Monosodium glutamate

Monosodium glutamate, more popularly known as "MSG" (chemical formula C5H8NO4Na), is a widely-used flavor additive known for its contribution to the fundamental flavor known as (savoriness). It is also the subject of food woo and chemophobia purporting it to be dangerous.
==What it is==
MSG is a sodium salt of glutamate, which in turn is the carboxylate anion of one of the twenty standard amino acids. Glutamic acid and its derivatives are essential to numerous functions in the body. As a standard amino acid, it is used to build proteins. Glutamate is a metabolic intermediate and neurotransmitter.
===Dietary sources===
MSG and similar sodium salts have been widely used in Asian cuisine for centuries; they are produced during the fermentation of such ingredients as soy sauce, and are also found in certain seaweeds. Now produced synthetically or by bacterial fermentation, MSG is one of the most common flavorings used in Chinese, Japanese, and Cantonese cooking. Through this, use of MSG spread into Europe and the United States. MSG is also used extensively in Native American cuisine, and in the 16th century spread to Italy and Asia, in the form of the MSG-rich fruit vegetable, the tomato. This is why if you aren't sure what to add to your recipe, you add tomatoes. No exceptions.
Other natural sources of glutamic acid include yeast (including that disgusting Marmite stuff), broccoli, wheat, meat, and cheese.Monosodium Glutamate, a Safety Assessment Glutamic acid can also be liberated from vegetable protein via acid hydrolysis; hydrolyzed soy protein is widely used as a food additive to improve flavor because it's a shelf-stable source of glutamic acid.
==Health concerns==
A lot of the scare regarding MSG can be traced to a 1968 letter published in the New England Journal of Medicine by Dr. Robert Ho Man Kwok speculated about what has been causing "radiating pain in his arms, weakness and heart palpitations" after eating Chinese foods at restaurants, ruling out home-cooked Chinese food but suggesting cooking wine, excessive salt, or MSG. It became widely believed in the 1980s in the United States that MSG posed a health hazard, with a phenomenon called "Chinese Restaurant Syndrome" reportedly resulting from the additive. Evidence for harmful effects from MSG is almost entirely anecdotal and filled with confirmation bias as well as less than savory (pun not intended) implications about Chinese food being singled out as opposed to Italian food or other MSG-laden food. In response, the Food and Drug Administration reviewed the literature and studied the chemical, determining: 
Though there are no large, reputable studies that show any reaction, and multiple studies demonstrate that there is no discernible syndromehttp://www.ncbi.nlm.nih.gov/pubmed/10736382http://www.sciencedirect.com/science/article/pii/027869159390012Nhttp://www.newscientist.com/article/dn23851-what-if-your-gluten-intolerance-is-all-in-your-head.html?full=true except for people taking the placebo,http://www.ncbi.nlm.nih.gov/pubmed/16999713 public-consumption websites still note that "A small percentage of people may have short-term reactions to MSG."http://www.mayoclinic.com/health/monosodium-glutamate/AN01251 While MSG is not considered dangerous by the scientific community, its use in food preparation is seen in culinary circles as "cheating", improving the flavour of substandard foods in the same way as adding a lot of common salt to fast food. From our point of view, this is just snobbish gatekeeping. An ingredient is an ingredient, and if it's important to making food taste great, then it's not a problem.
One of the most common claims made by woo-peddlers is that MSG will give you seizures or cause brain damage or autism in some way because of the glutamate it contains. This is based on the fact that high levels of glutamate can cause excitotoxicity in the brain. This is true, but the problem with this claim is that glutamate does not cross the blood-brain barrier in healthy humans (though it is a possibility for those with some disease that weakens the barrier).Hawkins, RA. The blood-brain barrier and glutamate. Am J Clin Nutr. 2009 Sep;90(3):867S-874S. Epub 2009 Jul 1. Thus, unless you inject it past the blood-brain barrier directly into the brain, it will have no effect on brain activity. 
Despite a widespread belief that MSG can elicit migraine headaches, there is no consistent clinical data to support this claim, nor is there evidence that some individuals are more sensitive to MSG than others. Jinap S., Hajeb P. Glutamate. Its applications in food and contribution to health. Appetite. 2010 Aug;55(1):1-10. Epub 2010 May 12.Williams AN, Woessner KM. Monosodium glutamate 'allergy': menace or myth? Clin Exp Allergy. 2009 May;39(5):640-6. Epub 2009 Apr 6.Freeman M. Reconsidering the effects of monosodium glutamate: a literature review. J Am Acad Nurse Pract. 2006 Oct;18(10):482-6.Geha RS, Beiser A, Ren C, Patterson R, Greenberger PA, Grammer LC, Ditto AM, Harris KE, Shaughnessy MA, Yarnold PR, Corren J, Saxon A. Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. J Nutr. 2000 Apr;130(4S Suppl):1058S-62S. It is more likely that migraines and the other alleged symptoms of "Chinese Food Syndrome" are caused by the high levels of salt, carbohydrates and oils.Skeptical Raptor MSG-myth versus science The term "Chinese Food Syndrome" was coined by Robert Ho Man Kwok in 1968.The Strange Case of Dr. Ho Man Kwok by Howard Steele, Colgate Magazine The term, and the pathologic aversion of MSG associated with it, is considered to be linked with xenophobia and anti-Asian racism.Is MSG Unhealthy? by McKenna Princing, Right as Rain by UW MedicineWe Can't Talk About MSG Without Talking About Racism by Frankie Huang, Men's Health
MSG — like any food additive — is forbidden in baby and infant food in the EU.EU Regulation (EC) No 1333/2008 Regulation (EC) No 1333/2008 of the European Parliament and of the Council of 16 December 2008 on food additives (Text with EEA relevance) Article 16, EU Publications. 2023-10-29
==See also==
*Gluten-free
*Food allergy
==External links==
*The Notorious MSG’s Unlikely Formula For Success (sadly, not about the Chinese-American hip-hop group "Notorious MSG")
*Skeptical Raptor's Blog: MSG-myth versus science
==References==
Category:Autism woo
Category:Chemicals
Category:Moral panics
Category:Racism
Category:Toxins