Scutellaréine

==Nom de la substance==
Scutellaréine
==Famille moléculaire==
* Flavonoïde (flavone)
** La scutellarine est le scutellaréine-7-glucuronide
==Source végétale==
* Scutellaires : Scutellaria lateriflora, Scutellaria galericulata, Scutellaria baicalensis
==Propriétés==
* Antiviral, inhibe l'hélicase du SRAS-Coronavirus (comme la myricétine) Yu MS, Lee J, Lee JM, Kim Y, Chin YW, Jee JG, Keum YS, Jeong YJ. Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4049-54. doi: 10.1016/j.bmcl.2012.04.081. PMID 22578462, Keum YS, Jeong YJ. Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target. Biochem Pharmacol. 2012 Nov 15;84(10):1351-8. doi: 10.1016/j.bcp.2012.08.012. PMID 22935448; PMCID: PMC7092843.
* Protège du processus d'ischémie-reperfusion Qian L, Shen M, Tang H, Tang Y, Zhang L, Fu Y, Shi Q, Li NG. Synthesis and protective effect of scutellarein on focal cerebral ischemia/reperfusion in rats. Molecules. 2012 Sep 6;17(9):10667-74. doi: 10.3390/molecules170910667. PMID 22955455; PMCID: PMC6268490., Qian LH, Li NG, Tang YP, Zhang L, Tang H, Wang ZJ, Liu L, Song SL, Guo JM, Ding AW. Synthesis and bio-activity evaluation of scutellarein as a potent agent for the therapy of ischemic cerebrovascular disease. Int J Mol Sci. 2011;12(11):8208-16. doi: 10.3390/ijms12118208. Epub 2011 Nov 18. PMID 22174659; PMCID: PMC3233465., prévention des complications cardiovasculaires de l'HTA, et des AVC 
* Améliore la dermatite atopique en inhibant l'expression du TRPV3 Wang Y, Tan L, Jiao K, Xue C, Tang Q, Jiang S, Ren Y, Chen H, El-Aziz TMA, Abdelazeem KNM, Yu Y, Zhao F, Zhu MX, Cao Z. Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2022 Oct;179(20):4792-4808. doi: 10.1111/bph.15913. PMID 35771623.
* Antitumoral : fibrosarcome Shi X, Chen G, Liu X, Qiu Y, Yang S, Zhang Y, Fang X, Zhang C, Liu X. Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. Int J Mol Med. 2015 Jan;35(1):31-8. doi: 10.3892/ijmm.2014.1997. PMID 25394920; PMCID: PMC4249742., cancer du colon Li Y, Wang J, Zhong S, Li J, Du W. Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination. Int J Mol Med. 2020 Apr;45(4):1059-1072. doi: 10.3892/ijmm.2020.4496. PMID 32124957; PMCID: PMC7053863., inducteur d'apoptose Sang Eun H, Seong Min K, Ho Jeong L, Vetrivel P, Venkatarame Gowda Saralamma V, Jeong Doo H, Eun Hee K, Sang Joon L, Gon Sup K. Scutellarein Induces Fas-Mediated Extrinsic Apoptosis and G2/M Cell Cycle Arrest in Hep3B Hepatocellular Carcinoma Cells. Nutrients. 2019 Jan 24;11(2):263. doi: 10.3390/nu11020263. PMID 30682875; PMCID: PMC6412708.
* Anti-inflammatoire Sung NY, Kim MY, Cho JY. Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity. Korean J Physiol Pharmacol. 2015 Sep;19(5):441-9. doi: 10.4196/kjpp.2015.19.5.441. PMID 26330757; PMCID: PMC4553404., Yoon, S. N., & Youl, C. J. (2015). Effects of scutellarein, a flavonoid of Scutellaria lateriflora, on inflammatory responses. 춘계총회 및 학술대회, 295-295., antioxydant
==Effet thérapeutique==
* Potentialités dans la maladie d'Alzheimer Huang XW, Xu Y, Sui X, Lin H, Xu JM, Han D, Ye DD, Lv GF, Liu YX, Qu XB, Duan MH. Scutellarein suppresses Aβ-induced memory impairment via inhibition of the NF-κB pathway in vivo and in vitro. Oncol Lett. 2019 Jun;17(6):5581-5589. doi: 10.3892/ol.2019.10274. PMID 31186780; PMCID: PMC6507344.
==Effets indésirables==
==Bibliographie==
Catégorie:principes actifs