Sildenafil and retinopathy of prematurity

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Sildenafil and retinopathy of prematurity
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bet | 558/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
Sildenafil and retinopathy of prematurity
Sildenafil is 10 x more selective for PDE5 as compared to PDE6. PDE6 is found in the retina. If used in extremely preterm neonates, sildenafil may increase the risk of severe retinopathy of prematurity. A retrospective, case-controlled study (n = 68) in neonates born before 30 weeks gestation showed sildenafil use did not increase the risk of retinopathy of prematurity.3
References
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