Practice Points - Neonatal Intensive Care Drug Manual

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Neonatal Intensive Care Drug Manual
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bet | 62/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
Practice Points
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The pharmacokinetics of clavulanate has not been evaluated in neonates. Further trials are needed to establish the safety and efficacy of iv-to-oral switch therapy in neonates, although some efficacy data exist for infants >1 month age. [9] [LOE I GOR C], Amoxicillin-clavulanic acid should be considered a 2nd line agent for infants with WHO defined non-, severe community-acquired pneumonia. There are no data for infants <3 months age. [LOE I, GOR B], Amoxicillin-clavulanate should be considered a 2nd line agent for infants with a urinary tract infection, or for oral to IV switch therapy for pyelonephritis with a sensitive organism for infants >1 month age.[LOE I GOR B],
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References
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