Blinky Bill, Hugo, and Rita on Zombie Island

== Plot ==
Hugo, Rita, Blinky Bill, Nutsy, Flaps, Splodge, and Marcia goes their separate ways after becoming bored of mystery-solving due to their monstrous culprits always being people in costumes. Nutsy, along with, starts running a successful television series, determined to hunt down a real ghost rather than a fake one. Blinky contacts Hugo, Rita, Flaps, Splodge, and Marcia and the entire gang is brought back together for Nutsy's birthday. They embark on a road trip scouting haunted locations across the U.S. for Daphne's show, only to encounter more fake monsters. Arriving in New Orleans, Louisiana, they are invited by a teenage counterpart-green gangster girl from The Powerpuff Girls Z named Ivy including that she brought her black-dog (One of the Bounty Hunters' Dog) that she calls her pet-dog "Alpha" that she named and called her, causing Blinky falls for Ivy that she meets and sees her for the first-time. to visit her workplace at Moonscar Island, an island allegedly haunted by the ghost of the pirate Morgan Moonscar. Though they are skeptical, the gang agrees. On the island, they meet ferryman named Mephiles the Dark, Ivy's employers, Himeko Shirogane with her white cat, Sapphire, Pink Lady Amoeba, and Sedusa from The Powerpuff Girls Z and their newest black alley-cat that she called her "Dark-Ronnie" that the ladies named her, who lives in a large mansion on a pepper plantation, and later, they encountered Himeko Shirogane's gardener Danny Dingo, Daisy, Meatball Dingo, and Shifty Dingo, that hired by Himeko Shirogane at the island in her mansion. Splodge, Flaps, Hugo, and Rita encounter the ghost of Moonscar, who becomes a zombie while the gang receives several ghostly warnings to leave. Despite this, they stay overnight, still skeptical.
That night, Splodge, Flaps, Hugo, and Rita are chased by a horde of zombies. Marcia suspects Danny and the dingoes while Blinky and Nutsy capture a zombie, believing it is a human culprit until Blinky pulls its head off, revealing that the zombies are real. As the horde chases them, the gang gets separated in the chaos and Nutsy accidentally causes Blinky to drop his video camera in quicksand, losing film evidence for their show. In a cave, Splodge, Flaps, Meatball, Hugo, and Rita encounter discover wax voodoo dolls resembling Blinky, Nutsy, and Marcia and play with them, involuntarily controlling their friends until the pair disturb a nest of bats.
The rest of the gang and the dingoes (aka Blinky, Nutsy, Marcia, Danny, Daisy, and Shiffy) discover a secret passageway in the house, where Ivy and her black-dog, Alpha, claim the zombies dragged Simone away. The passageway leads to a secret chamber for voodoo rituals, where Marcia confronts Ivy about her lie, having seen her footprints instead of drag marks. After trapping the gang with the voodoo dolls, Himeko Shirogane, Sapphire, Pink Lady Amoeba, Sedusa, and Ivy reveal themselves and Mephiles as Werewolverines. Sedusa explains that 200 years ago, she, Himeko Shirogane, Sapphire, Pink Lady Amoeba, and Ivy were part of a group of settlers on the island who worshiped a cat god. When Moonscar and his crew invaded the island, they chased the settlers into the bayou, where they were eaten alive by alligators, but Simone and Lena escaped. They prayed to their cat god to curse Moonscar and were transformed into immortal werecats. They killed the pirates, but later realized that invoking the cat god's power had also cursed them. Every harvest moon since, they lured and exploited victims to drain their lives and preserve their immortality, hiring Jacques along the way to facilitate their plot in exchange for making him immortal, with the zombies and ghosts being their previous victims who awaken every harvest moon to try to scare people away to prevent them from suffering the same fate. 
Sedusa lets Alpha the Black-Dog and Black-Ronnie to attack the gang and the dingoes, while Spoldge, Flaps, Meatball, Hugo, and Rita were being chased by Mephiles, poldge, Flaps, Meatball, Hugo, and Rita disrupt the werewolverines' draining ceremony, allowing the gang to free themselves. The werewolverines surround them, but realize too late that the harvest moon has passed, causing them to crumble to dust and allowing the zombies' souls to rest in peace. Danny Dingo reveals himself as an undercover police officer as the dingoes apologized to the gang who was sent to investigate disappearances on the island. Nutsy asks Danny and the dingoes to guest star on her show, and they all leave the island in the morning.