dubey SK, Misra K, Bharath MM. Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrite-mediated nitrosative stress and damage of brain mitochondria in vitro: implications for Parkinson's disease. Mol Cell Biochem. 2011 Jan;347(1-2):135-43. doi: 10.1007/s11010-010-0621-4. PMID 20972609, Chen J, Tang XQ, Zhi JL, Cui Y, Yu HM, Tang EH, Sun SN, Feng JQ, Chen PX. Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis. 2006 Jun;11(6):943-53. PMID 16547587, inhibition de la monoamine oxydase B Rajeswari A, Sabesan M. Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice. Inflammopharmacology. 2008 Apr;16(2):96-9. doi: 10.1007/s10787-007-1614-0. PMID 18408903
* Activité antivirale vis-à-vis du virus Chikungunya (avec la résine de Boswellia serrata von Rhein C, Weidner T, Henß L, Martin J, Weber C, Sliva K, Schnierle BS. Curcumin and Boswellia serrata gum resin extract inhibit chikungunya and vesicular stomatitis virus infections in vitro. Antiviral Res. 2016 Jan;125:51-7. doi: 10.1016/j.antiviral.2015.11.007. PMID 26611396
==Effet thérapeutique==
* Hypercholestérolémie, syndrome métabolique, affections hépatiques
* Maintien de la rémission dans la colite ulcéreuse quiescente Kumar S, Ahuja V, Sankar MJ, Kumar A, Moss AC. Curcumin for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2012 Oct 17;10:CD008424. doi: 10.1002/14651858.CD008424.pub2. PMID 23076948
* DMLA (dégénérescence maculaire liée à l'âge), la curcumine protège les cellules de l’épithélium pigmentaire rétinien contre les dommages oxydatifs induits par H2O2 Chang YC, Chang WC, Hung KH, Yang DM, Cheng YH, Liao YW, Woung LC, Tsai CY, Hsu CC, Lin TC, Liu JH, Chiou SH, Peng CH, Chen SJ. The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress. Front Aging Neurosci. 2014 Aug 1;6:191. doi: 10.3389/fnagi.2014.00191. eCollection 2014. PMID 25136316, elle régule l’expression des biomarqueurs de la prolifération, du stress oxydatif, et de l’apoptose des cellules rétiniennes Zhu W, Wu Y, Meng YF, Wang JY, Xu M, Tao JJ, Lu J. Effect of curcumin on aging retinal pigment epithelial cells. Drug Des Devel Ther. 2015 Sep 25;9:5337-44. doi: 10.2147/DDDT.S84979. eCollection 2015. PMID 26445530
* Cancers, chimioprévention et traitement des cancers du sein Wang K, Zhang C, Bao J, Jia X, Liang Y, Wang X, Chen M, Su H, Li P, Wan JB, He C. Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death. Sci Rep. 2016 Jun 6;6:26064. doi: 10.1038/srep26064. PMID 27263652
* Maladies auto-immunes
* Maladies de Parkinson et d'Alzheimer
* Arthrites Henrotin Y, Priem F, Mobasheri A. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus. 2013 Dec;2(1):56. doi: 10.1186/2193-1801-2-56. PMID 23487030 et arthrose (gonarthrose) Bannuru RR, Osani MC, Al-Eid F, Wang C. Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis. Semin Arthritis Rheum. 2018 Dec;48(3):416-429. doi: 10.1016/j.semarthrit.2018.03.001. PMID 29622343; PMCID: PMC6131088.
* Usage local dans le psoriasis, la sclérodermie (?), associée à l'eucalyptol Liu CH, Chang FY. Development and characterization of eucalyptol microemulsions for topic delivery of cur cumin. Chem Pharm Bull (Tokyo). 2011;59(2):172-8. PMID 21297295
* L'inclusion de la pipérine dans les formulations contenant de la curcumine est fortement recommandée pour inhiber la glucuroconjugaison de la curcumine et améliorer sa biodisponibilité Berginc K, Trontelj J, Basnet NS, Kristl A. Physiological barriers to the oral delivery of curcumin. Pharmazie. 2012 Jun;67(6):518-24. PMID 22822540
** La pipérine améliore la biodisponibilité de divers médicaments en induisant des modifications de la perméabilité intestinale, ainsi qu’une augmentation de la surface absorbante de l’intestin grêle Khajuria A, Thusu N, Zutshi U. Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics. Phytomedicine. 2002 Apr;9(3):224-31. PMID 12046863
==Effets indésirables==
* Très réduits, rares troubles gastriques
* Quelques interactions médicamenteuses
* Inhibition de l'agrégation plaquettaire Shah BH, Nawaz Z, Pertani SA, Roomi A, Mahmood H, Saeed SA, Gilani AH. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol. 1999 Oct 1;58(7):1167-72. PMID 10484074 par modulation de la biosynthèse des eicosanoïdes Srivastava KC, Bordia A, Verma SK. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids. 1995 Apr;52(4):223-7. PMID 7784468, éviter avec les anticoagulants oraux
* La biodisponibilité de la curcumine est faible (mauvaise absorption, métabolisme rapide, élimination systémique rapide), plusieurs pistes sont explorées pour l'améliorer Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007 Nov-Dec;4(6):807-18. PMID 17999464, Bisht S, Maitra A. Systemic delivery of curcumin: 21st century solutions for an ancient conundrum. Curr Drug Discov Technol. 2009 Sep;6(3):192-9. PMID 19496751 : 
** Usage d’adjuvant comme la pipérine, qui interfère avec la glucuroconjugaison
** Usage de curcumine liposomale
** Usage de curcumine encapsulée par des nanoparticules biodégradables (absorption 9 fois supérieure à celle de la curcumine administrée avec de la pipérine) Shaikh J, Ankola DD, Beniwal V, Singh D, Kumar MN. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci. 2009 Jun 28;37(3-4):223-30. doi: 10.1016/j.ejps.2009.02.019. PMID 19491009
** Usage de complexe de phospholipide de curcumine
** Usage d'analogues structuraux de la curcumine
==Bibliographie==
Catégorie:Principes actifs