Aroa Biosurgery

Aroa Biosurgery Limited (Auckland, New Zealand, formerly Mesynthes Limited, New Zealand) is a regenerative medicine company that develops, manufactures and distributes products for wound healing and soft tissue reconstruction. Aroa Biosurgery is headquartered in Auckland, New Zealand with a US office in San Diego, CA, USA and is listed on the Australian Securities Exchange (ASX: ARX). 
The company, originally known as Mesynthes Limited, was founded in 2008 by Veterinarian Surgeon Dr Brian Ward (BVSc).
The company develops and commercializes products based on its proprietary ovine forestomach matrix technology platform with products in wound healing (Endoform™ Natural, Endoform™ Antimicrobial and Symphony™) as well as plastics and reconstructive surgery (Myriad Matrix™, Myriad Forme™, Myriad Morcells™, Ovitex® PRS) and repair of hernia (Ovitex® and Myriad Ultra™). 
==Technology==
Aroa Biosurgery develops medical devices using its proprietary ovine forestomach matrix (OFM) technology. OFM is a layer of decellularized extracellular matrix (ECM) biomaterial isolated from the propria submucosa of the rumen of sheep.Lun, S., et al., A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 2010. 31(16): p. 4517-29.. OFM is used in tissue engineering and as a tissue scaffold for wound healing and surgical applications.
==History==
* 2008 – Mesynthes Limited (Wellington, New Zealand) was founded by Brian WardAroa Initial Public Offering Prospectus. 2020 16 March 2023]; Available from: https://wcsecure.weblink.com.au/pdf/ARX/02257873.pdf..
* 2008 – First patent of ovine forestomach matrix and reinforced biologicsWard, B.R., K.D. Johnson, and B.C.H. May, Tissue scaffolds derived from forestomach extracellular matrix, USPTO, Editor. 2008, Mesynthes Ltd.: US.. 
* 2010 – OFM first described in the scientific literatureLun, S., et al., A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 2010. 31(16): p. 4517-29.. 
* 2010 – OFM reinforced biologics first described in scientific literatureFloden, E.W., et al., Biophysical characterization of ovine forestomach extracellular matrix biomaterials. J Biomed Mater Res B Appl Biomater, 2011. 96(1): p. 67-75..
* 2011 – Partnership with Hollister Wound Care (Libertyville, IL) to launch and commercialize Endoform Natural™Aroa Initial Public Offering Prospectus. 2020 16 March 2023]; Available from: https://wcsecure.weblink.com.au/pdf/ARX/02257873.pdf..
* 2012 – Partnership with Tela Bio Inc. to commercialize reinforced biologicsAroa Initial Public Offering Prospectus. 2020 16 March 2023]; Available from: https://wcsecure.weblink.com.au/pdf/ARX/02257873.pdf..
* 2013 – OFM reinforced biologics (Ovitex®) cleared by US FDA for hernia repairPremarket notification, 510(k) : K130547. 2013; Available from: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm?ID=K130547..
* 2014 – Corporate headquarters relocated from Wellington New Zealand to Auckland New ZealandAroa Initial Public Offering Prospectus. 2020 16 March 2023]; Available from: https://wcsecure.weblink.com.au/pdf/ARX/02257873.pdf..
* 2015 – Company rebrands to Aroa Biosurgery LimitedAroa Biosurgery Poised for Global Growth. 2015 16 March 2023]; Available from: https://www.businesswire.com/news/home/20150622005454/en/Aroa-Biosurgery-Poised-for-Global-Growth.
* 2016 – Ovitex® launched in USA in partnership with Tela Bio Inc (Malvern, PA)Aroa Initial Public Offering Prospectus. 2020 16 March 2023]; Available from: https://wcsecure.weblink.com.au/pdf/ARX/02257873.pdf.. 
* 2017 – Endoform Antimicrobial™ cleared by the US FDAKrause, D. Premarket notification, 510(k) : K172318. 2017 13 Mar 2023]; Available from: https://www.accessdata.fda.gov/cdrh_docs/pdf17/K172318.pdf..
* 2017 – Myriad Matrix™ cleared by the US FDAKrause, D. Premarket notification, 510(k) : K153632. 2016; Available from: https://www.accessdata.fda.gov/cdrh_docs/pdf15/K153632.pdf..
* 2018 – Endoform Antimicrobial™ launched in USAAroa Initial Public Offering Prospectus. 2020 16 March 2023]; Available from: https://wcsecure.weblink.com.au/pdf/ARX/02257873.pdf.. 
* 2018 – Aroa Biosurgery opens first US office (San Diego, California)Aroa Biosurgery appoints new vice-president. 2019 16 March 2023]; Available from: https://www.nbr.co.nz/comings-and-goings/aroa-biosurgery-appoints-new-vice-president/..
* 2019 – Myriad Matrix™ launched in USA for plastic and reconstructive surgeryAroa Initial Public Offering Prospectus. 2020 16 March 2023]; Available from: https://wcsecure.weblink.com.au/pdf/ARX/02257873.pdf..
* 2020 – Symphony™ cleared by US FDAPremarket notification, 510(k) : K200413. 2020; Available from: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm?ID=K200413..
* 2021 – Myriad Morcells™ cleared by US FDALiu, L. Premarket notification, 510(k) : K200502. 2021; Available from: https://www.accessdata.fda.gov/cdrh_docs/pdf20/K200502.pdf..
* 2021 – Myriad Morcells™ launched in USA for plastic and reconstructive surgeryAroa Biosurgery Launches New Product, Myriad Morcells™ - Offering Highly Conformable Tissue Regeneration in Wound Beds - Following Recent FDA Clearance. 2021 16 March 2023]; Available from: https://www.businesswire.com/news/home/20210428005356/en/Aroa-Biosurgery-Launches-New-Product-Myriad-Morcells%E2%84%A2---Offering-Highly-Conformable-Tissue-Regeneration-in-Wound-Beds---Following-Recent-FDA-Clearance..
* 2022 – First scientific publication describing novel dead-space management negative pressure systemMason, I.T.T., et al., Evaluation of Tissue Apposition and Seroma Prevention in an Ovine Model of Surgical Dead Space using a Novel ‘Air-Purged Vacuum Closure’ System. ePlasty, 2022. 2022(22): p. e46.
* 2023 – Symphony™ launched in USA for advanced wound care.
==Awards==
* 2009 – Bayer Innovators Award; awarded by Bayer New ZealandBayer Honours New Zealand’s Leading Innovators. 2009 13 March 2023]; Available from: https://m.scoop.co.nz/stories/BU0908/S00782/bayer-honours-new-zealands-leading-innovators.htm.
* 2011 – Supreme Award, Endoform by Mesynthes; awarded by Wellington Gold AwardsRutherford, H. Mesynthes supreme winner at Wellington Gold Awards. 2011 13 March 2023]; Available from: https://www.stuff.co.nz/business/5023299/Mesynthes-supreme-winner-at-Wellington-Gold-Awards.
* 2014 – Fastest Growing Manufacturer; awarded by Deloitte Fast 50Listing likely for tissue repair company. 2014 13 March 2023]; Available from: https://www.stuff.co.nz/business/industries/10635849/Listing-likely-for-tissue-repair-company.
* 2015 – New Zealand’s Bioscience Company of the Year; awarded by NZBioNZ bioscience celebrates its innovators. 2015 24 September 2015 [cited 2023 13 March 2023]; Available from: https://www.scoop.co.nz/stories/SC1509/S00081/nz-bioscience-celebrates-its-innovators.htm.
* 2022 – Most Innovative Dressing or Device, Gold Award; awarded by Journal of Wound CareStadler, L. WUWHS – A Hybrid Wound Care Event with a Local Touch in Abu Dhabi. 2022 13 March 2023]; Available from: https://blog.smarttrak.com/wuwhs-a-hybrid-event-with-a-local-touch.
Category:Pharmaceutical companies
Category:Companies based in Auckland
Category:Pharmaceutical companies of New Zealand
Category:Pharmaceutical companies established in 2008