Lupéol

==Nom de la substance==
Lupéol
==Famille moléculaire==
Triterpène pentacyclique (alcool triterpénique)
==Source végétale==
Bouleau blanc, Verveine officinale, Souci des jardins, Chanvre du Canada, Tepescohuite, pissenlit, chou, poivron vert, fraise, olive, mangue, raisin
==Propriétés==
* Hypocholestérolémiant et préventif des lésions induites par l'hyperlipidémie Sudhahar V, Ashok Kumar S, Varalakshmi P, Sujatha V. Protective effect of lupeol and lupeol linoleate in hypercholesterolemia associated renal damage. Mol Cell Biochem. 2008 Oct;317(1-2):11-20. doi: 10.1007/s11010-008-9786-5. PMID 18563536, Papi Reddy K, Singh AB, Puri A, Srivastava AK, Narender T. Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4463-6. doi: 10.1016/j.bmcl.2009.05.034. PMID 19515563
* Anti-inflammatoire Geetha T, Varalakshmi P. Effect of lupeol and lupeol linoleate on lysosomal enzymes and collagen in adjuvant-induced arthritis in rats. Mol Cell Biochem. 1999 Nov;201(1-2):83-7. PMID 10630626, Margareth B. C. Gallo, Miranda J. Sarachine. Biological Activities of Lupeol. International Journal of Biomedical and Pharmaceutical Sciences ©2009 Global Science Books, Geetha T, Varalakshmi P, Latha RM. Effect of triterpenes from Crataeva nurvala stem bark on lipid peroxidation in adjuvant induced arthritis in rats. Pharmacol Res. 1998 Mar;37(3):191-5. PMID 9602466, analgésique, antipyrétique Singh S.,Bani S., Singh G. B., Gupta B. D., Banerjee S. K., Singh B. Anti-inflammatory activity of lupeol. Fitoterapia, 1997, vol. 68, no1, pp. 9-16 
* Agent de prévention anti-cancer Saleem M. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. S Cancer Lett. 2009 Nov 28;285(2):109-15. doi: 10.1016/j.canlet.2009.04.033. PMID 19464787, Dzubak P, Hajduch M, Vydra D, Hustova A, Kvasnica M, Biedermann D, Markova L, Urban M, Sarek J. Pharmacological activities of natural triterpenoids and their therapeutic implications. Nat Prod Rep. 2006 Jun;23(3):394-411. PMID 16741586, actif in vitro dans le cancer du pancréas Saleem M, Kaur S, Kweon MH, Adhami VM, Afaq F, Mukhtar H. Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway. Carcinogenesis. 2005 Nov;26(11):1956-64. PMID 15958516, dans les carcinomes épidermoïdes Prasad S, Madan E, Nigam N, Roy P, George J, Shukla Y. Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NFkappaB signaling pathways. Cancer Biol Ther. 2009 Sep;8(17):1632-9. PMID 19625778, activité antinéoplasique Wal, Pranay & Awani, Rai & Wal, Ankita & Sharma, Gaurav. (2011). Biological activities of lupeol. Systematic Reviews in Pharmacy. 2. 96. 10.4103/0975-8453.86298., activateur de différentiation de cellules de lignée cellulaire de leucémie myéloïde de souris Hata K, Ishikawa K, Hori K, Konishi T. Differentiation-inducing activity of lupeol, a lupane-type triterpene from Chinese dandelion root (Hokouei-kon), on a mouse melanoma cell line. Biol Pharm Bull. 2000 Aug;23(8):962-7. PMID 10963304
* Antimicrobien, anti-protozoaire Siddique HR, Saleem M. Beneficial health effects of lupeol triterpene: a review of preclinical studies. Life Sci. 2011 Feb 14;88(7-8):285-93. doi: 10.1016/j.lfs.2010.11.020. PMID 21118697
==Effet thérapeutique==
==Effets indésirables==
==Bibliographie==
Catégorie:principes actifs