Cinnamtanin

==Nom de la substance==
Cinnamtanin
==Famille moléculaire==
* Flavonoïde : flavanol
** Proanthocyanidine tétramère, précurseur de tanins
==Source végétale==
* Cannelle Cinnamomum verum, Lindera aggregata, Vaccinium vitis-idaea
==Propriétés==
* Antioxydant HO, K.Y., HUANG, J.S., TSAI, C.C., LIN, T.C., HSU, Y.F. and LIN, C.C. (1999), Antioxidant Activity of Tannin Components from Vaccinium vitis‐idaea L.. Journal of Pharmacy and Pharmacology, 51: 1075-1078. https://doi.org/10.1211/0022357991773410
* Protection des cellules pancréatiques bêta (cinnamtanin D-1) Wang, T., Sun, P., Chen, L., Huang, Q., Chen, K., Jia, Q., ... & Wang, H. (2014). Cinnamtannin D-1 protects pancreatic β-cells from palmitic acid-induced apoptosis by attenuating oxidative stress. Journal of agricultural and food chemistry, 62(22), 5038-5045., Chen, L., Chen, L., Wang, T., Yuan, P., Chen, K., Jia, Q., ... & Li, Y. (2016). Preparation of Methylated Products of A‐type Procyanidin Trimers in Cinnamon Bark and Their Protective Effects on Pancreatic β‐Cell. Journal of food science, 81(5), C1062-C1069.
* Neuroprotecteur (cinnamtanin B-1), protège les astrocytes Chi, Z., Ma, X., Cui, G., Li, M., & Li, F. (2013). Cinnamtannin B-1 regulates cell proliferation of spinal cord astrocytes and protects the cell from oxygen-glucose-serum deprivation/reoxygenation-induced apoptosis. International journal of molecular sciences, 14(8), 15827-15837.
* Antidiabétique (cinnamtanin A2), augmente le GLP-1 et la sécrétion d'insuline chez la souris Yamashita, Y., Okabe, M., Natsume, M., & Ashida, H. (2013). Cinnamtannin A2, a tetrameric procyanidin, increases GLP-1 and insulin secretion in mice. Bioscience, biotechnology, and biochemistry, 77(4), 888-891.
* Anti-agrégant plaquettaire (cinnamtanin B-1) Amor, N. B., Bouaziz, A., Romera-Castillo, C., Salido, S., Linares-Palomino, P. J., Bartegi, A., ... & Rosado, J. A. (2007). Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets. Journal of medicinal chemistry, 50(16), 3937-3944., Bouaziz, A., Salido, S., Linares-Palomino, P. J., Sanchez, A., Altarejos, J., Bartegi, A., ... & Rosado, J. A. (2007). Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients. Archives of biochemistry and biophysics, 457(2), 235-242., López, J. J., Jardín, I., Salido, G. M., & Rosado, J. A. (2008). Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor. Life sciences, 82(19-20), 977-982.
* Inhibition de l'enzyme HIV-intégrase Chaofeng, Z., Qishi, S., Zhengtao, W., Masao, H., & Supinya, T. (2003). Inhibitory activities of tannins extracted from stem of Lindera aggregata against HIV-1 integrase. Zhongguo yao xue za zhi (Zhongguo yao xue hui: 1989), 38(12), 911-914.
* Induit l'apoptose dans des cellules de cancer du colon (cinnamtanin B-1) Carriere, P. P., Kapur, N., Mir, H., Ward, A. B., & Singh, S. (2018). Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer. International journal of oncology, 53(4), 1442-1454.
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
* Salleh, W., & Hakimi, W. M. N. (2020). Lindera aggregata (Sims) Kosterm: Review on phytochemistry and biological activities. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 19(6).
Catégorie:principes actifs