https://www.who.int/medical_devices/diagnostics/selection_in-vitro/selection_in-vitro-meetings/00024_05_WJG-24-124.pdfRESULTSFifteen guidelines were identified. Six guidelines werepublished in North America, four in Europe, four in Asiaand one from the World Gastroenterology Organization. The majority of guidelines recommend screeningaverage-risk individuals between ages 50 and 75 usingcolonoscopy (every 10 years), or flexible sigmoidoscopy(FS, every 5 years) or fecal occult blood test (FOBT,mainly the Fecal Immunochemical Test, annually orbiennially). Disparities throughout the different guidelinesare found relating to the use of colonoscopy, rank orderbetween test, screening intervals and optimal ageranges for screening.CONCLUSIONAverage risk individuals between 50 and 75 yearsshould undergo CRC screening. Recommendationsfor optimal surveillance intervals, preferred tests/testcascade as well as the optimal timing when to startand stop screening differ regionally and should beconsidered for clinical decision making. Furthermore,local resource availability and patient preferences areimportant to increase CRC screening uptake, as anyscreening is better than none.Key words: Guidelines; Systematic review; fecal occul