Soft tissue sarcoma - historical

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The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. Is there a regimen missing from this list? See the main soft tissue sarcoma page for current regimens.
Last updated on 2024-07-23:2 regimens on this page
4 variants on this page
 
=Locally advanced or metastatic disease, first-line therapy=
==Doxorubicin & Olaratumab==
===Regimen===
Study 	Dates of enrollment	Evidence 	Comparator 	Comparative Efficacy
Tap et al. 2016 (CP15-0806)	2010-2013 	Randomized Phase 2 (E-RT-esc)	Doxorubicin	Longer OS (primary endpoint)
Tap et al. 2020 (ANNOUNCE) 	2015-2018 	Phase 3 (E-esc) 	Doxorubicin	Did not meet primary endpoint of OSMedian OS: 20.4 vs 19.7 mo(HR 1.05, 95% CI 0.84-1.30)
====Chemotherapy====
*Doxorubicin (Adriamycin) as follows:
**Cycles 1 to 8: 75 mg/m2 IV once on day 1
====Targeted therapy====
*Olaratumab (Lartruvo) 15 mg/kg IV once per day on days 1 & 8
21-day cycles
====Supportive therapy====
*CP15-0806, optional: Dexrazoxane (Zinecard) (dose not specified) IV once on day 1
===References===
# CP15-0806: Tap WD, Jones RL, Van Tine BA, Chmielowski B, Elias AD, Adkins D, Agulnik M, Cooney MM, Livingston MB, Pennock G, Hameed MR, Shah GD, Qin A, Shahir A, Cronier DM, Ilaria R Jr, Conti I, Cosaert J, Schwartz GK. Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: an open-label phase 1b and randomised phase 2 trial. Lancet. 2016 Jul 30;388(10043):488-97. Epub 2016 Jun 9. Erratum in: Lancet. 2016 Jul 30;388(10043):464. link to original article dosing details in manuscript have been reviewed by our editors link to PMC article EuroPMC NCT01185964
# ANNOUNCE: Tap WD, Wagner AJ, Schöffski P, Martin-Broto J, Krarup-Hansen A, Ganjoo KN, Yen CC, Abdul Razak AR, Spira A, Kawai A, Le Cesne A, Van Tine BA, Naito Y, Park SH, Fedenko A, Pápai Z, Soldatenkova V, Shahir A, Mo G, Wright J, Jones RL; ANNOUNCE Investigators. Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas: The ANNOUNCE Randomized Clinical Trial. JAMA. 2020 Apr 7;323(13):1266-1276. link to original article link to PMC article EuroPMC NCT02451943
=Locally advanced or metastatic disease, combination regimens=
==Dacarbazine & Doxorubicin==
AD: Adriamycin (Doxorubicin) & Dacarbazine
===Regimen variant #1===
Study 	Dates of enrollment	Evidence 	Comparator 	Comparative Efficacy
Baker et al. 1987 (SWOG S7613)	1976-1979 	Phase 3 (C)	1. AD & Cyclophosphamide2. AD & Dactinomycin	Did not meet endpoints of RR/OS
1In SWOG S8616, although the experimental arm seemed to have longer TTP, this arm seemed to have longer OS.
====Chemotherapy====
*Dacarbazine (DTIC) 250 mg/m2 IV once on day 1
*Doxorubicin (Adriamycin) 60 mg/m2 IV once on day 1
21-day cycles
===Regimen variant #2===
Study 	Dates of enrollment	Evidence 	Comparator 	Comparative Efficacy
Zalupski et al. 1991	1980-1986 	Phase 3 (C)	Dacarbazine & Doxorubicin; CI	Did not meet primary endpoint of OS50%
====Chemotherapy====
*Dacarbazine (DTIC) 750 mg/m2 IV once on day 1
*Doxorubicin (Adriamycin) 60 mg/m2 IV once on day 1
21-day cycles
===Regimen variant #3===
Study 	Dates of enrollment	Evidence 	Comparator	Comparative Efficacy
Antman et al. 1993 (SWOG S8616)	1987-1989 	Phase 3 (C)	MAID 	Seems to have longer OS1
====Chemotherapy====
*Dacarbazine (DTIC) 250 mg/m2/day IV continuous infusion over 96 hours, started on day 1 (total dose per cycle: 1000 mg/m2)
*Doxorubicin (Adriamycin) 15 mg/m2/day IV continuous infusion over 96 hours, started on day 1 (total dose per cycle: 60 mg/m2)
21-day cycles
===References===
# SWOG S7613: Baker LH, Frank J, Fine G, Balcerzak SP, Stephens RL, Stuckey WJ, Rivkin S, Saiki J, Ward JH. Combination chemotherapy using adriamycin, DTIC, cyclophosphamide, and actinomycin D for advanced soft tissue sarcomas: a randomized comparative trial: a phase III, Southwest Oncology Group Study (7613). J Clin Oncol. 1987 Jun;5(6):851-61. link to original article dosing details in abstract have been reviewed by our editors EuroPMC
# Zalupski M, Metch B, Balcerzak S, Fletcher WS, Chapman R, Bonnet JD, Weiss GR, Ryan J, Benjamin RS, Baker LH; SWOG. Phase III comparison of doxorubicin and dacarbazine given by bolus versus infusion in patients with soft-tissue sarcomas: a Southwest Oncology Group study. J Natl Cancer Inst. 1991 Jul 3;83(13):926-32. link to original article dosing details in abstract have been reviewed by our editors EuroPMC
# SWOG S8616: Antman K, Crowley J, Balcerzak SP, Rivkin SE, Weiss GR, Elias A, Natale RB, Cooper RM, Barlogie B, Trump DL, Doroshow JH, Aisner J, Pugh RP, Weiss RB, Cooper BA, Clamond GH, Baker LH. An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J Clin Oncol. 1993 Jul;11(7):1276-85. link to original article dosing details in manuscript have been reviewed by our editors EuroPMC
Category:Soft tissue sarcoma regimens
Category:Historical regimens
Category:Disease-specific pages
Category:Soft tissue sarcomas