Ptérostilbène

==Nom de la substance==
Ptérostilbène, trans-3,5-diméthoxy-4-hydroxystilbène
==Famille moléculaire==
Stilbène (polyphénol) proche du resvératrol
==Source végétale==
* Myrtilles et "bleuets" Vaccinium ashei, Vaccinium stamineum, Vaccinium myrtillus, bois d'arbres du genre Pterocarpus (kino de Malabar, santal rouge), Pterocarpus marsupium, raisin Vitis vinifera en plus faible teneur Duarte, N., Ramalhete, C., Rijo, P., Reis, M. A., & Ferreira, M. J. U. (2019). Stilbenoids in Grapes and Wine. Handbook of Dietary Phytochemicals, 1-28., propolis
==Propriétés==
* Puissantes capacités antioxydantes par activation du facteur de transcription Nrf2 capable de déclencher une réponse adaptative qui augmente la réponse antioxydante endogène Yang, Y., Fan, C., Wang, B., Ma, Z., Wang, D., Gong, B., ... & Luo, E. (2017). Pterostilbene attenuates high glucose-induced oxidative injury in hippocampal neuronal cells by activating nuclear factor erythroid 2-related factor 2. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(4), 827-837.
* Anti-inflammatoire, inhibe la signalisation par Nf-kB, diminue la production de facteurs pro-inflammatoires (TNF-alpha, IL-1, IL-6, IL-18, PGE2, COX-1 et COX-2) Hininger-Favier Isabelle. Le ptérostilbène: un antioxydant de nouvelle génération allié dans la lutte contre les effets du vieillissement. Phytothérapie Européenne, n° 120, jan/fév 2021, Dvorakova, M., & Landa, P. (2017). Anti-inflammatory activity of natural stilbenoids: A review. Pharmacological Research, 124, 126-145.
* Neuroprotecteur La Spina, M., Sansevero, G., Biasutto, L., Zoratti, M., Peruzzo, R., Berardi, N., ... & Azzolini, M. (2019). Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. Cell Physiol. Biochem, 52, 232-239., Wang, B., Liu, H., Yue, L., Li, X., Zhao, L., Yang, X., ... & Qu, Y. (2016). Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway. Brain research, 1643, 70-79., diminue les effets du processus ischémie-reperfusion chez le rat Zhou, Y., Zhang, X. M., Ma, A., Zhang, Y. L., Chen, Y. Y., Zhou, H., ... & Jin, X. (2015). Orally administrated pterostilbene attenuates acute cerebral ischemia–reperfusion injury in a dose-and time-dependent manner in mice. Pharmacology Biochemistry and Behavior, 135, 199-209., Liu, J., Xu, J., Mi, Y., Yang, Y., Li, Q., Zhou, D., ... & Hou, Y. (2020). Pterostilbene alleviates cerebral ischemia and reperfusion injury in rats by modulating microglial activation. Food & function, 11(6), 5432-5445.
* Antidiabétique McCormack, D., & McFadden, D. (2013). A review of pterostilbene antioxidant activity and disease modification. Oxidative medicine and cellular longevity, 2013., antistéatosique Gómez-Zorita, S., Milton-Laskíbar, I., Aguirre, L., Fernández-Quintela, A., Xiao, J., & Portillo, M. P. (2020). Effects of pterostilbene on diabetes, liver steatosis and serum lipids. Current medicinal chemistry, Volume 28, Number 2, 2021, pp. 238-252(15), Gómez-Zorita, S., Fernández-Quintela, A., Aguirre, L., Macarulla, M. T., Rimando, A. M., & Portillo, M. P. (2015). Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver. Food & function, 6(6), 1968-1976.
* Diminue la prise de poids de rats soumis à un régime obésogène Gomez-Zorita, S., Fernandez-Quintela, A., Lasa, A., Aguirre, L., Rimando, A. M., & Portillo, M. P. (2014). Pterostilbene, a dimethyl ether derivative of resveratrol, reduces fat accumulation in rats fed an obesogenic diet. Journal of agricultural and food chemistry, 62(33), 8371-8378.
* Potentialités anticancéreuses McCormack, D., & McFadden, D. (2012). Pterostilbene and cancer: current review. Journal of Surgical Research, 173(2), e53-e61., Younas, M., Hano, C., Giglioli-Guivarc'h, N., & Abbasi, B. H. (2018). Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives. RSC advances, 8(52), 29714-29744., Roca, P., Sastre-Serra, J., Nadal-Serrano, M., Pons, D. G., del Mar Blanquer-Rossello, M., & Oliver, J. (2014). Phytoestrogens and mitochondrial biogenesis in breast cancer. Influence of estrogen receptors ratio. Current pharmaceutical design, 20(35), 5594-5618., Jerzak, K. J., Duska, L., & MacKay, H. J. (2019). Endocrine therapy in endometrial cancer: An old dog with new tricks. Gynecologic oncology, 153(1), 175-183.
* Anti-vieillissement Zheng, J., Liu, W., Zhu, X., Ran, L., Lang, H., Yi, L., ... & Zhu, J. (2020). Pterostilbene enhances endurance capacity via promoting skeletal muscle adaptations to exercise training in rats. Molecules, 25(1), 186.
==Effet thérapeutique==
* Amélioration du déclin cognitif, des maladies neurodégénératives, du diabète, des maladies cardiovasculaires, du cancer
* Obésité
==Effets indésirables==
==Bibliographie==
* Azzolini, M., La Spina, M., Mattarei, A., Paradisi, C., Zoratti, M., & Biasutto, L. (2014). Pharmacokinetics and tissue distribution of pterostilbene in the rat. Molecular nutrition & food research, 58(11), 2122-2132.
Catégorie:principes actifs