Signs and Wonders/Trivia

* Over 50 snakes were used in the production under the strict supervision of handler Jules Sylvester.
* Before production on "Signs & Wonders", the producers organized several safety meetings to prevent any possible accidents on the set. One of the first orders of business was locating the nearest hospital, according to make-up effects coordinator John Vulich. 
* Fear of an accident was compounded by some of the cast and crew members' fear of snakes.
** Kim Manners, David Duchovny, and John Shiban have fear of snakes in real-life.
* An accident very nearly occurred when a live rattlesnake was brought to the show's set and escaped. It was eventually located hiding in Manners' office. 
* In order to prevent future accidents, the snakes had their fangs and venom glands removed (defanged and subjected to venomiod), with their venom milked before their mouths were sealed with sutures.
* None of the cast and crew were bitten.
* The father of Michael Childers—the actor who portrayed Reverend O'Connor—was a real-life snake-handling preacher who later gave up the practice. Childers, a native of West Virginia, attended a church in the same state where his father acted as one of its reverends and whose congregation frequently practiced snake-handling. 
** Coincidentally, Michael Childers also handled snakes during his late childhood years but gave up the practice later on.
* A deleted scene included O'Connor singing to his church group. It was cut due to time constraints.
* Enoch O'Connor is likely named after a person from the Book of Genesis in the Bible. An ancestor of Noah, the prophet Enoch "walked with God" and was transferred so as not to see death.
* 'Signs and Wonders' is a common biblical phrase used to describe the acts used to convince followers of the nature of Christ and his apostles, for example: Second Corinthians 12:12: "The signs of a true apostle were performed among you with all perseverance, by signs and wonders and miracles."
* Enoch O'Connor's name is also a likely homage to Southern Gothic writer Flannery O'Connor, who constantly featured themes of religious hypocrisy and the mysteries of faith and grace. Enoch Emery is a character in her first novel, Wise Blood.
* X-Files staff writer Jeffrey Bell researched on snake-handling and extremist religious sects prior while writing frafts for the episode.
* The casting for "Signs & Wonders" was "rather unorthodox". In order to prevent ophidiophobia from affecting the actors on the day of filming, live rattlesnakes were brought in during the casting sessions. Ironically, many of the actors were "thrilled" when they got to hold the snakes, according to Kim Manners. He later noted that "the funny thing was that the actors couldn't wait to hold the rattlesnakes ... but we were still nervous."