Géraniine

==Nom de la substance==
Géraniine
==Famille moléculaire==
* Tanin (ellagitanin, tanin hydrolysable)
==Source végétale==
* Geranium robertianum, Geranium thunbergii (utilisé comme antidiarrhéique au Japon), Elaeocarpus sylvestris var. ellipticus, Phyllanthus niruri, Phyllanthus amarus, Phyllanthus urinaria, Phyllanthus phillyreifolius, écorce de Nephelium lappaceum
==Propriétés==
* Astringent, antidiarrhéique
* Anti-hypertenseur Shyr-Yi Lin, Ching-Chiung Wang, Yeh-Lin Lu, Wen-Chun Wu, Wen-Chi Hou. Antioxidant, anti-semicarbazide-sensitive amine oxidase, and anti-hypertensive activities of geraniin isolated from Phyllanthus urinaria. Food and Chemical Toxicology, Volume 46, Issue 7, 2008, Pages 2485-2492, https://doi.org/10.1016/j.fct.2008.04.007., Cheng, J. T., Chang, S. S., & Hsu, F. L. (1994). Antihypertensive action of geraniin in rats. Journal of pharmacy and pharmacology, 46(1), 46-49., par effet d'inhibition de l'enzyme de conversion de l'angiotensine Ueno, H., Horie, S., Nishi, Y., Shogawa, H., Kawasaki, M., Suzuki, S., ... & Morita, N. (1988). Chemical and Pharmaceutical Studies on Medicinal Plants in Paraguay, Geraniin, an Angiotensin-Converting Enzyme Inhibitor from" Paraparai Mi," Phyllanthus niruri. Journal of natural products, 51(2), 357-359.
* Antalgique Miguel, O. G., Calixto, J. B., Santos, A. R., Messana, I., Ferrari, F., Cechinel Filho, V., ... & Yunes, R. A. (1996). Chemical and preliminary analgesic evaluation of geraniin and furosin isolated from Phyllanthus sellowianus. Planta Medica, 62(02), 146-149.
* Antidiabétique Cheng, H. S., Ton, S. H., & Kadir, K. A. (2017). Ellagitannin geraniin: a review of the natural sources, biosynthesis, pharmacokinetics and biological effects. Phytochemistry reviews, 16(1), 159-193.
* Antiviral (Enterovirus) Yajun Yang, Lianfeng Zhang, Xiaoxu Fan, Chuan Qin, Jiangning Liu. Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo. Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 6, 2012, Pages 2209-2211, https://doi.org/10.1016/j.bmcl.2012.01.102., inhibition des virus Zika et de la dengue Haddad JG, Grauzdytė D, Koishi AC, Viranaicken W, Venskutonis PR, Nunes Duarte Dos Santos C, Desprès P, Diotel N, El Kalamouni C. The Geraniin-Rich Extract from Reunion Island Endemic Medicinal Plant Phyllanthus phillyreifolius Inhibits Zika and Dengue Virus Infection at Non-Toxic Effect Doses in Zebrafish. Molecules. 2020 May 15;25(10):2316. doi: 10.3390/molecules25102316. PMID 32429073, Herpes virus I et II Chien-Min Yang, Hua-Yew Cheng, Ta-Chen Lin, Lien-Chai Chiang, Chun-Ching Lin. The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-β-d-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. Journal of Ethnopharmacology, Volume 110, Issue 3, 2007, Pages 555-558, https://doi.org/10.1016/j.jep.2006.09.039.
* La géraniine pourrait inhiber l'entrée du SRAS-CoV-2 dans les cellules épithéliales humaines en bloquant la liaison entre la protéine de pointe (spike) du SRAS-CoV-2 et le récepteur ACE2 Kim YS, Chung HS, Noh SG, Lee B, Chung HY, Choi JG. Geraniin Inhibits the Entry of SARS-CoV-2 by Blocking the Interaction between Spike Protein RBD and Human ACE2 Receptor. Int J Mol Sci. 2021 Aug 10;22(16):8604. doi: 10.3390/ijms22168604. PMID 34445310; PMCID: PMC8395245.
* Propriétés immunomodulantes, inhibe la libération du TNF-alpha (tumor necrosis factor-alpha) Okabe, S., Suganuma, M., Imayoshi, Y., Taniguchi, S., Yoshida, T., & Fujiki, H. (2001). New TNF-α releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki. Biological and Pharmaceutical Bulletin, 24(10), 1145-1148., dans les cellules de cancer ovarien Wang X, et al. Geraniin suppresses ovarian cancer growth through inhibition of NF-κB activation and downregulation of Mcl-1 expression. J Biochem Mol Toxicol. 2017 Sep;31(9)
* Médiateur d'apoptose dans les cellules de mélanome humain Lee, Jang-Chang; Tsai, Chih-Yen; Kao, Jung-Yie; Kao, Ming-Ching; Tsai, Shih-Chang; Chang, Chih-Shiang; Huang, Li-Jiau; Kuo, Sheng-Chu; et al. (2008). "Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells". Molecular Nutrition & Food Research. 52 (6): 655–63. doi:10.1002/mnfr.200700381. PMID 18435487.
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
Catégorie:principes actifs