Cisplatin (Platinol)

==General information==
Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.Cisplatin (Platinol) package insert Cisplatin (Platinol) package insert (locally hosted backup)
Route: IV, intracavitary (intraperitoneal)
Extravasation: vesicant (concentration ≥0.5 mg/mL)/irritant (concentration less than 0.5 mg/mL)
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias or the prescribing information.
==Diseases for which it is established (work in progress)==
*Bladder cancer
*Malignant pleural mesothelioma
*Nasopharyngeal carcinoma
*Non-Hodgkin lymphoma
**Mantle cell lymphoma
**Peripheral T-cell lymphoma
*Osteosarcoma 
*Ovarian cancer
*Testicular cancer
==Diseases for which it is used==
*Adrenocortical carcinoma
*Anal cancer
*Breast cancer
*Carcinoma of unknown primary 
*Cervical cancer
*Cholangiocarcinoma
*Cutaneous basal cell carcinoma
*Cutaneous squamous cell carcinoma
*Endometrial cancer
*Esophageal cancer
**Esophageal adenocarcinoma
**Esophageal squamous cell carcinoma
*Gallbladder cancer
*Gastric cancer
*Head and neck cancer
**Oropharyngeal cancer, HPV-positive
*Hepatoblastoma
*Classical Hodgkin lymphoma
*Low-grade glioma
**Low-grade glioma, pediatric
*Melanoma 
*Medulloblastoma
*Multiple myeloma
*Neuroblastoma
*Non-Hodgkin lymphoma
**Anaplastic large cell lymphoma
**Diffuse large B-cell lymphoma
**Extranodal NK- and T-cell lymphoma, nasal type
**NK- and T-cell lymphoma
**Primary mediastinal B-cell lymphoma
**Transformed lymphoma
*Non-small cell lung cancer
**Non-small cell lung cancer, nonsquamous
**Non-small cell lung cancer, squamous
*Pancreatic cancer
*Penile cancer 
*Small cell lung cancer
*Soft tissue sarcoma
*Thymoma
*Upper tract urothelial carcinoma
*Urothelial carcinoma
*Vulvar cancer
==Patient drug information==
*Cisplatin (Platinol) package insert
*Cisplatin (Platinol) patient drug information (Chemocare)Cisplatin (Platinol) patient drug information (Chemocare)
*Cisplatin (Platinol) patient drug information (UpToDate)Cisplatin (Platinol) patient drug information (UpToDate)
==History of changes in FDA indication==
*1978-12-19: Initial FDA approval
*2010-09-02 (oldest label available at Drugs @ FDA): Indicated in established combination therapy with other approved chemotherapeutic agents in patients with metastatic testicular tumors who have already received appropriate surgical and/or radiotherapeutic procedures. (No supporting studies are cited)
*2010-09-02 (oldest label available at Drugs @ FDA): Indicated in established combination therapy with other approved chemotherapeutic agents in patients with metastatic ovarian tumors who have already received appropriate surgical and/or radiotherapeutic procedures. An established combination consists of PLATINOL and cyclophosphamide. (Based on Wiernik et al. 1992a)
*2010-09-02 (oldest label available at Drugs @ FDA): PLATINOL, as a single agent, is indicated as secondary therapy in patients with metastatic ovarian tumors refractory to standard chemotherapy who have not previously received PLATINOL therapy. (Based on Wiernik et al. 1992a)
*2010-09-02 (oldest label available at Drugs @ FDA): Indicated as a single agent for patients with transitional cell bladder cancer which is no longer amenable to local treatments, such as surgery and/or radiotherapy. (No supporting studies are cited)
==History of changes in EMA indication==
*1978-12-19: EURD
==History of changes in PMDA indication==
*2012-02-22: New additional indication and a new dosage for the treatment of biliary tract cancer.
==Also known as==
*Code name: NSC-119875
*Generic names: CDDP, cis-diamminedichloroplatinum III, cis-platinum, cisplatinum, DACP, DDP
*Brand names:
Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms
Abiplatin 	Axiplat 	Biocisplatinum	Bioplatino 	Blastolem 	Briplatin 	Brisplatin 	C-Platin
Ceplatin 	Ciplatan 	Ciplexal 	Cis-GRY 	Cismaplat 	Cispatin 	Cisplamerck 	Cisplan
Cisplasol 	Cisplatex 	Cisplatine 	Cisplatino 	Cisplatyl 	Cisteen 	Citoplatino 	Citosin
Cysplatyna	Cytoplatin	Docistin 	Elvecis 	Fauldcispla 	Ifapla 	Kemoplat 	Lederplatin
Metaplatin	Neoplat 	Neoplatin 	Noveldexis 	Oncoplatin AQ 	Peyrone's Chloride	Peyrone's Salt	Placis
Plastistil	Platamin 	Platamine 	Platiblastin	Platicis 	Platidiam 	Platikem 	Platil
Platimit 	Platin 	Platinex 	Platinil 	Platino II Filaxis	Platinol 	Platinox 	Platinoxan
Platiran 	Platistil 	Platistin 	Platistine 	Platosin 	Randa 	Romcis 	Sicatem
Sinplatin 	Sisplanil 	Tecnoplatin 	Tisplal 	Unistin 	 	 	
==References==
Category:Drugs
Category:Intravenous medications
Category:Intracavitary medications
Category:Vesicant
Category:Irritant
Category:Platinum agents
Category:Alkylating agents
Category:Carcinoma of unknown primary medications 
Category:Adrenocortical carcinoma medications
Category:Anal cancer medications
Category:Anaplastic large cell lymphoma medications
Category:Cutaneous basal cell carcinoma medications
Category:Bladder cancer medications
Category:Breast cancer medications
Category:Cervical cancer medications
Category:Cholangiocarcinoma medications
Category:Cutaneous squamous cell carcinoma medications
Category:Diffuse large B-cell lymphoma medications
Category:Endometrial cancer medications
Category:Esophageal adenocarcinoma medications
Category:Esophageal cancer medications
Category:Esophageal squamous cell carcinoma medications
Category:Extranodal NK- and T-cell lymphoma, nasal type medications
Category:Gallbladder cancer medications
Category:Gastric cancer medications
Category:Head and neck cancer medications
Category:Hepatoblastoma medications
Category:Classical Hodgkin lymphoma medications
Category:Low-grade glioma medications
Category:Low-grade glioma, pediatric medications
Category:Mantle cell lymphoma medications
Category:Medulloblastoma medications
Category:Melanoma medications 
Category:Malignant pleural mesothelioma medications
Category:Multiple myeloma medications
Category:Nasopharyngeal carcinoma medications
Category:Neuroblastoma medications
Category:Neuroendocrine carcinoma medications
Category:NK- and T-cell lymphoma medications
Category:Non-small cell lung cancer medications
Category:Non-small cell lung cancer, nonsquamous medications
Category:Non-small cell lung cancer, squamous medications
Category:Oropharyngeal cancer medications
Category:Osteosarcoma medications 
Category:Ovarian cancer medications
Category:Pancreatic cancer medications
Category:Penile cancer medications 
Category:Peripheral T-cell lymphoma medications
Category:Primary mediastinal B-cell lymphoma medications 
Category:Small cell lung cancer medications
Category:Soft tissue sarcoma medications
Category:Testicular cancer medications
Category:Thymoma medications
Category:Transformed lymphoma medications
Category:Upper tract urothelial carcinoma medications
Category:Urothelial carcinoma medications
Category:Vulvar cancer medications
Category:FDA approved in 1978
Category:EMA approved in 1978
Category:WHO Essential Cancer Medicine