Spondyloarthritis

Category:Rheumatology
Spondyloarthritis (SpA) is characterised by inflammation in the axial skeleton (sacroiliitis, spondylitis), peripheral joints, and entheses. Extraskeletal manifestations can occur such as anterior uveitis, psoriasis, and inflammatory bowel disease. HLA-B27 is the major genetic risk factor.
== Epidemiology ==
The entire group of SpA has a global prevalence of 0.1% to 1.9%, with variations between countries and ethnicities. AS is the largest subgroup. The association with HLA-B27 ranges from ~50% to 95%. In the general population HLA-B27 is present in 8-10% of Caucasians. .About 5% of patients with chronic low back pain have a spondyloarthritis.
== Classification ==
Previously SpA was viewed as consisting of interrelated subgroups that included ankylosing spondylitis (AS), reactive arthritis, or undifferentiated spondyloarthritis. The current thinking distinguishes between predominant axial SpA and predominant peripheral SpA.
Validated classification criteria exist for both axial and peripheral SpA. Sacroiliitis on MRI is an important radiological finding in classification.
The term spondyloarthritis is preferred over spondyloarthropathy due to the inflammatory nature of the condition.
Sometimes the term seronegative spondyloarthritis is used which means that the patient is negative for rheumatoid factor and anti-CCP. Unlike Rheumatoid Arthritis, the distribution of the affected peripheral joints is asymmetrical, with the large joints of the lower limbs being predominantly affected in peripheral spondyloarthritis.
== Classification Criteria ==
=== Inflammatory Back Pain ===
The age of onset is typically under 40. They have stiffness that is worse with rest and improved with exercise. The "back" pain is typically in the buttock, and has an insidious onset. Mornings are usually the worst, and they may wake up in the second half of the night. Response to NSAIDs is the rule. 
Examination findings include an abnormal Shober test, and extraarticular manifestations such as psoriasis, uveitis, and inflammatory bowel disease.
Features that aren't suggestive of inflammatory back pain are older age (>40 years), diffuse ache, abrupt onset, history of trauma, radicular symptoms, weight loss, night sweats, fever, history of cancer, worsening with exercise and in the evenings, and generalised aching. NSAID response may be moderate at best.
Criteria for Inflammatory Back Pain (IBP)
Calin criteria 	Berlin criteria 	ASAS criteria
* Age at onset <40 yr
* Duration of back pain >3 mo
* Insidious onset
* Morning stiffness
* Improvement with exercise	
* Morning stiffness >30 min
* Improvement with exercise, not with rest
* Awakening at second half of the night because of pain
* Alternating buttock pain	
* Age at onset <40 yr
* Insidious onset
* Improvement with exercise
* No improvement with rest
* Pain at night (with improvement on rising)
(at least four of five present)	(at least two of four present)	(at least four of five present)
=== Axial Spondyloarthritis ===
Axial spondyloarthritis is a spectrum that runs from nonradiographic axial SpA (nr-axSpA) to ankylosing spondylitis. All patients with AS start as nr-axSpA, but not all patients with nr-axSpA progress to AS.
Modified New York Criteria for AS
>1 Clinical criteria PLUS Radiographic criteria
Clinical Criteria
* Low back pain and stiffness for >3 months which improves with exercise and not with rest
* Limitation in spinal motion in frontal and saggitalplanes
* Limitation of chest expansion compared to norms for age and gender
Radiographic Criteria
Radiographic sacroiliitis >Grade 2 bilaterally or >Grade 3-4 unilaterally
ASAS Classification Criteria For Axial Spondyloarthritis
In patients with back pain ≥ 3 months and age at onset < 45 years	In patients with back pain ≥ 3 months and age at onset < 45 years	In patients with back pain ≥ 3 months and age at onset < 45 years
Sacroiliitis on imaging*
plus
≥1 SpA feature† 	or 	HLA-B27
plus
≥2 other SpA features†
SpA features†: 	 	Sacroiliitis on imaging*:
* Inflammatory back pain
* Arthritis
* Enthesitis (heel)
* Uveitis
* Dactylitis
* Psoriasis
* Crohn disease or ulcerative colitis
* Good response to NSAIDs
* Family history of SpA
* HLA-B27
* Elevated CRP	 	
* Active (acute) inflammation on MRI highly suggestive of sacroiliitis associated with SpA
or
* Definite radiographic sacroiliitis according to modified New York criteria
*Sensitivity 82.9%, specificity 84.4%; n = 649 patients with chronic back pain and age at onset <45 years. Imaging arm (sacroiliitis) alone has a sensitivity of 66.2% and a specificity of 97.3%.
†Elevated CRP is considered an SpA feature in the context of chronic back pain.	*Sensitivity 82.9%, specificity 84.4%; n = 649 patients with chronic back pain and age at onset <45 years. Imaging arm (sacroiliitis) alone has a sensitivity of 66.2% and a specificity of 97.3%.
†Elevated CRP is considered an SpA feature in the context of chronic back pain.	*Sensitivity 82.9%, specificity 84.4%; n = 649 patients with chronic back pain and age at onset <45 years. Imaging arm (sacroiliitis) alone has a sensitivity of 66.2% and a specificity of 97.3%.
†Elevated CRP is considered an SpA feature in the context of chronic back pain.
=== Peripheral Spondyloarthritis ===
ASAS Classification Criteria for Peripheral Spondyloarthritis
Arthritis* or enthesitis or dactylitis	Arthritis* or enthesitis or dactylitis	Arthritis* or enthesitis or dactylitis
Plus ≥ 1 of 	or 	Plus ≥ 2 of the remaining:
* Psoriasis
* Inflammatory bowel disease
* Preceding infection
* HLA-B27
* Uveitis
* Sacroiliitis on imaging (radiographs or MRI)	 	
* Arthritis
* Enthesitis
* Dactylitis
* IBP in the past
* Positive family history
* of SpA
*Peripheral arthritis: usually predominantly lower limb and/or asymmetric arthritis.
IBP: inflammatory back pain.	*Peripheral arthritis: usually predominantly lower limb and/or asymmetric arthritis.
IBP: inflammatory back pain.	*Peripheral arthritis: usually predominantly lower limb and/or asymmetric arthritis.
IBP: inflammatory back pain.
== Clinical Features ==
There is a predilection for the axial skeleton and entheses. Sacroiliitis is the cardinal sign. HLA-B27 confers a genetic risk. Clinical manifestations are inflammatory low back pain, stiffness, and a late finding of limitation of spinal range of motion.
Extraarticular manifestations are acute anterior uveitis, psoriasis, and inflammatory bowel disease.
Peripheral features include asymmetrical, oligoarticular, lower limb predominant arthritis +/- enthesitis (e.g. plantar fasciitis, insertional Achilles tendonitis). This is compared to small joint symmetrical arthritis in Rheumatoid Arthritis.
The assessment includes
* Disease activity: BASDAI and bloods
* Structure: X-ray/MRI and DEXA
* Function: BASFI
* Movement: BASMI
=== Mnemonic ===
The mnemonic SCREEND'EM can be used to remember the extra-articular features of Spondyloarthropathy
== Imaging ==
Plain film radiographic features are more typical of later stage disease, however MRI can detect early disease.
Radiologic features of ankylosing spondylitis include 
* Sacroiliac joint: erosions, ankylosis, juxtaarticular osteopenia, ossification of the ligamentous attachment to the ischial tuberosity or iliac crest or the greater trochanter
* Spine: erosions at vertebral corners (shiny corners), squaring of the vertebral bodies (Romanus lesion), syndesmophytes, ossification of the annulus fibrosus and longitudinal ligament, erosions of the discovertebral junction, calcification of the intervertebral discs, pseudoarthrosis, and bone oedema especially if juxaarticular
MRI is the gold standard for assessment of inflammatory changes in the SIJ and spine.
Definitions of what constitutes a positive MRI of the SIJ and spine have been published by ASAS.
MRI findings in the SIJ of patients with AS 
Tissue 	Inflammatory Changes	Structural Changes
Bone marrow 	Sacroiliitis (bone marrow edema or
osteitis) in one or both parts of
the SI joint (sacral or iliac)	Subchondral sclerosis
Erosions
Fatty deposition
Bone bridges or ankylosis
Bone marrow 	Bone marrow edema related to SpA
is located periarticularly	Subchondral sclerosis
Erosions
Fatty deposition
Bone bridges or ankylosis
Synovium 	Synovitis: depicted only by T1/
Gd-DTPA sequences; STIR
sequences cannot differentiate
between synovitis and physiologic
joint fluid; synovitis is a rare lesion	Bone bridges or ankylosis
Joint capsule	Capsulitis: comparable to synovitis;
both anterior and posterior joint
capsule can be affected	Bone bridges or ankylosis
Ligaments 	Enthesitis: seen in the junction of
ligaments and tendons to the bone	Degeneration of ligament
MRI findings in the spine of patients with AS
Tissue 	Inflammatory Changes 	Structural Changes
Vertebral body 	Inflammation (spondylitis) in the bone marrow, mainly in the corners	New bone formation
(syndesmophytes, ankylosis),
eventually erosions or destruction of
the vertebral body (e.g., fracture)
Fatty degeneration
Intervertebral disc	Inflammation
(spondylodiscitis) 	Ossification of the disc
Facet and
costovertebral
joints	Inflammation with or
without involvement
of the vertebral body 	New bone formation and ankylosis in
advanced stages
Ligaments 	Enthesitis, mainly of
the supraspinal and
interspinal ligaments 	Degeneration of ligaments
== Management ==
Early diagnosis is essential for good outcomes, the average delay in diagnosis is 9 years. Obstacles that cause a delay are patient behaviour, chronic low back pain being extremely common, poor awareness, reliance on plain films in early disease, non- or misuse of HLA-B27. 
Physiotherapy plays a role in restoring and maintaining posture and movement. Home exercises must be continued for life. Exercise is critical at all stages and the patient should be referred early. 
Medical management for both axial and peripheral spondyloarthritis includes NSAIDs, anti-TNFα drugs (adalimumab, etanercept, infliximab), and more recently IL-17 inhibitors. 
The response to NSAIDs is almost 80% in AS vs ~15% in mechanical back pain, and they may reduce radiographic progression with continuous use.
For peripheral but not axial spondyloarthritis sulfasalazine and methotrexate may play a role as DMARDs, but not for axial disease. Local corticosteroid injections can be useful in oligoarticular forms of arthritis.
== Further Reading ==
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== References ==
Category:Sacroiliac Joint Conditions