Автор: Колдун-Баба Отправить автору личное сообщение  |  Отправить в Ева-Газету Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial.J Allergy Clin Immunol. 2007; 119(1):184-91 (ISSN: 0091-6749)Taylor AL; Dunstan JA; Prescott SLSchool of Paediatrics and Child Health, University of Western Australia, Perth, Australia.BACKGROUND: Despite preliminary evidence, the role of probiotics in allergy prevention is unclear. OBJECTIVE: To determine whether early probiotic supplementation prevents allergic disease in high-risk infants. METHODS: Newborns of women with allergy (n = 231) received either Lactobacillus acidophilus (LAVRI-A1) or placebo daily for the first 6 months of life. Children were assessed for atopic dermatitis (AD) and other symptoms at 6 and 12 months and had allergen skin prick tests (SPT) at 12 months of age. RESULTS: A total of 178 infants completed the supplementation period. Those in the probiotic group showed significantly higher rates of Lactobacillus colonization (P = .039). At 6 months, AD rates were similar in the probiotic (n = 23/89; 25.8%) and placebo (n = 20/88; 22.7%) groups (P = .629). There was also no difference at 12 months, although the proportion of children with SPT+AD was significantly higher in the probiotic group (P = .045). At 12 months, the rate of sensitization was significantly higher in the probiotic group (P = .030). The presence of culturable Lactobacilli or Bifidobacterium in stools in the first month of life was not associated with the risk of subsequent sensitization or disease; however, the presence of Lactobacillus at 6 months of age was associated with increased risk of subsequent cow's milk sensitization (P = .012). CONCLUSION: Early probiotic supplementation with L acidophilus did not reduce the risk of AD in high-risk infants and was associated with increased allergen sensitization in infants receiving supplements. The long-term significance of the increased rate of sensitization needs to be investigated in further studies. CLINICAL IMPLICATIONS: These findings challenge the role of probiotics in allergy prevention. "И твоя голова всегда в ответе за то, куда сядет твой зад" (Н.П.) Ответить | Для печати | Для печати всех сообщений | Отправить Адрес сообщения:http://www.eva.ru/main/forum/frames?idPost=40969792