Myricétine

==Nom de la substance==
Myricétine (= Myricétol)
==Famille moléculaire==
Flavonoïde (flavonol)
==Source végétale==
* Vigne rouge, busserole, euphorbe indienne, potentille ansérine, figuier de Barbarie, renouée des oiseaux, thé vert, haricots, raisin, ambrette
* Pollen apicole de diverses origines
==Propriétés==
* Proches de celles de la quercétine
* Anti-inflammatoire comme d'autres flavonoïdes (resvératrol) impliqués dans la suppression de l'inflammation et la prévention des cancers en exerçant leurs effets par inhibition probable de l'activation de NF-kB et en réduisant l'activation de IKK. Holmes-McNary, M.Q. and Baldwin, A.S., Jr. (2000): Chemopreventive properties of trans-Resveratrol are Associated with Inhibition of the Activation of IkB Kinase. Cancer Research, 60:3477-3483.
* Anti-allergique Medeiros, K. C., Figueiredo, C. A., Figueredo, T. B., Freire, K. R., Santos, F. A., Alcantara-Neves, N. M., Silva, T. M., & Piuvezam, M. R. (2008). Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice. Journal of ethnopharmacology, 119(1), 41–46. https://doi.org/10.1016/j.jep.2008.05.036 PMID 18588965
* Antidiabétique Liu IM, Liou SS, Lan TW, Hsu FL, Cheng JT. Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. 2005 Jul;71(7):617-21. PMID 16041646, Liu IM, Liou SS, Cheng JT. Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2006 Mar 8;104(1-2):199-206. PMID 16203117, Liu IM, Tzeng TF, Liou SS, Lan TW. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med. 2007 Aug;73(10):1054-60. PMID 17694473
* Antioxydant
* Antiviral, inhibiteur des protéases NS2B-NS3 du virus de la dengue de Sousa, L. R., Wu, H., Nebo, L., Fernandes, J. B., da Silva, M. F., Kiefer, W., Kanitz, M., Bodem, J., Diederich, W. E., Schirmeister, T., & Vieira, P. C. (2015). Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies. Bioorganic & medicinal chemistry, 23(3), 466–470. https://doi.org/10.1016/j.bmc.2014.12.015 PMID 25564380, anti-HIV Semwal DK, Semwal RB, Combrinck S, Viljoen A. Myricetin: A Dietary Molecule with Diverse Biological Activities. Nutrients. 2016 Feb 16;8(2):90. doi: 10.3390/nu8020090. PMID 26891321 PMCID: PMC4772053., inhibe l'hélicase du SRAS-Coronavirus Yu MS, Lee J, Lee JM, Kim Y, Chin YW, Jee JG, Keum YS, Jeong YJ. Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4049-54. doi: 10.1016/j.bmcl.2012.04.081. PMID 22578462, Keum YS, Jeong YJ. Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target. Biochem Pharmacol. 2012 Nov 15;84(10):1351-8. doi: 10.1016/j.bcp.2012.08.012. PMID 22935448; PMCID: PMC7092843.
* Activité antitumorale vis-à-vis de certaines cellules cancéreuses mammaires Carli CB, de Matos DC, Lopes FC, Maia DC, Dias MB, Sannomiya M, Rodrigues CM, Andreo MA, Vilegas W, Colombo LL, Carlos IZ. Isolated flavonoids against mammary tumour cells LM2. Z Naturforsch C. 2009 Jan-Feb;64(1-2):32-6. PMID 19323263
==Effet thérapeutique==
* Diminution du risque coronarien et cérébro-vasculaire
* Effet favorable dans la ménopause
* Effet favorable dans le cancer du sein, anti-apoptotique
==Effets indésirables==
==Bibliographie==
Catégorie:principes actifs