Citronnellal

==Nom de la substance==
Citronnellal (citronellal)
==Famille moléculaire==
Aldéhyde monoterpénique (famille des aldéhydes)
* Découvert en 1874 par Wright 
==Source végétale==
* Huiles essentielles dites citronnées :
** Combava petit grain (feuilles, rameaux et petits fruits verts), c'est l'HE qui en est la plus riche (≥ 80 %), eucalyptus citrin, verveine odorante, mélisse, litsée citronnée, citronnelle de Ceylan, citronnier (zeste), livèche, lemongrass
==Propriétés==
* Anti-inflammatoire puissant Melo MS, Guimarães AG, Santana MF, Siqueira RS, De Lima Ado C, Dias AS, Santos MR, Onofre AS, Quintans JS, De Sousa DP, Almeida JR, Estevam CS, Araujo BS, Quintans-Júnior LJ. Anti-inflammatory and redox-protective activities of citronellal. Biol Res. 2011;44(4):363-8. doi: /S0716-97602011000400008. PMID 22446600, Je-Hyuk Lee, Kyung-Mi Chang, Gun-Hee Kim. Composition and anti-inflammatory activities of Zanthoxylum schinifolium essential oil: suppression of inducible nitric oxide synthase, cyclooxygenase-2, cytokines and cellular adhesion. Journal of the Science of Food and Agriculture, Volume 89, Issue 10, pages 1762–1769, 15 August 2009 , inhibition de la lipoxygénase L-1 et de la cyclooxygénase G. Bedi Sahouo, Z.F. Tonzibo, B. Boti, C. Chopard, J.P. Mahy, Yao T. N’guessan. Anti-inflammatory and analgesic activities: Chemical constituents of essential oils of Ocimum gratissimum, Eucalyptus citriodora and Cymbopogon giganteus inhibited lipoxygenase L-1 and cyclooxygenase of PGHS. Bull. Chem. Soc. Ethiop. 2003, 17(2), 191-197., Joachin D. Gbenou, Judith F. Ahounou, Huguette B. Akakpo, Anatole Laleye, Eléonore Yayi, Fernand Gbaguidi, Lamine Baba-Moussa, Raphael Darboux, Pierre Dansou, Mansourou Moudachirou, Simeon O. Kotchoni. Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats. Molecular Biology Reports, February 2013, Volume 40, Issue 2, pp 1127-1134
* Antalgique Melo MS, Sena LC, Barreto FJ, Bonjardim LR, Almeida JR, Lima JT, De Sousa DP, Quintans-Júnior LJ. Antinociceptive effect of citronellal in mice. Pharm Biol. 2010 Apr;48(4):411-6. PMID 20645719, Quintans-Júnior L, da Rocha RF, Caregnato FF, Moreira JC, da Silva FA, Araújo AA, dos Santos JP, Melo MS, de Sousa DP, Bonjardim LR, Gelain DP. Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass. J Med Food. 2011 Jun;14(6):630-9. PMID 21480794, de Santana MT, de Oliveira MG, Santana MF, De Sousa DP, Santana DG, Camargo EA, de Oliveira AP, Almeida JR, Quintans-Júnior LJ Jr. Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice. Pharm Biol. 2013 Sep;51(9):1144-9. doi: 10.3109/13880209.2013.781656. PMID 23795810, Silva J, Abebe W, Sousa SM, Duarte VG, Machado MI, Matos FJ. Analgesic and anti-inflammatory effects of essential oils of Eucalyptus. J Ethnopharmacol. 2003 Dec;89(2-3):277-83. PMID 14611892, Quintans-Júnior LJ, Melo MS, De Sousa DP, Araujo AA, Onofre AC, Gelain DP, Gonçalves JC, Araújo DA, Almeida JR, Bonjardim LR. Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability. J Orofac Pain. 2010 Summer;24(3):305-12. PMID 20664833 
* Sédatif et hypnotique, potentialise l'activité du GABA-A et augmente son affinité vis-à-vis de ses récepteurs Aoshima H, Hamamoto K. Potentiation of GABAA receptors expressed in Xenopus oocytes by perfume and phytoncid. Bioscience, biotechnology, and biochemistry, 1999, vol. 63, no4, pp. 743-748 
* Antiseptique, antiviral sur Herpes simplex virus type-2 Allahverdiyev, A., Duran, N., Ozguven, M., & Koltas, S. (2004). Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2. Phytomedicine, 11(7-8), 657-661.
* Antifongique H. Ramezani, H.P. Singh, D.R. Batish, R.K. Kohli, J.S. Dargan. Fungicidal effect of volatile oils from Eucalyptus citriodora and its major constituent citronellal. New Zealand Plant Protection 55:327-330 (2002) Texte intégral 
* Anti-moustiques
* Anticancéreux Osato S. Chemotherapy of human carcinoma with citronellal and citral and their action on carcinoma tissue in its histological aspects up to healing. Tohoku J Exp Med. 1965 Jul 25;86(2):102-47. , Osato S, Mori H, Morita M. Experiments on the chemotherapeutic treatment of carcinoma with citral and citronellal and those combined with PCMB. Tohoku J Exp Med. 1961 Dec 25;75:223-33, Osato S, Oda K, Sato F. [Direct action of citral and citronellal on cancer cells.] C R Seances Soc Biol Fil. 1954 Apr;148(7-8):768-9.
==Effet thérapeutique==
==Effets indésirables==
* Pas de mutagénicité au test d’Ames Maria Regina Gomes-Carneiro, Israel Felzenszwalb, Francisco J.R Paumgartten, Mutagenicity testing of (±)-camphor, 1,8-cineole, citral, citronellal, (−)-menthol and terpineol with the Salmonella/microsome assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 416, Issues 1-2, 7 August 1998, Pages 129-136
* Inhibition du CYP 2E1 Kandagatla SK, Mack T, Simpson S, Sollenberger J, Helton E, Raner GM. Inhibition of human cytochrome P450 2E1 and 2A6 by aldehydes: structure and activity relationships. Inhibition CYP 2E1 Chem Biol Interact. 2014 Aug 5;219:195-202. doi: 10.1016/j.cbi.2014.05.014. PMID 24924949
==Bibliographie==
Catégorie:principes actifs