Turmérone

==Nom de la substance==
Turmérones : alpha-turmérone, bêta-turmérone, (aromatique) ar-turmérone
==Famille moléculaire==
Sesquiterpénoïdes (cétones sesquiterpéniques)
==Source végétale==
* Rhizome de curcuma, temoe-Lawaq et leurs huiles essentielles
==Propriétés==
* L'ar-turmérone induit l’apoptose sur des cellules de leucémie humaine Molt 4B et HL-60, mais pas sur celles du cancer de l’estomac KATO III Aratanechemuge Y, Komiya T, Moteki H, Katsuzaki H, Imai K, Hibasami H. Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line. Int J Mol Med. 2002 May;9(5):481-4. PMID 11956652.
* L’ar-turmérone est cytotoxique vis-à-vis de lignées cellulaires cancéreuses (L’K562, L1210, U937, RBL-2H3) Ji, M., Choi, J., Lee, J., & Lee, Y. (2004). Induction of apoptosis by ar-turmerone on various cell lines. International journal of molecular medicine, 14(2), 253-256. 
* Antidépresseur Liao J, Tsai J, Liu C, Huang H, Wu L, Peng W. Antidepressant-like activity of turmerone in behavioral despair tests in mice. BMC Complementary and Alternative Medicine 2013, 13:299 (1 November 2013) Abstract texte intégral
* Anti-inflammatoire Oh S, Han AR, Park HR, Jang EJ, Kim HK, Jeong MG, Song H, Park GH, Seo EK, Hwang ES. Suppression of Inflammatory cytokine production by ar-Turmerone isolated from Curcuma phaeocaulis. Chem Biodivers. 2014 Jul;11(7):1034-41. doi: 10.1002/cbdv.201300397. PMID 25044589
* Neuroprotecteur Park SY, Jin ML, Kim YH, Kim Y, Lee SJ. Anti-inflammatory effects of aromatic-turmerone through blocking of NF-κB, JNK, and p38 MAPK signaling pathways in amyloid β-stimulated microglia. Int Immunopharmacol. 2012 Sep;14(1):13-20. doi: 10.1016/j.intimp.2012.06.003. PMID 22728094, Park SY, Kim YH, Kim Y, Lee SJ. Aromatic-turmerone's anti-inflammatory effects in microglial cells are mediated by protein kinase A and heme oxygenase-1 signaling. Neurochem Int. 2012 Oct;61(5):767-77. doi: 10.1016/j.neuint.2012.06.020. PMID 22766494, améliorerait la récupération de lésions cérébrales après AVC (diminue la neuro-inflammation, améliore la mobilisation des cellules souches endogènes) Poser SW, Androutsellis-Theotokis A. Spicing up endogenous neural stem cells: aromatic-turmerone offers new possibilities for tackling neurodegeneration. Stem Cell Res Ther. 2014 Nov 17;5(6):127. doi: 10.1186/scrt517. PMID 25688994, inhibe l’activation de la microglie, neuroprotecteur dans les maladies neurodégénératives Hucklenbroich, J., Klein, R., Neumaier, B. et al. Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Res Ther 5, 100 (2014). https://doi.org/10.1186/scrt500
* Alexitère, neutralise la toxicité de venins de serpents Bothrops jararaca, Crotalus durissus terrificus Luiza A.F. Ferreira, Olga B. Henriques, Amelia A.S. Andreoni, Glaucio R.F. Vital, Marcia M.C. Campos, Gerhard G. Habermehl, Vera L.G. de Moraes. Antivenom and biological effects of ar-turmerone isolated from Curcuma longa (Zingiberaeae). Toxicon, Volume 30, Issue 10, 1992, Pages 1211-1218, https://doi.org/10.1016/0041-0101(92)90437-A.
* Inhibition de l’agrégation plaquettaire H.S. Lee. Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone. Bioresource Technology, Volume 97, Issue 12, 2006, Pages 1372-1376, 
* Antifongique (dermatophytes) Jankasem M, Wuthi-Udomlert M, Gritsanapan W. Antidermatophytic Properties of Ar-Turmerone, Turmeric Oil, and Curcuma longa Preparations. ISRN Dermatol. 2013 Aug 26;2013:250597. doi: 10.1155/2013/250597. PMID 24066236; PMCID: PMC3770062.
* Anti-épileptique Adriana Monserrath Orellana-Paucar, Tatiana Afrikanova, Joice Thomas, Yelaman K. Aibuldinov, Wim Dehaen, Peter A. M. de Witte, Camila V. Esguerra. Insights from Zebrafish and Mouse Models on the Activity and Safety of Ar-Turmerone as a Potential Drug Candidate for the Treatment of Epilepsy. Plos One, December 13, 2013 
==Effet thérapeutique==
* Anti-cancéreux (?)
* Maladies neuro-dégénératives (?)
==Effets indésirables==
==Bibliographie==
* Chae Hee Hong, Min Soo Noh, Woo Young Lee, Sang Kook Lee. Inhibitory Effects of Natural Sesquiterpenoids Isolated from the Rhizomes of Curcuma zedoaria on Prostaglandin E2 and Nitric Oxide Production. Planta Med 2002; 68: 545-547 
Catégorie:principes actifs