Joachim Lingner

Joachim Lingner (born 1962) is a Swiss molecular biologist. He is professor for life sciences at the École Polytechnique Fédérale de Lausanne (EPFL), where he heads the Lingner Lab.
== Career ==
Lingner obtained a PhD from the Biozentrum University of Basel|Biozentrum of the University of Basel in 1992. In 1993 he joined the Howard Hughes Medical Institute at University of Colorado Boulder|University of Colorado at Boulder for postdoctoral studies under the supervision Thomas Cech. He then joined Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland, first as a junior group leader in 1997 and became senior group leader in 2002. In 2005 he was nominated as Associate Professor at École Polytechnique Fédérale de Lausanne|EPFL. Since 2009 Lingner is Full Professor at École Polytechnique Fédérale de Lausanne|EPFL.
== Research ==
The Lingner Lab studies various aspects of the structure and function of essential and complex nucleoprotein complexes at the ends of Eukaryotic chromosome structure|eukaryotic chromosomes, the so-called Telomere|telomeres. They are also interested in function of telomeres in cell aging, which is also referred to as cellular senescence. Lingner's group develops Telomere|telomeric chromatin analysis protocols to determine telomere protein composition by mass spectrometry and elucidate its dynamics during replication under normal and pathological situations. They aim also at the elucidation of the regulation and function of telomerase at chromosome ends. Lingner also study the function of the TERRA (biology)|long noncoding telomeric repeat containing RNA (TERRA), which the group discovered. Finally they are interested in the establishment and applications of technologies that allow the analysis of the telomeric proteome during development and disease resulting among others in the discovery that telomerase is blocked by oxidative damage.
== Distinctions ==
Lingner obtained the Friedrich Miescher Prize (2002), is elected EMBO member (2005), European Research Council|ERC advanced investigator awardee (2008)https://erc.europa.eu/sites/default/files/content/selection_panel/advanced_grant_2008.pdf and elected member of the Academia Europaea (2020). 
 He serves as a scientific advisory board member in the Center of Integrative Genomics (CIG) of the University of Lausanne, and is European Research Council|ERC starting grant review panel member.https://erc.europa.eu/sites/default/files/document/file/erc_2018_stg_panel_members.pdf
== Publications ==
* Feretzaki M, Pospisilova M, Valador Fernandes R, Lunardi T, Krejci L, Lingner J. Rad51-dependent recruitment of TERRA lncRNA to telomeres through R-loops. Nature, Article, in press.
* Vančevska A, Ahmed W, Pfeiffer V, Feretzaki M, Boulton SJ, Lingner J. SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres. EMBO J. 2020;39(7):e102668. doi:10.15252/embj.2019102668
* Porro A, Feuerhahn S, Delafontaine J, Riethman H, Rougemont J, Lingner J. Functional characterization of the TERRA transcriptome at damaged telomeres. Nat Commun. 2014;5:5379. Published 2014 Oct 31. doi:10.1038/ncomms6379
* Pfeiffer V, Crittin J, Grolimund L, Lingner J. The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening. EMBO J. 2013;32(21):2861-2871. doi:10.1038/emboj.2013.217
* Grolimund L, Aeby E, Hamelin R, et al. A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun. 2013;4:2848. doi:10.1038/ncomms3848
* Chen LY, Redon S, Lingner J. The human CST complex is a terminator of telomerase activity. Nature. 2012;488(7412):540-544. doi:10.1038/nature11269
* Redon S, Reichenbach P, Lingner J. The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res. 2010;38(17):5797-5806. doi:10.1093/nar/gkq296
* Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J. Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends. Science. 2007;318(5851):798-801. doi:10.1126/science.1147182
== References ==
Category:Swiss biologists
Category:1962 births
Category:University of Basel alumni