Polio's Cancer Fun 2

Polio's Cancer Fun 2 is the sequel to the 1999 game Polio's Cancer Fun, released by Sex Pistols Interactive on December 23, 2000 for the PlayStation 2. The game was developed immediately after SPI co-founder Sid Vicious stole and reverse engineered an advance copy in order to develop games just in time for it's launch release (and profit more from illegally bundling their games in black market sales for the system).
Unlike the original, the sequel is based on an entirely new engine (to accommodate the 3D graphics) but still keeps the Mario-esque childish feel, as the original was a hack of the original Super Mario Bros. 1 ROM.
The first Polio game is also available in the extras menu.
In the sequel, Polio's brother Lupus dies from his terminal brain cancer, aged 36. Polio decides to travel across the world from Italy to the US in order to attend the world's cancer pride parade in honor of him. Unfortunately, his journey is marred by even more bad news; his lover Princess Smallpox also dies. Hungry for revenge, Polio faces off with the Grim Reaper once again in a massive showoff.