Growing Pains

Growing pains are also known as benign nocturnal limb pains of childhood. They are cramping pains of the thigh, shin, and calf that typically occurs in the evening or night and has an unknown aetiology.
== Definition ==
There is no consensus definition. 
== Epidemiology ==
The prevalence is 3-37%. The wide range is due to differences between populations, age, and definitions. It is slightly more common in boys than girls and usually begins between the ages of 3 to 12.
== Aetiology ==
The aetiology is unknown. Episodes of pain do not correlate with growth spurts nor do the areas of pain correlate with areas of growth. Growing pains also do not affect growth. Possible aetiologies include family history, higher pain sensitivity, foot malalignment or other mild orthopaedic abnormalities, hypermobility, reduced bone strength, local overuse, and low vitamin D. There may be increased pain following a bout of increased physical activity.
== Clinical Features ==
=== History ===
The pain is primarily in the lower limbs, however upper limb pain can occur in conjunction. The pain is typically bilateral and is felt deep in the lower limbs usually in the thigh, calf, popliteal fossa, or shin. The pain is paroxysmal and can be severe. In older children aged 6 to 12 the pain may be crampy and they may have restless legs. The pain is felt primarily in the evening or night and it can cause night time wakening. By the morning the pain has usually resolved however some children have daytime pain but this doesn't typically limit activities. In general the child is able to continue normal activities. It is a chronic condition with it often lasting many years but episodic in nature. There may be long pain-free periods. The pain is able to be relieved by simple analgesia, massage, or heat. Around one third of children also have recurrent abdominal pain and/or headaches due to an association with increased pain sensitivity. There is often a family history of growing pains or musculoskeletal problems.
=== Examination ===
The gait should be normal in growing pains. Assess for rheumatological and orthopaedic abnormalities including genu valgum, foot overpronation, generalised hypermobility, reduced range of motion, joint swelling, and focal tenderness. Look for lymphadenopathy and splenomegaly as a clue for malignancy, infection, and rheumatological conditions.
== Differential Diagnosis ==
There is an extensive list of differentials for paediatric lower limb pain. Growing pains can usually be differentiated from other conditions by a normal physical examination, lack of constitutional symptoms, and generally no limitations of activities. In some cases blood tests and radiographs are necessary.
Trauma: cardinal features of stress fractures and overuse syndromes in general are localised pain of insidious onset. The pain increases with activity and there is focal tenderness
Bone tumours and leukaemia: pain is usually at night which can make it difficult to distinguish from growing pains. However the pain is usually unilateral rather than bilateral in growing pains. There may be a palpable mass and focal tenderness. The pattern of pain in primary bone tumours such as Ewing sarcoma and osteoid osteomas is initially intermittent that increases in severity over time. In Ewing sarcoma the pain may disappear for long stretches of time.
Infection: The child may initially have a low-grade fever, malaise, irritability, decreased appetite, or decreased activity. With worsening of the infection there may be focal pain, reduced activity, and features on exam of infection.
Osteonecrosis: Perthes disease of the hip is the classic condition here. The pain is in the hip and insidious in onset. The child may have a limp or Trendelenburg gait.
Metabolic disease: In rickets there may be delayed fontanelle closure, parietal and frontal bossing, enlargement of the costochondral junction, widening of the wrist, and lateral bowing of the femur and tibia. The diagnosis can be made on radiographs along with elevated ALP.
Rheumatologic disorders: In juvenile idiopathic arthritis the child may have a limp and overt inflammation in one or more joints.Suzanne C Li. Growing Pains. UpToDate. 5 April 2021
== Investigations ==
Usually investigations are not required. Consider further evaluation in children with systemic symptoms, persisting or increasing unilateral leg pain, daytime pain, limp, reduction in physical activity, localised physical exam findings, suspicion of child abuse, and in children over the age of 12. Investigations to consider to exclude other causes are full blood count, ESR, CRP, vitamin D, and/or plain radiographs.
== Treatment ==
Reassure the child and caregiver about the benign nature of the condition. The child should continue usual activities. Reducing or ceasing physical activities is not helpful and can lead to hypervigilence.
For acute pain consider massage, paracetamol, ibuprofen, and heat. In children where increased physical activity tends to bring about a cluster of painful nights they can consider prophylactic ibuprofen at bedtime following a day of increased activity. This can also be considered to break the cycle of repeated painful nights. In some cases ibuprofen may be too short acting and naproxen can be used which has a longer half life.
Children with low vitamin D levels should take vitamin D and calcium supplements. Supplementation has been found to reduce pain in unblinded studies.Morandi G, Maines E, Piona C, Monti E, Sandri M, Gaudino R, Boner A, Antoniazzi F. Significant association among growing pains, vitamin D supplementation, and bone mineral status: results from a pilot cohort study. J Bone Miner Metab. 2015 Mar;33(2):201-6. doi: 10.1007/s00774-014-0579-5. Epub 2014 Mar 15. PMID: 24633492.Vehapoglu A, Turel O, Turkmen S, Inal BB, Aksoy T, Ozgurhan G, Ersoy M. Are Growing Pains Related to Vitamin D Deficiency? Efficacy of Vitamin D Therapy for Resolution of Symptoms. Med Princ Pract. 2015;24(4):332-8. doi: 10.1159/000431035. Epub 2015 May 27. PMID: 26022378; PMCID: PMC5588252.
Muscle stretching can help with the parent assisting. In one unblinded study, children who stretched twice daily had an average of zero episodes a month compared to one to two episodes a month in the control group. The stretching group also had more rapid resolution of symptoms.Baxter MP, Dulberg C. "Growing pains" in childhood--a proposal for treatment. J Pediatr Orthop. 1988 Jul-Aug;8(4):402-6. doi: 10.1097/01241398-198807000-00004. PMID: 3292578.
* Quadriceps: child prone, flex heel to buttock and hold, lift thigh off table to stretch
* Hamstrings: child supine, lift leg by heel, hold knee straight, flex hip to stretch
* Calf: child prone, knee flexed to 90 degrees, push foot down to stretch. child supine, knee straight, push foot up to stretch.
In children with hypermobility, food malalignment, genu valgum, or poor balance, physical therapy and/or custom molded orthotic to control for overpronation may be helpful.Lee HJ, Lim KB, Yoo J, Yoon SW, Jeong TH. Effect of foot orthoses on children with lower extremity growing pains. Ann Rehabil Med. 2015 Apr;39(2):285-93. doi: 10.5535/arm.2015.39.2.285. Epub 2015 Apr 24. PMID: 25932426; PMCID: PMC4414976.
== Further Reading ==
* Open access article by Lehman et al 2017 on Growing Pains here
== References ==
Category:Knee and Leg Conditions
Category:Paediatrics