Threat of Infection

Threat of Infection is a limited time event which focuses on Outbreaks. It features 14 generators and 60 upgrades that produce either Contagions or Immunity .
== Story ==
=== Opening ===
=== Ending ===
== Objectives & Rewards ==
 thumb | The requirements that have to be completed in order to get all rewards.
Explore Outbreaks (12 Requirements)
# Collect 10 Smallpox → 1 
# Collect Documentation, AD 165-180 → 2 
# Collect Four Humors → 3 
# Collect 125 Human Life → Immune System Badge
# Collect 5 Syphilis, Questions of Morality → 4 
# Collect Parasites and Protists, Aztec Epidemic → 6 
# Collect 5 Salmonella, Cocoliztli → 7 
# Collect Plague Doctors → Plague Badge
# Collect 4 Yellow Fever, 8 Tuberculosis → 8 
# Collect 500 Human Life → 9 
# Collect Extreme Hygiene, Antibiotics → 10 
# Collect Medical Technology, 2020-Present → CRISPR Badge
=== Badges ===
This exploration holds some rewards already mentioned above. The main ones being these three badges: Bronze: Immune System, Silver: Plague and Gold: CRISPR which have an effect on all other evolutionary branches, speeding up every simulation by 1%, and also speeding up production in future Threat of Infection simulations by 5, 10 and 15% respectively.
==== Immune System ====
==== Plague ====
==== CRISPR ====
== Generators ==
Icon	Name 	Description 	Base Cost	Base Production	Requires
 	Human Life 	Each human body is a biosphere containing trillions of microorganisms. While many of these life forms are beneficial, others invade the body and must be fought off by the immune system. 	30 	1/sec 	-
 	Smallpox 	Believed to have existed for at least 3,000 years, smallpox causes itchy, fluid-filled blisters that later scab. It is spread by coughing and sneezing, and also by handling the clothing of the infected. 	50 	1/sec 	Viruses
 	Plague 	Transmitted by flea bites, plague manifests in three clinical forms. The most common, bubonic, infects the body's lymph nodes, creating large, pus-filled lumps. 	75,000 	200/sec 	Bacteria
 	Syphilis 	A sexually transmitted disease, syphilis causes sores and rashes across the body. Symptoms can flare on and off for years, and in late stages can damage the cardiovascular system and cognitive function. 	2e11 	1e8/sec 	BacteriaQuarantines
 	Malaria 	Malaria is spread by a cycle of mosquitos biting infected humans and spreading the parasite to others. The disease causes severe illness and death in Africa for centuries before colonization spreads it across the world. 	5e12 	1e10/sec 	Parasites and Protists
 	Salmonella 	Caused by a bacterium common in many animals, humans catch salmonella from drinking contaminated water or eating undercooked food. Infections last up to 4 days in healthy adults, but can cause death due to untreated dehydration.	2e17 	2e13/sec 	BacteriaHerbs and Rituals
 	Yellow Fever	When infected with the disease, mosquitos can spread yellow fever through human populations. This virus, found in Africa and the Americas, can potentially give severe liver damage, causing yellow skin known as jaundice. 	4e20 	2.5e17/sec 	VirusesPreservation
 	Tuberculosis	Spread through the air by droplets, tuberculosis usually infects the alveoli, flooding them with fluids. It damages the lungs, causing necrosis, making the patient feel like they are drowning. 	1e24 	4e20/sec 	BacteriaScientific Survey
 	Cholera 	After ingesting contaminated food or water, cholera causes extreme dehydration, sometimes turning skin color blue-gray. Nicknamed "the Blue Death," it can become fatal within a few hours of symptoms first appearing. 	4e27 	1e24/sec 	BacteriaGerm Theory
 	Polio 	Like cholera, polio spreads when fecal matter contaminates water supplies. The virus attacks the motor neurons of the brain and spine, and in severe cases, can cause total or partial paralysis. 	3e33 	2.5e29/sec 	VirusesBurning it Down
 	Influenza 	Spread by the coughs and sneezes of the infected, influenza is marked by severe fatigue, aches, and chills. More than most other viruses, it mutates rapidly, with new strains appearing nearly every year. 	2e36 	3e32/sec 	VirusesVaccines
 	Typhus 	Commonly found in the close, unsanitary contacts brought on by war, typhus is spread by infected lice. Each time one bites a human, it defecates bacteria-rich feces near the wound, providing a pathway to the bloodstream. 	2e39 	4e35/sec 	BacteriaFever
 	HIV 	A sexually transmitted disease, Human Immunodeficiency Virus (HIV), damages white blood cells, reducing the immune system's ability to defend itself. HIV has no cure, and if untreated can lead to the development of AIDS. 	1e43 	7e38/sec 	VirusesAntibiotics
 	Coronavirus 	The spikes on coronaviruses give them their name, meaning crown. These viruses commonly spread among animals, but when spread to humans, they all can cause respiratory symptoms like bronchitis and pneumonia. 	5e46 	5e42/sec 	VirusesAntibodies
== Upgrades ==
=== Miscellaneous Effects ===
Icon	Name 	Description 	Cost 	Effect 	Requires
 	Viruses 	Fragments of foreign genetic information can infect the cells of a person or animal. Viruses cannot reproduce or carry out metabolic processes without a host, leading many scientists to question whether they are alive.	25 	Contagion Tap gains +1 per tap	Human Life
 	Bacteria 	Among the simplest of single celled organisms, bacteria comprise 13% of the world's biomass. Tens of thousands of distinct species have been discovered, and 5% of them can cause disease. 	200,000	Contagion Tap 1.5X 	AD 165-180
 	Parasites and Protists	Ranging in size from single-celled protists to tapeworms as long as twenty feet, various parasites can cause illness. If untreated, some parasitic diseases can have mortality rates near 100%. 	1e13 	Contagion Tap 1.5X 	Questions of Morality
=== Human Life Efficiency ===
Icon	Name 	Description 	Cost 	Efficiency	Requires
 	White Blood Cells 	When foreign substances enter the body, white blood cells gather at the point of infection. Some of these cells produce disease-killing proteins while others converge on the survivors, eating what remains. 	500 	150% 	Human LifeAntonine Plague
 	Lymphatic System 	A network of lymphatic tubes empties leftover substances from cells and tissues. This system maintains the body's fluid levels, produces white blood cells, and destroys bacteria and viruses in the lymph nodes. 	1e9 	500% 	Human LifeThe Black Death
 	Gut Bacteria 	The human body contains trillions of bacteria, most of them benign and even necessary for life. They additionally contribute to the body's immune system, competing with harmful bacteria for nutrients and space. 	3.2e21	800% 	Human LifeThe Blue Death
 	Fever 	When fighting off infection, the body's internal temperature can rise above 38 degrees Celsius. This slows microbial reproduction and speeds up the chemical processes which contribute to the immune response. 	1e27 	2500% 	Human LifeSpanish Flu
 	Antibodies 	Antigens are any substance foreign to the body. When harmful viruses or bacteria are detected, specialized white blood cells release custom proteins called antibodies to neutralize those specific antigens. 	2e33 	500% 	Human Life1494-1928
 	Documentation 	Greek physician Galen studies and documents the symptoms of each of his patients during the Antonine Plague. Galen doesn't find a cure in his lifetime, but his writings influence physicians for around 1,500 years. 	10,000	400% 	Antonine Plague
 	Four Humors 	To the Ancient Greeks, a healthy body contains a balance of four humors: bile, black bile, blood, and phlegm. A belief that lasts through the Middle Ages, when these substances are thrown out of balance, illness occurs. 	2e6 	250% 	Plague of Justinian
 	Fighting the Onryō	Turning to folklore for an explanation, vengeful spirits called onryo are blamed for the smallpox epidemic. They are believed to be warded off by the color red or calmed with appeasing dances. 	1e8 	500% 	Japanese Smallpox
 	Quarantines 	A city in modern Croatia, Ragusa issues the first quarantine in 1377. To protect the city from plague, visitors wait 40 days on a nearby island, threatened with torture and mutilation if they break their isolation early. 	2e10 	1000% 	The Black Death
 	Quinine 	Among the oldest treatments for malaria, quinine is made from the bark of the quina-quina tree to reduce the disease's symptoms. It is a key component in making tonic water, which colonial soldiers use to treat the disease. 	1e14 	50000% 	Malaria
 	Herbs and Rituals 	Aztec medicine is based in religion and herbology. Minor illnesses can be treated with herbal medicine alone, but more serious diseases, such as smallpox, require spiritual supervision from doctors called the ticitl. 	3e17 	5000% 	Aztec Epidemic
 	Plague Doctors 	As plague outbreaks persist through the 1600s, miasma theory states that the scent of rot poisons the air and spreads disease. When treating patients, plague doctors wear flower-filled, beak-shaped masks to ward off the bad air. 	2e19 	300% 	The Black Death1520
 	Preservation 	Spanish colonizers destroy most of the archives kept by the Aztecs. This inspires indigenous descendants to create detailed accounts of disease and history, ensuring the survival of their legacy in the face of annihilation. 	3e19 	400% 	Cocoliztli
 	Scientific Survey 	Noah Webster writes to physicians across the East Coast, asking for their theories and observations on the cause, spread and treatment of Yellow Fever. He accumulates their testimonies into the world's first scientific survey. 	6e22 	20000% 	Summer in Philadelphia
 	Germ Theory 	First raised in the 1800s, germ theory identifies microorganisms as the cause of disease. This idea revolutionizes medicine and imposes new standards in hygiene for surgical procedures, such as hand washing. 	7e25 	3000% 	Urban Epidemic
 	Sanitation 	During London's 1854 cholera outbreak, physician John Snow marks the locations of those infected on a map. He finds the outbreak's hot spots correlate with the city's water pumps, confirming contaminated water is causing the epidemic.	7e28 	1500% 	The Blue Death
 	Burning it Down 	Honolulu's Chinatown responds to the plague in 1900 by burning down contaminated buildings. Harsh winds hit the island, pushing the fires toward other homes, burning down most of the city and leaving thousands unhoused. 	1e33 	4000% 	Third Plague Epidemic
 	Vaccines 	By the late 1800's, scientists like Pasteur and Koch identify the microorganisms that cause specific diseases. Weakened strains of these contagions are later used to create vaccines, providing immunity to once-lethal infections. 	1e35 	3000% 	The New York Epidemic
 	Masking 	As Spanish Flu spreads in 1918, officials across the United States advocate for wearing masks. In some cases, newspapers print instructions for making homemade masks, and not wearing one could incur a fine. 	1e38 	2500% 	Spanish Flu
 	Extreme Hygiene 	The rest of the world war's combatants aren't spared from typhus, but they do fight back successfully. Delousing showers become a frequent routine for soldiers, who stand in high heat and steam to kill lice and destroy eggs. 	8e40 	1000% 	Russian Outbreak
 	Antibiotics 	In 1928, Alexander Fleming finds a mold contamination killed some of his bacterial cultures. A decade later, an Oxford team studies this phenemenon and creates the first antibiotic, and cure for syphilis, penicillin. 	1e42 	5000% 	Questions of Morality1918-1922
 	Prevention 	With the government silent, queer activists take initiative to educate others about HIV. Frequent testing and the use of condoms slow the spread until future treatments make the virus undetectable and untransmittable. 	3e45 	7000% 	1494-1928Silent Government
 	Medical Technology	Bacteria and viruses aren't the only ones evolving. As medical technology advances, diseases that once plagued humans can be eradicated. However, humans are always a few steps behind, vulnerable to whichever outbreak comes next. 	4e48 	10000% 	Covid-19
=== Smallpox Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	Antonine Plague 	In 165 CE, Rome is at the height of its power. However, soldiers returning from war carry what is most likely smallpox, killing around 2,000 people a day at its peak. By the epidemic's end, a third of the empire is dead. 	300 	300% 	Smallpox
 	Japanese Smallpox	Buddhist missionaries from Korea travel to Japan in the 6th century, bringing with them deadly waves of smallpox. In the year 735, the disease wipes out 30% of the Japanese population, decimating supply chains and the economy. 	4e7 	5000% 	SmallpoxFour Humors
 	Aztec Epidemic 	An unintentional ally during Cortes' invasion of Mexico, smallpox devastates Aztec populations lacking immunity to the virus. It kills up to 8 million people while incapacitating many survivors, leaving them vulnerable to future outbreaks.	4e16	2e9% 	SmallpoxQuinine
=== Plague Efficiency ===
Icon	Name 	Description 	Cost 	Efficiency	Requires
 	Plague of Justinian 	Carried by rats and transmitted along trade routes from North Africa, Bubonic Plague hits Constantinople in 542 CE. Further outbreaks continue over the next 225 years, killing nearly a quarter of the empire's population.	500,000	200% 	Plague
 	The Black Death 	One of history's most debilitating epidemics, the Black Death spreads across Europe in the mid-1300's. Roughly 1/3 of the overall population perishes in 5 years, with some cities seeing death rates of 50% or even higher.	8e9 	4000% 	PlagueFighting the Onryo
 	Third Plague Epidemic	Bubonic plague rears its head once more in 1855, this time hitting every inhabited continent. The world applies everything it learned from previous plagues, but the outbreak still kills 12 million people globally. 	5e30 	1e22% 	Plague1817-1860
=== Syphilis Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	Questions of Morality	As Western Europeans learn that syphilis is spread by sexual intercourse, it is seen as a sign of wickedness. Infected people are shunned and feared, with some physicians even refusing to treat the disease.	1e12	1000% 	Syphilis
=== Salmonella Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	Cocoliztli	Across the 16th century, Mexico is struck by a host of European diseases. Now believed to be salmonella, the Cocoliztli Plague is the worst of these outbreaks, killing as much as 80% of the remaining indigenous population.	3e18	2500% 	1520Salmonella
=== Yellow Fever Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	Summer in Philadelphia	The first pandemic in the United States hits Philadelphia in August of 1793. A tenth of the city's population dies from yellow fever as others flee the city, including President George Washington and his cabinet.	1e22	600% 	Yellow Fever
=== Tuberculosis Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	Urban Epidemic	The crowded conditions of industrial cities unleashes tuberculosis in the 1700s. By the late 1800s, it has infection rates close to 100% and is responsible for two out of five of all deaths in the urban working class.	2e25	200% 	Tuberculosis
=== Cholera Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	The Blue Death	The first global cholera pandemic emerges from Jessore, India in 1817. The disease spreads across Asia and into Persia, resurging multiple times over the following decades.	1e28	400% 	Cholera
=== Polio Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	The New York Epidemic	In 1916, polio devastates the United States' largest city. Entire neighborhoods are walled off, while millions of gallons of water are used daily to wash the streets. In the end, it leaves 20,000 paralyzed and 6,000 dead.	8e33	600% 	Polio
=== Influenza Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	Spanish Flu	Infecting half a billion worldwide, by 1920 the Spanish flu kills 50 million people. While other nations practice censorship during World War I, Spain reports on the epidemic, associating the country with the disease.	1e37	1000% 	Influenza
=== Typhus Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	Russian Outbreak	As typhus spreads in the trenches of World War I, an already destabilized Russia is ill-equipped to handle such an outbreak. An estimated 30 million Eastern Europeans are infected, with around 3 million fatal cases.	1e40	300% 	Typhus
=== HIV Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	Silent Government	The spread of HIV is widely associated with the LGBTQ+ community, creating a stigma around the virus. Thus, the US government remains silent through the epidemic's early years, leading to thousands of preventable deaths.	5e44	2500% 	HIV
=== Coronavirus Efficiency ===
Icon	Name 	Description 	Cost	Efficiency	Requires
 	Covid-19 	In 2020, the world is confronted with a health crisis that many haven't seen in their lifetime. Governments respond by enacting quarantines and travel bans. The virus claims over a million lives that year alone. 	2e47	500% 	Coronavirus
 	New-Age Contagions	The more humans use antibiotics, the more bacteria become resistant to them. Viruses mutate at a rapid pace, making previous vaccines ineffective. As contagions continue to evolve, human countermeasures struggle to keep up.	1e48	500% 	Covid-19
=== Disease Outbreaks ===
Icon	Name 	Description 	Cost 	Effect 	Requires
 	AD 165-180 	Outbreak: Antonine Plague, Infected Population: ~ 20 million, Infected Death Rate: 25% 	200,000	Smallpox 800% more efficient 	Documentation
 	AD 541-549 	Outbreak: Plague of Justinian, Infected Population: Unknown, Infected Death Rate: 60-85% 	2e6 	Plague 400% more efficient 	Four Humors
 	735-737 	Outbreak: Japanese Smallpox, Infected Population: ~ 4 million, Infected Death Rate: 25-35% 	3e7 	Smallpox 1000% more efficient 	Fighting the Onryo
 	1346-1353 	Outbreak: Black Death, Population: ~ 50 million, Infected Death Rate: 50% 	4e9 	Plague 2000% more efficient 	QuarantinesLymphatic System
 	1486 - Present	Outbreak: Malaria, Infected: Unknown, Infected Death Rate: 14-28% 	1e13 	Malaria 10000% more efficient 	Quinine
 	1520 	Outbreak: Aztec Smallpox, Infected Population: 5-8 million+, Infected Death Rate: 30-100% 	2e14 	Smallpox 500% more efficient 	Herbs and Rituals
 	1545-1576 	Outbreak: Cocoliztli, Infected Population: 7-17 million+, Infected Death Rate: 60-90% 	3e16 	Salmonella 2000% more efficient 	Preservation
 	1793-1794 	Outbreak: Yellow Fever, Infected Population: ~ 11,000, Infected Death Rate: 30-50% 	5e18 	Yellow Fever 2000% more efficient	Scientific Survey
 	1800-1922 	Outbreak: Tuberculosis, Infected Population: 4 million+, Infected Death Rate: 80% 	1.5e20 	Tuberculosis 2500% more efficient	Germ Theory
 	1817-1860 	Outbreak: Cholera, Infected Population: 1 million+, Infected Death Rate: 25-50% 	3e22 	Cholera 2000% more efficient 	SanitationGut Bacteria
 	1900 	Outbreak: Third Plague Epidemic, Infected Population: 15 million+, Infected Death Rate: 30-60%	1.5e24 	Plague 2000% more efficient 	Burning it Down
 	1916 	Outbreak: New York Polio, Population: 27,000+, Infected Death Rate: 5-15% 	6e25 	Polio 2000% more efficient 	Vaccines
 	1918-1920 	Outbreak: Spanish Flu, Infected Population: ~ 500 million, Infected Death Rate: 2.5% 	4e28 	Influenza 1500% more efficient 	Fever
 	1918-1922 	Outbreak: Russian Typhus, Population: 20-30 million+, Infected Death Rate: 20-60% 	4e29 	Typhus 2000% more efficient 	Extreme Hygiene
 	1494-1928 	Outbreak: Syphilis, Infected Population: Unknown, Infected Death Rate: 10% 	1e31 	Syphilis 2e31% more efficient 	Antibiotics
 	1981-1988 	Outbreak: HIV, Infected Population: ~42,000, Infected Death Rate: ~56% 	9e33 	HIV 4000% more efficient 	AntibodiesPrevention
 	2020-Present 	Outbreak: Covid-19, Infected Population: 5,817,385, Infected Death Rate: Varies 	1e36 	Human Life 100% more efficient 	Covid-19
==Tech Tree==
==Trivia==
*This event was formerly named Endless Infections it got renamed while it was in the beta.
*The final Contagions upgrade, Medical Technology, costs a whopping 4e48 Contagions, which is the costliest out of all the exploration events so far.
*This is the first event where more than 1 currency is unlocked at a time.
*This is also the first event where 1 generator produces one currency, while the rest produce the other.
Category:ExplorationCategory:Exploration Season 2