Epirubicin (Ellence)

==General information==
Class/mechanism: Anthracycline; binds and intercalates DNA, which triggers DNA cleavage by topoisomerase II; inhibits DNA/RNA synthesis. Inhibits DNA helicase activity, preventing enzymatic separation of double-stranded DNA.Epirubicin (Ellence) package insert Epirubicin (Ellence) package insert (locally hosted backup)
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias or the prescribing information. 
==Diseases for which it is used==
*Bladder cancer
*Breast cancer
*Cholangiocarcinoma
*Diffuse large B-cell lymphoma
*Esophageal cancer
**Esophageal adenocarcinoma
*Gallbladder cancer
*Gastric cancer
*Hepatocellular carcinoma
*Classical Hodgkin lymphoma
*Nasopharyngeal carcinoma
*Osteosarcoma
*Small cell lung cancer
*Soft tissue sarcoma
*Testicular cancer
==Diseases for which it was used==
*Ovarian cancer
*Pancreatic cancer
==Patient drug information==
*Epirubicin (Ellence) patient drug information (Chemocare)Epirubicin (Ellence) patient drug information (Chemocare)
*Brief patient counseling information can be found on pages 15-16 of the Epirubicin (Ellence) package insert
*Epirubicin (Ellence) patient drug information (UpToDate)Epirubicin (Ellence) patient drug information (UpToDate)
==History of changes in FDA indication==
* 1999-09-15: Initial approval as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer. (Based on FASG 05 & NCIC-CTG MA.5)
==History of changes in EMA indication==
The approval of this drug pre-dates the EMA.
*1982-06-28: EURD
==Also known as==
*Generic name: 4-epi-doxorubicin, epidoxorubicin
*Brand names: Alrubicin, Anthracin, Binarin, Bioepicyna, Crisabon, E.P.R Elvetium, Ellence, Epidoxo, Epifil, Epilem, Epirubicine, Epizin, Epricin, Eracin, Famorubicin, Farmorubicin, Farmorubicina, Farmorubicine, Pharmorubicin, Riboepi, Rubifarm
==References==
Category:Drugs
Category:Intravenous medications
Category:Vesicant
Category:Anthracyclines
Category:Topoisomerase II inhibitors
Category:Human DNA synthesis inhibitors
Category:Bladder cancer medications
Category:Breast cancer medications
Category:Cholangiocarcinoma medications
Category:Diffuse large B-cell lymphoma medications
Category:Esophageal adenocarcinoma medications
Category:Esophageal cancer medications
Category:Gallbladder cancer medications
Category:Gastric cancer medications
Category:Hepatocellular carcinoma medications
Category:Classical Hodgkin lymphoma medications
Category:Nasopharyngeal carcinoma medications
Category:Osteosarcoma medications 
Category:Small cell lung cancer medications
Category:Soft tissue sarcoma medications 
Category:Testicular cancer medications
Category:Ovarian cancer medications (historic)
Category:Pancreatic cancer medications (historic)
Category:FDA approved in 1999
Category:EMA approved in 1982