Vincristine (Oncovin)

==General information==
Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase.Vincristine (Oncovin) package insertVincristine (Oncovin) package insert (locally hosted backup)
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, or the prescribing information. 
==Diseases for which it is established (work in progress)==
*Non-Hodgkin lymphoma
**Follicular lymphoma
**Mantle cell lymphoma
**Peripheral T-cell lymphoma
==Diseases for which it is used==
*Acquired thrombotic thrombocytopenic purpura
*Adult T-cell leukemia-lymphoma
*Anaplastic glioma
*Anaplastic large cell lymphoma
*B-cell acute lymphoblastic leukemia
*Burkitt lymphoma
*Classical Hodgkin lymphoma
*CNS lymphoma
*Diffuse large B-cell lymphoma
*Ewing sarcoma
*Extranodal NK- and T-cell lymphoma, nasal type
*Gestational trophoblastic neoplasia
*Glioblastoma
*Hepatoblastoma
*HIV-associated lymphoma
*Hodgkin lymphoma, nodular lymphocyte-predominant
*Indolent lymphoma
*Kaposi sarcoma
*Low-grade glioma
**Low-grade glioma, pediatric
*Mediastinal gray-zone lymphoma
*Medulloblastoma
*Multiple myeloma
*Neuroblastoma
*Penile cancer
*Pheochromocytoma
*Post-transplant lymphoproliferative disorder
*Primary mediastinal B-cell lymphoma
*Retinoblastoma
*Rhabdomyosarcoma
*Soft tissue sarcoma
*T-cell acute lymphoblastic leukemia
*Testicular cancer
*Thymoma
*Transformed lymphoma
*Wilms tumor
==Diseases for which it was used==
*Acute myeloid leukemia
*Breast cancer
*Chronic lymphocytic leukemia
*Chronic myeloid leukemia
*Colon cancer
*Head and neck cancer
*Melanoma
*Osteosarcoma
*Small cell lung cancer
==Notable side effects==
*Neuropathy Broyl A, Corthals SL, Jongen JL, van der Holt B, Kuiper R, de Knegt Y, van Duin M, el Jarari L, Bertsch U, Lokhorst HM, Durie BG, Goldschmidt H, Sonneveld P. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. Epub 2010 Sep 21. link to original article dosing details in manuscript have been reviewed by our editors EuroPMC
==Patient drug information==
*Vincristine (Oncovin) patient drug information (Chemocare)Vincristine (Oncovin) patient drug information (Chemocare)
*Vincristine (Oncovin) patient drug information (UpToDate)Vincristine (Oncovin) patient drug information (UpToDate)
==History of changes in FDA indication==
* 1963-07-10: Initial FDA approval
*2014-08-05 (oldest label available at Drugs @ FDA): Indicated in acute leukemia. It has also been shown to be useful in combination with other oncolytic agents in Hodgkin’s disease, non-Hodgkin’s malignant lymphomas (lymphocytic, mixed-cell, histiocytic, undifferentiated, nodular, and diffuse types), rhabdomyosarcoma, neuroblastoma, and Wilms’ tumor. (No supporting studies are cited)
==History of changes in EMA indication==
*1995-04-12: EURD
==History of changes in PMDA indication==
*2013-03-25: New additional indication and a new dosage for the treatment of pheochromocytoma.
==Also known as==
*Generic names: LCR, leurocristine, VCR, vincristine sulfate
*Brand names:
Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms 	Synonyms
Alcrist 	Biocrist 	Biocrystin 	Cellcristin 	Citomid 	Crivosin 	Farmistin CS 	Fauldvincri
Krebin 	Kyocristine	Nevexitin 	Oncovin 	Onkocristin 	Pericristine	Pharmacristine	Tecnocris
Vincasar 	Vinces 	Vincosid 	Vincran 	Vincrex 	Vincrifil 	Vincrin 	Vincrisin
Vincrisol	Vincristin 	Vincristina	Vincristinesulfaat	Vincristinsulfat	Vincristinum	Vincrisul 	Vinracin
Vinracine	Vinstin 	Vintec 	 	 	 	 	
==References==
Category:Drugs
Category:Intravenous medications
Category:Vesicant
Category:Microtubule inhibitors
Category:Vinca alkaloids
Category:Acquired thrombotic thrombocytopenic purpura medications
Category:Adult T-cell leukemia-lymphoma medications
Category:Anaplastic glioma medications
Category:Anaplastic large cell lymphoma medications
Category:B-cell acute lymphoblastic leukemia medications
Category:Burkitt lymphoma medications
Category:Classical Hodgkin lymphoma medications
Category:CNS lymphoma medications
Category:Diffuse large B-cell lymphoma medications
Category:Ewing sarcoma medications
Category:Extranodal NK- and T-cell lymphoma, nasal type medications
Category:Follicular lymphoma medications
Category:Gestational trophoblastic neoplasia medications
Category:Glioblastoma medications
Category:Hepatoblastoma medications
Category:HIV-associated lymphoma medications
Category:Hodgkin lymphoma, nodular lymphocyte-predominant medications
Category:Indolent lymphoma medications
Category:Kaposi sarcoma medications
Category:Low-grade glioma medications
Category:Low-grade glioma, pediatric medications
Category:Mantle cell lymphoma medications
Category:Mediastinal gray-zone lymphoma medications
Category:Medulloblastoma medications
Category:Multiple myeloma medications
Category:Neuroblastoma medications
Category:Penile cancer medications
Category:Peripheral T-cell lymphoma medications
Category:Pheochromocytoma medications
Category:Post-transplant lymphoproliferative disorder‎ medications
Category:Primary mediastinal B-cell lymphoma medications
Category:Retinoblastoma medications
Category:Rhabdomyosarcoma medications
Category:Soft tissue sarcoma medications 
Category:T-cell acute lymphoblastic leukemia medications
Category:Testicular cancer medications
Category:Thymoma medications
Category:Transformed lymphoma medications
Category:Wilms tumor medications
Category:Acute myeloid leukemia medications (historic)
Category:Breast cancer medications (historic)
Category:Chronic lymphocytic leukemia medications (historic)
Category:Chronic myeloid leukemia medications (historic)
Category:Colon cancer medications (historic)
Category:Head and neck cancer medications (historic)
Category:Melanoma medications (historic)
Category:Osteosarcoma medications (historic)
Category:Small cell lung cancer medications (historic)
Category:FDA approved in 1963
Category:EMA approved in 1995
Category:WHO Essential Cancer Medicine