Disintegrate effect

Disintegrate is a status effect that kills whichever creature it is applied to, unless they are explicitly immune to it. If gore is enabled in the game options, the creature's gold and/or non-critical equipment may be disintegrated along with their body. A companion who is killed by disintegration can not be revived on higher difficulties.
Note: It is not the only status effect that kills a creature instantly -- other contenders are Kill target, Power Word Kill and Slay. The party should be immune to them in Story mode.
==Gameplay==
As is true with all status effects, application details vary depending on source -- what is causing the effect. The source may allow a saving throw with or without a penalty, may or may not be able to apply Disintegrate through the Cloak of Mirroring, ... Check the source you're interested in for such details. It is likely to help find ways to prevent Disintegrate from being applied to party members, so they don't have to resist it explicitly using one of the means described in this article.