Conclusion - Neonatal Intensive Care Drug Manual

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Neonatal Intensive Care Drug Manual
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bet | 118/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
Conclusion: Most children presenting with acute infective conjunctivitis in primary care will get better without topical antibiotic treatment. Moreover, failure of clinical cure is frequent with chloramphenicol. Treatment should be guided by microbiological testing including for chlamydia and gonococcus if clinically indicated or in areas of increased prevalence prior to initiation of eye drops.
References
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Rose PW, Harnden A, Brueggemann AB, Perera R, Sheikh A, Crook D, Mant D. Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: A randomised double-blind placebo-controlled trial. Lancet. 2005;366:37-43.
Fukuda M, Ohashi H, Matsumoto C, Mishima S, Shimomura Y. Methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus ocular surface infection: Efficacy of chloramphenicol eye drops. Cornea. 2002;21:S86-S9.
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Horven I. Acute conjuctivitis. A comparison of fusidic acid viscous eye drops and chloramphenicol. Acta Ophthalmologica. 1993;71:165-8.
Hvidberg J. Fusidic acid in acute conjunctivitis. Single-blind, randomized comparison of fusidic acid and chloramphenicol viscous eye drops. Acta Ophthalmologica. 1987;65:43-7.
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Dirdal M. Fucithalmic in acute conjunctivitis. Open, randomized comparison of fusidic acid, chloramphenicol and framycetin eye drops. Acta Ophthalmologica. 1987;65:129-33.
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Laporte JR, Vidal X, Ballarin E, Ibanez L. Possible association between ocular chloramphenicol and aplastic anaemia - The absolute risk is very low. British Journal of Clinical Pharmacology. 1998;46:181-4.
Walker S, Diaper CJM, Bowman R, Sweeney G, Seal DV, Kirkness CM. Lack of evidence for systemic toxicity following topical chloramphenicol use. Eye. 1998;12:875-9.
Amichai B, Grunwald MH, Halevy S. Erythema multiforme resulting from chloramphenicol in eye drops: Confirmation by mast cell degranulation test. Annals of Ophthalmology - Glaucoma. 1998;30:225-7.
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Darling EK, McDonald H. A Meta-analysis of the Efficacy of Ocular Prophylactic Agents Used for the Prevention of Gonococcal and Chlamydial Ophthalmia Neonatorum. Journal of Midwifery and Women's Health. 2010;55:319-27.
Schofield CBS, Shanks RA. Gonococcal ophthalmia neonatoriun despite treatment with antibacterial eye drops. British Medical Journal. 1971;1:257-9.
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Ramirez-Ortiz MA, Rodriguez-Almaraz M, Ochoa-DiazLopez H, Diaz-Prieto P, Rodriguez-Suarez RS. Randomised equivalency trial comparing 2.5% povidone-iodine eye drops and ophthalmic chloramphenicol for preventing neonatal conjunctivitis in a trachoma endemic area in southern Mexico. British Journal of Ophthalmology. 2007;91:1430-4.
Chloramphenicol eye drops. MIMS Online. Accessed on 15 June 2019.
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Original version Date: 21/06/2019
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Author: NeoMed Consensus Group
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Current Version number: 1
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Current Version Date: 21/06/2019
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Risk Rating: Low
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Due for Review: 21/06/2024
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Approved by: DTC
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Approval Date: TBA
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