Mother Brain

Mother Brain is the main antagonist of the Metroid franchise, having first appeared in the game of the same name. Mother Brain has made cameos and a few mentions in Mario-related media, in which she is first mentioned in the Nintendo Comics System comic "Duh Stoopid Bomb!," whereas Mother Brain's first physical appearance in a Mario-related game is WarioWare, Inc.: Mega Microgame$!.
==In Super Mario RPG: Legend of the Seven Stars==
Mother Brain is briefly mentioned by Samus Aran in the guest room of the Mushroom Castle, where Samus says she is resting up before battling Mother Brain. 
==In WarioWare, Inc.: Mega Microgame$!==
Mother Brain is featured within the microgame Metroid, which is a recreation of the final boss fight in the original Metroid. As such, Mother Brain's sprite is reused from the first Metroid. To win the microgame, Samus must blast Mother Brain repeatedly with missiles while dodging Mother Brain's attacks to defeat her.
== In the Super Smash Bros. series==
As of Super Smash Bros. for Nintendo 3DS, Mother Brain is featured as an Assist Trophy. Her first Super Smash Bros. appearance is in Super Smash Bros. Brawl, in which Mother Brain makes a cameo appearance as a sticker.
==In other media==
===Nintendo Comics System===
In the "Duh Stoopid Bomb!" story, Mother Brain (listed as "M. Brain" is listed among the characters who think that King Toadstool is stupid.
==Timeline==
==Navigation==
it:Mother Brain
Category:Aliens
Category:Characters in WarioWare, Inc.: Mega Microgame$!
Category:Characters not from the Mario Universe