Béta-élémène

==Nom de la substance==
Béta-élémène
==Famille moléculaire==
Hydrocarbure sesquiterpénique
==Source végétale==
* Huile essentielle de Nigella sativa, encens (Boswellia sp.), gingembre, myrrhe, Solidago canadensis, Curcuma wenyujin, Fritillaria thunbergii (remèdes de Médecine Traditionnelle Chinoise)
==Propriétés==
* Propriétés anticancéreuses Wang G, Li X, Huang F, Zhao J, Ding H, Cunningham C, Coad JE, Flynn DC, Reed E, Li QQ. Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci. 2005 Apr;62(7-8):881-93. PMID 15868411, Zhao J, Li QQ, Zou B, Wang G, Li X, Kim JE, Cuff CF, Huang L, Reed E, Gardner K. In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma. Int J Oncol. 2007 Aug;31(2):241-52., Edris AE. Anti-cancer properties of Nigella spp. Essential oils and their major constituents, thymoquinone and beta-elemene. Curr Clin Pharmacol. 2009 Jan;4(1):43-6. PMID 19149500, Yu Z, Wang R, Xu L, Dong J, Jing Y. N-(beta-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway. Cancer Lett. 2008 Sep 28;269(1):165-73., Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, Xu YH. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett. 2008 Jun 8;264(1):127-34., Dai ZJ, Tang W, Lu WF, Gao J, Kang HF, Ma XB, Min WL, Wang XJ, Wu WY. Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells. Cancer Cell Int. 2013 Mar 14;13(1):27. doi: 10.1186/1475-2867-13-27. PMID 23496852 texte intégral, induit l'activité des caspase-3, -7, -9, diminue l'expression de Bcl-2, entraine la libération de cytochrome c et augmente la concentration de caspase-9 et de poly(ADP-ribose) polymérase (dans cellules NSCLC épithéliales bronchiques et fibroblastiques de la langue), inhibe la prolifération des cellules de cancer ovarien résistantes au cis-platine, forte synergie avec le cis-platine Li X, Wang G, Zhao J, Ding H, Cunningham C, Chen F, Flynn DC, Reed E, Li QQ. Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase. Cell Mol Life Sci. 2005 Apr;62(7-8):894-904. PMID 15868412
* Inducteur d'apoptose, pourrait agir dans les leucémies et les tumeurs solides, le cancer du poumon (NSCLC), lignées cellulaires H460 et A549, en synergie avec le cis-platine Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E. beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncol Rep. 2009 Jul;22(1):161-70. PMID 19513519, cancer de la prostate Li QQ, Wang G, Huang F, Banda M, Reed E. Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. J Pharm Pharmacol. 2010 Aug;62(8):1018-27. doi: 10.1111/j.2042-7158.2010.01135.x. PMID 20663036, cancer du sein Guan C, Liu W, Yue Y, Jin H, Wang X, Wang XJ. Inhibitory effect of β-elemene on human breast cancer cells. Int J Clin Exp Pathol. 2014 Jun 15;7(7):3948-56. eCollection 2014. PMID 25120771, cancer de l'estomac Liu JS, He SC, Zhang ZL, Chen R, Fan L, Qiu GL, Chang S, Li L, Che XM. Anticancer effects of β-elemene in gastric cancer cells and its potential underlying proteins: A proteomic study. Oncol Rep. 2014 Dec;32(6):2635-47. doi: 10.3892/or.2014.3490. PMID 25333415
* Antitumoral dans cancers du poumon et du colon Sylvestre M, Pichette A, Longtin A, Nagau F, Legault J. Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. J Ethnopharmacol. 2006 Jan 3;103(1):99-102. PMID 16168586, les gliomes malins Zhou HY, Shen JK , Hou JS , Qiu YM, Luo QZ. Experimental study on apoptosis induced by elemene in glioma cells. Aizheng = Chinese Journal of Cancer, 01 Sep 2003, 22(9):959-963. PMID 12969529, Li CL, Chang L, Guo L, Zhao D, Liu HB, Wang QS, Zhang P, Du WZ, Liu X, Zhang HT, Liu Y, Zhang Y, Xie JH, Ming JG, Cui YQ, Sun Y, Zhang ZR, Jiang CL. β-elemene induces caspase-dependent apoptosis in human glioma cells in vitro through the upregulation of Bax and Fas/ FasL and downregulation of Bcl-2. Asian Pacific Journal of Cancer Prevention : APJCP [01 Jan 2014, 15(23):10407-10412] PMID 25556484, Zhang H, Xu F, Xie T, Jin H, Shi L. β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein. Oncol Rep. 2012 Dec;28(6):2083-90. doi: 10.3892/or.2012.2022. PMID 22965456, Xu YH, Dong B, Luo QZ, Zhou HY, Jia YC, Yang YF, Wang YZ. Influence of elemene on the expression of Bcl-2 family genes in rat C6 glioma cells. Zhonghua yi xue za zhi [01 Jun 2005, 85(24):1700-1703] PMID:16251076, Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, Xu YH. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett. 2008 Jun 8;264(1):127-34. doi: 10.1016/j.canlet.2008.01.049. PMID 18442668
* Néanmoins, diverses méta-analyses mentionnent une faible qualité méthodologique et demandent confirmation Peng X, Zhao Y, Liang X, Wu L, Cui S, Guo A, Wang W. Assessing the quality of RCTs on the effect of beta-elemene, one ingredient of a Chinese herb, against malignant tumors. Contemp Clin Trials. 2006 Feb;27(1):70-82. doi: 10.1016/j.cct.2005.07.002. PMID 16243588.
* Le bêta-élémène induit l'apoptose mitochondriale des synoviocytes de type fibroblastes, intérêt dans la polyarthrite rhumatoïde Zou S, Wang C, Cui Z, Guo P, Meng Q, Shi X, Gao Y, Yang G, Han Z. β-Elemene induces apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase. Pharmacol Rep. 2016 Feb;68(1):7-11. doi: 10.1016/j.pharep.2015.06.004. PMID 26721344.
==Effet thérapeutique==
* Diminue la synthèse et le dépôt excessif de collagène dans les cicatrisations hypertrophiques et les chéloïdes Guo Q, Li Y, Chen Y, Ji J, Zheng S, Xu X, Zhang B, Ye J. β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts. IUBMB Life. 2022 Jun;74(6):508-518. doi: 10.1002/iub.2614. PMID 35294085.
==Effets indésirables==
==Bibliographie==
Catégorie:principes actifs