Carboplatin (Paraplatin)

==General information==
Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.Carboplatin (Paraplatin) package insert Carboplatin (Paraplatin) package insert (locally hosted backup)
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, UpToDate Lexidrug,Medscape, or the prescribing information.
==Dosing information==
*Carboplatin AUC calculatorCarboplatin AUC calculator
===Calvert formula===
* Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME, Wiltshaw E. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989 Nov;7(11):1748-56. link to original article contains verified formula EuroPMC
==Diseases for which it is established (work in progress)==
*Malignant pleural mesothelioma
*Non-small cell lung cancer
**Non-small cell lung cancer, nonsquamous
**Non-small cell lung cancer, squamous
*Ovarian cancer
==Diseases for which it is used==
*Adult T-cell leukemia-lymphoma
*Anal cancer
*Anaplastic glioma
*Breast cancer
*Cervical cancer
*Diffuse large B-cell lymphoma
*Endometrial cancer
*Esophageal cancer
*Ewing sarcoma
*Extranodal NK- and T-cell lymphoma, nasal type
*Gastric cancer
*Glioblastoma
*Head and neck cancer
*Classical Hodgkin lymphoma
*Low-grade glioma
**Low-grade glioma, pediatric
*Mantle cell lymphoma
*Medulloblastoma
*Melanoma 
*Nasopharyngeal carcinoma
*Neuroblastoma
*Osteosarcoma
*Prostate cancer
*Retinoblastoma
*Small cell lung cancer
*Testicular cancer
*Thymoma
*Unknown primary
*Urothelial carcinoma
**Bladder cancer
**Upper tract urothelial carcinoma
==Diseases for which it was used==
*Pancreatic cancer
==Patient drug information==
*Carboplatin (Paraplatin) package insert
*Carboplatin (Paraplatin) patient drug information (Chemocare)Carboplatin (Paraplatin) patient drug information (Chemocare)
*Carboplatin (Paraplatin) patient drug information (UpToDate)Carboplatin (Paraplatin) patient drug information (UpToDate)
==History of changes in FDA indication==
* 1989-03-03: Initial approval as palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have previously been treated with cisplatin. (Based on SWOG 8412 and Swenerton et al. 1992)
==History of changes in EMA indication==
*1986-01-23: EURD
==History of changes in PMDA indication==
*2011-11-25: New additional indication and new dosages for the treatment of breast cancer.
==Also known as==
*Code name: JM-8
*Brand names:
Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms
Biocarb 	Biocarbo 	Bioplatinex	Biovinate	Blastocarb 	Bonaplatin 	Boplatex 	Carbo
Carbokem 	Carbomedac 	Carbomerck 	Carboplat	Carboplatine	Carboplatino	Carboplatinum	Carbosin
Carbotanil 	Carbotec 	Carbotinol 	Careptin 	Carplan 	Carplanil 	Carpsol 	Crobextin
Cycloplatin 	Cycloplatinum	Emorzim 	Erbakar 	Ercar 	Fauldcarbo 	Ifacap 	Kemocarb
Megaplatin 	Nealorin 	Neocarb 	Neocarbo 	Oncocarb 	Paraplatin 	Paraplatine 	Pharmaplatin
Platamine CS	Platinwas 	Ribocarbo 	Tecnocarb	Vancel 	CBDCA 	 	
==References==
Category:Drugs
Category:Intravenous medications
Category:Platinum agents
Category:Alkylating agents
Category:Irritant
Category:Adult T-cell leukemia-lymphoma medications
Category:Anal cancer medications
Category:Anaplastic glioma medications
Category:Bladder cancer medications
Category:Breast cancer medications
Category:Carcinoma of unknown primary medications 
Category:Cervical cancer medications
Category:Diffuse large B-cell lymphoma medications
Category:Endometrial cancer medications
Category:Esophageal cancer medications
Category:Ewing sarcoma medications
Category:Extranodal NK- and T-cell lymphoma, nasal type medications
Category:Gastric cancer medications
Category:Glioblastoma medications
Category:Head and neck cancer medications
Category:Classical Hodgkin lymphoma medications
Category:Low-grade glioma medications
Category:Low-grade glioma, pediatric medications
Category:Mantle cell lymphoma medications
Category:Medulloblastoma medications
Category:Melanoma medications 
Category:Malignant pleural mesothelioma medications
Category:Nasopharyngeal carcinoma medications
Category:Neuroblastoma medications
Category:Non-small cell lung cancer medications
Category:Non-small cell lung cancer, nonsquamous medications
Category:Non-small cell lung cancer, squamous medications
Category:Osteosarcoma medications
Category:Ovarian cancer medications
Category:Prostate cancer medications
Category:Retinoblastoma medications
Category:Small cell lung cancer medications
Category:Testicular cancer medications
Category:Thymoma medications
Category:Upper tract urothelial carcinoma medications
Category:Urothelial carcinoma medications
Category:Pancreatic cancer medications (historic)
Category:FDA approved in 1989
Category:EMA approved in 1986
Category:WHO Essential Cancer Medicine