Villains, for a given value of such

The Valley has no shortage of assholes. Some people have power, and some number of them will use that for selfish ends. The exact reasons vary from creature to creature, but the underlying need for some people to be assholes is a universal constant. 
The Valley, with its harsh conditions and enthusiastic evil gods suffers from a blight of assholes that's significantly worse than elsewhere. Here's just a few, although there are some real shitheels out there:
* Grand Cornu Theron Styx, Human Cleric of Orcus: An old man covered in scars, few people in the Valley are as mindlessly cruel and bitter as Theron. For a while, his truly awful nature held him back as he was unable to muster the grace and subtlety needed to climb the rungs of the Death's Head Cult (aka the Church of Orcus). With recent vacancies at the top, Theron finally has his moment in the spotlight.
* High Priestess Celeen, Human Cleric of Orcus: An equally scarred woman with a cleft in her face that looks like she tried to catch an axe with her nose, Celeen is Theron's lover, right-hand, and supportive partner. Not much is known about her hopes and dreams, but it's pretty certain that they're awful.
* Morask, Goblin Assassin: Morask was a priest of Snuurge, resisting the Orcusite incursion into Greznek, before some adventurers murdered his brother. He took his brother's name and bow, and pledged his loyalty to Orcus, so long as Orcus granted him the power to get his revenge. Orcus did so gladly, and Morask has been a hero of the Death's Head ever since.
* Toad Queen Grosso, Human Cleric of Tsathogga: A jovial, heavyset woman who is always up for a good time and a bottle of wine, Grosso is the leader of the church of Tsathogga. Grosso is very unusual, in that she's welcome in polite society and occasionally pops up at public events. She's friendly, helpful, and puts a winning smile on the face of the most powerful evil church currently operating. 
* Kruin, Human Kruin: A force of nature and ill-luck, Kruin was an original member of The Great Downwards. While she suffered much misfortune, she possessed a mastery of magic, axes, and being batshit insane that no one has ever rivaled. These days she does her own thing, and everyone's fine with that, so long as she does it a long way from them. The author feels bad about including her here, but since she was also included on the heroes list, it only seemed fair.
* Shen Peng Yan, Aberdeenian Aristocrat of Aberdeen: There's always one - someone who is willing to gently put a finger on the scales to tilt things slightly in their favor, while never getting caught out. Peng is one of the most powerful people in Aberdeen, and is always willing to strengthen his own power at any opportunity. Shades is pretty sure that he's The Worst, although that's hardly surprising, considering he's responsible for most of the persecution of the Tengu clans.
* High Arcanist Lady Maya D'Larariel, Elven Wizard of the Upper Dales: Besides being rich and powerful, Maya seems to be a genuinely nice person. She took refuge in the Valley during some turmoil in her home state, and helped Shades and the Dominion cement their power and independence. Still, there is a persistent rumor that the source of her power and influence doesn't come from the Dalish pantheon, but rather draws directly from the Nine Hells itself. It's just a rumor, of course.
* Sword Sister Lady Macry Marceline, Human Paladin, Chosen of Muir, Hallowed Be Her Name: Included for completeness's sake: Being an asshole is independent of alignment, and one of the Valley's most infamous monsters was a Lawful Good paladin. She attempted to act as a vessel for Muir herself (back when Muir was still alive) and planned to purge the Valley of evil in righteous fire. The church of Darach Albeth mobalised and slew her before the genocide could begin, and to say that this whole thing was divisive would be an understatement. Some believe that Macry was right, or at least just misguided, and the whole incident has left scars all over the Valley. Macry herself was nice enough as stories go, but she's held up as an example of how power always corrupts.
* Lord Regent Rolth, or I guess he's just Rolth now? Halfing Aristocrat in any case: Rolth is a fat Halfling with a truly magnificent beard. He looks every bit like a woodcutting of the “merchant king” although he always looks like he’s sat on a pin and is trying not to let it show. He was also the regent of Skor, an elected title. He earned this title after hundreds of thousands of gold to the Skorrian treasury, propelling him into a position of favour and allowing Skor to experience its greatest decade since the Righteous March. Rolth is probably the most significant individual contributing to the Valley’s current prosperity. He wasn't evil as such, and was certainly kind enough to Skor, but was just a general shitheel, according to Shades.