Terpinéol-4

==Nom de la substance==
Terpinène-4-ol, terpinèn-4-ol (terpinéol-4), terpinène-1-ol-4, 4-terpinéol
==Famille moléculaire==
Alcool monoterpénique (monoterpénol)
==Source végétale==
* Huile essentielle d'arbre à thé +++ minimum 30 %, niaouli, ravintsara, marjolaine, lavande, genévrier
==Propriétés==
* Anti-inflammatoire Nogueira MN, Aquino SG, Rossa Junior C, Spolidorio DM. Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1β, IL-6 and IL-10 on human macrophages. Inflamm Res. 2014 Sep;63(9):769-78. doi: 10.1007/s00011-014-0749-x. PMID 24947163, P.H. Hart, C. Brand, C.F. Carson, T.V. Riley, R.H. Prager, J.J. Finlay-Jon. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Inflammation Research. Volume 49, Number 11, 619-626 texte intégral
* Anti-bactérien puissant (Staphylococcus sp, Streptococcus sp, Haemophilus sp, Pseudomonas sp) et antiviral, antifongique (Candida sp, levures) Jirovetz L - Buchbauer G - Denkova Z - Stoyanova A - Murgov I - Schmidt E - Geissler M. Antimicrobial testings and gas chromatographic analysis of pure oxygenated monoterpenes 1,8- cineole, alpha-terpineol, terpinen-4-ol and camphor as well as target compounds in essential oils of pine (Pinus pinaster), rosemary (Rosmarinus officinalis), tea tree (Melaleuca alternifolia). Scientia Pharmaceutica, 2005, 73 pp. 27-38
** Effet anti-infectieux par activation des globules blancs, activation de la différentiation des monocytes Budhiraja SS, Cullum ME, Sioutis SS, Evangelista L, Habanova ST. Biological activity of Melaleuca alternifola (Tea Tree) oil component, terpinen-4-ol, in human myelocytic cell line HL-60. J Manipulative Physiol Ther. 1999 Sep;22(7):447-53. PMID 10519561
* Antiviral Garozzo, A., Timpanaro, R., Bisignano, B., Furneri, P. M., Bisignano, G., & Castro, A. (2009). In vitro antiviral activity of Melaleuca alternifolia essential oil. Letters in applied microbiology, 49(6), 806-808.
* Anticandidosique (candidose buccale) Ninomiya K, Maruyama N, Inoue S, Ishibashi H, Takizawa T, Oshima H, Abe S. The essential oil of Melaleuca alternifolia (tea tree oil) and its main component, terpinen-4-ol protect mice from experimental oral candidiasis. Biol Pharm Bull. 2012;35(6):861-5. PMID 22687476 et vaginale Williams LR. Clonal production of tea tree oil high in terpinen-4-ol for use in formulations for the treatment of thrush. Complement Ther Nurs Midwifery. 1998 Oct;4(5):133-6. PMID 9830943, avec effet anti-inflammatoire Ninomiya K, Hayama K, Ishijima SA, Maruyama N, Irie H, Kurihara J, Abe S. Suppression of inflammatory reactions by terpinen-4-ol, a main constituent of tea tree oil, in a murine model of oral candidiasis and its suppressive activity to cytokine production of macrophages in vitro. Biol Pharm Bull. 2013;36(5):838-44. PMID 23649340, actif contre des souches de Candida résistantes au fluconazole Marcos-Arias C, Eraso E, Madariaga L, Quindos G. In vitro activities of natural products against oral Candida isolates from denture wearers. BMC Complementary and Alternative Medicine 2011, 11:119 (26 November 2011. Texte intégral : 
* Anti-parasitaire Mikus J, Harkenthal M, Steverding D, Reichling J. In vitro Effect of Essential Oils and Isolated Mono- and Sesquiterpenes on Leishmania major and Trypanosoma brucei. Planta Med, 2000, 66 (04), pp 366-368.
* Anti-acnéique sur Propionibacterium acnes A. Raman, U. Weir, S.F. Bloomfield. Antimicrobial effects of tea-tree oil and its major components on Staphylococcus aureus, Staph. epidermidis and Propionibacterium acnes. Letters in Applied Microbiology, Volume 21, Issue 4, pages 242–245, October 1995
* Diminue la croissance de cellules mélaniques humaines (M14) et induit l'apoptose Calcabrini A, Stringaro A, Toccacieli L, Meschini S, Marra M, Colone M, Salvatore G, Mondello F, Arancia G, Molinari A. Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells. J Invest Dermatol. 2004 Feb;122(2):349-60. PMID 15009716
* Propriétés antitumorales in vitro vis-à-vis de tumeurs murines agressives, mésothéliome AE17 et mélanome B16 Greay SJ, Ireland DJ, Kissick HT, Levy A, Beilharz MW, Riley TV, Carson CF. Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol. Cancer Chemother Pharmacol. 2010 Apr;65(5):877-88. doi: 10.1007/s00280-009-1093-7. PMID 19680653
* Propriétés antitumorales vis-à-vis de tumeurs gastro-intestinales, restaure l'activité de drogues anticancéreuses Shapira S, Pleban S, Kazanov D, Tirosh P, Arber N. Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers. PLoS One. 2016 Jun 8;11(6):e0156540. doi: 10.1371/journal.pone.0156540. PMID: 27275783; PMCID: PMC4898785.
* Anticonvulsivant de Sousa DP, Nóbrega FF, de Morais LC, de Almeida RN. Evaluation of the anticonvulsant activity of terpinen-4-ol. Z Naturforsch C. 2009 Jan-Feb;64(1-2):1-5. PMID 19323258, Nóbrega FF, Salvadori MG, Masson CJ, Mello CF, Nascimento TS, Leal-Cardoso JH, de Sousa DP, Almeida RN. Monoterpenoid terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. Oxid Med Cell Longev. 2014;2014:703848. doi: 10.1155/2014/703848. PMID 25180069
* Diurétique, hypotenseur par relaxation musculaire vasculaire Lahlou S, Interaminense LF, Leal-Cardoso JH, Duarte GP. Antihypertensive effects of the essential oil of Alpinia zerumbet and its main constituent, terpinen-4-ol, in DOCA-salt hypertensive conscious rats. Fundam Clin Pharmacol. 2003 Jun;17(3):323-30. PMID 12803571
==Effet thérapeutique==
* Voir arbre à thé
==Effets indésirables==
==Bibliographie==
Catégorie:principes actifs