Ginkgétine

==Nom de la substance==
Ginkgétine
==Famille moléculaire==
* Biflavonoïde (biflavone) 
==Source végétale==
* Ginkgo biloba L.
==Propriétés==
* Antiviral vis-à-vis des Herpes virus type 1 (HSV-1) et 2 (HSV-2) et du Cytomegalovirus, par inhibition de la réplication et inhibition de la transcription des gènes Hayashi, K. Y. O. K. O., Hayashi, T., & Morita, N. (1992). Mechanism of action of the antiherpesvirus biflavone ginkgetin. Antimicrobial agents and chemotherapy, 36(9), 1890-1893.
* Inhibiteur de la phospholipase A2, antalgique et anti-inflammatoire Kim, H. K., Son, K. H., Chang, H. W., Kang, S. S., & Kim, H. P. (1999). Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from Ginkgo biloba leaves. Planta medica, 65(05), 465-467., Lim, H., Son, K. H., Chang, H. W., Kang, S. S., & Kim, H. P. (2006). Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation. Biological and Pharmaceutical Bulletin, 29(5), 1046-1049., inhibe la production de prostaglandine E2 à partir de cellules RAW 264.7 induites par les lipopolysaccharides Kwak, W. J., Han, C. K., Son, K. H., Chang, H. W., Kang, S. S., Park, B. K., & Kim, H. P. (2002). Effects of Ginkgetin from Ginkgo biloba leaves on cyclooxygenases and in vivo skin inflammation. Planta medica, 68(04), 316-321., inhibe la cyclooxygénase-2 et la 5-lipoxygénase Son, J. K., Son, M. J., Lee, E., Moon, T. C., Son, K. H., Kim, C. H., ... & Chang, H. W. (2005). Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Biological and Pharmaceutical Bulletin, 28(12), 2181-2184.
* Neuroprotecteur sur modèle de la maladie de Parkinson Wang, Y. Q., Wang, M. Y., Fu, X. R., Peng-Yu, Gao, G. F., Fan, Y. M., ... & Shi, Z. H. (2015). Neuroprotective effects of ginkgetin against neuroinjury in Parkinson's disease model induced by MPTP via chelating iron. Free Radical Research, 49(9), 1069-1080., et sur le processus d’ischémie-reperfusion expérimentale Tian, Z., Tang, C., & Wang, Z. (2019). Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation. Journal of cellular biochemistry, 120(10), 18487-18495., Li, Q., Ye, T., Long, T., & Peng, X. (2019). Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Bioscience, biotechnology, and biochemistry, 83(4), 675-683., Zhang, L., Liu, J., & Geng, T. (2019). Ginkgetin aglycone attenuates the apoptosis and inflammation response through nuclear factor‐kB signaling pathway in ischemic‐reperfusion injury. Journal of cellular biochemistry, 120(5), 8078-8085.
* Potentialités anticancéreuses : cancer du poumon non à petites cellules Lou, J. S., Bi, W. C., Chan, G. K., Jin, Y., Wong, C. W., Zhou, Z. Y., ... & Tsim, K. W. (2017). Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget, 8(54), 93131., cancer de la prostate (inducteur d’apoptose) You, O. H., Kim, S. H., Kim, B., Sohn, E. J., Lee, H. J., Shim, B. S., ... & Kim, S. H. (2013). Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells. Bioorganic & medicinal chemistry letters, 23(9), 2692-2695., Jeon, Y. J., Jung, S. N., Yun, J., Lee, C. W., Choi, J., Lee, Y. J., ... & Kwon, B. M. (2015). Ginkgetin inhibits the growth of DU− 145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity. Cancer science, 106(4), 413-420., du sein Cao, J., Tong, C., Liu, Y., Wang, J., Ni, X., & Xiong, M. M. (2017). Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway. Biomedicine & Pharmacotherapy, 96, 450-458., ostéosarcome Xiong, M., Wang, L., Yu, H. L., Han, H., Mao, D., Chen, J., ... & Wang, Y. A. (2016). Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncology reports, 35(2), 1034-1040., Ye, Z. N., Yu, M. Y., Kong, L. M., Wang, W. H., Yang, Y. F., Liu, J. Q., ... & Li, Y. (2015). Biflavone ginkgetin, a novel Wnt inhibitor, suppresses the growth of medulloblastoma. Natural products and bioprospecting, 5(2), 91-97., côlon Lee, Y. J., Kang, Y. R., Lee, S. Y., Jin, Y., Han, D. C., & Kwon, B. M. (2017). Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of b Myb and miRNA34a expression. International journal of oncology, 51(4), 1331-1342.
* Réduit l’athérosclérose chez le rat Lian, N., Tong, J., Li, W., Wu, J., & Li, Y. (2018). Ginkgetin ameliorates experimental atherosclerosis in rats. Biomedicine & Pharmacotherapy, 102, 510-516.
* Prévient l’adipogenèse Cho, Y. L., Park, J. G., Kang, H. J., Kim, W., Cho, M. J., Jang, J. H., ... & Min, J. K. (2019). Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation. Pharmacological research, 139, 325-336.
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
Catégorie:principes actifs