Citronnellol

==Nom de la substance==
Citronnellol
==Famille moléculaire==
Alcool monoterpénique
==Source végétale==
* Huile essentielle de rose, eucalyptus citrin, géranium rosat, citronnelle de Ceylan, basilic
==Propriétés==
* Calmant, antiseptique, antiviral, tonique
* Antifongique, potentialise les effets de l’amphotéricine B et du kétoconazole sur Aspergillus (comme le géraniol)
* Antalgique Brito RG, Guimarães AG, Quintans JS, Santos MR, De Sousa DP, Badaue-Passos D Jr, de Lucca W Jr, Brito FA, Barreto EO, Oliveira AP, Quintans LJ Jr. Citronellol, a monoterpene alcohol, reduces nociceptive and inflammatory activities in rodents. J Nat Med. 2012 Oct;66(4):637-44. doi: 10.1007/s11418-012-0632-4. PMID 22350215, Brito, R. G., Dos Santos, P. L., Quintans, J. S., de Lucca Júnior, W., Araújo, A. A., Saravanan, S., ... & Quintans-Júnior, L. J. (2015). Citronellol, a natural acyclic monoterpene, attenuates mechanical hyperalgesia response in mice: Evidence of the spinal cord lamina I inhibition. Chemico-Biological Interactions, 239, 111-117.
* Spasmolytique, inhibe les contractions de l'iléon Sadraei H, Asghari G, Emami S. Inhibitory effect of Rosa damascena Mill flower essential oil, geraniol and citronellol on rat ileum contraction. Res Pharm Sci. 2013 Jan;8(1):17-23. PMID 24459472
* Anticonvulsivant de Sousa DP, Gonçalves JC, Quintans-Júnior L, Cruz JS, Araújo DA, de Almeida RN. Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents. Neurosci Lett. 2006 Jul 3;401(3):231-5. PMID 16650577
* Potentialise l'activité du GABA-A et augmente son affinité vis-à-vis de ses récepteurs Aoshima H, Hamamoto K. Potentiation of GABAA receptors expressed in Xenopus oocytes by perfume and phytoncid. Bioscience, biotechnology, and biochemistry, 1999, vol. 63, no4, pp. 743-748 (22 ref.) 
* Anti-allergique Pina LTS, Ferro JNS, Rabelo TK, Oliveira MA, Scotti L, Scotti MT, Walker CIB, Barreto EO, Quintans Júnior LJ, Guimarães AG. Alcoholic monoterpenes found in essential oil of aromatic spices reduce allergic inflammation by the modulation of inflammatory cytokines. Nat Prod Res. 2019 Jun;33(12):1773-1777. doi: 10.1080/14786419.2018.1434634. PMID 29394874
* Immuno-modulant, limite la neutropénie et la lymphopénie lors des chimiothérapies anticancéreuses Zhuang SR, Chen SL, Tsai JH, Huang CC, Wu TC, Liu WS, Tseng HC, Lee HS, Huang MC, Shane GT, Yang CH, Shen YC, Yan YY, Wang CK. Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy. Phytother Res. 2009 Jun;23(6):785-90. PMID 19145638
* Activité répulsive vis-à-vis des insectes, effet répulsif contre les tiques Ixodes Rhipicephalus sanguineus et Amblyomma sculptum Ferreira LL, Oliveira Filho JG, Mascarin GM, León AAP, Borges LMF. In vitro repellency of DEET and β-citronellol against the ticks Rhipicephalus sanguineus sensu lato and Amblyomma sculptum. T Vet Parasitol. 2017 May 30;239:42-45. doi: 10.1016/j.vetpar.2017.04.021. PMID 28495195, toxicité vis-à-vis du virus du Nil occidental et de l'agent de la filariose Culex pipiens (association citronnellol, géraniol, linalol dans l'huile essentielle de Pelargonium roseum) Tabari, M. A., Youssefi, M. R., Esfandiari, A., & Benelli, G. (2017). Toxicity of β-citronellol, geraniol and linalool from Pelargonium roseum essential oil against the West Nile and filariasis vector Culex pipiens (Diptera: Culicidae). Research in veterinary science, 114, 36-40.
* Activité herbicide par inhibition de la mitose
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
Catégorie:principes actifs