The triple screen is - as it’s name implies - just a screening test. It cannot tell for sure if your baby has Down syndrome, but it can tell if your risk is higher. If your screening test is positive, it simply means your risk of having a baby with Down syndrome is higher than other women your age. But even with a positive screening test, most women will have babies without Down syndrome. Conversely, a negative triple screen means that the chance of Down syndrome is low but not zero. It doesn't guarantee a baby without Down syndrome.A cut-off point of 1 in 300 in first trimester screening (and 1 in 250 for second semester screening) is usually used. If your risk is less than that, you will be described as 'screen negative' or 'low-risk', which means that you are unlikely to be carrying a baby with Down syndrome (but it's not impossible).