The Binding of Isaac: Symphony of Sorrow/Trinkets

This is a list of every single Trinket found in The Binding of Isaac: Symphony of Sorrow.
Trinkets are a collectible type that take up a slot near the bottom left side of the HUD when grabbed, granting passive effects. In most cases, only one trinket can be held at a time, though certain items can increase the limit to 2, and Trinkets can be absorbed via the use of certain items or a Gulp pill, in which their effects will be permanently kept.
Additionally, after defeating The Colosseum as Tainted Keeper, all Trinkets have a chance to become Golden. Golden Trinkets have enhanced effects, often doubling the original effect of the Trinket, though other Golden Trinkets have more unique effects. Trinket effects can also be enhanced through the use of Mom's Box or by carrying a copy of it, often doubling their effect.
Symphony of Sorrow includes 209 different Trinkets, both old and new. Like Items, not all Trinkets from the previous game return, though many brand new Trinkets are introduced to compensate.
(Note: Text in signifies a Trinket's effect when it is Golden or with Mom's Box. Text in signifies a Trinket's effect when it is both Golden and is held with Mom's Box)
Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets 	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets	Trinkets
Swallowed Penny 	Swallowed Penny 	Swallowed Penny 	Swallowed Penny 	Swallowed Penny 	Swallowed Penny 	Swallowed Penny 	Gulp! 	Gulp! 	Gulp! 	Gulp! 	Gulp! 	Gulp! 	Gulp! 	
* Taking damage has Isaac drop 1 coin
* If playing as The Keeper or Tainted Keeper, then there is a 50% chance to drop a coin
* Can drop after breaking urns in Haunted Forest, Hollow, or Gate	
* Taking damage has Isaac drop 1 coin
* If playing as The Keeper or Tainted Keeper, then there is a 50% chance to drop a coin
* Can drop after breaking urns in Haunted Forest, Hollow, or Gate	
* Taking damage has Isaac drop 1 coin
* If playing as The Keeper or Tainted Keeper, then there is a 50% chance to drop a coin
* Can drop after breaking urns in Haunted Forest, Hollow, or Gate	
* Taking damage has Isaac drop 1 coin
* If playing as The Keeper or Tainted Keeper, then there is a 50% chance to drop a coin
* Can drop after breaking urns in Haunted Forest, Hollow, or Gate	
* Taking damage has Isaac drop 1 coin
* If playing as The Keeper or Tainted Keeper, then there is a 50% chance to drop a coin
* Can drop after breaking urns in Haunted Forest, Hollow, or Gate	
* Taking damage has Isaac drop 1 coin
* If playing as The Keeper or Tainted Keeper, then there is a 50% chance to drop a coin
* Can drop after breaking urns in Haunted Forest, Hollow, or Gate	
* Taking damage has Isaac drop 1 coin
* If playing as The Keeper or Tainted Keeper, then there is a 50% chance to drop a coin
* Can drop after breaking urns in Haunted Forest, Hollow, or Gate	
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Triple A Battery 	Triple A Battery 	Triple A Battery 	Triple A Battery 	Triple A Battery 	Triple A Battery 	Triple A Battery 	Trickle charge 	Trickle charge 	Trickle charge 	Trickle charge 	Trickle charge 	Trickle charge 	Trickle charge 	
* Reduces the charges needed to charge Active items by 1
* Does not affect items with only one charge needed to use, or items with timed charges or no charges at all	
* Reduces the charges needed to charge Active items by 1
* Does not affect items with only one charge needed to use, or items with timed charges or no charges at all	
* Reduces the charges needed to charge Active items by 1
* Does not affect items with only one charge needed to use, or items with timed charges or no charges at all	
* Reduces the charges needed to charge Active items by 1
* Does not affect items with only one charge needed to use, or items with timed charges or no charges at all	
* Reduces the charges needed to charge Active items by 1
* Does not affect items with only one charge needed to use, or items with timed charges or no charges at all	
* Reduces the charges needed to charge Active items by 1
* Does not affect items with only one charge needed to use, or items with timed charges or no charges at all	
* Reduces the charges needed to charge Active items by 1
* Does not affect items with only one charge needed to use, or items with timed charges or no charges at all	
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Purple Heart 	Purple Heart 	Purple Heart 	Purple Heart 	Purple Heart 	Purple Heart 	Purple Heart 	Challenge up! 	Challenge up! 	Challenge up! 	Challenge up! 	Challenge up! 	Challenge up! 	Challenge up! 	
* Enemies have an increased chance to spawn as Champions, including bosses
* Champion enemies have an increased chance to drop their associated reward on death	
* Enemies have an increased chance to spawn as Champions, including bosses
* Champion enemies have an increased chance to drop their associated reward on death	
* Enemies have an increased chance to spawn as Champions, including bosses
* Champion enemies have an increased chance to drop their associated reward on death	
* Enemies have an increased chance to spawn as Champions, including bosses
* Champion enemies have an increased chance to drop their associated reward on death	
* Enemies have an increased chance to spawn as Champions, including bosses
* Champion enemies have an increased chance to drop their associated reward on death	
* Enemies have an increased chance to spawn as Champions, including bosses
* Champion enemies have an increased chance to drop their associated reward on death	
* Enemies have an increased chance to spawn as Champions, including bosses
* Champion enemies have an increased chance to drop their associated reward on death	
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Broken Magnet 	Broken Magnet 	Broken Magnet 	Broken Magnet 	Broken Magnet 	Broken Magnet 	Broken Magnet 	It kinda works! 	It kinda works! 	It kinda works! 	It kinda works! 	It kinda works! 	It kinda works! 	It kinda works! 	
* All types of coins are automatically pulled towards Isaac	
* All types of coins are automatically pulled towards Isaac	
* All types of coins are automatically pulled towards Isaac	
* All types of coins are automatically pulled towards Isaac	
* All types of coins are automatically pulled towards Isaac	
* All types of coins are automatically pulled towards Isaac	
* All types of coins are automatically pulled towards Isaac	
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Cartridge 	Cartridge 	Cartridge 	Cartridge 	Cartridge 	Cartridge 	Cartridge 	I remember these 	I remember these 	I remember these 	I remember these 	I remember these 	I remember these 	I remember these 	
* 5% chance to trigger the Power Pill effect when Isaac takes damage, granting him temporary invincibility and contact damage and giving all enemies Fear
* 100% chance at 38 Luck	
* 5% chance to trigger the Power Pill effect when Isaac takes damage, granting him temporary invincibility and contact damage and giving all enemies Fear
* 100% chance at 38 Luck	
* 5% chance to trigger the Power Pill effect when Isaac takes damage, granting him temporary invincibility and contact damage and giving all enemies Fear
* 100% chance at 38 Luck	
* 5% chance to trigger the Power Pill effect when Isaac takes damage, granting him temporary invincibility and contact damage and giving all enemies Fear
* 100% chance at 38 Luck	
* 5% chance to trigger the Power Pill effect when Isaac takes damage, granting him temporary invincibility and contact damage and giving all enemies Fear
* 100% chance at 38 Luck	
* 5% chance to trigger the Power Pill effect when Isaac takes damage, granting him temporary invincibility and contact damage and giving all enemies Fear
* 100% chance at 38 Luck	
* 5% chance to trigger the Power Pill effect when Isaac takes damage, granting him temporary invincibility and contact damage and giving all enemies Fear
* 100% chance at 38 Luck	
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Pulse Worm 	Pulse Worm 	Pulse Worm 	Pulse Worm 	Pulse Worm 	Pulse Worm 	Pulse Worm 	Wub wub! 	Wub wub! 	Wub wub! 	Wub wub! 	Wub wub! 	Wub wub! 	Wub wub! 	
* Isaac's tears pulsate in size as they travel
* Has no effect on damage	
* Isaac's tears pulsate in size as they travel
* Has no effect on damage	
* Isaac's tears pulsate in size as they travel
* Has no effect on damage	
* Isaac's tears pulsate in size as they travel
* Has no effect on damage	
* Isaac's tears pulsate in size as they travel
* Has no effect on damage	
* Isaac's tears pulsate in size as they travel
* Has no effect on damage	
* Isaac's tears pulsate in size as they travel
* Has no effect on damage	
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Wiggle Worm 	Wiggle Worm 	Wiggle Worm 	Wiggle Worm 	Wiggle Worm 	Wiggle Worm 	Wiggle Worm 	Wiggle waggle! 	Wiggle waggle! 	Wiggle waggle! 	Wiggle waggle! 	Wiggle waggle! 	Wiggle waggle! 	Wiggle waggle! 	
* +0.4 tears
* Grants spectral tears
* Isaac's tears travel in a wave-like pattern	
* +0.4 tears
* Grants spectral tears
* Isaac's tears travel in a wave-like pattern	
* +0.4 tears
* Grants spectral tears
* Isaac's tears travel in a wave-like pattern	
* +0.4 tears
* Grants spectral tears
* Isaac's tears travel in a wave-like pattern	
* +0.4 tears
* Grants spectral tears
* Isaac's tears travel in a wave-like pattern	
* +0.4 tears
* Grants spectral tears
* Isaac's tears travel in a wave-like pattern	
* +0.4 tears
* Grants spectral tears
* Isaac's tears travel in a wave-like pattern	
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Ring Worm 	Ring Worm 	Ring Worm 	Ring Worm 	Ring Worm 	Ring Worm 	Ring Worm 	Woop woop! 	Woop woop! 	Woop woop! 	Woop woop! 	Woop woop! 	Woop woop! 	Woop woop! 	
* +0.4 tears
* Grants spectral tears
* Isaac’s tears travel in a spiral pattern	
* +0.4 tears
* Grants spectral tears
* Isaac’s tears travel in a spiral pattern	
* +0.4 tears
* Grants spectral tears
* Isaac’s tears travel in a spiral pattern	
* +0.4 tears
* Grants spectral tears
* Isaac’s tears travel in a spiral pattern	
* +0.4 tears
* Grants spectral tears
* Isaac’s tears travel in a spiral pattern	
* +0.4 tears
* Grants spectral tears
* Isaac’s tears travel in a spiral pattern	
* +0.4 tears
* Grants spectral tears
* Isaac’s tears travel in a spiral pattern	
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Flat Worm 	Flat Worm 	Flat Worm 	Flat Worm 	Flat Worm 	Flat Worm 	Flat Worm 	Blub blub! 	Blub blub! 	Blub blub! 	Blub blub! 	Blub blub! 	Blub blub! 	Blub blub! 	
* Isaac’s tears are 50% wider	
* Isaac’s tears are 50% wider	
* Isaac’s tears are 50% wider	
* Isaac’s tears are 50% wider	
* Isaac’s tears are 50% wider	
* Isaac’s tears are 50% wider	
* Isaac’s tears are 50% wider	
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Store Credit 	Store Credit 	Store Credit 	Store Credit 	Store Credit 	Store Credit 	Store Credit 	YES! 	YES! 	YES! 	YES! 	YES! 	YES! 	YES! 	
* All shop items become free
* Destroys itself upon purchasing an item	
* All shop items become free
* Destroys itself upon purchasing an item	
* All shop items become free
* Destroys itself upon purchasing an item	
* All shop items become free
* Destroys itself upon purchasing an item	
* All shop items become free
* Destroys itself upon purchasing an item	
* All shop items become free
* Destroys itself upon purchasing an item	
* All shop items become free
* Destroys itself upon purchasing an item	
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* 	Defeat The Onlookers as The Keeper 	Defeat The Onlookers as The Keeper 	Defeat The Onlookers as The Keeper 	Defeat The Onlookers as The Keeper 	Defeat The Onlookers as The Keeper 	Defeat The Onlookers as The Keeper 	Defeat The Onlookers as The Keeper 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Callus 	Callus 	Callus 	Callus 	Callus 	Callus 	Callus 	Your feet feel stronger 	Your feet feel stronger 	Your feet feel stronger 	Your feet feel stronger 	Your feet feel stronger 	Your feet feel stronger 	Your feet feel stronger 	
* Grants immunity to spikes and creep	
* Grants immunity to spikes and creep	
* Grants immunity to spikes and creep	
* Grants immunity to spikes and creep	
* Grants immunity to spikes and creep	
* Grants immunity to spikes and creep	
* Grants immunity to spikes and creep	
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* 	Complete the Boss Rush as ??? 	Complete the Boss Rush as ??? 	Complete the Boss Rush as ??? 	Complete the Boss Rush as ??? 	Complete the Boss Rush as ??? 	Complete the Boss Rush as ??? 	Complete the Boss Rush as ??? 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Lucky Rock 	Lucky Rock 	Lucky Rock 	Lucky Rock 	Lucky Rock 	Lucky Rock 	Lucky Rock 	There’s something inside it… 	There’s something inside it… 	There’s something inside it… 	There’s something inside it… 	There’s something inside it… 	There’s something inside it… 	There’s something inside it… 	
* Destroyed rocks have a 33% chance to drop a penny	
* Destroyed rocks have a 33% chance to drop a penny	
* Destroyed rocks have a 33% chance to drop a penny	
* Destroyed rocks have a 33% chance to drop a penny	
* Destroyed rocks have a 33% chance to drop a penny	
* Destroyed rocks have a 33% chance to drop a penny	
* Destroyed rocks have a 33% chance to drop a penny	
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* 	Get The Small Rock item 3 times across separate runs 	Get The Small Rock item 3 times across separate runs 	Get The Small Rock item 3 times across separate runs 	Get The Small Rock item 3 times across separate runs 	Get The Small Rock item 3 times across separate runs 	Get The Small Rock item 3 times across separate runs 	Get The Small Rock item 3 times across separate runs 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Black Lipstick 	Black Lipstick 	Black Lipstick 	Black Lipstick 	Black Lipstick 	Black Lipstick 	Black Lipstick 	Evil up 	Evil up 	Evil up 	Evil up 	Evil up 	Evil up 	Evil up 	
* Red Hearts and their variants have a 20% chance to be replaced with Black Hearts
** Half Red Hearts are replaced by Half Black Hearts
** Double Red Hearts are replaced by two Black Hearts	
* Red Hearts and their variants have a 20% chance to be replaced with Black Hearts
** Half Red Hearts are replaced by Half Black Hearts
** Double Red Hearts are replaced by two Black Hearts	
* Red Hearts and their variants have a 20% chance to be replaced with Black Hearts
** Half Red Hearts are replaced by Half Black Hearts
** Double Red Hearts are replaced by two Black Hearts	
* Red Hearts and their variants have a 20% chance to be replaced with Black Hearts
** Half Red Hearts are replaced by Half Black Hearts
** Double Red Hearts are replaced by two Black Hearts	
* Red Hearts and their variants have a 20% chance to be replaced with Black Hearts
** Half Red Hearts are replaced by Half Black Hearts
** Double Red Hearts are replaced by two Black Hearts	
* Red Hearts and their variants have a 20% chance to be replaced with Black Hearts
** Half Red Hearts are replaced by Half Black Hearts
** Double Red Hearts are replaced by two Black Hearts	
* Red Hearts and their variants have a 20% chance to be replaced with Black Hearts
** Half Red Hearts are replaced by Half Black Hearts
** Double Red Hearts are replaced by two Black Hearts	
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* 	Defeat Mommy & Daddy as Eve 	Defeat Mommy & Daddy as Eve 	Defeat Mommy & Daddy as Eve 	Defeat Mommy & Daddy as Eve 	Defeat Mommy & Daddy as Eve 	Defeat Mommy & Daddy as Eve 	Defeat Mommy & Daddy as Eve 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Bible Tract 	Bible Tract 	Bible Tract 	Bible Tract 	Bible Tract 	Bible Tract 	Bible Tract 	Faith up 	Faith up 	Faith up 	Faith up 	Faith up 	Faith up 	Faith up 	
* Red Hearts and their variants have a 5% chance to be replaced by Eternal or Immortal Hearts
** Both Half Red Hearts and Red Hearts are replaced by Eternal Hearts
** Double Red Hearts are replaced by Immortal Hearts	
* Red Hearts and their variants have a 5% chance to be replaced by Eternal or Immortal Hearts
** Both Half Red Hearts and Red Hearts are replaced by Eternal Hearts
** Double Red Hearts are replaced by Immortal Hearts	
* Red Hearts and their variants have a 5% chance to be replaced by Eternal or Immortal Hearts
** Both Half Red Hearts and Red Hearts are replaced by Eternal Hearts
** Double Red Hearts are replaced by Immortal Hearts	
* Red Hearts and their variants have a 5% chance to be replaced by Eternal or Immortal Hearts
** Both Half Red Hearts and Red Hearts are replaced by Eternal Hearts
** Double Red Hearts are replaced by Immortal Hearts	
* Red Hearts and their variants have a 5% chance to be replaced by Eternal or Immortal Hearts
** Both Half Red Hearts and Red Hearts are replaced by Eternal Hearts
** Double Red Hearts are replaced by Immortal Hearts	
* Red Hearts and their variants have a 5% chance to be replaced by Eternal or Immortal Hearts
** Both Half Red Hearts and Red Hearts are replaced by Eternal Hearts
** Double Red Hearts are replaced by Immortal Hearts	
* Red Hearts and their variants have a 5% chance to be replaced by Eternal or Immortal Hearts
** Both Half Red Hearts and Red Hearts are replaced by Eternal Hearts
** Double Red Hearts are replaced by Immortal Hearts	
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* 	Defeat Mommy & Daddy as Bethany 	Defeat Mommy & Daddy as Bethany 	Defeat Mommy & Daddy as Bethany 	Defeat Mommy & Daddy as Bethany 	Defeat Mommy & Daddy as Bethany 	Defeat Mommy & Daddy as Bethany 	Defeat Mommy & Daddy as Bethany 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Paper Clip 	Paper Clip 	Paper Clip 	Paper Clip 	Paper Clip 	Paper Clip 	Paper Clip 	Master of lockpicking 	Master of lockpicking 	Master of lockpicking 	Master of lockpicking 	Master of lockpicking 	Master of lockpicking 	Master of lockpicking 	
* Locked Chests, Old Chests and Eternal Chests can be opened for free without keys
* Can be dropped from Key Masters as a reward	
* Locked Chests, Old Chests and Eternal Chests can be opened for free without keys
* Can be dropped from Key Masters as a reward	
* Locked Chests, Old Chests and Eternal Chests can be opened for free without keys
* Can be dropped from Key Masters as a reward	
* Locked Chests, Old Chests and Eternal Chests can be opened for free without keys
* Can be dropped from Key Masters as a reward	
* Locked Chests, Old Chests and Eternal Chests can be opened for free without keys
* Can be dropped from Key Masters as a reward	
* Locked Chests, Old Chests and Eternal Chests can be opened for free without keys
* Can be dropped from Key Masters as a reward	
* Locked Chests, Old Chests and Eternal Chests can be opened for free without keys
* Can be dropped from Key Masters as a reward	
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Missing Poster 	Missing Poster 	Missing Poster 	Missing Poster 	Missing Poster 	Missing Poster 	Missing Poster 	??? 	??? 	??? 	??? 	??? 	??? 	??? 	
* Dying respawns the player in the previous room as The Lost
* Tainted Lost revives as himself	
* Dying respawns the player in the previous room as The Lost
* Tainted Lost revives as himself	
* Dying respawns the player in the previous room as The Lost
* Tainted Lost revives as himself	
* Dying respawns the player in the previous room as The Lost
* Tainted Lost revives as himself	
* Dying respawns the player in the previous room as The Lost
* Tainted Lost revives as himself	
* Dying respawns the player in the previous room as The Lost
* Tainted Lost revives as himself	
* Dying respawns the player in the previous room as The Lost
* Tainted Lost revives as himself	
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*	Defeat Mommy & Daddy as The Lost 	Defeat Mommy & Daddy as The Lost 	Defeat Mommy & Daddy as The Lost 	Defeat Mommy & Daddy as The Lost 	Defeat Mommy & Daddy as The Lost 	Defeat Mommy & Daddy as The Lost 	Defeat Mommy & Daddy as The Lost 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Mysterious Candy 	Mysterious Candy 	Mysterious Candy 	Mysterious Candy 	Mysterious Candy 	Mysterious Candy 	Mysterious Candy 	Uh-oh! 	Uh-oh! 	Uh-oh! 	Uh-oh! 	Uh-oh! 	Uh-oh! 	Uh-oh! 	
* 25% chance to spawn an IBS poop every 30 seconds	
* 25% chance to spawn an IBS poop every 30 seconds	
* 25% chance to spawn an IBS poop every 30 seconds	
* 25% chance to spawn an IBS poop every 30 seconds	
* 25% chance to spawn an IBS poop every 30 seconds	
* 25% chance to spawn an IBS poop every 30 seconds	
* 25% chance to spawn an IBS poop every 30 seconds	
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Hook Worm 	Hook Worm 	Hook Worm 	Hook Worm 	Hook Worm 	Hook Worm 	Hook Worm 	Zip zoop! 	Zip zoop! 	Zip zoop! 	Zip zoop! 	Zip zoop! 	Zip zoop! 	Zip zoop! 	
* +0.4 tears
* +1.5 range
* Isaac’s tears shift left-to-right in a square-wave pattern	
* +0.4 tears
* +1.5 range
* Isaac’s tears shift left-to-right in a square-wave pattern	
* +0.4 tears
* +1.5 range
* Isaac’s tears shift left-to-right in a square-wave pattern	
* +0.4 tears
* +1.5 range
* Isaac’s tears shift left-to-right in a square-wave pattern	
* +0.4 tears
* +1.5 range
* Isaac’s tears shift left-to-right in a square-wave pattern	
* +0.4 tears
* +1.5 range
* Isaac’s tears shift left-to-right in a square-wave pattern	
* +0.4 tears
* +1.5 range
* Isaac’s tears shift left-to-right in a square-wave pattern	
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*	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Whip Worm 	Whip Worm 	Whip Worm 	Whip Worm 	Whip Worm 	Whip Worm 	Whip Worm 	Whoosh! 	Whoosh! 	Whoosh! 	Whoosh! 	Whoosh! 	Whoosh! 	Whoosh! 	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Broken Ankh 	Broken Ankh 	Broken Ankh 	Broken Ankh 	Broken Ankh 	Broken Ankh 	Broken Ankh 	Eternal life? 	Eternal life? 	Eternal life? 	Eternal life? 	Eternal life? 	Eternal life? 	Eternal life? 	
* 33% chance to revive as ??? on death in the previous room
* Tainted ??? simply revives
* Can occur multiple times in one run	
* 33% chance to revive as ??? on death in the previous room
* Tainted ??? simply revives
* Can occur multiple times in one run	
* 33% chance to revive as ??? on death in the previous room
* Tainted ??? simply revives
* Can occur multiple times in one run	
* 33% chance to revive as ??? on death in the previous room
* Tainted ??? simply revives
* Can occur multiple times in one run	
* 33% chance to revive as ??? on death in the previous room
* Tainted ??? simply revives
* Can occur multiple times in one run	
* 33% chance to revive as ??? on death in the previous room
* Tainted ??? simply revives
* Can occur multiple times in one run	
* 33% chance to revive as ??? on death in the previous room
* Tainted ??? simply revives
* Can occur multiple times in one run	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Lazarus 	Complete the Boss Rush as Lazarus 	Complete the Boss Rush as Lazarus 	Complete the Boss Rush as Lazarus 	Complete the Boss Rush as Lazarus 	Complete the Boss Rush as Lazarus 	Complete the Boss Rush as Lazarus 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Fish Head 	Fish Head 	Fish Head 	Fish Head 	Fish Head 	Fish Head 	Fish Head 	It stinks! 	It stinks! 	It stinks! 	It stinks! 	It stinks! 	It stinks! 	It stinks! 	
* Isaac spawns a Blue Fly whenever he takes damage	
* Isaac spawns a Blue Fly whenever he takes damage	
* Isaac spawns a Blue Fly whenever he takes damage	
* Isaac spawns a Blue Fly whenever he takes damage	
* Isaac spawns a Blue Fly whenever he takes damage	
* Isaac spawns a Blue Fly whenever he takes damage	
* Isaac spawns a Blue Fly whenever he takes damage	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Pinky Eye 	Pinky Eye 	Pinky Eye 	Pinky Eye 	Pinky Eye 	Pinky Eye 	Pinky Eye 	Poison shots 	Poison shots 	Poison shots 	Poison shots 	Poison shots 	Poison shots 	Poison shots 	
* Luck-based chance to fire a tear that inflicts Poison onto enemies
* Poisoned enemies take damage over time
* 100% chance at 18 Luck	
* Luck-based chance to fire a tear that inflicts Poison onto enemies
* Poisoned enemies take damage over time
* 100% chance at 18 Luck	
* Luck-based chance to fire a tear that inflicts Poison onto enemies
* Poisoned enemies take damage over time
* 100% chance at 18 Luck	
* Luck-based chance to fire a tear that inflicts Poison onto enemies
* Poisoned enemies take damage over time
* 100% chance at 18 Luck	
* Luck-based chance to fire a tear that inflicts Poison onto enemies
* Poisoned enemies take damage over time
* 100% chance at 18 Luck	
* Luck-based chance to fire a tear that inflicts Poison onto enemies
* Poisoned enemies take damage over time
* 100% chance at 18 Luck	
* Luck-based chance to fire a tear that inflicts Poison onto enemies
* Poisoned enemies take damage over time
* 100% chance at 18 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Liberty Cap 	Liberty Cap 	Liberty Cap 	Liberty Cap 	Liberty Cap 	Liberty Cap 	Liberty Cap 	Touch fuzzy, get dizzy 	Touch fuzzy, get dizzy 	Touch fuzzy, get dizzy 	Touch fuzzy, get dizzy 	Touch fuzzy, get dizzy 	Touch fuzzy, get dizzy 	Touch fuzzy, get dizzy 	
* Entering a room has a 25% chance to grant Isaac the effect of one of the following mushroom items:
** Magic Mushroom
** Mini Mushroom
** Odd Mushroom (Thin)
** Odd Mushroom (Large)
** His Flesh	
* Entering a room has a 25% chance to grant Isaac the effect of one of the following mushroom items:
** Magic Mushroom
** Mini Mushroom
** Odd Mushroom (Thin)
** Odd Mushroom (Large)
** His Flesh	
* Entering a room has a 25% chance to grant Isaac the effect of one of the following mushroom items:
** Magic Mushroom
** Mini Mushroom
** Odd Mushroom (Thin)
** Odd Mushroom (Large)
** His Flesh	
* Entering a room has a 25% chance to grant Isaac the effect of one of the following mushroom items:
** Magic Mushroom
** Mini Mushroom
** Odd Mushroom (Thin)
** Odd Mushroom (Large)
** His Flesh	
* Entering a room has a 25% chance to grant Isaac the effect of one of the following mushroom items:
** Magic Mushroom
** Mini Mushroom
** Odd Mushroom (Thin)
** Odd Mushroom (Large)
** His Flesh	
* Entering a room has a 25% chance to grant Isaac the effect of one of the following mushroom items:
** Magic Mushroom
** Mini Mushroom
** Odd Mushroom (Thin)
** Odd Mushroom (Large)
** His Flesh	
* Entering a room has a 25% chance to grant Isaac the effect of one of the following mushroom items:
** Magic Mushroom
** Mini Mushroom
** Odd Mushroom (Thin)
** Odd Mushroom (Large)
** His Flesh	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Child’s Heart 	Child’s Heart 	Child’s Heart 	Child’s Heart 	Child’s Heart 	Child’s Heart 	Child’s Heart 	It calls out to its brothers 	It calls out to its brothers 	It calls out to its brothers 	It calls out to its brothers 	It calls out to its brothers 	It calls out to its brothers 	It calls out to its brothers 	
* 10% chance to replace a room’s clear reward with a random heart
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random heart in addition to their usual drops
* Has a chance to drop from a Blood Donation Machine	
* 10% chance to replace a room’s clear reward with a random heart
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random heart in addition to their usual drops
* Has a chance to drop from a Blood Donation Machine	
* 10% chance to replace a room’s clear reward with a random heart
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random heart in addition to their usual drops
* Has a chance to drop from a Blood Donation Machine	
* 10% chance to replace a room’s clear reward with a random heart
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random heart in addition to their usual drops
* Has a chance to drop from a Blood Donation Machine	
* 10% chance to replace a room’s clear reward with a random heart
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random heart in addition to their usual drops
* Has a chance to drop from a Blood Donation Machine	
* 10% chance to replace a room’s clear reward with a random heart
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random heart in addition to their usual drops
* Has a chance to drop from a Blood Donation Machine	
* 10% chance to replace a room’s clear reward with a random heart
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random heart in addition to their usual drops
* Has a chance to drop from a Blood Donation Machine	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Curved Horn 	Curved Horn 	Curved Horn 	Curved Horn 	Curved Horn 	Curved Horn 	Curved Horn 	Damage up 	Damage up 	Damage up 	Damage up 	Damage up 	Damage up 	Damage up 	
* +2 damage	
* +2 damage	
* +2 damage	
* +2 damage	
* +2 damage	
* +2 damage	
* +2 damage	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Rusted Key 	Rusted Key 	Rusted Key 	Rusted Key 	Rusted Key 	Rusted Key 	Rusted Key 	Worn mystery 	Worn mystery 	Worn mystery 	Worn mystery 	Worn mystery 	Worn mystery 	Worn mystery 	
* 10% chance to replace a room’s clear reward with a random key
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random key in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random key
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random key in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random key
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random key in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random key
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random key in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random key
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random key in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random key
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random key in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random key
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random key in addition to their usual drops	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Goat Hoof 	Goat Hoof 	Goat Hoof 	Goat Hoof 	Goat Hoof 	Goat Hoof 	Goat Hoof 	Speed up 	Speed up 	Speed up 	Speed up 	Speed up 	Speed up 	Speed up 	
* +0.15 speed	
* +0.15 speed	
* +0.15 speed	
* +0.15 speed	
* +0.15 speed	
* +0.15 speed	
* +0.15 speed	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Mom’s Pearl 	Mom’s Pearl 	Mom’s Pearl 	Mom’s Pearl 	Mom’s Pearl 	Mom’s Pearl 	Mom’s Pearl 	It emanates purity 	It emanates purity 	It emanates purity 	It emanates purity 	It emanates purity 	It emanates purity 	It emanates purity 	
* All heart types have a 5% chance to be replaced by a Soul Heart	
* All heart types have a 5% chance to be replaced by a Soul Heart	
* All heart types have a 5% chance to be replaced by a Soul Heart	
* All heart types have a 5% chance to be replaced by a Soul Heart	
* All heart types have a 5% chance to be replaced by a Soul Heart	
* All heart types have a 5% chance to be replaced by a Soul Heart	
* All heart types have a 5% chance to be replaced by a Soul Heart	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Cancer 	Cancer 	Cancer 	Cancer 	Cancer 	Cancer 	Cancer 	Yay, cancer! 	Yay, cancer! 	Yay, cancer! 	Yay, cancer! 	Yay, cancer! 	Yay, cancer! 	Yay, cancer! 	
* +1 tears	
* +1 tears	
* +1 tears	
* +1 tears	
* +1 tears	
* +1 tears	
* +1 tears	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Red Patch 	Red Patch 	Red Patch 	Red Patch 	Red Patch 	Red Patch 	Red Patch 	Your rage grows 	Your rage grows 	Your rage grows 	Your rage grows 	Your rage grows 	Your rage grows 	Your rage grows 	
* Whenever Isaac takes damage, there is a 20% chance for him to get a 1.2 damage increase for the current room
* 100% chance at 8 Luck	
* Whenever Isaac takes damage, there is a 20% chance for him to get a 1.2 damage increase for the current room
* 100% chance at 8 Luck	
* Whenever Isaac takes damage, there is a 20% chance for him to get a 1.2 damage increase for the current room
* 100% chance at 8 Luck	
* Whenever Isaac takes damage, there is a 20% chance for him to get a 1.2 damage increase for the current room
* 100% chance at 8 Luck	
* Whenever Isaac takes damage, there is a 20% chance for him to get a 1.2 damage increase for the current room
* 100% chance at 8 Luck	
* Whenever Isaac takes damage, there is a 20% chance for him to get a 1.2 damage increase for the current room
* 100% chance at 8 Luck	
* Whenever Isaac takes damage, there is a 20% chance for him to get a 1.2 damage increase for the current room
* 100% chance at 8 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as Samson 	Defeat Mommy & Daddy as Samson 	Defeat Mommy & Daddy as Samson 	Defeat Mommy & Daddy as Samson 	Defeat Mommy & Daddy as Samson 	Defeat Mommy & Daddy as Samson 	Defeat Mommy & Daddy as Samson 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Match Stick 	Match Stick 	Match Stick 	Match Stick 	Match Stick 	Match Stick 	Match Stick 	Tastes like burning 	Tastes like burning 	Tastes like burning 	Tastes like burning 	Tastes like burning 	Tastes like burning 	Tastes like burning 	
* 10% chance to replace a room’s clear reward with a random bomb
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random bomb in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random bomb
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random bomb in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random bomb
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random bomb in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random bomb
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random bomb in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random bomb
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random bomb in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random bomb
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random bomb in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random bomb
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random bomb in addition to their usual drops	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Lucky Toe 	Lucky Toe 	Lucky Toe 	Lucky Toe 	Lucky Toe 	Lucky Toe 	Lucky Toe 	Luck up! 	Luck up! 	Luck up! 	Luck up! 	Luck up! 	Luck up! 	Luck up! 	
* +1 luck
* Increases the chance of getting a room clear reward
* Blowing up a machine or Tinted Rock has a chance to drop an extra pick-up	
* +1 luck
* Increases the chance of getting a room clear reward
* Blowing up a machine or Tinted Rock has a chance to drop an extra pick-up	
* +1 luck
* Increases the chance of getting a room clear reward
* Blowing up a machine or Tinted Rock has a chance to drop an extra pick-up	
* +1 luck
* Increases the chance of getting a room clear reward
* Blowing up a machine or Tinted Rock has a chance to drop an extra pick-up	
* +1 luck
* Increases the chance of getting a room clear reward
* Blowing up a machine or Tinted Rock has a chance to drop an extra pick-up	
* +1 luck
* Increases the chance of getting a room clear reward
* Blowing up a machine or Tinted Rock has a chance to drop an extra pick-up	
* +1 luck
* Increases the chance of getting a room clear reward
* Blowing up a machine or Tinted Rock has a chance to drop an extra pick-up	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Cursed Skull 	Cursed Skull 	Cursed Skull 	Cursed Skull 	Cursed Skull 	Cursed Skull 	Cursed Skull 	Cursed? 	Cursed? 	Cursed? 	Cursed? 	Cursed? 	Cursed? 	Cursed? 	
* After taking damage, if Isaac is left at half a heart or less, he is teleported to a random other room	
* After taking damage, if Isaac is left at half a heart or less, he is teleported to a random other room	
* After taking damage, if Isaac is left at half a heart or less, he is teleported to a random other room	
* After taking damage, if Isaac is left at half a heart or less, he is teleported to a random other room	
* After taking damage, if Isaac is left at half a heart or less, he is teleported to a random other room	
* After taking damage, if Isaac is left at half a heart or less, he is teleported to a random other room	
* After taking damage, if Isaac is left at half a heart or less, he is teleported to a random other room	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Safety Cap 	Safety Cap 	Safety Cap 	Safety Cap 	Safety Cap 	Safety Cap 	Safety Cap 	Don’t swallow it 	Don’t swallow it 	Don’t swallow it 	Don’t swallow it 	Don’t swallow it 	Don’t swallow it 	Don’t swallow it 	
* 10% chance to replace a room’s clear reward with a random pill
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random pill in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random pill
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random pill in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random pill
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random pill in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random pill
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random pill in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random pill
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random pill in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random pill
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random pill in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random pill
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random pill in addition to their usual drops	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Ace of Spades 	Ace of Spades 	Ace of Spades 	Ace of Spades 	Ace of Spades 	Ace of Spades 	Ace of Spades 	Luck of the draw 	Luck of the draw 	Luck of the draw 	Luck of the draw 	Luck of the draw 	Luck of the draw 	Luck of the draw 	
* 10% chance to replace a room’s clear reward with a random card
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random card in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random card
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random card in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random card
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random card in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random card
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random card in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random card
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random card in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random card
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random card in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random card
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random card in addition to their usual drops	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Isaac’s Fork 	Isaac’s Fork 	Isaac’s Fork 	Isaac’s Fork 	Isaac’s Fork 	Isaac’s Fork 	Isaac’s Fork 	Consume thy enemy! 	Consume thy enemy! 	Consume thy enemy! 	Consume thy enemy! 	Consume thy enemy! 	Consume thy enemy! 	Consume thy enemy! 	
* Luck-based chance to heal Isaac for half a heart upon clearing a room
*100% chance at 18 Luck	
* Luck-based chance to heal Isaac for half a heart upon clearing a room
*100% chance at 18 Luck	
* Luck-based chance to heal Isaac for half a heart upon clearing a room
*100% chance at 18 Luck	
* Luck-based chance to heal Isaac for half a heart upon clearing a room
*100% chance at 18 Luck	
* Luck-based chance to heal Isaac for half a heart upon clearing a room
*100% chance at 18 Luck	
* Luck-based chance to heal Isaac for half a heart upon clearing a room
*100% chance at 18 Luck	
* Luck-based chance to heal Isaac for half a heart upon clearing a room
*100% chance at 18 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as Isaac 	Defeat Mommy & Daddy as Isaac 	Defeat Mommy & Daddy as Isaac 	Defeat Mommy & Daddy as Isaac 	Defeat Mommy & Daddy as Isaac 	Defeat Mommy & Daddy as Isaac 	Defeat Mommy & Daddy as Isaac 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
A Missing Page 	A Missing Page 	A Missing Page 	A Missing Page 	A Missing Page 	A Missing Page 	A Missing Page 	It glows with power 	It glows with power 	It glows with power 	It glows with power 	It glows with power 	It glows with power 	It glows with power 	
* Necronomicon effects, such as those via the Necronomicon itself, black hearts, etc. deal double damage
* 5% chance to activate the Necronomicon effect upon taking damage
* 50% at 23 Luck	
* Necronomicon effects, such as those via the Necronomicon itself, black hearts, etc. deal double damage
* 5% chance to activate the Necronomicon effect upon taking damage
* 50% at 23 Luck	
* Necronomicon effects, such as those via the Necronomicon itself, black hearts, etc. deal double damage
* 5% chance to activate the Necronomicon effect upon taking damage
* 50% at 23 Luck	
* Necronomicon effects, such as those via the Necronomicon itself, black hearts, etc. deal double damage
* 5% chance to activate the Necronomicon effect upon taking damage
* 50% at 23 Luck	
* Necronomicon effects, such as those via the Necronomicon itself, black hearts, etc. deal double damage
* 5% chance to activate the Necronomicon effect upon taking damage
* 50% at 23 Luck	
* Necronomicon effects, such as those via the Necronomicon itself, black hearts, etc. deal double damage
* 5% chance to activate the Necronomicon effect upon taking damage
* 50% at 23 Luck	
* Necronomicon effects, such as those via the Necronomicon itself, black hearts, etc. deal double damage
* 5% chance to activate the Necronomicon effect upon taking damage
* 50% at 23 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Judas 	Complete Greedier Mode as Judas 	Complete Greedier Mode as Judas 	Complete Greedier Mode as Judas 	Complete Greedier Mode as Judas 	Complete Greedier Mode as Judas 	Complete Greedier Mode as Judas 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Bloody Penny 	Bloody Penny 	Bloody Penny 	Bloody Penny 	Bloody Penny 	Bloody Penny 	Bloody Penny 	Wealth of health 	Wealth of health 	Wealth of health 	Wealth of health 	Wealth of health 	Wealth of health 	Wealth of health 	
* Collecting a coin has a chance to drop a Half Red Heart
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a Half Red Heart
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a Half Red Heart
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a Half Red Heart
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a Half Red Heart
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a Half Red Heart
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a Half Red Heart
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as Samson 	Complete the Colosseum as Samson 	Complete the Colosseum as Samson 	Complete the Colosseum as Samson 	Complete the Colosseum as Samson 	Complete the Colosseum as Samson 	Complete the Colosseum as Samson 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Burnt Penny 	Burnt Penny 	Burnt Penny 	Burnt Penny 	Burnt Penny 	Burnt Penny 	Burnt Penny 	Wealth of chaos 	Wealth of chaos 	Wealth of chaos 	Wealth of chaos 	Wealth of chaos 	Wealth of chaos 	Wealth of chaos 	
* Collecting a coin has a chance to drop a random Bomb of any type (except Troll Bombs)
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random Bomb of any type (except Troll Bombs)
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random Bomb of any type (except Troll Bombs)
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random Bomb of any type (except Troll Bombs)
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random Bomb of any type (except Troll Bombs)
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random Bomb of any type (except Troll Bombs)
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random Bomb of any type (except Troll Bombs)
* The chance increases based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Kill 100 enemies with bombs or explosions of any kind 	Kill 100 enemies with bombs or explosions of any kind 	Kill 100 enemies with bombs or explosions of any kind 	Kill 100 enemies with bombs or explosions of any kind 	Kill 100 enemies with bombs or explosions of any kind 	Kill 100 enemies with bombs or explosions of any kind 	Kill 100 enemies with bombs or explosions of any kind 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Flat Penny 	Flat Penny 	Flat Penny 	Flat Penny 	Flat Penny 	Flat Penny 	Flat Penny 	Wealth of answers 	Wealth of answers 	Wealth of answers 	Wealth of answers 	Wealth of answers 	Wealth of answers 	Wealth of answers 	
* Collecting a coin has a chance to drop a random key
* The chance is based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random key
* The chance is based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random key
* The chance is based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random key
* The chance is based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random key
* The chance is based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random key
* The chance is based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* Collecting a coin has a chance to drop a random key
* The chance is based on the coin’s worth
* Can be dropped via destroying Special Shopkeepers	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greed Mode as Bethany 	Complete Greed Mode as Bethany 	Complete Greed Mode as Bethany 	Complete Greed Mode as Bethany 	Complete Greed Mode as Bethany 	Complete Greed Mode as Bethany 	Complete Greed Mode as Bethany 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Counterfeit Penny 	Counterfeit Penny 	Counterfeit Penny 	Counterfeit Penny 	Counterfeit Penny 	Counterfeit Penny 	Counterfeit Penny 	Wealth of wealth 	Wealth of wealth 	Wealth of wealth 	Wealth of wealth 	Wealth of wealth 	Wealth of wealth 	Wealth of wealth 	
* Collecting a coin has a chance to increase its value by 1
* The chance depends on the coin’s worth
* Can be dropped by destroying a Special Shopkeeper or Golden Poop	
* Collecting a coin has a chance to increase its value by 1
* The chance depends on the coin’s worth
* Can be dropped by destroying a Special Shopkeeper or Golden Poop	
* Collecting a coin has a chance to increase its value by 1
* The chance depends on the coin’s worth
* Can be dropped by destroying a Special Shopkeeper or Golden Poop	
* Collecting a coin has a chance to increase its value by 1
* The chance depends on the coin’s worth
* Can be dropped by destroying a Special Shopkeeper or Golden Poop	
* Collecting a coin has a chance to increase its value by 1
* The chance depends on the coin’s worth
* Can be dropped by destroying a Special Shopkeeper or Golden Poop	
* Collecting a coin has a chance to increase its value by 1
* The chance depends on the coin’s worth
* Can be dropped by destroying a Special Shopkeeper or Golden Poop	
* Collecting a coin has a chance to increase its value by 1
* The chance depends on the coin’s worth
* Can be dropped by destroying a Special Shopkeeper or Golden Poop	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the challenge ‘Change of Heart’ 	Complete the challenge ‘Change of Heart’ 	Complete the challenge ‘Change of Heart’ 	Complete the challenge ‘Change of Heart’ 	Complete the challenge ‘Change of Heart’ 	Complete the challenge ‘Change of Heart’ 	Complete the challenge ‘Change of Heart’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Tick 	Tick 	Tick 	Tick 	Tick 	Tick 	Tick 	Well, that’s not coming off 	Well, that’s not coming off 	Well, that’s not coming off 	Well, that’s not coming off 	Well, that’s not coming off 	Well, that’s not coming off 	Well, that’s not coming off 	
* Enemies and bosses that have more than 60 HP have their health reduced by 15%
* Heals a heart container upon entering a Boss Room
* Cannot be removed after being picked up, unless it is gulped or the Match Stick trinket is picked up	
* Enemies and bosses that have more than 60 HP have their health reduced by 15%
* Heals a heart container upon entering a Boss Room
* Cannot be removed after being picked up, unless it is gulped or the Match Stick trinket is picked up	
* Enemies and bosses that have more than 60 HP have their health reduced by 15%
* Heals a heart container upon entering a Boss Room
* Cannot be removed after being picked up, unless it is gulped or the Match Stick trinket is picked up	
* Enemies and bosses that have more than 60 HP have their health reduced by 15%
* Heals a heart container upon entering a Boss Room
* Cannot be removed after being picked up, unless it is gulped or the Match Stick trinket is picked up	
* Enemies and bosses that have more than 60 HP have their health reduced by 15%
* Heals a heart container upon entering a Boss Room
* Cannot be removed after being picked up, unless it is gulped or the Match Stick trinket is picked up	
* Enemies and bosses that have more than 60 HP have their health reduced by 15%
* Heals a heart container upon entering a Boss Room
* Cannot be removed after being picked up, unless it is gulped or the Match Stick trinket is picked up	
* Enemies and bosses that have more than 60 HP have their health reduced by 15%
* Heals a heart container upon entering a Boss Room
* Cannot be removed after being picked up, unless it is gulped or the Match Stick trinket is picked up	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	Complete Greed Mode as Lazarus 	Complete Greed Mode as Lazarus 	Complete Greed Mode as Lazarus 	Complete Greed Mode as Lazarus 	Complete Greed Mode as Lazarus 	Complete Greed Mode as Lazarus 	Complete Greed Mode as Lazarus 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Isaac’s Head 	Isaac’s Head 	Isaac’s Head 	Isaac’s Head 	Isaac’s Head 	Isaac’s Head 	Isaac’s Head 	Dead Friend 	Dead Friend 	Dead Friend 	Dead Friend 	Dead Friend 	Dead Friend 	Dead Friend 	
* Grants a familiar that follows Isaac, firing piercing tears
* The tears deal 3.5 damage and are fired every 3/4ths of a second	
* Grants a familiar that follows Isaac, firing piercing tears
* The tears deal 3.5 damage and are fired every 3/4ths of a second	
* Grants a familiar that follows Isaac, firing piercing tears
* The tears deal 3.5 damage and are fired every 3/4ths of a second	
* Grants a familiar that follows Isaac, firing piercing tears
* The tears deal 3.5 damage and are fired every 3/4ths of a second	
* Grants a familiar that follows Isaac, firing piercing tears
* The tears deal 3.5 damage and are fired every 3/4ths of a second	
* Grants a familiar that follows Isaac, firing piercing tears
* The tears deal 3.5 damage and are fired every 3/4ths of a second	
* Grants a familiar that follows Isaac, firing piercing tears
* The tears deal 3.5 damage and are fired every 3/4ths of a second	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	Complete the Boss Rush as Isaac 	Complete the Boss Rush as Isaac 	Complete the Boss Rush as Isaac 	Complete the Boss Rush as Isaac 	Complete the Boss Rush as Isaac 	Complete the Boss Rush as Isaac 	Complete the Boss Rush as Isaac 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Maggy’s Faith 	Maggy’s Faith 	Maggy’s Faith 	Maggy’s Faith 	Maggy’s Faith 	Maggy’s Faith 	Maggy’s Faith 	Faith's reward 	Faith's reward 	Faith's reward 	Faith's reward 	Faith's reward 	Faith's reward 	Faith's reward 	
* Entering a new floor grants an Eternal Heart	
* Entering a new floor grants an Eternal Heart	
* Entering a new floor grants an Eternal Heart	
* Entering a new floor grants an Eternal Heart	
* Entering a new floor grants an Eternal Heart	
* Entering a new floor grants an Eternal Heart	
* Entering a new floor grants an Eternal Heart	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the challenge ‘His Orders’ 	Complete the challenge ‘His Orders’ 	Complete the challenge ‘His Orders’ 	Complete the challenge ‘His Orders’ 	Complete the challenge ‘His Orders’ 	Complete the challenge ‘His Orders’ 	Complete the challenge ‘His Orders’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Judas’ Tongue 	Judas’ Tongue 	Judas’ Tongue 	Judas’ Tongue 	Judas’ Tongue 	Judas’ Tongue 	Judas’ Tongue 	Payment received 	Payment received 	Payment received 	Payment received 	Payment received 	Payment received 	Payment received 	
* Reduces the price of all Devil Deal and Black Market items to one heart container
* No effect on Soul Heart deals	
* Reduces the price of all Devil Deal and Black Market items to one heart container
* No effect on Soul Heart deals	
* Reduces the price of all Devil Deal and Black Market items to one heart container
* No effect on Soul Heart deals	
* Reduces the price of all Devil Deal and Black Market items to one heart container
* No effect on Soul Heart deals	
* Reduces the price of all Devil Deal and Black Market items to one heart container
* No effect on Soul Heart deals	
* Reduces the price of all Devil Deal and Black Market items to one heart container
* No effect on Soul Heart deals	
* Reduces the price of all Devil Deal and Black Market items to one heart container
* No effect on Soul Heart deals	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as Judas 	Complete the Colosseum as Judas 	Complete the Colosseum as Judas 	Complete the Colosseum as Judas 	Complete the Colosseum as Judas 	Complete the Colosseum as Judas 	Complete the Colosseum as Judas 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Cain’s Eye 	Cain’s Eye 	Cain’s Eye 	Cain’s Eye 	Cain’s Eye 	Cain’s Eye 	Cain’s Eye 	May you see your destination 	May you see your destination 	May you see your destination 	May you see your destination 	May you see your destination 	May you see your destination 	May you see your destination 	
* Entering a new floor has a luck-based chance to reveal all Special Room icons on the map
* 100% chance at 5 Luck	
* Entering a new floor has a luck-based chance to reveal all Special Room icons on the map
* 100% chance at 5 Luck	
* Entering a new floor has a luck-based chance to reveal all Special Room icons on the map
* 100% chance at 5 Luck	
* Entering a new floor has a luck-based chance to reveal all Special Room icons on the map
* 100% chance at 5 Luck	
* Entering a new floor has a luck-based chance to reveal all Special Room icons on the map
* 100% chance at 5 Luck	
* Entering a new floor has a luck-based chance to reveal all Special Room icons on the map
* 100% chance at 5 Luck	
* Entering a new floor has a luck-based chance to reveal all Special Room icons on the map
* 100% chance at 5 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Cain 	Complete the Boss Rush as Cain 	Complete the Boss Rush as Cain 	Complete the Boss Rush as Cain 	Complete the Boss Rush as Cain 	Complete the Boss Rush as Cain 	Complete the Boss Rush as Cain 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Eve’s Bird Foot 	Eve’s Bird Foot 	Eve’s Bird Foot 	Eve’s Bird Foot 	Eve’s Bird Foot 	Eve’s Bird Foot 	Eve’s Bird Foot 	Revenge from beyond 	Revenge from beyond 	Revenge from beyond 	Revenge from beyond 	Revenge from beyond 	Revenge from beyond 	Revenge from beyond 	
* Killing an enemy has a luck-based chance to spawn a Dead Bird familiar for the room
* 100% chance at 8 Luck	
* Killing an enemy has a luck-based chance to spawn a Dead Bird familiar for the room
* 100% chance at 8 Luck	
* Killing an enemy has a luck-based chance to spawn a Dead Bird familiar for the room
* 100% chance at 8 Luck	
* Killing an enemy has a luck-based chance to spawn a Dead Bird familiar for the room
* 100% chance at 8 Luck	
* Killing an enemy has a luck-based chance to spawn a Dead Bird familiar for the room
* 100% chance at 8 Luck	
* Killing an enemy has a luck-based chance to spawn a Dead Bird familiar for the room
* 100% chance at 8 Luck	
* Killing an enemy has a luck-based chance to spawn a Dead Bird familiar for the room
* 100% chance at 8 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Eve 	Complete the Boss Rush as Eve 	Complete the Boss Rush as Eve 	Complete the Boss Rush as Eve 	Complete the Boss Rush as Eve 	Complete the Boss Rush as Eve 	Complete the Boss Rush as Eve 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
The Left Hand 	The Left Hand 	The Left Hand 	The Left Hand 	The Left Hand 	The Left Hand 	The Left Hand 	The left-hand path reaps dark rewards 	The left-hand path reaps dark rewards 	The left-hand path reaps dark rewards 	The left-hand path reaps dark rewards 	The left-hand path reaps dark rewards 	The left-hand path reaps dark rewards 	The left-hand path reaps dark rewards 	
* All chests that spawn are replaced with Red Chests	
* All chests that spawn are replaced with Red Chests	
* All chests that spawn are replaced with Red Chests	
* All chests that spawn are replaced with Red Chests	
* All chests that spawn are replaced with Red Chests	
* All chests that spawn are replaced with Red Chests	
* All chests that spawn are replaced with Red Chests	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the challenge ‘The Real Lefty’ 	Complete the challenge ‘The Real Lefty’ 	Complete the challenge ‘The Real Lefty’ 	Complete the challenge ‘The Real Lefty’ 	Complete the challenge ‘The Real Lefty’ 	Complete the challenge ‘The Real Lefty’ 	Complete the challenge ‘The Real Lefty’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Rainbow Worm 	Rainbow Worm 	Rainbow Worm 	Rainbow Worm 	Rainbow Worm 	Rainbow Worm 	Rainbow Worm 	Bleep bloop blop 	Bleep bloop blop 	Bleep bloop blop 	Bleep bloop blop 	Bleep bloop blop 	Bleep bloop blop 	Bleep bloop blop 	
* Grants a random worm trinket effect every 3 seconds	
* Grants a random worm trinket effect every 3 seconds	
* Grants a random worm trinket effect every 3 seconds	
* Grants a random worm trinket effect every 3 seconds	
* Grants a random worm trinket effect every 3 seconds	
* Grants a random worm trinket effect every 3 seconds	
* Grants a random worm trinket effect every 3 seconds	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the challenge ‘Oh, Worm?’ 	Complete the challenge ‘Oh, Worm?’ 	Complete the challenge ‘Oh, Worm?’ 	Complete the challenge ‘Oh, Worm?’ 	Complete the challenge ‘Oh, Worm?’ 	Complete the challenge ‘Oh, Worm?’ 	Complete the challenge ‘Oh, Worm?’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Tape Worm 	Tape Worm 	Tape Worm 	Tape Worm 	Tape Worm 	Tape Worm 	Tape Worm 	Floooooooooop! 	Floooooooooop! 	Floooooooooop! 	Floooooooooop! 	Floooooooooop! 	Floooooooooop! 	Floooooooooop! 	
* +3 Range	
* +3 Range	
* +3 Range	
* +3 Range	
* +3 Range	
* +3 Range	
* +3 Range	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Lazy Worm 	Lazy Worm 	Lazy Worm 	Lazy Worm 	Lazy Worm 	Lazy Worm 	Lazy Worm 	Pft 	Pft 	Pft 	Pft 	Pft 	Pft 	Pft 	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* +0.5 shot speed	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Cracked Dice 	Cracked Dice 	Cracked Dice 	Cracked Dice 	Cracked Dice 	Cracked Dice 	Cracked Dice 	You feel cursed… kinda 	You feel cursed… kinda 	You feel cursed… kinda 	You feel cursed… kinda 	You feel cursed… kinda 	You feel cursed… kinda 	You feel cursed… kinda 	
* 25% chance to activate one of the following dice effects when taking damage:
** The D6
** D8
** D10
** D12
** D20	
* 25% chance to activate one of the following dice effects when taking damage:
** The D6
** D8
** D10
** D12
** D20	
* 25% chance to activate one of the following dice effects when taking damage:
** The D6
** D8
** D10
** D12
** D20	
* 25% chance to activate one of the following dice effects when taking damage:
** The D6
** D8
** D10
** D12
** D20	
* 25% chance to activate one of the following dice effects when taking damage:
** The D6
** D8
** D10
** D12
** D20	
* 25% chance to activate one of the following dice effects when taking damage:
** The D6
** D8
** D10
** D12
** D20	
* 25% chance to activate one of the following dice effects when taking damage:
** The D6
** D8
** D10
** D12
** D20	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Reroll an item into one of lower quality 5 times 	Reroll an item into one of lower quality 5 times 	Reroll an item into one of lower quality 5 times 	Reroll an item into one of lower quality 5 times 	Reroll an item into one of lower quality 5 times 	Reroll an item into one of lower quality 5 times 	Reroll an item into one of lower quality 5 times 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Faded Polaroid 	Faded Polaroid 	Faded Polaroid 	Faded Polaroid 	Faded Polaroid 	Faded Polaroid 	Faded Polaroid 	You feel faded 	You feel faded 	You feel faded 	You feel faded 	You feel faded 	You feel faded 	You feel faded 	
* Isaac periodically turns invisible, giving all enemies in the room Confusion temporarily
* Confused enemies move randomly around the room, not directly targeting Isaac	
* Isaac periodically turns invisible, giving all enemies in the room Confusion temporarily
* Confused enemies move randomly around the room, not directly targeting Isaac	
* Isaac periodically turns invisible, giving all enemies in the room Confusion temporarily
* Confused enemies move randomly around the room, not directly targeting Isaac	
* Isaac periodically turns invisible, giving all enemies in the room Confusion temporarily
* Confused enemies move randomly around the room, not directly targeting Isaac	
* Isaac periodically turns invisible, giving all enemies in the room Confusion temporarily
* Confused enemies move randomly around the room, not directly targeting Isaac	
* Isaac periodically turns invisible, giving all enemies in the room Confusion temporarily
* Confused enemies move randomly around the room, not directly targeting Isaac	
* Isaac periodically turns invisible, giving all enemies in the room Confusion temporarily
* Confused enemies move randomly around the room, not directly targeting Isaac	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Tainted Lost 	Complete the Boss Rush as Tainted Lost 	Complete the Boss Rush as Tainted Lost 	Complete the Boss Rush as Tainted Lost 	Complete the Boss Rush as Tainted Lost 	Complete the Boss Rush as Tainted Lost 	Complete the Boss Rush as Tainted Lost 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Louse 	Louse 	Louse 	Louse 	Louse 	Louse 	Louse 	Itchy, tasty… 	Itchy, tasty… 	Itchy, tasty… 	Itchy, tasty… 	Itchy, tasty… 	Itchy, tasty… 	Itchy, tasty… 	
* While in an uncleared room, Isaac has a chance to spawn a Blue Spider every 30 seconds	
* While in an uncleared room, Isaac has a chance to spawn a Blue Spider every 30 seconds	
* While in an uncleared room, Isaac has a chance to spawn a Blue Spider every 30 seconds	
* While in an uncleared room, Isaac has a chance to spawn a Blue Spider every 30 seconds	
* While in an uncleared room, Isaac has a chance to spawn a Blue Spider every 30 seconds	
* While in an uncleared room, Isaac has a chance to spawn a Blue Spider every 30 seconds	
* While in an uncleared room, Isaac has a chance to spawn a Blue Spider every 30 seconds	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
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* 	
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* 	
* 
* 	Complete Greedier Mode as Guppy 	Complete Greedier Mode as Guppy 	Complete Greedier Mode as Guppy 	Complete Greedier Mode as Guppy 	Complete Greedier Mode as Guppy 	Complete Greedier Mode as Guppy 	Complete Greedier Mode as Guppy 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Bob’s Bladder 	Bob’s Bladder 	Bob’s Bladder 	Bob’s Bladder 	Bob’s Bladder 	Bob’s Bladder 	Bob’s Bladder 	Creepy bombs 	Creepy bombs 	Creepy bombs 	Creepy bombs 	Creepy bombs 	Creepy bombs 	Creepy bombs 	
* Isaac’s bombs leave behind green creep that damage enemies on it
* The creep lasts for 7 seconds	
* Isaac’s bombs leave behind green creep that damage enemies on it
* The creep lasts for 7 seconds	
* Isaac’s bombs leave behind green creep that damage enemies on it
* The creep lasts for 7 seconds	
* Isaac’s bombs leave behind green creep that damage enemies on it
* The creep lasts for 7 seconds	
* Isaac’s bombs leave behind green creep that damage enemies on it
* The creep lasts for 7 seconds	
* Isaac’s bombs leave behind green creep that damage enemies on it
* The creep lasts for 7 seconds	
* Isaac’s bombs leave behind green creep that damage enemies on it
* The creep lasts for 7 seconds	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Watch Battery 	Watch Battery 	Watch Battery 	Watch Battery 	Watch Battery 	Watch Battery 	Watch Battery 	Lil charge 	Lil charge 	Lil charge 	Lil charge 	Lil charge 	Lil charge 	Lil charge 	
* 10% chance to replace a room’s clear reward with a random battery
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random battery in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random battery
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random battery in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random battery
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random battery in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random battery
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random battery in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random battery
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random battery in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random battery
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random battery in addition to their usual drops	
* 10% chance to replace a room’s clear reward with a random battery
* Chests, Tinted Rocks, Slot Machines, and Fortune Telling Machines have a chance of spawning a random battery in addition to their usual drops	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
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* 
*	
* 
* 
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*	
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* 
*	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Error 	Error 	Error 	Error 	Error 	Error 	Error 	Effect not found? 	Effect not found? 	Effect not found? 	Effect not found? 	Effect not found? 	Effect not found? 	Effect not found? 	
* Mimics a random other Trinket effect in every room	
* Mimics a random other Trinket effect in every room	
* Mimics a random other Trinket effect in every room	
* Mimics a random other Trinket effect in every room	
* Mimics a random other Trinket effect in every room	
* Mimics a random other Trinket effect in every room	
* Mimics a random other Trinket effect in every room	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greed Mode as Tainted Eden 	Complete Greed Mode as Tainted Eden 	Complete Greed Mode as Tainted Eden 	Complete Greed Mode as Tainted Eden 	Complete Greed Mode as Tainted Eden 	Complete Greed Mode as Tainted Eden 	Complete Greed Mode as Tainted Eden 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Poker Chip 	Poker Chip 	Poker Chip 	Poker Chip 	Poker Chip 	Poker Chip 	Poker Chip 	Its double down time! 	Its double down time! 	Its double down time! 	Its double down time! 	Its double down time! 	Its double down time! 	Its double down time! 	
* Opening a chest has a 50/50 chance to either drop extra pick-ups or replace all pick-ups with a Black Fly
* No effect on Red Chests, Mega Chests, or chests that don’t contain pick-ups	
* Opening a chest has a 50/50 chance to either drop extra pick-ups or replace all pick-ups with a Black Fly
* No effect on Red Chests, Mega Chests, or chests that don’t contain pick-ups	
* Opening a chest has a 50/50 chance to either drop extra pick-ups or replace all pick-ups with a Black Fly
* No effect on Red Chests, Mega Chests, or chests that don’t contain pick-ups	
* Opening a chest has a 50/50 chance to either drop extra pick-ups or replace all pick-ups with a Black Fly
* No effect on Red Chests, Mega Chests, or chests that don’t contain pick-ups	
* Opening a chest has a 50/50 chance to either drop extra pick-ups or replace all pick-ups with a Black Fly
* No effect on Red Chests, Mega Chests, or chests that don’t contain pick-ups	
* Opening a chest has a 50/50 chance to either drop extra pick-ups or replace all pick-ups with a Black Fly
* No effect on Red Chests, Mega Chests, or chests that don’t contain pick-ups	
* Opening a chest has a 50/50 chance to either drop extra pick-ups or replace all pick-ups with a Black Fly
* No effect on Red Chests, Mega Chests, or chests that don’t contain pick-ups	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Isaac 	Complete Greedier Mode as Isaac 	Complete Greedier Mode as Isaac 	Complete Greedier Mode as Isaac 	Complete Greedier Mode as Isaac 	Complete Greedier Mode as Isaac 	Complete Greedier Mode as Isaac 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Blister 	Blister 	Blister 	Blister 	Blister 	Blister 	Blister 	Bounce back! 	Bounce back! 	Bounce back! 	Bounce back! 	Bounce back! 	Bounce back! 	Bounce back! 	
* Isaac’s tears deal additional knockback to enemies	
* Isaac’s tears deal additional knockback to enemies	
* Isaac’s tears deal additional knockback to enemies	
* Isaac’s tears deal additional knockback to enemies	
* Isaac’s tears deal additional knockback to enemies	
* Isaac’s tears deal additional knockback to enemies	
* Isaac’s tears deal additional knockback to enemies	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Second Hand 	Second Hand 	Second Hand 	Second Hand 	Second Hand 	Second Hand 	Second Hand 	Extended status time! 	Extended status time! 	Extended status time! 	Extended status time! 	Extended status time! 	Extended status time! 	Extended status time! 	
* Doubles the length of status effects inflicted onto enemies	
* Doubles the length of status effects inflicted onto enemies	
* Doubles the length of status effects inflicted onto enemies	
* Doubles the length of status effects inflicted onto enemies	
* Doubles the length of status effects inflicted onto enemies	
* Doubles the length of status effects inflicted onto enemies	
* Doubles the length of status effects inflicted onto enemies	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Blind Rage 	Blind Rage 	Blind Rage 	Blind Rage 	Blind Rage 	Blind Rage 	Blind Rage 	Blind to damage 	Blind to damage 	Blind to damage 	Blind to damage 	Blind to damage 	Blind to damage 	Blind to damage 	
* Doubles Isaac’s invulnerability frames upon taking damage	
* Doubles Isaac’s invulnerability frames upon taking damage	
* Doubles Isaac’s invulnerability frames upon taking damage	
* Doubles Isaac’s invulnerability frames upon taking damage	
* Doubles Isaac’s invulnerability frames upon taking damage	
* Doubles Isaac’s invulnerability frames upon taking damage	
* Doubles Isaac’s invulnerability frames upon taking damage	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Tainted Samson 	Complete the Boss Rush as Tainted Samson 	Complete the Boss Rush as Tainted Samson 	Complete the Boss Rush as Tainted Samson 	Complete the Boss Rush as Tainted Samson 	Complete the Boss Rush as Tainted Samson 	Complete the Boss Rush as Tainted Samson 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Golden Horseshoe 	Golden Horseshoe 	Golden Horseshoe 	Golden Horseshoe 	Golden Horseshoe 	Golden Horseshoe 	Golden Horseshoe 	Feel lucky? 	Feel lucky? 	Feel lucky? 	Feel lucky? 	Feel lucky? 	Feel lucky? 	Feel lucky? 	
* Treasure Rooms have a 15% chance to contain two item pedestals
* Only one can be taken	
* Treasure Rooms have a 15% chance to contain two item pedestals
* Only one can be taken	
* Treasure Rooms have a 15% chance to contain two item pedestals
* Only one can be taken	
* Treasure Rooms have a 15% chance to contain two item pedestals
* Only one can be taken	
* Treasure Rooms have a 15% chance to contain two item pedestals
* Only one can be taken	
* Treasure Rooms have a 15% chance to contain two item pedestals
* Only one can be taken	
* Treasure Rooms have a 15% chance to contain two item pedestals
* Only one can be taken	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Store Key 	Store Key 	Store Key 	Store Key 	Store Key 	Store Key 	Store Key 	Stores are open 	Stores are open 	Stores are open 	Stores are open 	Stores are open 	Stores are open 	Stores are open 	
* Shops can be entered for free	
* Shops can be entered for free	
* Shops can be entered for free	
* Shops can be entered for free	
* Shops can be entered for free	
* Shops can be entered for free	
* Shops can be entered for free	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as The Keeper 	Defeat Mommy & Daddy as The Keeper 	Defeat Mommy & Daddy as The Keeper 	Defeat Mommy & Daddy as The Keeper 	Defeat Mommy & Daddy as The Keeper 	Defeat Mommy & Daddy as The Keeper 	Defeat Mommy & Daddy as The Keeper 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Rib of Greed 	Rib of Greed 	Rib of Greed 	Rib of Greed 	Rib of Greed 	Rib of Greed 	Rib of Greed 	Feels greedy 	Feels greedy 	Feels greedy 	Feels greedy 	Feels greedy 	Feels greedy 	Feels greedy 	
* Greed and Super Greed can no longer appear in Shops
* Hearts that spawn have a chance to be replaced with coins	
* Greed and Super Greed can no longer appear in Shops
* Hearts that spawn have a chance to be replaced with coins	
* Greed and Super Greed can no longer appear in Shops
* Hearts that spawn have a chance to be replaced with coins	
* Greed and Super Greed can no longer appear in Shops
* Hearts that spawn have a chance to be replaced with coins	
* Greed and Super Greed can no longer appear in Shops
* Hearts that spawn have a chance to be replaced with coins	
* Greed and Super Greed can no longer appear in Shops
* Hearts that spawn have a chance to be replaced with coins	
* Greed and Super Greed can no longer appear in Shops
* Hearts that spawn have a chance to be replaced with coins	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as the Keeper 	Complete the Boss Rush as the Keeper 	Complete the Boss Rush as the Keeper 	Complete the Boss Rush as the Keeper 	Complete the Boss Rush as the Keeper 	Complete the Boss Rush as the Keeper 	Complete the Boss Rush as the Keeper 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Mom’s Locket 	Mom’s Locket 	Mom’s Locket 	Mom’s Locket 	Mom’s Locket 	Mom’s Locket 	Mom’s Locket 	You feel her love 	You feel her love 	You feel her love 	You feel her love 	You feel her love 	You feel her love 	You feel her love 	
* Using a key heals half a heart
* Turns half Red Hearts into full Red Hearts	
* Using a key heals half a heart
* Turns half Red Hearts into full Red Hearts	
* Using a key heals half a heart
* Turns half Red Hearts into full Red Hearts	
* Using a key heals half a heart
* Turns half Red Hearts into full Red Hearts	
* Using a key heals half a heart
* Turns half Red Hearts into full Red Hearts	
* Using a key heals half a heart
* Turns half Red Hearts into full Red Hearts	
* Using a key heals half a heart
* Turns half Red Hearts into full Red Hearts	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greed Mode as Tainted Magdalene 	Complete Greed Mode as Tainted Magdalene 	Complete Greed Mode as Tainted Magdalene 	Complete Greed Mode as Tainted Magdalene 	Complete Greed Mode as Tainted Magdalene 	Complete Greed Mode as Tainted Magdalene 	Complete Greed Mode as Tainted Magdalene 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
NO! 	NO! 	NO! 	NO! 	NO! 	NO! 	NO! 	Never again! 	Never again! 	Never again! 	Never again! 	Never again! 	Never again! 	Never again! 	
* Prevents Active items from spawning, replacing them with Passive items	
* Prevents Active items from spawning, replacing them with Passive items	
* Prevents Active items from spawning, replacing them with Passive items	
* Prevents Active items from spawning, replacing them with Passive items	
* Prevents Active items from spawning, replacing them with Passive items	
* Prevents Active items from spawning, replacing them with Passive items	
* Prevents Active items from spawning, replacing them with Passive items	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Tainted Alexandria’ 	Complete the Boss Rush as Tainted Alexandria’ 	Complete the Boss Rush as Tainted Alexandria’ 	Complete the Boss Rush as Tainted Alexandria’ 	Complete the Boss Rush as Tainted Alexandria’ 	Complete the Boss Rush as Tainted Alexandria’ 	Complete the Boss Rush as Tainted Alexandria’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Child Leash 	Child Leash 	Child Leash 	Child Leash 	Child Leash 	Child Leash 	Child Leash 	Keep your friends close… 	Keep your friends close… 	Keep your friends close… 	Keep your friends close… 	Keep your friends close… 	Keep your friends close… 	Keep your friends close… 	
* Familiars stay a fixed distance close to Isaac	
* Familiars stay a fixed distance close to Isaac	
* Familiars stay a fixed distance close to Isaac	
* Familiars stay a fixed distance close to Isaac	
* Familiars stay a fixed distance close to Isaac	
* Familiars stay a fixed distance close to Isaac	
* Familiars stay a fixed distance close to Isaac	
* 
* 	
* 
* 	
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* 	
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* 	
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* 	
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* 	
* 
* 	Complete the Boss Rush as Tainted Lilith 	Complete the Boss Rush as Tainted Lilith 	Complete the Boss Rush as Tainted Lilith 	Complete the Boss Rush as Tainted Lilith 	Complete the Boss Rush as Tainted Lilith 	Complete the Boss Rush as Tainted Lilith 	Complete the Boss Rush as Tainted Lilith 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Fish Tail 	Fish Tail 	Fish Tail 	Fish Tail 	Fish Tail 	Fish Tail 	Fish Tail 	It also stinks! 	It also stinks! 	It also stinks! 	It also stinks! 	It also stinks! 	It also stinks! 	It also stinks! 	
* Doubles all Blue Flies that spawn	
* Doubles all Blue Flies that spawn	
* Doubles all Blue Flies that spawn	
* Doubles all Blue Flies that spawn	
* Doubles all Blue Flies that spawn	
* Doubles all Blue Flies that spawn	
* Doubles all Blue Flies that spawn	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Tainted Guppy 	Complete the Boss Rush as Tainted Guppy 	Complete the Boss Rush as Tainted Guppy 	Complete the Boss Rush as Tainted Guppy 	Complete the Boss Rush as Tainted Guppy 	Complete the Boss Rush as Tainted Guppy 	Complete the Boss Rush as Tainted Guppy 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Black Tooth 	Black Tooth 	Black Tooth 	Black Tooth 	Black Tooth 	Black Tooth 	Black Tooth 	It looks dead 	It looks dead 	It looks dead 	It looks dead 	It looks dead 	It looks dead 	It looks dead 	
* Luck-based chance to fire a black tooth that deals 2x Isaac’s damage and inflicts Poison onto enemies
* 100% chance at 30 Luck
* All Poison effects on enemies deal twice as much damage	
* Luck-based chance to fire a black tooth that deals 2x Isaac’s damage and inflicts Poison onto enemies
* 100% chance at 30 Luck
* All Poison effects on enemies deal twice as much damage	
* Luck-based chance to fire a black tooth that deals 2x Isaac’s damage and inflicts Poison onto enemies
* 100% chance at 30 Luck
* All Poison effects on enemies deal twice as much damage	
* Luck-based chance to fire a black tooth that deals 2x Isaac’s damage and inflicts Poison onto enemies
* 100% chance at 30 Luck
* All Poison effects on enemies deal twice as much damage	
* Luck-based chance to fire a black tooth that deals 2x Isaac’s damage and inflicts Poison onto enemies
* 100% chance at 30 Luck
* All Poison effects on enemies deal twice as much damage	
* Luck-based chance to fire a black tooth that deals 2x Isaac’s damage and inflicts Poison onto enemies
* 100% chance at 30 Luck
* All Poison effects on enemies deal twice as much damage	
* Luck-based chance to fire a black tooth that deals 2x Isaac’s damage and inflicts Poison onto enemies
* 100% chance at 30 Luck
* All Poison effects on enemies deal twice as much damage	
* 
* 	
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* 	
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* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Nose Goblin 	Nose Goblin 	Nose Goblin 	Nose Goblin 	Nose Goblin 	Nose Goblin 	Nose Goblin 	Seems magic… 	Seems magic… 	Seems magic… 	Seems magic… 	Seems magic… 	Seems magic… 	Seems magic… 	
* 10% chance to fire a booger tear that sticks to enemies, damaging them over time and sticking onto other enemies if the enemy in question dies
* Booger tears have a 50% chance to have homing properties	
* 10% chance to fire a booger tear that sticks to enemies, damaging them over time and sticking onto other enemies if the enemy in question dies
* Booger tears have a 50% chance to have homing properties	
* 10% chance to fire a booger tear that sticks to enemies, damaging them over time and sticking onto other enemies if the enemy in question dies
* Booger tears have a 50% chance to have homing properties	
* 10% chance to fire a booger tear that sticks to enemies, damaging them over time and sticking onto other enemies if the enemy in question dies
* Booger tears have a 50% chance to have homing properties	
* 10% chance to fire a booger tear that sticks to enemies, damaging them over time and sticking onto other enemies if the enemy in question dies
* Booger tears have a 50% chance to have homing properties	
* 10% chance to fire a booger tear that sticks to enemies, damaging them over time and sticking onto other enemies if the enemy in question dies
* Booger tears have a 50% chance to have homing properties	
* 10% chance to fire a booger tear that sticks to enemies, damaging them over time and sticking onto other enemies if the enemy in question dies
* Booger tears have a 50% chance to have homing properties	
* 
* 	
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* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Super Ball 	Super Ball 	Super Ball 	Super Ball 	Super Ball 	Super Ball 	Super Ball 	Boing! 	Boing! 	Boing! 	Boing! 	Boing! 	Boing! 	Boing! 	
* 13% chance to fire a tear that bounces off walls, enemies, and obstacles	
* 13% chance to fire a tear that bounces off walls, enemies, and obstacles	
* 13% chance to fire a tear that bounces off walls, enemies, and obstacles	
* 13% chance to fire a tear that bounces off walls, enemies, and obstacles	
* 13% chance to fire a tear that bounces off walls, enemies, and obstacles	
* 13% chance to fire a tear that bounces off walls, enemies, and obstacles	
* 13% chance to fire a tear that bounces off walls, enemies, and obstacles	
* 
* 	
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* 	
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* 	
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* 	
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* 	
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* 	
* 
* 	Complete the Boss Rush as Leah 	Complete the Boss Rush as Leah 	Complete the Boss Rush as Leah 	Complete the Boss Rush as Leah 	Complete the Boss Rush as Leah 	Complete the Boss Rush as Leah 	Complete the Boss Rush as Leah 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Vibrant Bulb 	Vibrant Bulb 	Vibrant Bulb 	Vibrant Bulb 	Vibrant Bulb 	Vibrant Bulb 	Vibrant Bulb 	It needs power 	It needs power 	It needs power 	It needs power 	It needs power 	It needs power 	It needs power 	
* If Isaac’s Active item is fully charged, grants the following stats:
** +0.25 Speed
** +0.75 Range
** +0.2 Tears
** +0.1 Shot Speed
** +0.5 Damage
** +1 Luck	
* If Isaac’s Active item is fully charged, grants the following stats:
** +0.25 Speed
** +0.75 Range
** +0.2 Tears
** +0.1 Shot Speed
** +0.5 Damage
** +1 Luck	
* If Isaac’s Active item is fully charged, grants the following stats:
** +0.25 Speed
** +0.75 Range
** +0.2 Tears
** +0.1 Shot Speed
** +0.5 Damage
** +1 Luck	
* If Isaac’s Active item is fully charged, grants the following stats:
** +0.25 Speed
** +0.75 Range
** +0.2 Tears
** +0.1 Shot Speed
** +0.5 Damage
** +1 Luck	
* If Isaac’s Active item is fully charged, grants the following stats:
** +0.25 Speed
** +0.75 Range
** +0.2 Tears
** +0.1 Shot Speed
** +0.5 Damage
** +1 Luck	
* If Isaac’s Active item is fully charged, grants the following stats:
** +0.25 Speed
** +0.75 Range
** +0.2 Tears
** +0.1 Shot Speed
** +0.5 Damage
** +1 Luck	
* If Isaac’s Active item is fully charged, grants the following stats:
** +0.25 Speed
** +0.75 Range
** +0.2 Tears
** +0.1 Shot Speed
** +0.5 Damage
** +1 Luck	
* 
* 	
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* 	
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* 	
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* 	
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* 	
* 
* 	Collect 100 batteries 	Collect 100 batteries 	Collect 100 batteries 	Collect 100 batteries 	Collect 100 batteries 	Collect 100 batteries 	Collect 100 batteries 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Dim Bulb 	Dim Bulb 	Dim Bulb 	Dim Bulb 	Dim Bulb 	Dim Bulb 	Dim Bulb 	I think it’s broken… 	I think it’s broken… 	I think it’s broken… 	I think it’s broken… 	I think it’s broken… 	I think it’s broken… 	I think it’s broken… 	
* If Isaac’s Active item is completely uncharged, grants the following stats:
** +0.5 Speed
** +1.5 Range
** +0.5 Tears
** +0.3 Shot Speed
** +1.5 Damage
** +2 Luck	
* If Isaac’s Active item is completely uncharged, grants the following stats:
** +0.5 Speed
** +1.5 Range
** +0.5 Tears
** +0.3 Shot Speed
** +1.5 Damage
** +2 Luck	
* If Isaac’s Active item is completely uncharged, grants the following stats:
** +0.5 Speed
** +1.5 Range
** +0.5 Tears
** +0.3 Shot Speed
** +1.5 Damage
** +2 Luck	
* If Isaac’s Active item is completely uncharged, grants the following stats:
** +0.5 Speed
** +1.5 Range
** +0.5 Tears
** +0.3 Shot Speed
** +1.5 Damage
** +2 Luck	
* If Isaac’s Active item is completely uncharged, grants the following stats:
** +0.5 Speed
** +1.5 Range
** +0.5 Tears
** +0.3 Shot Speed
** +1.5 Damage
** +2 Luck	
* If Isaac’s Active item is completely uncharged, grants the following stats:
** +0.5 Speed
** +1.5 Range
** +0.5 Tears
** +0.3 Shot Speed
** +1.5 Damage
** +2 Luck	
* If Isaac’s Active item is completely uncharged, grants the following stats:
** +0.5 Speed
** +1.5 Range
** +0.5 Tears
** +0.3 Shot Speed
** +1.5 Damage
** +2 Luck	
* 
* 	
* 
* 	
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* 	
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* 	
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* 	
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* 	
* 
* 	Use Active items 100 times 	Use Active items 100 times 	Use Active items 100 times 	Use Active items 100 times 	Use Active items 100 times 	Use Active items 100 times 	Use Active items 100 times 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Fragmented Card 	Fragmented Card 	Fragmented Card 	Fragmented Card 	Fragmented Card 	Fragmented Card 	Fragmented Card 	Double moon 	Double moon 	Double moon 	Double moon 	Double moon 	Double moon 	Double moon 	
* Spawns an additional Secret Room in every floor	
* Spawns an additional Secret Room in every floor	
* Spawns an additional Secret Room in every floor	
* Spawns an additional Secret Room in every floor	
* Spawns an additional Secret Room in every floor	
* Spawns an additional Secret Room in every floor	
* Spawns an additional Secret Room in every floor	
* 
* 	
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* 	
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* 	
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* 	
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* 
* 	Defeat Mother’s Soul as Tainted Forgotten 	Defeat Mother’s Soul as Tainted Forgotten 	Defeat Mother’s Soul as Tainted Forgotten 	Defeat Mother’s Soul as Tainted Forgotten 	Defeat Mother’s Soul as Tainted Forgotten 	Defeat Mother’s Soul as Tainted Forgotten 	Defeat Mother’s Soul as Tainted Forgotten 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Lost Cork 	Lost Cork 	Lost Cork 	Lost Cork 	Lost Cork 	Lost Cork 	Lost Cork 	Uncorked 	Uncorked 	Uncorked 	Uncorked 	Uncorked 	Uncorked 	Uncorked 	
* Doubles the size of Isaac’s creep	
* Doubles the size of Isaac’s creep	
* Doubles the size of Isaac’s creep	
* Doubles the size of Isaac’s creep	
* Doubles the size of Isaac’s creep	
* Doubles the size of Isaac’s creep	
* Doubles the size of Isaac’s creep	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Crow’s Heart 	Crow’s Heart 	Crow’s Heart 	Crow’s Heart 	Crow’s Heart 	Crow’s Heart 	Crow’s Heart 	Drain me 	Drain me 	Drain me 	Drain me 	Drain me 	Drain me 	Drain me 	
* Causes Red Heart damage to taken before Soul Hearts, Black Hearts, and all other heart types	
* Causes Red Heart damage to taken before Soul Hearts, Black Hearts, and all other heart types	
* Causes Red Heart damage to taken before Soul Hearts, Black Hearts, and all other heart types	
* Causes Red Heart damage to taken before Soul Hearts, Black Hearts, and all other heart types	
* Causes Red Heart damage to taken before Soul Hearts, Black Hearts, and all other heart types	
* Causes Red Heart damage to taken before Soul Hearts, Black Hearts, and all other heart types	
* Causes Red Heart damage to taken before Soul Hearts, Black Hearts, and all other heart types	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Tainted Eve 	Complete the Boss Rush as Tainted Eve 	Complete the Boss Rush as Tainted Eve 	Complete the Boss Rush as Tainted Eve 	Complete the Boss Rush as Tainted Eve 	Complete the Boss Rush as Tainted Eve 	Complete the Boss Rush as Tainted Eve 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Walnut 	Walnut 	Walnut 	Walnut 	Walnut 	Walnut 	Walnut 	That’s a tough nut to crack! 	That’s a tough nut to crack! 	That’s a tough nut to crack! 	That’s a tough nut to crack! 	That’s a tough nut to crack! 	That’s a tough nut to crack! 	That’s a tough nut to crack! 	
* Getting hit by an explosion has a chance to drop a coin, a heart, a key, a bomb, and a random other Trinket, destroying Walnut in the process	
* Getting hit by an explosion has a chance to drop a coin, a heart, a key, a bomb, and a random other Trinket, destroying Walnut in the process	
* Getting hit by an explosion has a chance to drop a coin, a heart, a key, a bomb, and a random other Trinket, destroying Walnut in the process	
* Getting hit by an explosion has a chance to drop a coin, a heart, a key, a bomb, and a random other Trinket, destroying Walnut in the process	
* Getting hit by an explosion has a chance to drop a coin, a heart, a key, a bomb, and a random other Trinket, destroying Walnut in the process	
* Getting hit by an explosion has a chance to drop a coin, a heart, a key, a bomb, and a random other Trinket, destroying Walnut in the process	
* Getting hit by an explosion has a chance to drop a coin, a heart, a key, a bomb, and a random other Trinket, destroying Walnut in the process	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as Jacob & Esau 	Defeat Mommy & Daddy as Jacob & Esau 	Defeat Mommy & Daddy as Jacob & Esau 	Defeat Mommy & Daddy as Jacob & Esau 	Defeat Mommy & Daddy as Jacob & Esau 	Defeat Mommy & Daddy as Jacob & Esau 	Defeat Mommy & Daddy as Jacob & Esau 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Duct Tape 	Duct Tape 	Duct Tape 	Duct Tape 	Duct Tape 	Duct Tape 	Duct Tape 	Stuck 	Stuck 	Stuck 	Stuck 	Stuck 	Stuck 	Stuck 	
* All Familiars become completely idle, and cannot move	
* All Familiars become completely idle, and cannot move	
* All Familiars become completely idle, and cannot move	
* All Familiars become completely idle, and cannot move	
* All Familiars become completely idle, and cannot move	
* All Familiars become completely idle, and cannot move	
* All Familiars become completely idle, and cannot move	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Silver Dollar 	Silver Dollar 	Silver Dollar 	Silver Dollar 	Silver Dollar 	Silver Dollar 	Silver Dollar 	Feels lucky… 	Feels lucky… 	Feels lucky… 	Feels lucky… 	Feels lucky… 	Feels lucky… 	Feels lucky… 	
* Shops can appear in Chapter 4	
* Shops can appear in Chapter 4	
* Shops can appear in Chapter 4	
* Shops can appear in Chapter 4	
* Shops can appear in Chapter 4	
* Shops can appear in Chapter 4	
* Shops can appear in Chapter 4	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as the Keeper 	Complete the Colosseum as the Keeper 	Complete the Colosseum as the Keeper 	Complete the Colosseum as the Keeper 	Complete the Colosseum as the Keeper 	Complete the Colosseum as the Keeper 	Complete the Colosseum as the Keeper 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Bat Wing 	Bat Wing 	Bat Wing 	Bat Wing 	Bat Wing 	Bat Wing 	Bat Wing 	They’re growing… 	They’re growing… 	They’re growing… 	They’re growing… 	They’re growing… 	They’re growing… 	They’re growing… 	
* Killing an enemy has a 5% chance to grant flight for the current room	
* Killing an enemy has a 5% chance to grant flight for the current room	
* Killing an enemy has a 5% chance to grant flight for the current room	
* Killing an enemy has a 5% chance to grant flight for the current room	
* Killing an enemy has a 5% chance to grant flight for the current room	
* Killing an enemy has a 5% chance to grant flight for the current room	
* Killing an enemy has a 5% chance to grant flight for the current room	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Thanatos as Tainted Azazel 	Defeat Thanatos as Tainted Azazel 	Defeat Thanatos as Tainted Azazel 	Defeat Thanatos as Tainted Azazel 	Defeat Thanatos as Tainted Azazel 	Defeat Thanatos as Tainted Azazel 	Defeat Thanatos as Tainted Azazel 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Hairpin 	Hairpin 	Hairpin 	Hairpin 	Hairpin 	Hairpin 	Hairpin 	Danger charge 	Danger charge 	Danger charge 	Danger charge 	Danger charge 	Danger charge 	Danger charge 	
* Entering a Boss Room fully charges Isaac’s Active item	
* Entering a Boss Room fully charges Isaac’s Active item	
* Entering a Boss Room fully charges Isaac’s Active item	
* Entering a Boss Room fully charges Isaac’s Active item	
* Entering a Boss Room fully charges Isaac’s Active item	
* Entering a Boss Room fully charges Isaac’s Active item	
* Entering a Boss Room fully charges Isaac’s Active item	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as Ehud’ 	Defeat Mommy & Daddy as Ehud’ 	Defeat Mommy & Daddy as Ehud’ 	Defeat Mommy & Daddy as Ehud’ 	Defeat Mommy & Daddy as Ehud’ 	Defeat Mommy & Daddy as Ehud’ 	Defeat Mommy & Daddy as Ehud’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Wooden Cross 	Wooden Cross 	Wooden Cross 	Wooden Cross 	Wooden Cross 	Wooden Cross 	Wooden Cross 	My faith protects me 	My faith protects me 	My faith protects me 	My faith protects me 	My faith protects me 	My faith protects me 	My faith protects me 	
* Once a floor, grants a one-time Holy Mantle shield that blocks the first source of damage Isaac takes on the floor	
* Once a floor, grants a one-time Holy Mantle shield that blocks the first source of damage Isaac takes on the floor	
* Once a floor, grants a one-time Holy Mantle shield that blocks the first source of damage Isaac takes on the floor	
* Once a floor, grants a one-time Holy Mantle shield that blocks the first source of damage Isaac takes on the floor	
* Once a floor, grants a one-time Holy Mantle shield that blocks the first source of damage Isaac takes on the floor	
* Once a floor, grants a one-time Holy Mantle shield that blocks the first source of damage Isaac takes on the floor	
* Once a floor, grants a one-time Holy Mantle shield that blocks the first source of damage Isaac takes on the floor	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Tainted Lost 	Complete Greedier Mode as Tainted Lost 	Complete Greedier Mode as Tainted Lost 	Complete Greedier Mode as Tainted Lost 	Complete Greedier Mode as Tainted Lost 	Complete Greedier Mode as Tainted Lost 	Complete Greedier Mode as Tainted Lost 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Butter! 	Butter! 	Butter! 	Butter! 	Butter! 	Butter! 	Butter! 	Can’t hold it! 	Can’t hold it! 	Can’t hold it! 	Can’t hold it! 	Can’t hold it! 	Can’t hold it! 	Can’t hold it! 	
* Using an Active item drops it onto the ground as a pedestal item
* Taking damage has a 2% chance to drop one of Isaac’s Passive items as a pedestal item.	
* Using an Active item drops it onto the ground as a pedestal item
* Taking damage has a 2% chance to drop one of Isaac’s Passive items as a pedestal item.	
* Using an Active item drops it onto the ground as a pedestal item
* Taking damage has a 2% chance to drop one of Isaac’s Passive items as a pedestal item.	
* Using an Active item drops it onto the ground as a pedestal item
* Taking damage has a 2% chance to drop one of Isaac’s Passive items as a pedestal item.	
* Using an Active item drops it onto the ground as a pedestal item
* Taking damage has a 2% chance to drop one of Isaac’s Passive items as a pedestal item.	
* Using an Active item drops it onto the ground as a pedestal item
* Taking damage has a 2% chance to drop one of Isaac’s Passive items as a pedestal item.	
* Using an Active item drops it onto the ground as a pedestal item
* Taking damage has a 2% chance to drop one of Isaac’s Passive items as a pedestal item.	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Door Stop 	Door Stop 	Door Stop 	Door Stop 	Door Stop 	Door Stop 	Door Stop 	Hold the door 	Hold the door 	Hold the door 	Hold the door 	Hold the door 	Hold the door 	Hold the door 	
* The last door Isaac exited will always stay open, even if the current room is uncleared	
* The last door Isaac exited will always stay open, even if the current room is uncleared	
* The last door Isaac exited will always stay open, even if the current room is uncleared	
* The last door Isaac exited will always stay open, even if the current room is uncleared	
* The last door Isaac exited will always stay open, even if the current room is uncleared	
* The last door Isaac exited will always stay open, even if the current room is uncleared	
* The last door Isaac exited will always stay open, even if the current room is uncleared	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Extension Cord 	Extension Cord 	Extension Cord 	Extension Cord 	Extension Cord 	Extension Cord 	Extension Cord 	Charged friends 	Charged friends 	Charged friends 	Charged friends 	Charged friends 	Charged friends 	Charged friends 	
* All of Isaac’s familiars are connected by a laser that damages enemies in it
* The laser deals 6 damage	
* All of Isaac’s familiars are connected by a laser that damages enemies in it
* The laser deals 6 damage	
* All of Isaac’s familiars are connected by a laser that damages enemies in it
* The laser deals 6 damage	
* All of Isaac’s familiars are connected by a laser that damages enemies in it
* The laser deals 6 damage	
* All of Isaac’s familiars are connected by a laser that damages enemies in it
* The laser deals 6 damage	
* All of Isaac’s familiars are connected by a laser that damages enemies in it
* The laser deals 6 damage	
* All of Isaac’s familiars are connected by a laser that damages enemies in it
* The laser deals 6 damage	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Rotten Penny 	Rotten Penny 	Rotten Penny 	Rotten Penny 	Rotten Penny 	Rotten Penny 	Rotten Penny 	Wealth of flies 	Wealth of flies 	Wealth of flies 	Wealth of flies 	Wealth of flies 	Wealth of flies 	Wealth of flies 	
* Collecting a coin spawns a Blue Fly	
* Collecting a coin spawns a Blue Fly	
* Collecting a coin spawns a Blue Fly	
* Collecting a coin spawns a Blue Fly	
* Collecting a coin spawns a Blue Fly	
* Collecting a coin spawns a Blue Fly	
* Collecting a coin spawns a Blue Fly	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greed Mode as Tainted Guppy 	Complete Greed Mode as Tainted Guppy 	Complete Greed Mode as Tainted Guppy 	Complete Greed Mode as Tainted Guppy 	Complete Greed Mode as Tainted Guppy 	Complete Greed Mode as Tainted Guppy 	Complete Greed Mode as Tainted Guppy 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Baby Bender 	Baby Bender 	Baby Bender 	Baby Bender 	Baby Bender 	Baby Bender 	Baby Bender 	Feed them magic! 	Feed them magic! 	Feed them magic! 	Feed them magic! 	Feed them magic! 	Feed them magic! 	Feed them magic! 	
* All projectiles that Familiars fire have homing properties	
* All projectiles that Familiars fire have homing properties	
* All projectiles that Familiars fire have homing properties	
* All projectiles that Familiars fire have homing properties	
* All projectiles that Familiars fire have homing properties	
* All projectiles that Familiars fire have homing properties	
* All projectiles that Familiars fire have homing properties	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mother’s Soul as Tainted Lilith 	Defeat Mother’s Soul as Tainted Lilith 	Defeat Mother’s Soul as Tainted Lilith 	Defeat Mother’s Soul as Tainted Lilith 	Defeat Mother’s Soul as Tainted Lilith 	Defeat Mother’s Soul as Tainted Lilith 	Defeat Mother’s Soul as Tainted Lilith 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Jawbreaker 	Jawbreaker 	Jawbreaker 	Jawbreaker 	Jawbreaker 	Jawbreaker 	Jawbreaker 	Don’t chew on it! 	Don’t chew on it! 	Don’t chew on it! 	Don’t chew on it! 	Don’t chew on it! 	Don’t chew on it! 	Don’t chew on it! 	
* Luck-based chance to fire a tooth that deals 3.2x Isaac’s damage
* 100% chance at 13 Luck	
* Luck-based chance to fire a tooth that deals 3.2x Isaac’s damage
* 100% chance at 13 Luck	
* Luck-based chance to fire a tooth that deals 3.2x Isaac’s damage
* 100% chance at 13 Luck	
* Luck-based chance to fire a tooth that deals 3.2x Isaac’s damage
* 100% chance at 13 Luck	
* Luck-based chance to fire a tooth that deals 3.2x Isaac’s damage
* 100% chance at 13 Luck	
* Luck-based chance to fire a tooth that deals 3.2x Isaac’s damage
* 100% chance at 13 Luck	
* Luck-based chance to fire a tooth that deals 3.2x Isaac’s damage
* 100% chance at 13 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as The Forgotten’ 	Defeat Mommy & Daddy as The Forgotten’ 	Defeat Mommy & Daddy as The Forgotten’ 	Defeat Mommy & Daddy as The Forgotten’ 	Defeat Mommy & Daddy as The Forgotten’ 	Defeat Mommy & Daddy as The Forgotten’ 	Defeat Mommy & Daddy as The Forgotten’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Chewed Pen 	Chewed Pen 	Chewed Pen 	Chewed Pen 	Chewed Pen 	Chewed Pen 	Chewed Pen 	It’s leaking… 	It’s leaking… 	It’s leaking… 	It’s leaking… 	It’s leaking… 	It’s leaking… 	It’s leaking… 	
* Luck-based chance to fire a black tear that slows enemies down temporarily
* 100% chance at 18 Luck	
* Luck-based chance to fire a black tear that slows enemies down temporarily
* 100% chance at 18 Luck	
* Luck-based chance to fire a black tear that slows enemies down temporarily
* 100% chance at 18 Luck	
* Luck-based chance to fire a black tear that slows enemies down temporarily
* 100% chance at 18 Luck	
* Luck-based chance to fire a black tear that slows enemies down temporarily
* 100% chance at 18 Luck	
* Luck-based chance to fire a black tear that slows enemies down temporarily
* 100% chance at 18 Luck	
* Luck-based chance to fire a black tear that slows enemies down temporarily
* 100% chance at 18 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Leah 	Complete Greedier Mode as Leah 	Complete Greedier Mode as Leah 	Complete Greedier Mode as Leah 	Complete Greedier Mode as Leah 	Complete Greedier Mode as Leah 	Complete Greedier Mode as Leah 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Blessed Penny 	Blessed Penny 	Blessed Penny 	Blessed Penny 	Blessed Penny 	Blessed Penny 	Blessed Penny 	Wealth of purity 	Wealth of purity 	Wealth of purity 	Wealth of purity 	Wealth of purity 	Wealth of purity 	Wealth of purity 	
* Collecting a coin has a chance to drop half a Soul Heart
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to drop half a Soul Heart
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to drop half a Soul Heart
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to drop half a Soul Heart
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to drop half a Soul Heart
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to drop half a Soul Heart
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to drop half a Soul Heart
* The chance scales with the coin’s worth	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Bethany 	Complete Greedier Mode as Bethany 	Complete Greedier Mode as Bethany 	Complete Greedier Mode as Bethany 	Complete Greedier Mode as Bethany 	Complete Greedier Mode as Bethany 	Complete Greedier Mode as Bethany 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Broken Syringe 	Broken Syringe 	Broken Syringe 	Broken Syringe 	Broken Syringe 	Broken Syringe 	Broken Syringe 	Mystery medicine 	Mystery medicine 	Mystery medicine 	Mystery medicine 	Mystery medicine 	Mystery medicine 	Mystery medicine 	
* Entering a room has a chance to grant Isaac the effect of one of the following Syringe items for the duration of it:
** The Virus
** Roid Rage
** Growth Hormones
** Speed Ball
** Experimental Treatment
** Synthoil
** Adrenaline	
* Entering a room has a chance to grant Isaac the effect of one of the following Syringe items for the duration of it:
** The Virus
** Roid Rage
** Growth Hormones
** Speed Ball
** Experimental Treatment
** Synthoil
** Adrenaline	
* Entering a room has a chance to grant Isaac the effect of one of the following Syringe items for the duration of it:
** The Virus
** Roid Rage
** Growth Hormones
** Speed Ball
** Experimental Treatment
** Synthoil
** Adrenaline	
* Entering a room has a chance to grant Isaac the effect of one of the following Syringe items for the duration of it:
** The Virus
** Roid Rage
** Growth Hormones
** Speed Ball
** Experimental Treatment
** Synthoil
** Adrenaline	
* Entering a room has a chance to grant Isaac the effect of one of the following Syringe items for the duration of it:
** The Virus
** Roid Rage
** Growth Hormones
** Speed Ball
** Experimental Treatment
** Synthoil
** Adrenaline	
* Entering a room has a chance to grant Isaac the effect of one of the following Syringe items for the duration of it:
** The Virus
** Roid Rage
** Growth Hormones
** Speed Ball
** Experimental Treatment
** Synthoil
** Adrenaline	
* Entering a room has a chance to grant Isaac the effect of one of the following Syringe items for the duration of it:
** The Virus
** Roid Rage
** Growth Hormones
** Speed Ball
** Experimental Treatment
** Synthoil
** Adrenaline	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as Lazaruu 	Complete the Colosseum as Lazaruu 	Complete the Colosseum as Lazaruu 	Complete the Colosseum as Lazaruu 	Complete the Colosseum as Lazaruu 	Complete the Colosseum as Lazaruu 	Complete the Colosseum as Lazaruu 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
A Lighter 	A Lighter 	A Lighter 	A Lighter 	A Lighter 	A Lighter 	A Lighter 	Watch the world burn 	Watch the world burn 	Watch the world burn 	Watch the world burn 	Watch the world burn 	Watch the world burn 	Watch the world burn 	
* Entering a new room has a luck-based chance to inflict all enemies inside with Burn, damaging them over time
* 100% chance at 40 Luck	
* Entering a new room has a luck-based chance to inflict all enemies inside with Burn, damaging them over time
* 100% chance at 40 Luck	
* Entering a new room has a luck-based chance to inflict all enemies inside with Burn, damaging them over time
* 100% chance at 40 Luck	
* Entering a new room has a luck-based chance to inflict all enemies inside with Burn, damaging them over time
* 100% chance at 40 Luck	
* Entering a new room has a luck-based chance to inflict all enemies inside with Burn, damaging them over time
* 100% chance at 40 Luck	
* Entering a new room has a luck-based chance to inflict all enemies inside with Burn, damaging them over time
* 100% chance at 40 Luck	
* Entering a new room has a luck-based chance to inflict all enemies inside with Burn, damaging them over time
* 100% chance at 40 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Broken Padlock 	Broken Padlock 	Broken Padlock 	Broken Padlock 	Broken Padlock 	Broken Padlock 	Broken Padlock 	Bombs are key 	Bombs are key 	Bombs are key 	Bombs are key 	Bombs are key 	Bombs are key 	Bombs are key 	
* Explosions are capable of opening locked doors and chests	
* Explosions are capable of opening locked doors and chests	
* Explosions are capable of opening locked doors and chests	
* Explosions are capable of opening locked doors and chests	
* Explosions are capable of opening locked doors and chests	
* Explosions are capable of opening locked doors and chests	
* Explosions are capable of opening locked doors and chests	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Tainted Apollyon 	Complete the Boss Rush as Tainted Apollyon 	Complete the Boss Rush as Tainted Apollyon 	Complete the Boss Rush as Tainted Apollyon 	Complete the Boss Rush as Tainted Apollyon 	Complete the Boss Rush as Tainted Apollyon 	Complete the Boss Rush as Tainted Apollyon 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Myosotis 	Myosotis 	Myosotis 	Myosotis 	Myosotis 	Myosotis 	Myosotis 	Forget me not… 	Forget me not… 	Forget me not… 	Forget me not… 	Forget me not… 	Forget me not… 	Forget me not… 	
* Upon entering a new floor, 4 random pick-ups from the previous floor spawn in the starting room	
* Upon entering a new floor, 4 random pick-ups from the previous floor spawn in the starting room	
* Upon entering a new floor, 4 random pick-ups from the previous floor spawn in the starting room	
* Upon entering a new floor, 4 random pick-ups from the previous floor spawn in the starting room	
* Upon entering a new floor, 4 random pick-ups from the previous floor spawn in the starting room	
* Upon entering a new floor, 4 random pick-ups from the previous floor spawn in the starting room	
* Upon entering a new floor, 4 random pick-ups from the previous floor spawn in the starting room	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as Eden 	Defeat Mommy & Daddy as Eden 	Defeat Mommy & Daddy as Eden 	Defeat Mommy & Daddy as Eden 	Defeat Mommy & Daddy as Eden 	Defeat Mommy & Daddy as Eden 	Defeat Mommy & Daddy as Eden 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Teardrop Charm 	Teardrop Charm 	Teardrop Charm 	Teardrop Charm 	Teardrop Charm 	Teardrop Charm 	Teardrop Charm 	I feel lucky? 	I feel lucky? 	I feel lucky? 	I feel lucky? 	I feel lucky? 	I feel lucky? 	I feel lucky? 	
* Increases the chance of luck-based tear effects to occur, equivalent to +4 Luck	
* Increases the chance of luck-based tear effects to occur, equivalent to +4 Luck	
* Increases the chance of luck-based tear effects to occur, equivalent to +4 Luck	
* Increases the chance of luck-based tear effects to occur, equivalent to +4 Luck	
* Increases the chance of luck-based tear effects to occur, equivalent to +4 Luck	
* Increases the chance of luck-based tear effects to occur, equivalent to +4 Luck	
* Increases the chance of luck-based tear effects to occur, equivalent to +4 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as Leah 	Complete the Colosseum as Leah 	Complete the Colosseum as Leah 	Complete the Colosseum as Leah 	Complete the Colosseum as Leah 	Complete the Colosseum as Leah 	Complete the Colosseum as Leah 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Apple of Sodom 	Apple of Sodom 	Apple of Sodom 	Apple of Sodom 	Apple of Sodom 	Apple of Sodom 	Apple of Sodom 	It feels empty 	It feels empty 	It feels empty 	It feels empty 	It feels empty 	It feels empty 	It feels empty 	
* Collecting Red Hearts has a chance to cause a fart to occur, spawning Blue Spiders
* The number of Blue Spiders that spawn scales with the value of the heart
* 100% chance to occur if Isaac is at full health	
* Collecting Red Hearts has a chance to cause a fart to occur, spawning Blue Spiders
* The number of Blue Spiders that spawn scales with the value of the heart
* 100% chance to occur if Isaac is at full health	
* Collecting Red Hearts has a chance to cause a fart to occur, spawning Blue Spiders
* The number of Blue Spiders that spawn scales with the value of the heart
* 100% chance to occur if Isaac is at full health	
* Collecting Red Hearts has a chance to cause a fart to occur, spawning Blue Spiders
* The number of Blue Spiders that spawn scales with the value of the heart
* 100% chance to occur if Isaac is at full health	
* Collecting Red Hearts has a chance to cause a fart to occur, spawning Blue Spiders
* The number of Blue Spiders that spawn scales with the value of the heart
* 100% chance to occur if Isaac is at full health	
* Collecting Red Hearts has a chance to cause a fart to occur, spawning Blue Spiders
* The number of Blue Spiders that spawn scales with the value of the heart
* 100% chance to occur if Isaac is at full health	
* Collecting Red Hearts has a chance to cause a fart to occur, spawning Blue Spiders
* The number of Blue Spiders that spawn scales with the value of the heart
* 100% chance to occur if Isaac is at full health	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greed Mode as Ehud 	Complete Greed Mode as Ehud 	Complete Greed Mode as Ehud 	Complete Greed Mode as Ehud 	Complete Greed Mode as Ehud 	Complete Greed Mode as Ehud 	Complete Greed Mode as Ehud 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Forgotten Lullaby 	Forgotten Lullaby 	Forgotten Lullaby 	Forgotten Lullaby 	Forgotten Lullaby 	Forgotten Lullaby 	Forgotten Lullaby 	Sing for your friends 	Sing for your friends 	Sing for your friends 	Sing for your friends 	Sing for your friends 	Sing for your friends 	Sing for your friends 	
* Doubles the fire rate of Isaac’s shooting Familiars	
* Doubles the fire rate of Isaac’s shooting Familiars	
* Doubles the fire rate of Isaac’s shooting Familiars	
* Doubles the fire rate of Isaac’s shooting Familiars	
* Doubles the fire rate of Isaac’s shooting Familiars	
* Doubles the fire rate of Isaac’s shooting Familiars	
* Doubles the fire rate of Isaac’s shooting Familiars	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Tainted Magdalene 	Complete the Boss Rush as Tainted Magdalene 	Complete the Boss Rush as Tainted Magdalene 	Complete the Boss Rush as Tainted Magdalene 	Complete the Boss Rush as Tainted Magdalene 	Complete the Boss Rush as Tainted Magdalene 	Complete the Boss Rush as Tainted Magdalene 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Old Capacitor 	Old Capacitor 	Old Capacitor 	Old Capacitor 	Old Capacitor 	Old Capacitor 	Old Capacitor 	Voltage starving 	Voltage starving 	Voltage starving 	Voltage starving 	Voltage starving 	Voltage starving 	Voltage starving 	
* Active items no longer gain charges when clearing rooms
* Clearing a room has a luck-based chance to spawn a Lil’ Battery in addition to the regular room drops
* 33% chance at 4 Luck	
* Active items no longer gain charges when clearing rooms
* Clearing a room has a luck-based chance to spawn a Lil’ Battery in addition to the regular room drops
* 33% chance at 4 Luck	
* Active items no longer gain charges when clearing rooms
* Clearing a room has a luck-based chance to spawn a Lil’ Battery in addition to the regular room drops
* 33% chance at 4 Luck	
* Active items no longer gain charges when clearing rooms
* Clearing a room has a luck-based chance to spawn a Lil’ Battery in addition to the regular room drops
* 33% chance at 4 Luck	
* Active items no longer gain charges when clearing rooms
* Clearing a room has a luck-based chance to spawn a Lil’ Battery in addition to the regular room drops
* 33% chance at 4 Luck	
* Active items no longer gain charges when clearing rooms
* Clearing a room has a luck-based chance to spawn a Lil’ Battery in addition to the regular room drops
* 33% chance at 4 Luck	
* Active items no longer gain charges when clearing rooms
* Clearing a room has a luck-based chance to spawn a Lil’ Battery in addition to the regular room drops
* 33% chance at 4 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Perfection 	Perfection 	Perfection 	Perfection 	Perfection 	Perfection 	Perfection 	Luck way up, don’t lose it! 	Luck way up, don’t lose it! 	Luck way up, don’t lose it! 	Luck way up, don’t lose it! 	Luck way up, don’t lose it! 	Luck way up, don’t lose it! 	Luck way up, don’t lose it! 	
* +10 Luck
* Taking non-self damage drops and destroys the trinket
* Can only spawn after defeating the boss of the third floor without taking any damage in the first 3 floors	
* +10 Luck
* Taking non-self damage drops and destroys the trinket
* Can only spawn after defeating the boss of the third floor without taking any damage in the first 3 floors	
* +10 Luck
* Taking non-self damage drops and destroys the trinket
* Can only spawn after defeating the boss of the third floor without taking any damage in the first 3 floors	
* +10 Luck
* Taking non-self damage drops and destroys the trinket
* Can only spawn after defeating the boss of the third floor without taking any damage in the first 3 floors	
* +10 Luck
* Taking non-self damage drops and destroys the trinket
* Can only spawn after defeating the boss of the third floor without taking any damage in the first 3 floors	
* +10 Luck
* Taking non-self damage drops and destroys the trinket
* Can only spawn after defeating the boss of the third floor without taking any damage in the first 3 floors	
* +10 Luck
* Taking non-self damage drops and destroys the trinket
* Can only spawn after defeating the boss of the third floor without taking any damage in the first 3 floors	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete a run without taking any damage 	Complete a run without taking any damage 	Complete a run without taking any damage 	Complete a run without taking any damage 	Complete a run without taking any damage 	Complete a run without taking any damage 	Complete a run without taking any damage 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Charged Penny 	Charged Penny 	Charged Penny 	Charged Penny 	Charged Penny 	Charged Penny 	Charged Penny 	Wealth of power 	Wealth of power 	Wealth of power 	Wealth of power 	Wealth of power 	Wealth of power 	Wealth of power 	
* Collecting a coin has a chance to grant one charge to Isaac’s Active item
* The chance depends on the coin’s worth	
* Collecting a coin has a chance to grant one charge to Isaac’s Active item
* The chance depends on the coin’s worth	
* Collecting a coin has a chance to grant one charge to Isaac’s Active item
* The chance depends on the coin’s worth	
* Collecting a coin has a chance to grant one charge to Isaac’s Active item
* The chance depends on the coin’s worth	
* Collecting a coin has a chance to grant one charge to Isaac’s Active item
* The chance depends on the coin’s worth	
* Collecting a coin has a chance to grant one charge to Isaac’s Active item
* The chance depends on the coin’s worth	
* Collecting a coin has a chance to grant one charge to Isaac’s Active item
* The chance depends on the coin’s worth	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Friendship Necklace 	Friendship Necklace 	Friendship Necklace 	Friendship Necklace 	Friendship Necklace 	Friendship Necklace 	Friendship Necklace 	Gather round 	Gather round 	Gather round 	Gather round 	Gather round 	Gather round 	Gather round 	
* All of Isaac’s familiars now orbit him	
* All of Isaac’s familiars now orbit him	
* All of Isaac’s familiars now orbit him	
* All of Isaac’s familiars now orbit him	
* All of Isaac’s familiars now orbit him	
* All of Isaac’s familiars now orbit him	
* All of Isaac’s familiars now orbit him	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Magdalene 	Complete Greedier Mode as Magdalene 	Complete Greedier Mode as Magdalene 	Complete Greedier Mode as Magdalene 	Complete Greedier Mode as Magdalene 	Complete Greedier Mode as Magdalene 	Complete Greedier Mode as Magdalene 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Panic Button 	Panic Button 	Panic Button 	Panic Button 	Panic Button 	Panic Button 	Panic Button 	Push in case of emergency 	Push in case of emergency 	Push in case of emergency 	Push in case of emergency 	Push in case of emergency 	Push in case of emergency 	Push in case of emergency 	
* If Isaac were about to take damage, his Active item is activated right beforehand	
* If Isaac were about to take damage, his Active item is activated right beforehand	
* If Isaac were about to take damage, his Active item is activated right beforehand	
* If Isaac were about to take damage, his Active item is activated right beforehand	
* If Isaac were about to take damage, his Active item is activated right beforehand	
* If Isaac were about to take damage, his Active item is activated right beforehand	
* If Isaac were about to take damage, his Active item is activated right beforehand	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Telescope Lens 	Telescope Lens 	Telescope Lens 	Telescope Lens 	Telescope Lens 	Telescope Lens 	Telescope Lens 	Seek the stars 	Seek the stars 	Seek the stars 	Seek the stars 	Seek the stars 	Seek the stars 	Seek the stars 	
* Increases the chance for Planetariums to spawn by 15%
* Sets the minimum chance to encounter a Planetarium to 10%
* Planetariums can appear in Chapter 4	
* Increases the chance for Planetariums to spawn by 15%
* Sets the minimum chance to encounter a Planetarium to 10%
* Planetariums can appear in Chapter 4	
* Increases the chance for Planetariums to spawn by 15%
* Sets the minimum chance to encounter a Planetarium to 10%
* Planetariums can appear in Chapter 4	
* Increases the chance for Planetariums to spawn by 15%
* Sets the minimum chance to encounter a Planetarium to 10%
* Planetariums can appear in Chapter 4	
* Increases the chance for Planetariums to spawn by 15%
* Sets the minimum chance to encounter a Planetarium to 10%
* Planetariums can appear in Chapter 4	
* Increases the chance for Planetariums to spawn by 15%
* Sets the minimum chance to encounter a Planetarium to 10%
* Planetariums can appear in Chapter 4	
* Increases the chance for Planetariums to spawn by 15%
* Sets the minimum chance to encounter a Planetarium to 10%
* Planetariums can appear in Chapter 4	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	Enter 3 Planetariums 	Enter 3 Planetariums 	Enter 3 Planetariums 	Enter 3 Planetariums 	Enter 3 Planetariums 	Enter 3 Planetariums 	Enter 3 Planetariums 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Dice Bag 	Dice Bag 	Dice Bag 	Dice Bag 	Dice Bag 	Dice Bag 	Dice Bag 	Bonus roll 	Bonus roll 	Bonus roll 	Bonus roll 	Bonus roll 	Bonus roll 	Bonus roll 	
* Entering a hostile room has a 50% chance to grant Isaac a random Dice Shard consumable
* The Dice Shards can replace any other consumable that Isaac is holding	
* Entering a hostile room has a 50% chance to grant Isaac a random Dice Shard consumable
* The Dice Shards can replace any other consumable that Isaac is holding	
* Entering a hostile room has a 50% chance to grant Isaac a random Dice Shard consumable
* The Dice Shards can replace any other consumable that Isaac is holding	
* Entering a hostile room has a 50% chance to grant Isaac a random Dice Shard consumable
* The Dice Shards can replace any other consumable that Isaac is holding	
* Entering a hostile room has a 50% chance to grant Isaac a random Dice Shard consumable
* The Dice Shards can replace any other consumable that Isaac is holding	
* Entering a hostile room has a 50% chance to grant Isaac a random Dice Shard consumable
* The Dice Shards can replace any other consumable that Isaac is holding	
* Entering a hostile room has a 50% chance to grant Isaac a random Dice Shard consumable
* The Dice Shards can replace any other consumable that Isaac is holding	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Thanatos as Tainted Isaac 	Defeat Thanatos as Tainted Isaac 	Defeat Thanatos as Tainted Isaac 	Defeat Thanatos as Tainted Isaac 	Defeat Thanatos as Tainted Isaac 	Defeat Thanatos as Tainted Isaac 	Defeat Thanatos as Tainted Isaac 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Mother’s Kiss 	Mother’s Kiss 	Mother’s Kiss 	Mother’s Kiss 	Mother’s Kiss 	Mother’s Kiss 	Mother’s Kiss 	HP Up 	HP Up 	HP Up 	HP Up 	HP Up 	HP Up 	HP Up 	
* Grants a Heart Container while held
* Grants an extra Coin Heart as the Keeper or Tainted Keeper	
* Grants a Heart Container while held
* Grants an extra Coin Heart as the Keeper or Tainted Keeper	
* Grants a Heart Container while held
* Grants an extra Coin Heart as the Keeper or Tainted Keeper	
* Grants a Heart Container while held
* Grants an extra Coin Heart as the Keeper or Tainted Keeper	
* Grants a Heart Container while held
* Grants an extra Coin Heart as the Keeper or Tainted Keeper	
* Grants a Heart Container while held
* Grants an extra Coin Heart as the Keeper or Tainted Keeper	
* Grants a Heart Container while held
* Grants an extra Coin Heart as the Keeper or Tainted Keeper	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Torn Pocket 	Torn Pocket 	Torn Pocket 	Torn Pocket 	Torn Pocket 	Torn Pocket 	Torn Pocket 	A hole in your pocket 	A hole in your pocket 	A hole in your pocket 	A hole in your pocket 	A hole in your pocket 	A hole in your pocket 	A hole in your pocket 	
* Taking damage has Isaac drop one of his keys, coins, or bombs onto the ground
* The dropped pick-ups can be converted to other variants of themselves (i.e a dropped penny can turn into a nickel)	
* Taking damage has Isaac drop one of his keys, coins, or bombs onto the ground
* The dropped pick-ups can be converted to other variants of themselves (i.e a dropped penny can turn into a nickel)	
* Taking damage has Isaac drop one of his keys, coins, or bombs onto the ground
* The dropped pick-ups can be converted to other variants of themselves (i.e a dropped penny can turn into a nickel)	
* Taking damage has Isaac drop one of his keys, coins, or bombs onto the ground
* The dropped pick-ups can be converted to other variants of themselves (i.e a dropped penny can turn into a nickel)	
* Taking damage has Isaac drop one of his keys, coins, or bombs onto the ground
* The dropped pick-ups can be converted to other variants of themselves (i.e a dropped penny can turn into a nickel)	
* Taking damage has Isaac drop one of his keys, coins, or bombs onto the ground
* The dropped pick-ups can be converted to other variants of themselves (i.e a dropped penny can turn into a nickel)	
* Taking damage has Isaac drop one of his keys, coins, or bombs onto the ground
* The dropped pick-ups can be converted to other variants of themselves (i.e a dropped penny can turn into a nickel)	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as Tainted Alexandria 	Defeat Mommy & Daddy as Tainted Alexandria 	Defeat Mommy & Daddy as Tainted Alexandria 	Defeat Mommy & Daddy as Tainted Alexandria 	Defeat Mommy & Daddy as Tainted Alexandria 	Defeat Mommy & Daddy as Tainted Alexandria 	Defeat Mommy & Daddy as Tainted Alexandria 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Gilded Key 	Gilded Key 	Gilded Key 	Gilded Key 	Gilded Key 	Gilded Key 	Gilded Key 	Less is more 	Less is more 	Less is more 	Less is more 	Less is more 	Less is more 	Less is more 	
* Grants one key when picked up for the first time
* All chests are converted into Locked Chests
* Locked Chests can now drop more pick-ups when opened	
* Grants one key when picked up for the first time
* All chests are converted into Locked Chests
* Locked Chests can now drop more pick-ups when opened	
* Grants one key when picked up for the first time
* All chests are converted into Locked Chests
* Locked Chests can now drop more pick-ups when opened	
* Grants one key when picked up for the first time
* All chests are converted into Locked Chests
* Locked Chests can now drop more pick-ups when opened	
* Grants one key when picked up for the first time
* All chests are converted into Locked Chests
* Locked Chests can now drop more pick-ups when opened	
* Grants one key when picked up for the first time
* All chests are converted into Locked Chests
* Locked Chests can now drop more pick-ups when opened	
* Grants one key when picked up for the first time
* All chests are converted into Locked Chests
* Locked Chests can now drop more pick-ups when opened	
* 
* 
*	
* 
* 
*	
* 
* 
*	
* 
* 
*	
* 
* 
*	
* 
* 
*	
* 
* 
*	Defeat Mother’s Soul as Tainted Cain 	Defeat Mother’s Soul as Tainted Cain 	Defeat Mother’s Soul as Tainted Cain 	Defeat Mother’s Soul as Tainted Cain 	Defeat Mother’s Soul as Tainted Cain 	Defeat Mother’s Soul as Tainted Cain 	Defeat Mother’s Soul as Tainted Cain 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Dingle Berry 	Dingle Berry 	Dingle Berry 	Dingle Berry 	Dingle Berry 	Dingle Berry 	Dingle Berry 	Oops! 	Oops! 	Oops! 	Oops! 	Oops! 	Oops! 	Oops! 	
* Killing an enemy spawns a random friendly Dip
* Makes all Dip enemies friendly	
* Killing an enemy spawns a random friendly Dip
* Makes all Dip enemies friendly	
* Killing an enemy spawns a random friendly Dip
* Makes all Dip enemies friendly	
* Killing an enemy spawns a random friendly Dip
* Makes all Dip enemies friendly	
* Killing an enemy spawns a random friendly Dip
* Makes all Dip enemies friendly	
* Killing an enemy spawns a random friendly Dip
* Makes all Dip enemies friendly	
* Killing an enemy spawns a random friendly Dip
* Makes all Dip enemies friendly	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as Tainted ??? 	Defeat Mommy & Daddy as Tainted ??? 	Defeat Mommy & Daddy as Tainted ??? 	Defeat Mommy & Daddy as Tainted ??? 	Defeat Mommy & Daddy as Tainted ??? 	Defeat Mommy & Daddy as Tainted ??? 	Defeat Mommy & Daddy as Tainted ??? 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Nuh-uh! 	Nuh-uh! 	Nuh-uh! 	Nuh-uh! 	Nuh-uh! 	Nuh-uh! 	Nuh-uh! 	Don’t want! 	Don’t want! 	Don’t want! 	Don’t want! 	Don’t want! 	Don’t want! 	Don’t want! 	
* Keys and coins that spawn in Chapter 4 and beyond are replaced with another random pick-up	
* Keys and coins that spawn in Chapter 4 and beyond are replaced with another random pick-up	
* Keys and coins that spawn in Chapter 4 and beyond are replaced with another random pick-up	
* Keys and coins that spawn in Chapter 4 and beyond are replaced with another random pick-up	
* Keys and coins that spawn in Chapter 4 and beyond are replaced with another random pick-up	
* Keys and coins that spawn in Chapter 4 and beyond are replaced with another random pick-up	
* Keys and coins that spawn in Chapter 4 and beyond are replaced with another random pick-up	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Onlookers as Lilith’ 	Defeat the Onlookers as Lilith’ 	Defeat the Onlookers as Lilith’ 	Defeat the Onlookers as Lilith’ 	Defeat the Onlookers as Lilith’ 	Defeat the Onlookers as Lilith’ 	Defeat the Onlookers as Lilith’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Kid’s Drawing 	Kid’s Drawing 	Kid’s Drawing 	Kid’s Drawing 	Kid’s Drawing 	Kid’s Drawing 	Kid’s Drawing 	Looks familiar… 	Looks familiar… 	Looks familiar… 	Looks familiar… 	Looks familiar… 	Looks familiar… 	Looks familiar… 	
* When dead, the player respawns as Guppy in the previous room, destroying the trinket in the process
* Tainted Guppy respawns as himself	
* When dead, the player respawns as Guppy in the previous room, destroying the trinket in the process
* Tainted Guppy respawns as himself	
* When dead, the player respawns as Guppy in the previous room, destroying the trinket in the process
* Tainted Guppy respawns as himself	
* When dead, the player respawns as Guppy in the previous room, destroying the trinket in the process
* Tainted Guppy respawns as himself	
* When dead, the player respawns as Guppy in the previous room, destroying the trinket in the process
* Tainted Guppy respawns as himself	
* When dead, the player respawns as Guppy in the previous room, destroying the trinket in the process
* Tainted Guppy respawns as himself	
* When dead, the player respawns as Guppy in the previous room, destroying the trinket in the process
* Tainted Guppy respawns as himself	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
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* 
*	
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* 
* 
*	Obtain all completion marks as Guppy 	Obtain all completion marks as Guppy 	Obtain all completion marks as Guppy 	Obtain all completion marks as Guppy 	Obtain all completion marks as Guppy 	Obtain all completion marks as Guppy 	Obtain all completion marks as Guppy 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Keeper’s Bargain 	Keeper’s Bargain 	Keeper’s Bargain 	Keeper’s Bargain 	Keeper’s Bargain 	Keeper’s Bargain 	Keeper’s Bargain 	Money talks 	Money talks 	Money talks 	Money talks 	Money talks 	Money talks 	Money talks 	
* Devil Deals and Black Market items have a chance to cost coins instead of health
* 1 health deals cost 15 coins, while 2 health deals cost 30 coins	
* Devil Deals and Black Market items have a chance to cost coins instead of health
* 1 health deals cost 15 coins, while 2 health deals cost 30 coins	
* Devil Deals and Black Market items have a chance to cost coins instead of health
* 1 health deals cost 15 coins, while 2 health deals cost 30 coins	
* Devil Deals and Black Market items have a chance to cost coins instead of health
* 1 health deals cost 15 coins, while 2 health deals cost 30 coins	
* Devil Deals and Black Market items have a chance to cost coins instead of health
* 1 health deals cost 15 coins, while 2 health deals cost 30 coins	
* Devil Deals and Black Market items have a chance to cost coins instead of health
* 1 health deals cost 15 coins, while 2 health deals cost 30 coins	
* Devil Deals and Black Market items have a chance to cost coins instead of health
* 1 health deals cost 15 coins, while 2 health deals cost 30 coins	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as Tainted Keeper 	Complete the Colosseum as Tainted Keeper 	Complete the Colosseum as Tainted Keeper 	Complete the Colosseum as Tainted Keeper 	Complete the Colosseum as Tainted Keeper 	Complete the Colosseum as Tainted Keeper 	Complete the Colosseum as Tainted Keeper 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Cursed Penny 	Cursed Penny 	Cursed Penny 	Cursed Penny 	Cursed Penny 	Cursed Penny 	Cursed Penny 	Wealth of misery 	Wealth of misery 	Wealth of misery 	Wealth of misery 	Wealth of misery 	Wealth of misery 	Wealth of misery 	
* Collecting a coin teleports Isaac to a random room	
* Collecting a coin teleports Isaac to a random room	
* Collecting a coin teleports Isaac to a random room	
* Collecting a coin teleports Isaac to a random room	
* Collecting a coin teleports Isaac to a random room	
* Collecting a coin teleports Isaac to a random room	
* Collecting a coin teleports Isaac to a random room	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat The Onlookers as Tainted Keeper 	Defeat The Onlookers as Tainted Keeper 	Defeat The Onlookers as Tainted Keeper 	Defeat The Onlookers as Tainted Keeper 	Defeat The Onlookers as Tainted Keeper 	Defeat The Onlookers as Tainted Keeper 	Defeat The Onlookers as Tainted Keeper 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Your Soul 	Your Soul 	Your Soul 	Your Soul 	Your Soul 	Your Soul 	Your Soul 	Give it to me 	Give it to me 	Give it to me 	Give it to me 	Give it to me 	Give it to me 	Give it to me 	
* Taking a Devil Deal or Black Market item destroys the trinket and grants it to Isaac for free	
* Taking a Devil Deal or Black Market item destroys the trinket and grants it to Isaac for free	
* Taking a Devil Deal or Black Market item destroys the trinket and grants it to Isaac for free	
* Taking a Devil Deal or Black Market item destroys the trinket and grants it to Isaac for free	
* Taking a Devil Deal or Black Market item destroys the trinket and grants it to Isaac for free	
* Taking a Devil Deal or Black Market item destroys the trinket and grants it to Isaac for free	
* Taking a Devil Deal or Black Market item destroys the trinket and grants it to Isaac for free	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Azazel 	Complete the Boss Rush as Azazel 	Complete the Boss Rush as Azazel 	Complete the Boss Rush as Azazel 	Complete the Boss Rush as Azazel 	Complete the Boss Rush as Azazel 	Complete the Boss Rush as Azazel 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Number Magnet 	Number Magnet 	Number Magnet 	Number Magnet 	Number Magnet 	Number Magnet 	Number Magnet 	6 	6 	6 	6 	6 	6 	6 	
* +10% Devil Deal chance
* Improves the layout of Devil Deals, having them contain more items inside, as well as bonuses in the form of Black Hearts and Red Chests	
* +10% Devil Deal chance
* Improves the layout of Devil Deals, having them contain more items inside, as well as bonuses in the form of Black Hearts and Red Chests	
* +10% Devil Deal chance
* Improves the layout of Devil Deals, having them contain more items inside, as well as bonuses in the form of Black Hearts and Red Chests	
* +10% Devil Deal chance
* Improves the layout of Devil Deals, having them contain more items inside, as well as bonuses in the form of Black Hearts and Red Chests	
* +10% Devil Deal chance
* Improves the layout of Devil Deals, having them contain more items inside, as well as bonuses in the form of Black Hearts and Red Chests	
* +10% Devil Deal chance
* Improves the layout of Devil Deals, having them contain more items inside, as well as bonuses in the form of Black Hearts and Red Chests	
* +10% Devil Deal chance
* Improves the layout of Devil Deals, having them contain more items inside, as well as bonuses in the form of Black Hearts and Red Chests	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Thanatos as Tainted Judas 	Defeat Thanatos as Tainted Judas 	Defeat Thanatos as Tainted Judas 	Defeat Thanatos as Tainted Judas 	Defeat Thanatos as Tainted Judas 	Defeat Thanatos as Tainted Judas 	Defeat Thanatos as Tainted Judas 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Lil’ Clot 	Lil’ Clot 	Lil’ Clot 	Lil’ Clot 	Lil’ Clot 	Lil’ Clot 	Lil’ Clot 	Mini friend 	Mini friend 	Mini friend 	Mini friend 	Mini friend 	Mini friend 	Mini friend 	
* Spawns a Blood Clot familiar that moves and shoots using the same inputs as Isaac, copying his stats and tear effects and dealing 0.35x his damage
* Dies in 3 hits, but respawns on room clear.	
* Spawns a Blood Clot familiar that moves and shoots using the same inputs as Isaac, copying his stats and tear effects and dealing 0.35x his damage
* Dies in 3 hits, but respawns on room clear.	
* Spawns a Blood Clot familiar that moves and shoots using the same inputs as Isaac, copying his stats and tear effects and dealing 0.35x his damage
* Dies in 3 hits, but respawns on room clear.	
* Spawns a Blood Clot familiar that moves and shoots using the same inputs as Isaac, copying his stats and tear effects and dealing 0.35x his damage
* Dies in 3 hits, but respawns on room clear.	
* Spawns a Blood Clot familiar that moves and shoots using the same inputs as Isaac, copying his stats and tear effects and dealing 0.35x his damage
* Dies in 3 hits, but respawns on room clear.	
* Spawns a Blood Clot familiar that moves and shoots using the same inputs as Isaac, copying his stats and tear effects and dealing 0.35x his damage
* Dies in 3 hits, but respawns on room clear.	
* Spawns a Blood Clot familiar that moves and shoots using the same inputs as Isaac, copying his stats and tear effects and dealing 0.35x his damage
* Dies in 3 hits, but respawns on room clear.	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mother’s Soul as Tainted Eve 	Defeat Mother’s Soul as Tainted Eve 	Defeat Mother’s Soul as Tainted Eve 	Defeat Mother’s Soul as Tainted Eve 	Defeat Mother’s Soul as Tainted Eve 	Defeat Mother’s Soul as Tainted Eve 	Defeat Mother’s Soul as Tainted Eve 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Temporary Tattoo 	Temporary Tattoo 	Temporary Tattoo 	Temporary Tattoo 	Temporary Tattoo 	Temporary Tattoo 	Temporary Tattoo 	You feel braver 	You feel braver 	You feel braver 	You feel braver 	You feel braver 	You feel braver 	You feel braver 	
* Spawns a chest after clearing a Challenge Room
* Spawns a Boss item after clearing a Boss Challenge Room	
* Spawns a chest after clearing a Challenge Room
* Spawns a Boss item after clearing a Boss Challenge Room	
* Spawns a chest after clearing a Challenge Room
* Spawns a Boss item after clearing a Boss Challenge Room	
* Spawns a chest after clearing a Challenge Room
* Spawns a Boss item after clearing a Boss Challenge Room	
* Spawns a chest after clearing a Challenge Room
* Spawns a Boss item after clearing a Boss Challenge Room	
* Spawns a chest after clearing a Challenge Room
* Spawns a Boss item after clearing a Boss Challenge Room	
* Spawns a chest after clearing a Challenge Room
* Spawns a Boss item after clearing a Boss Challenge Room	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
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* 
* 
*	
* 
* 
* 
*	Complete Greedier Mode as Tainted Samson 	Complete Greedier Mode as Tainted Samson 	Complete Greedier Mode as Tainted Samson 	Complete Greedier Mode as Tainted Samson 	Complete Greedier Mode as Tainted Samson 	Complete Greedier Mode as Tainted Samson 	Complete Greedier Mode as Tainted Samson 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Swallowed M80 	Swallowed M80 	Swallowed M80 	Swallowed M80 	Swallowed M80 	Swallowed M80 	Swallowed M80 	Bang! 	Bang! 	Bang! 	Bang! 	Bang! 	Bang! 	Bang! 	
* Taking damage has a 50% chance for Isaac to explode, dealing heavy damage to nearby enemies and destroying grid objects
* The explosion copies all of Isaac’s bomb effects	
* Taking damage has a 50% chance for Isaac to explode, dealing heavy damage to nearby enemies and destroying grid objects
* The explosion copies all of Isaac’s bomb effects	
* Taking damage has a 50% chance for Isaac to explode, dealing heavy damage to nearby enemies and destroying grid objects
* The explosion copies all of Isaac’s bomb effects	
* Taking damage has a 50% chance for Isaac to explode, dealing heavy damage to nearby enemies and destroying grid objects
* The explosion copies all of Isaac’s bomb effects	
* Taking damage has a 50% chance for Isaac to explode, dealing heavy damage to nearby enemies and destroying grid objects
* The explosion copies all of Isaac’s bomb effects	
* Taking damage has a 50% chance for Isaac to explode, dealing heavy damage to nearby enemies and destroying grid objects
* The explosion copies all of Isaac’s bomb effects	
* Taking damage has a 50% chance for Isaac to explode, dealing heavy damage to nearby enemies and destroying grid objects
* The explosion copies all of Isaac’s bomb effects	
* 
* 	
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* 	
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* 	
* 
* 	Complete the Boss Rush as Tainted Ehud 	Complete the Boss Rush as Tainted Ehud 	Complete the Boss Rush as Tainted Ehud 	Complete the Boss Rush as Tainted Ehud 	Complete the Boss Rush as Tainted Ehud 	Complete the Boss Rush as Tainted Ehud 	Complete the Boss Rush as Tainted Ehud 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
RC Remote 	RC Remote 	RC Remote 	RC Remote 	RC Remote 	RC Remote 	RC Remote 	Controllable buddys! 	Controllable buddys! 	Controllable buddys! 	Controllable buddys! 	Controllable buddys! 	Controllable buddys! 	Controllable buddys! 	
* Isaac’s familiars are now controlled with Isaac’s inputs, similarly to Jacob & Esau
* Familiars can be held in place by holding the drop button	
* Isaac’s familiars are now controlled with Isaac’s inputs, similarly to Jacob & Esau
* Familiars can be held in place by holding the drop button	
* Isaac’s familiars are now controlled with Isaac’s inputs, similarly to Jacob & Esau
* Familiars can be held in place by holding the drop button	
* Isaac’s familiars are now controlled with Isaac’s inputs, similarly to Jacob & Esau
* Familiars can be held in place by holding the drop button	
* Isaac’s familiars are now controlled with Isaac’s inputs, similarly to Jacob & Esau
* Familiars can be held in place by holding the drop button	
* Isaac’s familiars are now controlled with Isaac’s inputs, similarly to Jacob & Esau
* Familiars can be held in place by holding the drop button	
* Isaac’s familiars are now controlled with Isaac’s inputs, similarly to Jacob & Esau
* Familiars can be held in place by holding the drop button	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greed Mode as Jacob & Esau 	Complete Greed Mode as Jacob & Esau 	Complete Greed Mode as Jacob & Esau 	Complete Greed Mode as Jacob & Esau 	Complete Greed Mode as Jacob & Esau 	Complete Greed Mode as Jacob & Esau 	Complete Greed Mode as Jacob & Esau 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Expansion Pack 	Expansion Pack 	Expansion Pack 	Expansion Pack 	Expansion Pack 	Expansion Pack 	Expansion Pack 	Fun extras 	Fun extras 	Fun extras 	Fun extras 	Fun extras 	Fun extras 	Fun extras 	
* Using an Active item activates an additional effect of another Active item
* The other effect activated will always be from an Active item with 1 - 2 charges	
* Using an Active item activates an additional effect of another Active item
* The other effect activated will always be from an Active item with 1 - 2 charges	
* Using an Active item activates an additional effect of another Active item
* The other effect activated will always be from an Active item with 1 - 2 charges	
* Using an Active item activates an additional effect of another Active item
* The other effect activated will always be from an Active item with 1 - 2 charges	
* Using an Active item activates an additional effect of another Active item
* The other effect activated will always be from an Active item with 1 - 2 charges	
* Using an Active item activates an additional effect of another Active item
* The other effect activated will always be from an Active item with 1 - 2 charges	
* Using an Active item activates an additional effect of another Active item
* The other effect activated will always be from an Active item with 1 - 2 charges	
* 
* 	
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* 	
* 
* 	Complete the Colosseum as Tainted Eden 	Complete the Colosseum as Tainted Eden 	Complete the Colosseum as Tainted Eden 	Complete the Colosseum as Tainted Eden 	Complete the Colosseum as Tainted Eden 	Complete the Colosseum as Tainted Eden 	Complete the Colosseum as Tainted Eden 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
The Twins 	The Twins 	The Twins 	The Twins 	The Twins 	The Twins 	The Twins 	I’m seeing double… 	I’m seeing double… 	I’m seeing double… 	I’m seeing double… 	I’m seeing double… 	I’m seeing double… 	I’m seeing double… 	
* Entering a hostile room has a 50% chance to spawn a clone of one of Isaac’s Familiars for the current room
* If Isaac has no Familiars, then there is a chance to grant him Brother Bobby or Sister Maggy for the room instead	
* Entering a hostile room has a 50% chance to spawn a clone of one of Isaac’s Familiars for the current room
* If Isaac has no Familiars, then there is a chance to grant him Brother Bobby or Sister Maggy for the room instead	
* Entering a hostile room has a 50% chance to spawn a clone of one of Isaac’s Familiars for the current room
* If Isaac has no Familiars, then there is a chance to grant him Brother Bobby or Sister Maggy for the room instead	
* Entering a hostile room has a 50% chance to spawn a clone of one of Isaac’s Familiars for the current room
* If Isaac has no Familiars, then there is a chance to grant him Brother Bobby or Sister Maggy for the room instead	
* Entering a hostile room has a 50% chance to spawn a clone of one of Isaac’s Familiars for the current room
* If Isaac has no Familiars, then there is a chance to grant him Brother Bobby or Sister Maggy for the room instead	
* Entering a hostile room has a 50% chance to spawn a clone of one of Isaac’s Familiars for the current room
* If Isaac has no Familiars, then there is a chance to grant him Brother Bobby or Sister Maggy for the room instead	
* Entering a hostile room has a 50% chance to spawn a clone of one of Isaac’s Familiars for the current room
* If Isaac has no Familiars, then there is a chance to grant him Brother Bobby or Sister Maggy for the room instead	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Everything as Tainted Lilith 	Defeat Everything as Tainted Lilith 	Defeat Everything as Tainted Lilith 	Defeat Everything as Tainted Lilith 	Defeat Everything as Tainted Lilith 	Defeat Everything as Tainted Lilith 	Defeat Everything as Tainted Lilith 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Adoption Papers 	Adoption Papers 	Adoption Papers 	Adoption Papers 	Adoption Papers 	Adoption Papers 	Adoption Papers 	Give them a home 	Give them a home 	Give them a home 	Give them a home 	Give them a home 	Give them a home 	Give them a home 	
* Shops now sell an assortment of Familiars for 10 coins instead of regular items	
* Shops now sell an assortment of Familiars for 10 coins instead of regular items	
* Shops now sell an assortment of Familiars for 10 coins instead of regular items	
* Shops now sell an assortment of Familiars for 10 coins instead of regular items	
* Shops now sell an assortment of Familiars for 10 coins instead of regular items	
* Shops now sell an assortment of Familiars for 10 coins instead of regular items	
* Shops now sell an assortment of Familiars for 10 coins instead of regular items	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
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* 	
* 
* 	Defeat the Onlookers as Tainted Lilith 	Defeat the Onlookers as Tainted Lilith 	Defeat the Onlookers as Tainted Lilith 	Defeat the Onlookers as Tainted Lilith 	Defeat the Onlookers as Tainted Lilith 	Defeat the Onlookers as Tainted Lilith 	Defeat the Onlookers as Tainted Lilith 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Apollyon’s Best Friend 	Apollyon’s Best Friend 	Apollyon’s Best Friend 	Apollyon’s Best Friend 	Apollyon’s Best Friend 	Apollyon’s Best Friend 	Apollyon’s Best Friend 	Attack buddy 	Attack buddy 	Attack buddy 	Attack buddy 	Attack buddy 	Attack buddy 	Attack buddy 	
* Grants Isaac 1 Abyss Locust while held	
* Grants Isaac 1 Abyss Locust while held	
* Grants Isaac 1 Abyss Locust while held	
* Grants Isaac 1 Abyss Locust while held	
* Grants Isaac 1 Abyss Locust while held	
* Grants Isaac 1 Abyss Locust while held	
* Grants Isaac 1 Abyss Locust while held	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Onlookers as Tainted Apollyon 	Defeat the Onlookers as Tainted Apollyon 	Defeat the Onlookers as Tainted Apollyon 	Defeat the Onlookers as Tainted Apollyon 	Defeat the Onlookers as Tainted Apollyon 	Defeat the Onlookers as Tainted Apollyon 	Defeat the Onlookers as Tainted Apollyon 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Ice Cube 	Ice Cube 	Ice Cube 	Ice Cube 	Ice Cube 	Ice Cube 	Ice Cube 	Stay frosty 	Stay frosty 	Stay frosty 	Stay frosty 	Stay frosty 	Stay frosty 	Stay frosty 	
* Entering a hostile room grants a 20% chance for each enemy to be inflicted with Chill
* Chilled enemies are slowed down and are frozen on death, in which they can be kicked towards enemies to Chill them and smash into a spread of 8 icicle projectiles on contact
* 100% chance at 40 Luck	
* Entering a hostile room grants a 20% chance for each enemy to be inflicted with Chill
* Chilled enemies are slowed down and are frozen on death, in which they can be kicked towards enemies to Chill them and smash into a spread of 8 icicle projectiles on contact
* 100% chance at 40 Luck	
* Entering a hostile room grants a 20% chance for each enemy to be inflicted with Chill
* Chilled enemies are slowed down and are frozen on death, in which they can be kicked towards enemies to Chill them and smash into a spread of 8 icicle projectiles on contact
* 100% chance at 40 Luck	
* Entering a hostile room grants a 20% chance for each enemy to be inflicted with Chill
* Chilled enemies are slowed down and are frozen on death, in which they can be kicked towards enemies to Chill them and smash into a spread of 8 icicle projectiles on contact
* 100% chance at 40 Luck	
* Entering a hostile room grants a 20% chance for each enemy to be inflicted with Chill
* Chilled enemies are slowed down and are frozen on death, in which they can be kicked towards enemies to Chill them and smash into a spread of 8 icicle projectiles on contact
* 100% chance at 40 Luck	
* Entering a hostile room grants a 20% chance for each enemy to be inflicted with Chill
* Chilled enemies are slowed down and are frozen on death, in which they can be kicked towards enemies to Chill them and smash into a spread of 8 icicle projectiles on contact
* 100% chance at 40 Luck	
* Entering a hostile room grants a 20% chance for each enemy to be inflicted with Chill
* Chilled enemies are slowed down and are frozen on death, in which they can be kicked towards enemies to Chill them and smash into a spread of 8 icicle projectiles on contact
* 100% chance at 40 Luck	
* 
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* 	Defeat Mommy & Daddy as Tainted Guppy 	Defeat Mommy & Daddy as Tainted Guppy 	Defeat Mommy & Daddy as Tainted Guppy 	Defeat Mommy & Daddy as Tainted Guppy 	Defeat Mommy & Daddy as Tainted Guppy 	Defeat Mommy & Daddy as Tainted Guppy 	Defeat Mommy & Daddy as Tainted Guppy 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
20 Ton Weight 	20 Ton Weight 	20 Ton Weight 	20 Ton Weight 	20 Ton Weight 	20 Ton Weight 	20 Ton Weight 	Weighed down 	Weighed down 	Weighed down 	Weighed down 	Weighed down 	Weighed down 	Weighed down 	
* Flying enemies are now stuck to the ground and can no longer fly
* Enemies that are affected by this are heavily slowed down and can be damaged by creep, spikes and other grounded attacks, and cannot fly over obstacles
* Flying enemies, if stuck, can slowly fly over obstacles before falling back down	
* Flying enemies are now stuck to the ground and can no longer fly
* Enemies that are affected by this are heavily slowed down and can be damaged by creep, spikes and other grounded attacks, and cannot fly over obstacles
* Flying enemies, if stuck, can slowly fly over obstacles before falling back down	
* Flying enemies are now stuck to the ground and can no longer fly
* Enemies that are affected by this are heavily slowed down and can be damaged by creep, spikes and other grounded attacks, and cannot fly over obstacles
* Flying enemies, if stuck, can slowly fly over obstacles before falling back down	
* Flying enemies are now stuck to the ground and can no longer fly
* Enemies that are affected by this are heavily slowed down and can be damaged by creep, spikes and other grounded attacks, and cannot fly over obstacles
* Flying enemies, if stuck, can slowly fly over obstacles before falling back down	
* Flying enemies are now stuck to the ground and can no longer fly
* Enemies that are affected by this are heavily slowed down and can be damaged by creep, spikes and other grounded attacks, and cannot fly over obstacles
* Flying enemies, if stuck, can slowly fly over obstacles before falling back down	
* Flying enemies are now stuck to the ground and can no longer fly
* Enemies that are affected by this are heavily slowed down and can be damaged by creep, spikes and other grounded attacks, and cannot fly over obstacles
* Flying enemies, if stuck, can slowly fly over obstacles before falling back down	
* Flying enemies are now stuck to the ground and can no longer fly
* Enemies that are affected by this are heavily slowed down and can be damaged by creep, spikes and other grounded attacks, and cannot fly over obstacles
* Flying enemies, if stuck, can slowly fly over obstacles before falling back down	
* 
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* 	Defeat Mother’s Soul as Samson 	Defeat Mother’s Soul as Samson 	Defeat Mother’s Soul as Samson 	Defeat Mother’s Soul as Samson 	Defeat Mother’s Soul as Samson 	Defeat Mother’s Soul as Samson 	Defeat Mother’s Soul as Samson 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Beth’s Hope 	Beth’s Hope 	Beth’s Hope 	Beth’s Hope 	Beth’s Hope 	Beth’s Hope 	Beth’s Hope 	Prevail 	Prevail 	Prevail 	Prevail 	Prevail 	Prevail 	Prevail 	
* Fighting an end-game boss (Mommy & Daddy, The Onlookers, etc.) grants Isaac a +20% damage up, a +10% tears up, and flight	
* Fighting an end-game boss (Mommy & Daddy, The Onlookers, etc.) grants Isaac a +20% damage up, a +10% tears up, and flight	
* Fighting an end-game boss (Mommy & Daddy, The Onlookers, etc.) grants Isaac a +20% damage up, a +10% tears up, and flight	
* Fighting an end-game boss (Mommy & Daddy, The Onlookers, etc.) grants Isaac a +20% damage up, a +10% tears up, and flight	
* Fighting an end-game boss (Mommy & Daddy, The Onlookers, etc.) grants Isaac a +20% damage up, a +10% tears up, and flight	
* Fighting an end-game boss (Mommy & Daddy, The Onlookers, etc.) grants Isaac a +20% damage up, a +10% tears up, and flight	
* Fighting an end-game boss (Mommy & Daddy, The Onlookers, etc.) grants Isaac a +20% damage up, a +10% tears up, and flight	
* 
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* 	Defeat Everything as Bethany 	Defeat Everything as Bethany 	Defeat Everything as Bethany 	Defeat Everything as Bethany 	Defeat Everything as Bethany 	Defeat Everything as Bethany 	Defeat Everything as Bethany 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Blank Shell 	Blank Shell 	Blank Shell 	Blank Shell 	Blank Shell 	Blank Shell 	Blank Shell 	No more bullets! 	No more bullets! 	No more bullets! 	No more bullets! 	No more bullets! 	No more bullets! 	No more bullets! 	
* Clearing a room removes all enemy projectiles, enemy creep, and hostile obstacles	
* Clearing a room removes all enemy projectiles, enemy creep, and hostile obstacles	
* Clearing a room removes all enemy projectiles, enemy creep, and hostile obstacles	
* Clearing a room removes all enemy projectiles, enemy creep, and hostile obstacles	
* Clearing a room removes all enemy projectiles, enemy creep, and hostile obstacles	
* Clearing a room removes all enemy projectiles, enemy creep, and hostile obstacles	
* Clearing a room removes all enemy projectiles, enemy creep, and hostile obstacles	
* 
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* 	Complete the challenge ‘Enter the Forest’ 	Complete the challenge ‘Enter the Forest’ 	Complete the challenge ‘Enter the Forest’ 	Complete the challenge ‘Enter the Forest’ 	Complete the challenge ‘Enter the Forest’ 	Complete the challenge ‘Enter the Forest’ 	Complete the challenge ‘Enter the Forest’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Broken Chain 	Broken Chain 	Broken Chain 	Broken Chain 	Broken Chain 	Broken Chain 	Broken Chain 	Charred shots 	Charred shots 	Charred shots 	Charred shots 	Charred shots 	Charred shots 	Charred shots 	
* Hitting an enemy has a luck-based chance to ensnare them in Anima Sola chains for 2 seconds
* 100% chance at 37 Luck	
* Hitting an enemy has a luck-based chance to ensnare them in Anima Sola chains for 2 seconds
* 100% chance at 37 Luck	
* Hitting an enemy has a luck-based chance to ensnare them in Anima Sola chains for 2 seconds
* 100% chance at 37 Luck	
* Hitting an enemy has a luck-based chance to ensnare them in Anima Sola chains for 2 seconds
* 100% chance at 37 Luck	
* Hitting an enemy has a luck-based chance to ensnare them in Anima Sola chains for 2 seconds
* 100% chance at 37 Luck	
* Hitting an enemy has a luck-based chance to ensnare them in Anima Sola chains for 2 seconds
* 100% chance at 37 Luck	
* Hitting an enemy has a luck-based chance to ensnare them in Anima Sola chains for 2 seconds
* 100% chance at 37 Luck	
* 
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* 	Defeat Mother’s Soul as Tainted Jacob’ 	Defeat Mother’s Soul as Tainted Jacob’ 	Defeat Mother’s Soul as Tainted Jacob’ 	Defeat Mother’s Soul as Tainted Jacob’ 	Defeat Mother’s Soul as Tainted Jacob’ 	Defeat Mother’s Soul as Tainted Jacob’ 	Defeat Mother’s Soul as Tainted Jacob’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Dad’s Wallet 	Dad’s Wallet 	Dad’s Wallet 	Dad’s Wallet 	Dad’s Wallet 	Dad’s Wallet 	Dad’s Wallet 	It’s empty… 	It’s empty… 	It’s empty… 	It’s empty… 	It’s empty… 	It’s empty… 	It’s empty… 	
* While held, increases the amount of coins Isaac can carry to 150
* Dropping the trinket with over 99 coins will keep the remaining coins within the wallet until you pick it back up	
* While held, increases the amount of coins Isaac can carry to 150
* Dropping the trinket with over 99 coins will keep the remaining coins within the wallet until you pick it back up	
* While held, increases the amount of coins Isaac can carry to 150
* Dropping the trinket with over 99 coins will keep the remaining coins within the wallet until you pick it back up	
* While held, increases the amount of coins Isaac can carry to 150
* Dropping the trinket with over 99 coins will keep the remaining coins within the wallet until you pick it back up	
* While held, increases the amount of coins Isaac can carry to 150
* Dropping the trinket with over 99 coins will keep the remaining coins within the wallet until you pick it back up	
* While held, increases the amount of coins Isaac can carry to 150
* Dropping the trinket with over 99 coins will keep the remaining coins within the wallet until you pick it back up	
* While held, increases the amount of coins Isaac can carry to 150
* Dropping the trinket with over 99 coins will keep the remaining coins within the wallet until you pick it back up	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Boss Rush as Tainted Isaac 	Complete the Boss Rush as Tainted Isaac 	Complete the Boss Rush as Tainted Isaac 	Complete the Boss Rush as Tainted Isaac 	Complete the Boss Rush as Tainted Isaac 	Complete the Boss Rush as Tainted Isaac 	Complete the Boss Rush as Tainted Isaac 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Glitch Penny 	Glitch Penny 	Glitch Penny 	Glitch Penny 	Glitch Penny 	Glitch Penny 	Glitch Penny 	description="Wealth oofofofoffogfof" gfx="trinke	description="Wealth oofofofoffogfof" gfx="trinke	description="Wealth oofofofoffogfof" gfx="trinke	description="Wealth oofofofoffogfof" gfx="trinke	description="Wealth oofofofoffogfof" gfx="trinke	description="Wealth oofofofoffogfof" gfx="trinke	description="Wealth oofofofoffogfof" gfx="trinke	
* Collecting a coin has a chance to reroll a random Passive item that Isaac has
* The chance is based on the coin’s value
* Rerolled items always retain the item pool they came from	
* Collecting a coin has a chance to reroll a random Passive item that Isaac has
* The chance is based on the coin’s value
* Rerolled items always retain the item pool they came from	
* Collecting a coin has a chance to reroll a random Passive item that Isaac has
* The chance is based on the coin’s value
* Rerolled items always retain the item pool they came from	
* Collecting a coin has a chance to reroll a random Passive item that Isaac has
* The chance is based on the coin’s value
* Rerolled items always retain the item pool they came from	
* Collecting a coin has a chance to reroll a random Passive item that Isaac has
* The chance is based on the coin’s value
* Rerolled items always retain the item pool they came from	
* Collecting a coin has a chance to reroll a random Passive item that Isaac has
* The chance is based on the coin’s value
* Rerolled items always retain the item pool they came from	
* Collecting a coin has a chance to reroll a random Passive item that Isaac has
* The chance is based on the coin’s value
* Rerolled items always retain the item pool they came from	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Tainted Eden 	Complete Greedier Mode as Tainted Eden 	Complete Greedier Mode as Tainted Eden 	Complete Greedier Mode as Tainted Eden 	Complete Greedier Mode as Tainted Eden 	Complete Greedier Mode as Tainted Eden 	Complete Greedier Mode as Tainted Eden 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Happy Pills 	Happy Pills 	Happy Pills 	Happy Pills 	Happy Pills 	Happy Pills 	Happy Pills 	Can’t live without ‘em 	Can’t live without ‘em 	Can’t live without ‘em 	Can’t live without ‘em 	Can’t live without ‘em 	Can’t live without ‘em 	Can’t live without ‘em 	
* Taking a pill has a 50% chance to heal Isaac for half a heart	
* Taking a pill has a 50% chance to heal Isaac for half a heart	
* Taking a pill has a 50% chance to heal Isaac for half a heart	
* Taking a pill has a 50% chance to heal Isaac for half a heart	
* Taking a pill has a 50% chance to heal Isaac for half a heart	
* Taking a pill has a 50% chance to heal Isaac for half a heart	
* Taking a pill has a 50% chance to heal Isaac for half a heart	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mommy & Daddy as Tainted Cain 	Defeat Mommy & Daddy as Tainted Cain 	Defeat Mommy & Daddy as Tainted Cain 	Defeat Mommy & Daddy as Tainted Cain 	Defeat Mommy & Daddy as Tainted Cain 	Defeat Mommy & Daddy as Tainted Cain 	Defeat Mommy & Daddy as Tainted Cain 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Isaac’s Eye 	Isaac’s Eye 	Isaac’s Eye 	Isaac’s Eye 	Isaac’s Eye 	Isaac’s Eye 	Isaac’s Eye 	Witness your destiny 	Witness your destiny 	Witness your destiny 	Witness your destiny 	Witness your destiny 	Witness your destiny 	Witness your destiny 	
* At the start of every floor, spawns a D6 Shard
* If Isaac is holding an item that can reroll items, the item one would reroll into is shown behind it, slightly faded	
* At the start of every floor, spawns a D6 Shard
* If Isaac is holding an item that can reroll items, the item one would reroll into is shown behind it, slightly faded	
* At the start of every floor, spawns a D6 Shard
* If Isaac is holding an item that can reroll items, the item one would reroll into is shown behind it, slightly faded	
* At the start of every floor, spawns a D6 Shard
* If Isaac is holding an item that can reroll items, the item one would reroll into is shown behind it, slightly faded	
* At the start of every floor, spawns a D6 Shard
* If Isaac is holding an item that can reroll items, the item one would reroll into is shown behind it, slightly faded	
* At the start of every floor, spawns a D6 Shard
* If Isaac is holding an item that can reroll items, the item one would reroll into is shown behind it, slightly faded	
* At the start of every floor, spawns a D6 Shard
* If Isaac is holding an item that can reroll items, the item one would reroll into is shown behind it, slightly faded	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	Defeat the Onlookers as Tainted Isaac 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Just a Pen 	Just a Pen 	Just a Pen 	Just a Pen 	Just a Pen 	Just a Pen 	Just a Pen 	The only one you need 	The only one you need 	The only one you need 	The only one you need 	The only one you need 	The only one you need 	The only one you need 	
* Entering a hostile room has a 5% chance to remove all enemies in it save for one
* The remaining enemy in the room gains the max health of all the enemies removed combined	
* Entering a hostile room has a 5% chance to remove all enemies in it save for one
* The remaining enemy in the room gains the max health of all the enemies removed combined	
* Entering a hostile room has a 5% chance to remove all enemies in it save for one
* The remaining enemy in the room gains the max health of all the enemies removed combined	
* Entering a hostile room has a 5% chance to remove all enemies in it save for one
* The remaining enemy in the room gains the max health of all the enemies removed combined	
* Entering a hostile room has a 5% chance to remove all enemies in it save for one
* The remaining enemy in the room gains the max health of all the enemies removed combined	
* Entering a hostile room has a 5% chance to remove all enemies in it save for one
* The remaining enemy in the room gains the max health of all the enemies removed combined	
* Entering a hostile room has a 5% chance to remove all enemies in it save for one
* The remaining enemy in the room gains the max health of all the enemies removed combined	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Onlookers as Eden 	Defeat the Onlookers as Eden 	Defeat the Onlookers as Eden 	Defeat the Onlookers as Eden 	Defeat the Onlookers as Eden 	Defeat the Onlookers as Eden 	Defeat the Onlookers as Eden 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Pocket Bible 	Pocket Bible 	Pocket Bible 	Pocket Bible 	Pocket Bible 	Pocket Bible 	Pocket Bible 	Faith on the go! 	Faith on the go! 	Faith on the go! 	Faith on the go! 	Faith on the go! 	Faith on the go! 	Faith on the go! 	
* All sources of Faith are increased by 1	
* All sources of Faith are increased by 1	
* All sources of Faith are increased by 1	
* All sources of Faith are increased by 1	
* All sources of Faith are increased by 1	
* All sources of Faith are increased by 1	
* All sources of Faith are increased by 1	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mother’s Soul as Alexandria 	Defeat Mother’s Soul as Alexandria 	Defeat Mother’s Soul as Alexandria 	Defeat Mother’s Soul as Alexandria 	Defeat Mother’s Soul as Alexandria 	Defeat Mother’s Soul as Alexandria 	Defeat Mother’s Soul as Alexandria 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Price Tag 	Price Tag 	Price Tag 	Price Tag 	Price Tag 	Price Tag 	Price Tag 	A deal is a deal 	A deal is a deal 	A deal is a deal 	A deal is a deal 	A deal is a deal 	A deal is a deal 	A deal is a deal 	
* Decreases the prices for shop items by 1	
* Decreases the prices for shop items by 1	
* Decreases the prices for shop items by 1	
* Decreases the prices for shop items by 1	
* Decreases the prices for shop items by 1	
* Decreases the prices for shop items by 1	
* Decreases the prices for shop items by 1	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Thanatos as The Keeper 	Defeat Thanatos as The Keeper 	Defeat Thanatos as The Keeper 	Defeat Thanatos as The Keeper 	Defeat Thanatos as The Keeper 	Defeat Thanatos as The Keeper 	Defeat Thanatos as The Keeper 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Smoking Doorknob 	Smoking Doorknob 	Smoking Doorknob 	Smoking Doorknob 	Smoking Doorknob 	Smoking Doorknob 	Smoking Doorknob 	Spice on entrance 	Spice on entrance 	Spice on entrance 	Spice on entrance 	Spice on entrance 	Spice on entrance 	Spice on entrance 	
* Entering a hostile room has a 25% chance to hurt Isaac without damaging him, activating on-hit effects	
* Entering a hostile room has a 25% chance to hurt Isaac without damaging him, activating on-hit effects	
* Entering a hostile room has a 25% chance to hurt Isaac without damaging him, activating on-hit effects	
* Entering a hostile room has a 25% chance to hurt Isaac without damaging him, activating on-hit effects	
* Entering a hostile room has a 25% chance to hurt Isaac without damaging him, activating on-hit effects	
* Entering a hostile room has a 25% chance to hurt Isaac without damaging him, activating on-hit effects	
* Entering a hostile room has a 25% chance to hurt Isaac without damaging him, activating on-hit effects	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the challenge ‘Beyond Cursed’ 	Complete the challenge ‘Beyond Cursed’ 	Complete the challenge ‘Beyond Cursed’ 	Complete the challenge ‘Beyond Cursed’ 	Complete the challenge ‘Beyond Cursed’ 	Complete the challenge ‘Beyond Cursed’ 	Complete the challenge ‘Beyond Cursed’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Witch Hazel 	Witch Hazel 	Witch Hazel 	Witch Hazel 	Witch Hazel 	Witch Hazel 	Witch Hazel 	Bewitching flora 	Bewitching flora 	Bewitching flora 	Bewitching flora 	Bewitching flora 	Bewitching flora 	Bewitching flora 	
* Entering a hostile room has a 50% chance to Bewitch a random enemy
* Bewitched enemies are rerolled into a weaker version of themselves	
* Entering a hostile room has a 50% chance to Bewitch a random enemy
* Bewitched enemies are rerolled into a weaker version of themselves	
* Entering a hostile room has a 50% chance to Bewitch a random enemy
* Bewitched enemies are rerolled into a weaker version of themselves	
* Entering a hostile room has a 50% chance to Bewitch a random enemy
* Bewitched enemies are rerolled into a weaker version of themselves	
* Entering a hostile room has a 50% chance to Bewitch a random enemy
* Bewitched enemies are rerolled into a weaker version of themselves	
* Entering a hostile room has a 50% chance to Bewitch a random enemy
* Bewitched enemies are rerolled into a weaker version of themselves	
* Entering a hostile room has a 50% chance to Bewitch a random enemy
* Bewitched enemies are rerolled into a weaker version of themselves	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Onlookers as Tainted Bethany 	Defeat the Onlookers as Tainted Bethany 	Defeat the Onlookers as Tainted Bethany 	Defeat the Onlookers as Tainted Bethany 	Defeat the Onlookers as Tainted Bethany 	Defeat the Onlookers as Tainted Bethany 	Defeat the Onlookers as Tainted Bethany 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Wormhole 	Wormhole 	Wormhole 	Wormhole 	Wormhole 	Wormhole 	Wormhole 	Blip! 	Blip! 	Blip! 	Blip! 	Blip! 	Blip! 	Blip! 	
* +3 range
* +0.2 shot speed
* Tears that fly nearby an enemy teleport towards the enemy in a random cardinal direction	
* +3 range
* +0.2 shot speed
* Tears that fly nearby an enemy teleport towards the enemy in a random cardinal direction	
* +3 range
* +0.2 shot speed
* Tears that fly nearby an enemy teleport towards the enemy in a random cardinal direction	
* +3 range
* +0.2 shot speed
* Tears that fly nearby an enemy teleport towards the enemy in a random cardinal direction	
* +3 range
* +0.2 shot speed
* Tears that fly nearby an enemy teleport towards the enemy in a random cardinal direction	
* +3 range
* +0.2 shot speed
* Tears that fly nearby an enemy teleport towards the enemy in a random cardinal direction	
* +3 range
* +0.2 shot speed
* Tears that fly nearby an enemy teleport towards the enemy in a random cardinal direction	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	
* 
* 
* 
*	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Blow Fly Head 	Blow Fly Head 	Blow Fly Head 	Blow Fly Head 	Blow Fly Head 	Blow Fly Head 	Blow Fly Head 	Filled friends 	Filled friends 	Filled friends 	Filled friends 	Filled friends 	Filled friends 	Filled friends 	
* Blue Flies that hit an enemy fire a tear in a random direction
* The tear copies Isaac’s damage and tear effects.	
* Blue Flies that hit an enemy fire a tear in a random direction
* The tear copies Isaac’s damage and tear effects.	
* Blue Flies that hit an enemy fire a tear in a random direction
* The tear copies Isaac’s damage and tear effects.	
* Blue Flies that hit an enemy fire a tear in a random direction
* The tear copies Isaac’s damage and tear effects.	
* Blue Flies that hit an enemy fire a tear in a random direction
* The tear copies Isaac’s damage and tear effects.	
* Blue Flies that hit an enemy fire a tear in a random direction
* The tear copies Isaac’s damage and tear effects.	
* Blue Flies that hit an enemy fire a tear in a random direction
* The tear copies Isaac’s damage and tear effects.	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Thanatos as Tainted Lazarus 	Defeat Thanatos as Tainted Lazarus 	Defeat Thanatos as Tainted Lazarus 	Defeat Thanatos as Tainted Lazarus 	Defeat Thanatos as Tainted Lazarus 	Defeat Thanatos as Tainted Lazarus 	Defeat Thanatos as Tainted Lazarus 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Brim Pebble 	Brim Pebble 	Brim Pebble 	Brim Pebble 	Brim Pebble 	Brim Pebble 	Brim Pebble 	A taste of rage 	A taste of rage 	A taste of rage 	A taste of rage 	A taste of rage 	A taste of rage 	A taste of rage 	
* Killing an enemy has a luck-based chance to grant Isaac Brimstone
* After firing a single laser, the effects go away
* 100% chance at 30 Luck	
* Killing an enemy has a luck-based chance to grant Isaac Brimstone
* After firing a single laser, the effects go away
* 100% chance at 30 Luck	
* Killing an enemy has a luck-based chance to grant Isaac Brimstone
* After firing a single laser, the effects go away
* 100% chance at 30 Luck	
* Killing an enemy has a luck-based chance to grant Isaac Brimstone
* After firing a single laser, the effects go away
* 100% chance at 30 Luck	
* Killing an enemy has a luck-based chance to grant Isaac Brimstone
* After firing a single laser, the effects go away
* 100% chance at 30 Luck	
* Killing an enemy has a luck-based chance to grant Isaac Brimstone
* After firing a single laser, the effects go away
* 100% chance at 30 Luck	
* Killing an enemy has a luck-based chance to grant Isaac Brimstone
* After firing a single laser, the effects go away
* 100% chance at 30 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mother’s Soul as Tainted Azazel 	Defeat Mother’s Soul as Tainted Azazel 	Defeat Mother’s Soul as Tainted Azazel 	Defeat Mother’s Soul as Tainted Azazel 	Defeat Mother’s Soul as Tainted Azazel 	Defeat Mother’s Soul as Tainted Azazel 	Defeat Mother’s Soul as Tainted Azazel 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Tentacle of the Leviathan	Tentacle of the Leviathan	Tentacle of the Leviathan	Tentacle of the Leviathan	Tentacle of the Leviathan	Tentacle of the Leviathan	Tentacle of the Leviathan	Sin is everything 	Sin is everything 	Sin is everything 	Sin is everything 	Sin is everything 	Sin is everything 	Sin is everything 	
* Pick-ups have a chance to be replaced by their ‘evil’ counterparts. These include:
** Hearts - Black Hearts
** Cards - ‘The Devil’ and ‘The Empress’ Tarot cards
** Coins - Sticky Nickels
** Bombs - Rage Bombs
** Runs - Soul of Judas, Soul of Eve, Soul of Azazel, and Soul of Lilith
** Chests - Red Chests	
* Pick-ups have a chance to be replaced by their ‘evil’ counterparts. These include:
** Hearts - Black Hearts
** Cards - ‘The Devil’ and ‘The Empress’ Tarot cards
** Coins - Sticky Nickels
** Bombs - Rage Bombs
** Runs - Soul of Judas, Soul of Eve, Soul of Azazel, and Soul of Lilith
** Chests - Red Chests	
* Pick-ups have a chance to be replaced by their ‘evil’ counterparts. These include:
** Hearts - Black Hearts
** Cards - ‘The Devil’ and ‘The Empress’ Tarot cards
** Coins - Sticky Nickels
** Bombs - Rage Bombs
** Runs - Soul of Judas, Soul of Eve, Soul of Azazel, and Soul of Lilith
** Chests - Red Chests	
* Pick-ups have a chance to be replaced by their ‘evil’ counterparts. These include:
** Hearts - Black Hearts
** Cards - ‘The Devil’ and ‘The Empress’ Tarot cards
** Coins - Sticky Nickels
** Bombs - Rage Bombs
** Runs - Soul of Judas, Soul of Eve, Soul of Azazel, and Soul of Lilith
** Chests - Red Chests	
* Pick-ups have a chance to be replaced by their ‘evil’ counterparts. These include:
** Hearts - Black Hearts
** Cards - ‘The Devil’ and ‘The Empress’ Tarot cards
** Coins - Sticky Nickels
** Bombs - Rage Bombs
** Runs - Soul of Judas, Soul of Eve, Soul of Azazel, and Soul of Lilith
** Chests - Red Chests	
* Pick-ups have a chance to be replaced by their ‘evil’ counterparts. These include:
** Hearts - Black Hearts
** Cards - ‘The Devil’ and ‘The Empress’ Tarot cards
** Coins - Sticky Nickels
** Bombs - Rage Bombs
** Runs - Soul of Judas, Soul of Eve, Soul of Azazel, and Soul of Lilith
** Chests - Red Chests	
* Pick-ups have a chance to be replaced by their ‘evil’ counterparts. These include:
** Hearts - Black Hearts
** Cards - ‘The Devil’ and ‘The Empress’ Tarot cards
** Coins - Sticky Nickels
** Bombs - Rage Bombs
** Runs - Soul of Judas, Soul of Eve, Soul of Azazel, and Soul of Lilith
** Chests - Red Chests	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Tainted Judas 	Complete Greedier Mode as Tainted Judas 	Complete Greedier Mode as Tainted Judas 	Complete Greedier Mode as Tainted Judas 	Complete Greedier Mode as Tainted Judas 	Complete Greedier Mode as Tainted Judas 	Complete Greedier Mode as Tainted Judas 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Chunk of Amber 	Chunk of Amber 	Chunk of Amber 	Chunk of Amber 	Chunk of Amber 	Chunk of Amber 	Chunk of Amber 	There’s something inside… 	There’s something inside… 	There’s something inside… 	There’s something inside… 	There’s something inside… 	There’s something inside… 	There’s something inside… 	
* Clearing a hostile room has a 15% chance to spawn a random friendly Fly enemy	
* Clearing a hostile room has a 15% chance to spawn a random friendly Fly enemy	
* Clearing a hostile room has a 15% chance to spawn a random friendly Fly enemy	
* Clearing a hostile room has a 15% chance to spawn a random friendly Fly enemy	
* Clearing a hostile room has a 15% chance to spawn a random friendly Fly enemy	
* Clearing a hostile room has a 15% chance to spawn a random friendly Fly enemy	
* Clearing a hostile room has a 15% chance to spawn a random friendly Fly enemy	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Guardian as Tainted Guppy 	Defeat the Guardian as Tainted Guppy 	Defeat the Guardian as Tainted Guppy 	Defeat the Guardian as Tainted Guppy 	Defeat the Guardian as Tainted Guppy 	Defeat the Guardian as Tainted Guppy 	Defeat the Guardian as Tainted Guppy 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Game Squid 	Game Squid 	Game Squid 	Game Squid 	Game Squid 	Game Squid 	Game Squid 	Eternal friend 	Eternal friend 	Eternal friend 	Eternal friend 	Eternal friend 	Eternal friend 	Eternal friend 	
* Tears have a chance to either deal +1 damage and inflict slowing onto enemies or to phase through enemies without dealing damage	
* Tears have a chance to either deal +1 damage and inflict slowing onto enemies or to phase through enemies without dealing damage	
* Tears have a chance to either deal +1 damage and inflict slowing onto enemies or to phase through enemies without dealing damage	
* Tears have a chance to either deal +1 damage and inflict slowing onto enemies or to phase through enemies without dealing damage	
* Tears have a chance to either deal +1 damage and inflict slowing onto enemies or to phase through enemies without dealing damage	
* Tears have a chance to either deal +1 damage and inflict slowing onto enemies or to phase through enemies without dealing damage	
* Tears have a chance to either deal +1 damage and inflict slowing onto enemies or to phase through enemies without dealing damage	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the challenge ‘Eternal rage’ 	Complete the challenge ‘Eternal rage’ 	Complete the challenge ‘Eternal rage’ 	Complete the challenge ‘Eternal rage’ 	Complete the challenge ‘Eternal rage’ 	Complete the challenge ‘Eternal rage’ 	Complete the challenge ‘Eternal rage’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Midas’ Hand 	Midas’ Hand 	Midas’ Hand 	Midas’ Hand 	Midas’ Hand 	Midas’ Hand 	Midas’ Hand 	Touch me, Midas 	Touch me, Midas 	Touch me, Midas 	Touch me, Midas 	Touch me, Midas 	Touch me, Midas 	Touch me, Midas 	
* Increases the chance for Golden pick-ups to spawn, including Golden Coins, Golden Keys, Golden Bombs, Golden Hearts, and Golden Pills	
* Increases the chance for Golden pick-ups to spawn, including Golden Coins, Golden Keys, Golden Bombs, Golden Hearts, and Golden Pills	
* Increases the chance for Golden pick-ups to spawn, including Golden Coins, Golden Keys, Golden Bombs, Golden Hearts, and Golden Pills	
* Increases the chance for Golden pick-ups to spawn, including Golden Coins, Golden Keys, Golden Bombs, Golden Hearts, and Golden Pills	
* Increases the chance for Golden pick-ups to spawn, including Golden Coins, Golden Keys, Golden Bombs, Golden Hearts, and Golden Pills	
* Increases the chance for Golden pick-ups to spawn, including Golden Coins, Golden Keys, Golden Bombs, Golden Hearts, and Golden Pills	
* Increases the chance for Golden pick-ups to spawn, including Golden Coins, Golden Keys, Golden Bombs, Golden Hearts, and Golden Pills	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Unlock every Golden pick-up 	Unlock every Golden pick-up 	Unlock every Golden pick-up 	Unlock every Golden pick-up 	Unlock every Golden pick-up 	Unlock every Golden pick-up 	Unlock every Golden pick-up 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Old Key 	Old Key 	Old Key 	Old Key 	Old Key 	Old Key 	Old Key 	Key to the forgotten 	Key to the forgotten 	Key to the forgotten 	Key to the forgotten 	Key to the forgotten 	Key to the forgotten 	Key to the forgotten 	
* Chests of any type have a chance to be replaced by Old Chests	
* Chests of any type have a chance to be replaced by Old Chests	
* Chests of any type have a chance to be replaced by Old Chests	
* Chests of any type have a chance to be replaced by Old Chests	
* Chests of any type have a chance to be replaced by Old Chests	
* Chests of any type have a chance to be replaced by Old Chests	
* Chests of any type have a chance to be replaced by Old Chests	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Unlock Old Chests 	Unlock Old Chests 	Unlock Old Chests 	Unlock Old Chests 	Unlock Old Chests 	Unlock Old Chests 	Unlock Old Chests 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Serpent’s Tongue 	Serpent’s Tongue 	Serpent’s Tongue 	Serpent’s Tongue 	Serpent’s Tongue 	Serpent’s Tongue 	Serpent’s Tongue 	No one is safe from temptation 	No one is safe from temptation 	No one is safe from temptation 	No one is safe from temptation 	No one is safe from temptation 	No one is safe from temptation 	No one is safe from temptation 	
* Adds an additional item that can be taken from Serpette’s shop	
* Adds an additional item that can be taken from Serpette’s shop	
* Adds an additional item that can be taken from Serpette’s shop	
* Adds an additional item that can be taken from Serpette’s shop	
* Adds an additional item that can be taken from Serpette’s shop	
* Adds an additional item that can be taken from Serpette’s shop	
* Adds an additional item that can be taken from Serpette’s shop	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as Eve 	Complete the Colosseum as Eve 	Complete the Colosseum as Eve 	Complete the Colosseum as Eve 	Complete the Colosseum as Eve 	Complete the Colosseum as Eve 	Complete the Colosseum as Eve 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Skunk Tail 	Skunk Tail 	Skunk Tail 	Skunk Tail 	Skunk Tail 	Skunk Tail 	Skunk Tail 	P U! 	P U! 	P U! 	P U! 	P U! 	P U! 	P U! 	
* While in hostile rooms, every 15 seconds has Isaac release a fart that pushes back enemies and projectiles	
* While in hostile rooms, every 15 seconds has Isaac release a fart that pushes back enemies and projectiles	
* While in hostile rooms, every 15 seconds has Isaac release a fart that pushes back enemies and projectiles	
* While in hostile rooms, every 15 seconds has Isaac release a fart that pushes back enemies and projectiles	
* While in hostile rooms, every 15 seconds has Isaac release a fart that pushes back enemies and projectiles	
* While in hostile rooms, every 15 seconds has Isaac release a fart that pushes back enemies and projectiles	
* While in hostile rooms, every 15 seconds has Isaac release a fart that pushes back enemies and projectiles	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Onlookers as ??? 	Defeat the Onlookers as ??? 	Defeat the Onlookers as ??? 	Defeat the Onlookers as ??? 	Defeat the Onlookers as ??? 	Defeat the Onlookers as ??? 	Defeat the Onlookers as ??? 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Smart Penny 	Smart Penny 	Smart Penny 	Smart Penny 	Smart Penny 	Smart Penny 	Smart Penny 	Wealth of knowledge 	Wealth of knowledge 	Wealth of knowledge 	Wealth of knowledge 	Wealth of knowledge 	Wealth of knowledge 	Wealth of knowledge 	
* Collecting a coin has a chance to reveal a random room on the map or unlock a random locked chest/door
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to reveal a random room on the map or unlock a random locked chest/door
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to reveal a random room on the map or unlock a random locked chest/door
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to reveal a random room on the map or unlock a random locked chest/door
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to reveal a random room on the map or unlock a random locked chest/door
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to reveal a random room on the map or unlock a random locked chest/door
* The chance scales with the coin’s worth	
* Collecting a coin has a chance to reveal a random room on the map or unlock a random locked chest/door
* The chance scales with the coin’s worth	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Thanatos as Alexandria 	Defeat Thanatos as Alexandria 	Defeat Thanatos as Alexandria 	Defeat Thanatos as Alexandria 	Defeat Thanatos as Alexandria 	Defeat Thanatos as Alexandria 	Defeat Thanatos as Alexandria 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Wanted Poster 	Wanted Poster 	Wanted Poster 	Wanted Poster 	Wanted Poster 	Wanted Poster 	Wanted Poster 	Dead or alive 	Dead or alive 	Dead or alive 	Dead or alive 	Dead or alive 	Dead or alive 	Dead or alive 	
* Entering a hostile room grants a random enemy in the room Marked
* Marked enemies can be targeted and damaged by other enemies	
* Entering a hostile room grants a random enemy in the room Marked
* Marked enemies can be targeted and damaged by other enemies	
* Entering a hostile room grants a random enemy in the room Marked
* Marked enemies can be targeted and damaged by other enemies	
* Entering a hostile room grants a random enemy in the room Marked
* Marked enemies can be targeted and damaged by other enemies	
* Entering a hostile room grants a random enemy in the room Marked
* Marked enemies can be targeted and damaged by other enemies	
* Entering a hostile room grants a random enemy in the room Marked
* Marked enemies can be targeted and damaged by other enemies	
* Entering a hostile room grants a random enemy in the room Marked
* Marked enemies can be targeted and damaged by other enemies	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Guardian as Tainted Cain 	Defeat the Guardian as Tainted Cain 	Defeat the Guardian as Tainted Cain 	Defeat the Guardian as Tainted Cain 	Defeat the Guardian as Tainted Cain 	Defeat the Guardian as Tainted Cain 	Defeat the Guardian as Tainted Cain 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
An Emerald 	An Emerald 	An Emerald 	An Emerald 	An Emerald 	An Emerald 	An Emerald 	Tool of the trade 	Tool of the trade 	Tool of the trade 	Tool of the trade 	Tool of the trade 	Tool of the trade 	Tool of the trade 	
* All machines (except Donation Machines) are replaced by corresponding Beggars
** Slot Machine - Beggar
** Fortune Telling Machine - Key Master
** Blood Donation Machine - Devil Beggar
** Reroll Machine - Shell Game
** Crane Game - Hell Game
** Confessional - Bombshell Game
** Battle Machine - Bomb Bum
** Iron Maiden - Junkie	
* All machines (except Donation Machines) are replaced by corresponding Beggars
** Slot Machine - Beggar
** Fortune Telling Machine - Key Master
** Blood Donation Machine - Devil Beggar
** Reroll Machine - Shell Game
** Crane Game - Hell Game
** Confessional - Bombshell Game
** Battle Machine - Bomb Bum
** Iron Maiden - Junkie	
* All machines (except Donation Machines) are replaced by corresponding Beggars
** Slot Machine - Beggar
** Fortune Telling Machine - Key Master
** Blood Donation Machine - Devil Beggar
** Reroll Machine - Shell Game
** Crane Game - Hell Game
** Confessional - Bombshell Game
** Battle Machine - Bomb Bum
** Iron Maiden - Junkie	
* All machines (except Donation Machines) are replaced by corresponding Beggars
** Slot Machine - Beggar
** Fortune Telling Machine - Key Master
** Blood Donation Machine - Devil Beggar
** Reroll Machine - Shell Game
** Crane Game - Hell Game
** Confessional - Bombshell Game
** Battle Machine - Bomb Bum
** Iron Maiden - Junkie	
* All machines (except Donation Machines) are replaced by corresponding Beggars
** Slot Machine - Beggar
** Fortune Telling Machine - Key Master
** Blood Donation Machine - Devil Beggar
** Reroll Machine - Shell Game
** Crane Game - Hell Game
** Confessional - Bombshell Game
** Battle Machine - Bomb Bum
** Iron Maiden - Junkie	
* All machines (except Donation Machines) are replaced by corresponding Beggars
** Slot Machine - Beggar
** Fortune Telling Machine - Key Master
** Blood Donation Machine - Devil Beggar
** Reroll Machine - Shell Game
** Crane Game - Hell Game
** Confessional - Bombshell Game
** Battle Machine - Bomb Bum
** Iron Maiden - Junkie	
* All machines (except Donation Machines) are replaced by corresponding Beggars
** Slot Machine - Beggar
** Fortune Telling Machine - Key Master
** Blood Donation Machine - Devil Beggar
** Reroll Machine - Shell Game
** Crane Game - Hell Game
** Confessional - Bombshell Game
** Battle Machine - Bomb Bum
** Iron Maiden - Junkie	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Ehud’ 	Complete Greedier Mode as Ehud’ 	Complete Greedier Mode as Ehud’ 	Complete Greedier Mode as Ehud’ 	Complete Greedier Mode as Ehud’ 	Complete Greedier Mode as Ehud’ 	Complete Greedier Mode as Ehud’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Cosmic Crown 	Cosmic Crown 	Cosmic Crown 	Cosmic Crown 	Cosmic Crown 	Cosmic Crown 	Cosmic Crown 	Walk the path beyond 	Walk the path beyond 	Walk the path beyond 	Walk the path beyond 	Walk the path beyond 	Walk the path beyond 	Walk the path beyond 	
* Treasure Rooms can appear in Chapter 4	
* Treasure Rooms can appear in Chapter 4	
* Treasure Rooms can appear in Chapter 4	
* Treasure Rooms can appear in Chapter 4	
* Treasure Rooms can appear in Chapter 4	
* Treasure Rooms can appear in Chapter 4	
* Treasure Rooms can appear in Chapter 4	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Failure 	Failure 	Failure 	Failure 	Failure 	Failure 	Failure 	A disgrace 	A disgrace 	A disgrace 	A disgrace 	A disgrace 	A disgrace 	A disgrace 	
* -10 Luck
* Luck works inversely for tear effects; The lower Luck you have, the more likely luck-based tear effects will occur
* Having negative luck still worsens other factors like room drops and using machines/beggars	
* -10 Luck
* Luck works inversely for tear effects; The lower Luck you have, the more likely luck-based tear effects will occur
* Having negative luck still worsens other factors like room drops and using machines/beggars	
* -10 Luck
* Luck works inversely for tear effects; The lower Luck you have, the more likely luck-based tear effects will occur
* Having negative luck still worsens other factors like room drops and using machines/beggars	
* -10 Luck
* Luck works inversely for tear effects; The lower Luck you have, the more likely luck-based tear effects will occur
* Having negative luck still worsens other factors like room drops and using machines/beggars	
* -10 Luck
* Luck works inversely for tear effects; The lower Luck you have, the more likely luck-based tear effects will occur
* Having negative luck still worsens other factors like room drops and using machines/beggars	
* -10 Luck
* Luck works inversely for tear effects; The lower Luck you have, the more likely luck-based tear effects will occur
* Having negative luck still worsens other factors like room drops and using machines/beggars	
* -10 Luck
* Luck works inversely for tear effects; The lower Luck you have, the more likely luck-based tear effects will occur
* Having negative luck still worsens other factors like room drops and using machines/beggars	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Obtain Perfection and lose it on the same floor you obtained it	Obtain Perfection and lose it on the same floor you obtained it	Obtain Perfection and lose it on the same floor you obtained it	Obtain Perfection and lose it on the same floor you obtained it	Obtain Perfection and lose it on the same floor you obtained it	Obtain Perfection and lose it on the same floor you obtained it	Obtain Perfection and lose it on the same floor you obtained it	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Fastpass 	Fastpass 	Fastpass 	Fastpass 	Fastpass 	Fastpass 	Fastpass 	Why wait in line? 	Why wait in line? 	Why wait in line? 	Why wait in line? 	Why wait in line? 	Why wait in line? 	Why wait in line? 	
* At the start of every floor, a portal to the Shop will be present
* The portal disappears when existing the room	
* At the start of every floor, a portal to the Shop will be present
* The portal disappears when existing the room	
* At the start of every floor, a portal to the Shop will be present
* The portal disappears when existing the room	
* At the start of every floor, a portal to the Shop will be present
* The portal disappears when existing the room	
* At the start of every floor, a portal to the Shop will be present
* The portal disappears when existing the room	
* At the start of every floor, a portal to the Shop will be present
* The portal disappears when existing the room	
* At the start of every floor, a portal to the Shop will be present
* The portal disappears when existing the room	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as Lazarus 	Complete the Colosseum as Lazarus 	Complete the Colosseum as Lazarus 	Complete the Colosseum as Lazarus 	Complete the Colosseum as Lazarus 	Complete the Colosseum as Lazarus 	Complete the Colosseum as Lazarus 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Bee Wing 	Bee Wing 	Bee Wing 	Bee Wing 	Bee Wing 	Bee Wing 	Bee Wing 	Fat flight 	Fat flight 	Fat flight 	Fat flight 	Fat flight 	Fat flight 	Fat flight 	
* At the start of every room, Isaac has 5 seconds of flight
* If Isaac is stuck when he loses flight, he is teleported to the nearest entrance	
* At the start of every room, Isaac has 5 seconds of flight
* If Isaac is stuck when he loses flight, he is teleported to the nearest entrance	
* At the start of every room, Isaac has 5 seconds of flight
* If Isaac is stuck when he loses flight, he is teleported to the nearest entrance	
* At the start of every room, Isaac has 5 seconds of flight
* If Isaac is stuck when he loses flight, he is teleported to the nearest entrance	
* At the start of every room, Isaac has 5 seconds of flight
* If Isaac is stuck when he loses flight, he is teleported to the nearest entrance	
* At the start of every room, Isaac has 5 seconds of flight
* If Isaac is stuck when he loses flight, he is teleported to the nearest entrance	
* At the start of every room, Isaac has 5 seconds of flight
* If Isaac is stuck when he loses flight, he is teleported to the nearest entrance	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Toploader 	Toploader 	Toploader 	Toploader 	Toploader 	Toploader 	Toploader 	Worth a fortune 	Worth a fortune 	Worth a fortune 	Worth a fortune 	Worth a fortune 	Worth a fortune 	Worth a fortune 	
* Tarot, Reverse Tarot, and Playing Cards have a chance to be replaced by more rarer cards of different types	
* Tarot, Reverse Tarot, and Playing Cards have a chance to be replaced by more rarer cards of different types	
* Tarot, Reverse Tarot, and Playing Cards have a chance to be replaced by more rarer cards of different types	
* Tarot, Reverse Tarot, and Playing Cards have a chance to be replaced by more rarer cards of different types	
* Tarot, Reverse Tarot, and Playing Cards have a chance to be replaced by more rarer cards of different types	
* Tarot, Reverse Tarot, and Playing Cards have a chance to be replaced by more rarer cards of different types	
* Tarot, Reverse Tarot, and Playing Cards have a chance to be replaced by more rarer cards of different types	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Unlock every card in the game 	Unlock every card in the game 	Unlock every card in the game 	Unlock every card in the game 	Unlock every card in the game 	Unlock every card in the game 	Unlock every card in the game 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Red Paper Clip 	Red Paper Clip 	Red Paper Clip 	Red Paper Clip 	Red Paper Clip 	Red Paper Clip 	Red Paper Clip 	Trade offer 	Trade offer 	Trade offer 	Trade offer 	Trade offer 	Trade offer 	Trade offer 	
* Interacting with a Beggar instantly destroys the trinket and has the beggar instantly pay out with an item for free	
* Interacting with a Beggar instantly destroys the trinket and has the beggar instantly pay out with an item for free	
* Interacting with a Beggar instantly destroys the trinket and has the beggar instantly pay out with an item for free	
* Interacting with a Beggar instantly destroys the trinket and has the beggar instantly pay out with an item for free	
* Interacting with a Beggar instantly destroys the trinket and has the beggar instantly pay out with an item for free	
* Interacting with a Beggar instantly destroys the trinket and has the beggar instantly pay out with an item for free	
* Interacting with a Beggar instantly destroys the trinket and has the beggar instantly pay out with an item for free	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the challenge ‘Art of Charity'’ 	Complete the challenge ‘Art of Charity'’ 	Complete the challenge ‘Art of Charity'’ 	Complete the challenge ‘Art of Charity'’ 	Complete the challenge ‘Art of Charity'’ 	Complete the challenge ‘Art of Charity'’ 	Complete the challenge ‘Art of Charity'’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Horse Radish 	Horse Radish 	Horse Radish 	Horse Radish 	Horse Radish 	Horse Radish 	Horse Radish 	I hate the pill 	I hate the pill 	I hate the pill 	I hate the pill 	I hate the pill 	I hate the pill 	I hate the pill 	
* Increases the chance for Horse Pills to spawn	
* Increases the chance for Horse Pills to spawn	
* Increases the chance for Horse Pills to spawn	
* Increases the chance for Horse Pills to spawn	
* Increases the chance for Horse Pills to spawn	
* Increases the chance for Horse Pills to spawn	
* Increases the chance for Horse Pills to spawn	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Take 3 negative Horse Pills 	Take 3 negative Horse Pills 	Take 3 negative Horse Pills 	Take 3 negative Horse Pills 	Take 3 negative Horse Pills 	Take 3 negative Horse Pills 	Take 3 negative Horse Pills 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Bloody Needle 	Bloody Needle 	Bloody Needle 	Bloody Needle 	Bloody Needle 	Bloody Needle 	Bloody Needle 	It still drips 	It still drips 	It still drips 	It still drips 	It still drips 	It still drips 	It still drips 	
* Luck-based chance to fire a piercing tear that inflicts Bleeding onto enemies
* Bleeding enemies leave behind red creep and take damage over time that scales with how fast they are moving
* 100% chance at 32 Luck	
* Luck-based chance to fire a piercing tear that inflicts Bleeding onto enemies
* Bleeding enemies leave behind red creep and take damage over time that scales with how fast they are moving
* 100% chance at 32 Luck	
* Luck-based chance to fire a piercing tear that inflicts Bleeding onto enemies
* Bleeding enemies leave behind red creep and take damage over time that scales with how fast they are moving
* 100% chance at 32 Luck	
* Luck-based chance to fire a piercing tear that inflicts Bleeding onto enemies
* Bleeding enemies leave behind red creep and take damage over time that scales with how fast they are moving
* 100% chance at 32 Luck	
* Luck-based chance to fire a piercing tear that inflicts Bleeding onto enemies
* Bleeding enemies leave behind red creep and take damage over time that scales with how fast they are moving
* 100% chance at 32 Luck	
* Luck-based chance to fire a piercing tear that inflicts Bleeding onto enemies
* Bleeding enemies leave behind red creep and take damage over time that scales with how fast they are moving
* 100% chance at 32 Luck	
* Luck-based chance to fire a piercing tear that inflicts Bleeding onto enemies
* Bleeding enemies leave behind red creep and take damage over time that scales with how fast they are moving
* 100% chance at 32 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greed Mode as Tainted Eve 	Complete Greed Mode as Tainted Eve 	Complete Greed Mode as Tainted Eve 	Complete Greed Mode as Tainted Eve 	Complete Greed Mode as Tainted Eve 	Complete Greed Mode as Tainted Eve 	Complete Greed Mode as Tainted Eve 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Broken Crayon 	Broken Crayon 	Broken Crayon 	Broken Crayon 	Broken Crayon 	Broken Crayon 	Broken Crayon 	Taste the rainbow 	Taste the rainbow 	Taste the rainbow 	Taste the rainbow 	Taste the rainbow 	Taste the rainbow 	Taste the rainbow 	
* Luck-based chance to fire a tear that inflicts a random status effect onto enemies
* 100% chance at 31 Luck	
* Luck-based chance to fire a tear that inflicts a random status effect onto enemies
* 100% chance at 31 Luck	
* Luck-based chance to fire a tear that inflicts a random status effect onto enemies
* 100% chance at 31 Luck	
* Luck-based chance to fire a tear that inflicts a random status effect onto enemies
* 100% chance at 31 Luck	
* Luck-based chance to fire a tear that inflicts a random status effect onto enemies
* 100% chance at 31 Luck	
* Luck-based chance to fire a tear that inflicts a random status effect onto enemies
* 100% chance at 31 Luck	
* Luck-based chance to fire a tear that inflicts a random status effect onto enemies
* 100% chance at 31 Luck	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Cut of Cheese 	Cut of Cheese 	Cut of Cheese 	Cut of Cheese 	Cut of Cheese 	Cut of Cheese 	Cut of Cheese 	Post-mortem toots 	Post-mortem toots 	Post-mortem toots 	Post-mortem toots 	Post-mortem toots 	Post-mortem toots 	Post-mortem toots 	
* Enemies release a fart on death that pushes back Isaac, projectiles, and other enemies.	
* Enemies release a fart on death that pushes back Isaac, projectiles, and other enemies.	
* Enemies release a fart on death that pushes back Isaac, projectiles, and other enemies.	
* Enemies release a fart on death that pushes back Isaac, projectiles, and other enemies.	
* Enemies release a fart on death that pushes back Isaac, projectiles, and other enemies.	
* Enemies release a fart on death that pushes back Isaac, projectiles, and other enemies.	
* Enemies release a fart on death that pushes back Isaac, projectiles, and other enemies.	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Flush 	Flush 	Flush 	Flush 	Flush 	Flush 	Flush 	Horribly optimized 	Horribly optimized 	Horribly optimized 	Horribly optimized 	Horribly optimized 	Horribly optimized 	Horribly optimized 	
* Enemies have a chance to be periodically frozen	
* Enemies have a chance to be periodically frozen	
* Enemies have a chance to be periodically frozen	
* Enemies have a chance to be periodically frozen	
* Enemies have a chance to be periodically frozen	
* Enemies have a chance to be periodically frozen	
* Enemies have a chance to be periodically frozen	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the challenge ‘Symphony of the Lamb’ 	Complete the challenge ‘Symphony of the Lamb’ 	Complete the challenge ‘Symphony of the Lamb’ 	Complete the challenge ‘Symphony of the Lamb’ 	Complete the challenge ‘Symphony of the Lamb’ 	Complete the challenge ‘Symphony of the Lamb’ 	Complete the challenge ‘Symphony of the Lamb’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Keeper’s Penny 	Keeper’s Penny 	Keeper’s Penny 	Keeper’s Penny 	Keeper’s Penny 	Keeper’s Penny 	Keeper’s Penny 	Wealth of greed 	Wealth of greed 	Wealth of greed 	Wealth of greed 	Wealth of greed 	Wealth of greed 	Wealth of greed 	
* Collecting a coin has a chance to spawn a random Shop item
* The chance is based on the coin’s value	
* Collecting a coin has a chance to spawn a random Shop item
* The chance is based on the coin’s value	
* Collecting a coin has a chance to spawn a random Shop item
* The chance is based on the coin’s value	
* Collecting a coin has a chance to spawn a random Shop item
* The chance is based on the coin’s value	
* Collecting a coin has a chance to spawn a random Shop item
* The chance is based on the coin’s value	
* Collecting a coin has a chance to spawn a random Shop item
* The chance is based on the coin’s value	
* Collecting a coin has a chance to spawn a random Shop item
* The chance is based on the coin’s value	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Everything as Tainted Keeper 	Defeat Everything as Tainted Keeper 	Defeat Everything as Tainted Keeper 	Defeat Everything as Tainted Keeper 	Defeat Everything as Tainted Keeper 	Defeat Everything as Tainted Keeper 	Defeat Everything as Tainted Keeper 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Night Vision Goggles 	Night Vision Goggles 	Night Vision Goggles 	Night Vision Goggles 	Night Vision Goggles 	Night Vision Goggles 	Night Vision Goggles 	Nothing hides from you 	Nothing hides from you 	Nothing hides from you 	Nothing hides from you 	Nothing hides from you 	Nothing hides from you 	Nothing hides from you 	
* Tinted Rocks, Secret Room entrances, and enemies that turn invisible, glow a bright green	
* Tinted Rocks, Secret Room entrances, and enemies that turn invisible, glow a bright green	
* Tinted Rocks, Secret Room entrances, and enemies that turn invisible, glow a bright green	
* Tinted Rocks, Secret Room entrances, and enemies that turn invisible, glow a bright green	
* Tinted Rocks, Secret Room entrances, and enemies that turn invisible, glow a bright green	
* Tinted Rocks, Secret Room entrances, and enemies that turn invisible, glow a bright green	
* Tinted Rocks, Secret Room entrances, and enemies that turn invisible, glow a bright green	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Phantom Limb 	Phantom Limb 	Phantom Limb 	Phantom Limb 	Phantom Limb 	Phantom Limb 	Phantom Limb 	Feelings beyond 	Feelings beyond 	Feelings beyond 	Feelings beyond 	Feelings beyond 	Feelings beyond 	Feelings beyond 	
* Doubles the size of Isaac’s hitbox for grabbing items and pick-ups while not increasing his hitbox for taking damage	
* Doubles the size of Isaac’s hitbox for grabbing items and pick-ups while not increasing his hitbox for taking damage	
* Doubles the size of Isaac’s hitbox for grabbing items and pick-ups while not increasing his hitbox for taking damage	
* Doubles the size of Isaac’s hitbox for grabbing items and pick-ups while not increasing his hitbox for taking damage	
* Doubles the size of Isaac’s hitbox for grabbing items and pick-ups while not increasing his hitbox for taking damage	
* Doubles the size of Isaac’s hitbox for grabbing items and pick-ups while not increasing his hitbox for taking damage	
* Doubles the size of Isaac’s hitbox for grabbing items and pick-ups while not increasing his hitbox for taking damage	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Spectral Evidence 	Spectral Evidence 	Spectral Evidence 	Spectral Evidence 	Spectral Evidence 	Spectral Evidence 	Spectral Evidence 	Seen with the devil 	Seen with the devil 	Seen with the devil 	Seen with the devil 	Seen with the devil 	Seen with the devil 	Seen with the devil 	
* Taking damage has a chance to produce a spirit that flies into the closest enemy, exploding on contact	
* Taking damage has a chance to produce a spirit that flies into the closest enemy, exploding on contact	
* Taking damage has a chance to produce a spirit that flies into the closest enemy, exploding on contact	
* Taking damage has a chance to produce a spirit that flies into the closest enemy, exploding on contact	
* Taking damage has a chance to produce a spirit that flies into the closest enemy, exploding on contact	
* Taking damage has a chance to produce a spirit that flies into the closest enemy, exploding on contact	
* Taking damage has a chance to produce a spirit that flies into the closest enemy, exploding on contact	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Tainted Bethany 	Complete Greedier Mode as Tainted Bethany 	Complete Greedier Mode as Tainted Bethany 	Complete Greedier Mode as Tainted Bethany 	Complete Greedier Mode as Tainted Bethany 	Complete Greedier Mode as Tainted Bethany 	Complete Greedier Mode as Tainted Bethany 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Trick Penny 	Trick Penny 	Trick Penny 	Trick Penny 	Trick Penny 	Trick Penny 	Trick Penny 	Duped 	Duped 	Duped 	Duped 	Duped 	Duped 	Duped 	
* Using a machine or beggar that takes coins has a 25% chance to not take any at all	
* Using a machine or beggar that takes coins has a 25% chance to not take any at all	
* Using a machine or beggar that takes coins has a 25% chance to not take any at all	
* Using a machine or beggar that takes coins has a 25% chance to not take any at all	
* Using a machine or beggar that takes coins has a 25% chance to not take any at all	
* Using a machine or beggar that takes coins has a 25% chance to not take any at all	
* Using a machine or beggar that takes coins has a 25% chance to not take any at all	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Tainted Cain’ 	Complete Greedier Mode as Tainted Cain’ 	Complete Greedier Mode as Tainted Cain’ 	Complete Greedier Mode as Tainted Cain’ 	Complete Greedier Mode as Tainted Cain’ 	Complete Greedier Mode as Tainted Cain’ 	Complete Greedier Mode as Tainted Cain’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
The Polaroid 	The Polaroid 	The Polaroid 	The Polaroid 	The Polaroid 	The Polaroid 	The Polaroid 	Fate chosen 	Fate chosen 	Fate chosen 	Fate chosen 	Fate chosen 	Fate chosen 	Fate chosen 	
* Taking damage to half a heart makes Isaac temporarily invincible	
* Taking damage to half a heart makes Isaac temporarily invincible	
* Taking damage to half a heart makes Isaac temporarily invincible	
* Taking damage to half a heart makes Isaac temporarily invincible	
* Taking damage to half a heart makes Isaac temporarily invincible	
* Taking damage to half a heart makes Isaac temporarily invincible	
* Taking damage to half a heart makes Isaac temporarily invincible	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mother’s Soul for the first time 	Defeat Mother’s Soul for the first time 	Defeat Mother’s Soul for the first time 	Defeat Mother’s Soul for the first time 	Defeat Mother’s Soul for the first time 	Defeat Mother’s Soul for the first time 	Defeat Mother’s Soul for the first time 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
The Negative 	The Negative 	The Negative 	The Negative 	The Negative 	The Negative 	The Negative 	nesohc etaF 	nesohc etaF 	nesohc etaF 	nesohc etaF 	nesohc etaF 	nesohc etaF 	nesohc etaF 	
* Taking damage to half a heart activates a Necronomicon effect, dealing 80 damage to all enemies in the room	
* Taking damage to half a heart activates a Necronomicon effect, dealing 80 damage to all enemies in the room	
* Taking damage to half a heart activates a Necronomicon effect, dealing 80 damage to all enemies in the room	
* Taking damage to half a heart activates a Necronomicon effect, dealing 80 damage to all enemies in the room	
* Taking damage to half a heart activates a Necronomicon effect, dealing 80 damage to all enemies in the room	
* Taking damage to half a heart activates a Necronomicon effect, dealing 80 damage to all enemies in the room	
* Taking damage to half a heart activates a Necronomicon effect, dealing 80 damage to all enemies in the room	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mother’s Soul as Azazel 	Defeat Mother’s Soul as Azazel 	Defeat Mother’s Soul as Azazel 	Defeat Mother’s Soul as Azazel 	Defeat Mother’s Soul as Azazel 	Defeat Mother’s Soul as Azazel 	Defeat Mother’s Soul as Azazel 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Abel’s Flock 	Abel’s Flock 	Abel’s Flock 	Abel’s Flock 	Abel’s Flock 	Abel’s Flock 	Abel’s Flock 	Follow the heard 	Follow the heard 	Follow the heard 	Follow the heard 	Follow the heard 	Follow the heard 	Follow the heard 	
* All of Isaac’s familiars now mirror him and fire towards him	
* All of Isaac’s familiars now mirror him and fire towards him	
* All of Isaac’s familiars now mirror him and fire towards him	
* All of Isaac’s familiars now mirror him and fire towards him	
* All of Isaac’s familiars now mirror him and fire towards him	
* All of Isaac’s familiars now mirror him and fire towards him	
* All of Isaac’s familiars now mirror him and fire towards him	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the challenge ‘Opposite Day’ 	Complete the challenge ‘Opposite Day’ 	Complete the challenge ‘Opposite Day’ 	Complete the challenge ‘Opposite Day’ 	Complete the challenge ‘Opposite Day’ 	Complete the challenge ‘Opposite Day’ 	Complete the challenge ‘Opposite Day’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Baby Tooth 	Baby Tooth 	Baby Tooth 	Baby Tooth 	Baby Tooth 	Baby Tooth 	Baby Tooth 	They’re coming in! 	They’re coming in! 	They’re coming in! 	They’re coming in! 	They’re coming in! 	They’re coming in! 	They’re coming in! 	
* Entering a hostile room has a 25% chance to grant Isaac a random familiar for the duration of it	
* Entering a hostile room has a 25% chance to grant Isaac a random familiar for the duration of it	
* Entering a hostile room has a 25% chance to grant Isaac a random familiar for the duration of it	
* Entering a hostile room has a 25% chance to grant Isaac a random familiar for the duration of it	
* Entering a hostile room has a 25% chance to grant Isaac a random familiar for the duration of it	
* Entering a hostile room has a 25% chance to grant Isaac a random familiar for the duration of it	
* Entering a hostile room has a 25% chance to grant Isaac a random familiar for the duration of it	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greed Mode as Tainted Lilith 	Complete Greed Mode as Tainted Lilith 	Complete Greed Mode as Tainted Lilith 	Complete Greed Mode as Tainted Lilith 	Complete Greed Mode as Tainted Lilith 	Complete Greed Mode as Tainted Lilith 	Complete Greed Mode as Tainted Lilith 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Feather of Gabriel 	Feather of Gabriel 	Feather of Gabriel 	Feather of Gabriel 	Feather of Gabriel 	Feather of Gabriel 	Feather of Gabriel 	Your faith remains 	Your faith remains 	Your faith remains 	Your faith remains 	Your faith remains 	Your faith remains 	Your faith remains 	
* +15% Angel Deal chance
* Angel Deals can appear in Chapter 5	
* +15% Angel Deal chance
* Angel Deals can appear in Chapter 5	
* +15% Angel Deal chance
* Angel Deals can appear in Chapter 5	
* +15% Angel Deal chance
* Angel Deals can appear in Chapter 5	
* +15% Angel Deal chance
* Angel Deals can appear in Chapter 5	
* +15% Angel Deal chance
* Angel Deals can appear in Chapter 5	
* +15% Angel Deal chance
* Angel Deals can appear in Chapter 5	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Guardian as Apollyon 	Defeat the Guardian as Apollyon 	Defeat the Guardian as Apollyon 	Defeat the Guardian as Apollyon 	Defeat the Guardian as Apollyon 	Defeat the Guardian as Apollyon 	Defeat the Guardian as Apollyon 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Horn of the Beast 	Horn of the Beast 	Horn of the Beast 	Horn of the Beast 	Horn of the Beast 	Horn of the Beast 	Horn of the Beast 	Your sins remain 	Your sins remain 	Your sins remain 	Your sins remain 	Your sins remain 	Your sins remain 	Your sins remain 	
* +15% Devil Deal chance
* Devil Deals can appear in Chapter 5	
* +15% Devil Deal chance
* Devil Deals can appear in Chapter 5	
* +15% Devil Deal chance
* Devil Deals can appear in Chapter 5	
* +15% Devil Deal chance
* Devil Deals can appear in Chapter 5	
* +15% Devil Deal chance
* Devil Deals can appear in Chapter 5	
* +15% Devil Deal chance
* Devil Deals can appear in Chapter 5	
* +15% Devil Deal chance
* Devil Deals can appear in Chapter 5	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Mother’s Soul as Apollyon'’ 	Defeat Mother’s Soul as Apollyon'’ 	Defeat Mother’s Soul as Apollyon'’ 	Defeat Mother’s Soul as Apollyon'’ 	Defeat Mother’s Soul as Apollyon'’ 	Defeat Mother’s Soul as Apollyon'’ 	Defeat Mother’s Soul as Apollyon'’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Lil’ Abyss 	Lil’ Abyss 	Lil’ Abyss 	Lil’ Abyss 	Lil’ Abyss 	Lil’ Abyss 	Lil’ Abyss 	Its hunger insatiable 	Its hunger insatiable 	Its hunger insatiable 	Its hunger insatiable 	Its hunger insatiable 	Its hunger insatiable 	Its hunger insatiable 	
* While held, all future trinkets that Isaac picks up are consumed, granting their effects to Lil’ Abyss and allowing multiple effects to be kept
* All effects are lost when Lil’ Abyss is dropped	
* While held, all future trinkets that Isaac picks up are consumed, granting their effects to Lil’ Abyss and allowing multiple effects to be kept
* All effects are lost when Lil’ Abyss is dropped	
* While held, all future trinkets that Isaac picks up are consumed, granting their effects to Lil’ Abyss and allowing multiple effects to be kept
* All effects are lost when Lil’ Abyss is dropped	
* While held, all future trinkets that Isaac picks up are consumed, granting their effects to Lil’ Abyss and allowing multiple effects to be kept
* All effects are lost when Lil’ Abyss is dropped	
* While held, all future trinkets that Isaac picks up are consumed, granting their effects to Lil’ Abyss and allowing multiple effects to be kept
* All effects are lost when Lil’ Abyss is dropped	
* While held, all future trinkets that Isaac picks up are consumed, granting their effects to Lil’ Abyss and allowing multiple effects to be kept
* All effects are lost when Lil’ Abyss is dropped	
* While held, all future trinkets that Isaac picks up are consumed, granting their effects to Lil’ Abyss and allowing multiple effects to be kept
* All effects are lost when Lil’ Abyss is dropped	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Everything as Tainted Apollyon 	Defeat Everything as Tainted Apollyon 	Defeat Everything as Tainted Apollyon 	Defeat Everything as Tainted Apollyon 	Defeat Everything as Tainted Apollyon 	Defeat Everything as Tainted Apollyon 	Defeat Everything as Tainted Apollyon 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Untranslated Slab 	Untranslated Slab 	Untranslated Slab 	Untranslated Slab 	Untranslated Slab 	Untranslated Slab 	Untranslated Slab 	Lost with time 	Lost with time 	Lost with time 	Lost with time 	Lost with time 	Lost with time 	Lost with time 	
* Entering a hostile room has a 25% chance to activate the effect of one of the following book items:
** The Bible
** The Book of Belial
** The Necronomicon
** Book of Shadows
** Anarchist Cookbook
** Book of Revelations
** Book of Sin
** Monster Manual
** Telepathy for Dummies
** Satanic Bible
** Book of Virtues
** Lemegeton
** Book of Despair
** Sad Poem	
* Entering a hostile room has a 25% chance to activate the effect of one of the following book items:
** The Bible
** The Book of Belial
** The Necronomicon
** Book of Shadows
** Anarchist Cookbook
** Book of Revelations
** Book of Sin
** Monster Manual
** Telepathy for Dummies
** Satanic Bible
** Book of Virtues
** Lemegeton
** Book of Despair
** Sad Poem	
* Entering a hostile room has a 25% chance to activate the effect of one of the following book items:
** The Bible
** The Book of Belial
** The Necronomicon
** Book of Shadows
** Anarchist Cookbook
** Book of Revelations
** Book of Sin
** Monster Manual
** Telepathy for Dummies
** Satanic Bible
** Book of Virtues
** Lemegeton
** Book of Despair
** Sad Poem	
* Entering a hostile room has a 25% chance to activate the effect of one of the following book items:
** The Bible
** The Book of Belial
** The Necronomicon
** Book of Shadows
** Anarchist Cookbook
** Book of Revelations
** Book of Sin
** Monster Manual
** Telepathy for Dummies
** Satanic Bible
** Book of Virtues
** Lemegeton
** Book of Despair
** Sad Poem	
* Entering a hostile room has a 25% chance to activate the effect of one of the following book items:
** The Bible
** The Book of Belial
** The Necronomicon
** Book of Shadows
** Anarchist Cookbook
** Book of Revelations
** Book of Sin
** Monster Manual
** Telepathy for Dummies
** Satanic Bible
** Book of Virtues
** Lemegeton
** Book of Despair
** Sad Poem	
* Entering a hostile room has a 25% chance to activate the effect of one of the following book items:
** The Bible
** The Book of Belial
** The Necronomicon
** Book of Shadows
** Anarchist Cookbook
** Book of Revelations
** Book of Sin
** Monster Manual
** Telepathy for Dummies
** Satanic Bible
** Book of Virtues
** Lemegeton
** Book of Despair
** Sad Poem	
* Entering a hostile room has a 25% chance to activate the effect of one of the following book items:
** The Bible
** The Book of Belial
** The Necronomicon
** Book of Shadows
** Anarchist Cookbook
** Book of Revelations
** Book of Sin
** Monster Manual
** Telepathy for Dummies
** Satanic Bible
** Book of Virtues
** Lemegeton
** Book of Despair
** Sad Poem	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Guardian as Tainted Alexandria 	Defeat the Guardian as Tainted Alexandria 	Defeat the Guardian as Tainted Alexandria 	Defeat the Guardian as Tainted Alexandria 	Defeat the Guardian as Tainted Alexandria 	Defeat the Guardian as Tainted Alexandria 	Defeat the Guardian as Tainted Alexandria 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Eve’s Scars 	Eve’s Scars 	Eve’s Scars 	Eve’s Scars 	Eve’s Scars 	Eve’s Scars 	Eve’s Scars 	They’re still fresh 	They’re still fresh 	They’re still fresh 	They’re still fresh 	They’re still fresh 	They’re still fresh 	They’re still fresh 	
* Taking damage has a chance to create a Blood Clot
* The type of Blood Clot created depends on the heart type that was damaged	
* Taking damage has a chance to create a Blood Clot
* The type of Blood Clot created depends on the heart type that was damaged	
* Taking damage has a chance to create a Blood Clot
* The type of Blood Clot created depends on the heart type that was damaged	
* Taking damage has a chance to create a Blood Clot
* The type of Blood Clot created depends on the heart type that was damaged	
* Taking damage has a chance to create a Blood Clot
* The type of Blood Clot created depends on the heart type that was damaged	
* Taking damage has a chance to create a Blood Clot
* The type of Blood Clot created depends on the heart type that was damaged	
* Taking damage has a chance to create a Blood Clot
* The type of Blood Clot created depends on the heart type that was damaged	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Tainted Eve 	Complete Greedier Mode as Tainted Eve 	Complete Greedier Mode as Tainted Eve 	Complete Greedier Mode as Tainted Eve 	Complete Greedier Mode as Tainted Eve 	Complete Greedier Mode as Tainted Eve 	Complete Greedier Mode as Tainted Eve 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Fairy in a Jar 	Fairy in a Jar 	Fairy in a Jar 	Fairy in a Jar 	Fairy in a Jar 	Fairy in a Jar 	Fairy in a Jar 	Last chance 	Last chance 	Last chance 	Last chance 	Last chance 	Last chance 	Last chance 	
* Taking fatal damage in a room destroys the trinket and fully heals Isaac
* Grants a heart container if Isaac has none
* Grants a Soul Heart if the player can’t get heart containers	
* Taking fatal damage in a room destroys the trinket and fully heals Isaac
* Grants a heart container if Isaac has none
* Grants a Soul Heart if the player can’t get heart containers	
* Taking fatal damage in a room destroys the trinket and fully heals Isaac
* Grants a heart container if Isaac has none
* Grants a Soul Heart if the player can’t get heart containers	
* Taking fatal damage in a room destroys the trinket and fully heals Isaac
* Grants a heart container if Isaac has none
* Grants a Soul Heart if the player can’t get heart containers	
* Taking fatal damage in a room destroys the trinket and fully heals Isaac
* Grants a heart container if Isaac has none
* Grants a Soul Heart if the player can’t get heart containers	
* Taking fatal damage in a room destroys the trinket and fully heals Isaac
* Grants a heart container if Isaac has none
* Grants a Soul Heart if the player can’t get heart containers	
* Taking fatal damage in a room destroys the trinket and fully heals Isaac
* Grants a heart container if Isaac has none
* Grants a Soul Heart if the player can’t get heart containers	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Guardian as Tainted Ehud 	Defeat the Guardian as Tainted Ehud 	Defeat the Guardian as Tainted Ehud 	Defeat the Guardian as Tainted Ehud 	Defeat the Guardian as Tainted Ehud 	Defeat the Guardian as Tainted Ehud 	Defeat the Guardian as Tainted Ehud 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Flypaper 	Flypaper 	Flypaper 	Flypaper 	Flypaper 	Flypaper 	Flypaper 	Stuck on you 	Stuck on you 	Stuck on you 	Stuck on you 	Stuck on you 	Stuck on you 	Stuck on you 	
* Blue Flies and Blue Spiders no longer attack enemies automatically
* Blue Flies and Blue Spiders only attack enemies that Isaac is damaging	
* Blue Flies and Blue Spiders no longer attack enemies automatically
* Blue Flies and Blue Spiders only attack enemies that Isaac is damaging	
* Blue Flies and Blue Spiders no longer attack enemies automatically
* Blue Flies and Blue Spiders only attack enemies that Isaac is damaging	
* Blue Flies and Blue Spiders no longer attack enemies automatically
* Blue Flies and Blue Spiders only attack enemies that Isaac is damaging	
* Blue Flies and Blue Spiders no longer attack enemies automatically
* Blue Flies and Blue Spiders only attack enemies that Isaac is damaging	
* Blue Flies and Blue Spiders no longer attack enemies automatically
* Blue Flies and Blue Spiders only attack enemies that Isaac is damaging	
* Blue Flies and Blue Spiders no longer attack enemies automatically
* Blue Flies and Blue Spiders only attack enemies that Isaac is damaging	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as Guppy’ 	Complete the Colosseum as Guppy’ 	Complete the Colosseum as Guppy’ 	Complete the Colosseum as Guppy’ 	Complete the Colosseum as Guppy’ 	Complete the Colosseum as Guppy’ 	Complete the Colosseum as Guppy’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Heart of Greed 	Heart of Greed 	Heart of Greed 	Heart of Greed 	Heart of Greed 	Heart of Greed 	Heart of Greed 	Coin up 	Coin up 	Coin up 	Coin up 	Coin up 	Coin up 	Coin up 	
* Grants a Coin Heart at the end of Isaac’s hearts
* Coin Hearts do not affect deal chance, and can be replenished by collecting a coin	
* Grants a Coin Heart at the end of Isaac’s hearts
* Coin Hearts do not affect deal chance, and can be replenished by collecting a coin	
* Grants a Coin Heart at the end of Isaac’s hearts
* Coin Hearts do not affect deal chance, and can be replenished by collecting a coin	
* Grants a Coin Heart at the end of Isaac’s hearts
* Coin Hearts do not affect deal chance, and can be replenished by collecting a coin	
* Grants a Coin Heart at the end of Isaac’s hearts
* Coin Hearts do not affect deal chance, and can be replenished by collecting a coin	
* Grants a Coin Heart at the end of Isaac’s hearts
* Coin Hearts do not affect deal chance, and can be replenished by collecting a coin	
* Grants a Coin Heart at the end of Isaac’s hearts
* Coin Hearts do not affect deal chance, and can be replenished by collecting a coin	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Unlock The Keeper 	Unlock The Keeper 	Unlock The Keeper 	Unlock The Keeper 	Unlock The Keeper 	Unlock The Keeper 	Unlock The Keeper 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Shard of Apollyon 	Shard of Apollyon 	Shard of Apollyon 	Shard of Apollyon 	Shard of Apollyon 	Shard of Apollyon 	Shard of Apollyon 	Fractured calamity 	Fractured calamity 	Fractured calamity 	Fractured calamity 	Fractured calamity 	Fractured calamity 	Fractured calamity 	
* Collecting an item pedestal has a 10% chance to grant its respective Abyss Locust to Isaac	
* Collecting an item pedestal has a 10% chance to grant its respective Abyss Locust to Isaac	
* Collecting an item pedestal has a 10% chance to grant its respective Abyss Locust to Isaac	
* Collecting an item pedestal has a 10% chance to grant its respective Abyss Locust to Isaac	
* Collecting an item pedestal has a 10% chance to grant its respective Abyss Locust to Isaac	
* Collecting an item pedestal has a 10% chance to grant its respective Abyss Locust to Isaac	
* Collecting an item pedestal has a 10% chance to grant its respective Abyss Locust to Isaac	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Thanatos as Tainted Apollyon 	Defeat Thanatos as Tainted Apollyon 	Defeat Thanatos as Tainted Apollyon 	Defeat Thanatos as Tainted Apollyon 	Defeat Thanatos as Tainted Apollyon 	Defeat Thanatos as Tainted Apollyon 	Defeat Thanatos as Tainted Apollyon 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Chocolate Penny 	Chocolate Penny 	Chocolate Penny 	Chocolate Penny 	Chocolate Penny 	Chocolate Penny 	Chocolate Penny 	Wealth of yum 	Wealth of yum 	Wealth of yum 	Wealth of yum 	Wealth of yum 	Wealth of yum 	Wealth of yum 	
* If Isaac is not at full health, coins heal Isaac for half a heart instead of graning coins	
* If Isaac is not at full health, coins heal Isaac for half a heart instead of graning coins	
* If Isaac is not at full health, coins heal Isaac for half a heart instead of graning coins	
* If Isaac is not at full health, coins heal Isaac for half a heart instead of graning coins	
* If Isaac is not at full health, coins heal Isaac for half a heart instead of graning coins	
* If Isaac is not at full health, coins heal Isaac for half a heart instead of graning coins	
* If Isaac is not at full health, coins heal Isaac for half a heart instead of graning coins	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Tainted Magdalene 	Complete Greedier Mode as Tainted Magdalene 	Complete Greedier Mode as Tainted Magdalene 	Complete Greedier Mode as Tainted Magdalene 	Complete Greedier Mode as Tainted Magdalene 	Complete Greedier Mode as Tainted Magdalene 	Complete Greedier Mode as Tainted Magdalene 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Cursed Reverse 	Cursed Reverse 	Cursed Reverse 	Cursed Reverse 	Cursed Reverse 	Cursed Reverse 	Cursed Reverse 	No, you 	No, you 	No, you 	No, you 	No, you 	No, you 	No, you 	
* Taking damage has a chance to teleport a random enemy to a different area in the room	
* Taking damage has a chance to teleport a random enemy to a different area in the room	
* Taking damage has a chance to teleport a random enemy to a different area in the room	
* Taking damage has a chance to teleport a random enemy to a different area in the room	
* Taking damage has a chance to teleport a random enemy to a different area in the room	
* Taking damage has a chance to teleport a random enemy to a different area in the room	
* Taking damage has a chance to teleport a random enemy to a different area in the room	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Guppy’s Box 	Guppy’s Box 	Guppy’s Box 	Guppy’s Box 	Guppy’s Box 	Guppy’s Box 	Guppy’s Box 	Alive or dead 	Alive or dead 	Alive or dead 	Alive or dead 	Alive or dead 	Alive or dead 	Alive or dead 	
* Entering a new room paralyzes all enemies until they enter Isaac’s line of sight	
* Entering a new room paralyzes all enemies until they enter Isaac’s line of sight	
* Entering a new room paralyzes all enemies until they enter Isaac’s line of sight	
* Entering a new room paralyzes all enemies until they enter Isaac’s line of sight	
* Entering a new room paralyzes all enemies until they enter Isaac’s line of sight	
* Entering a new room paralyzes all enemies until they enter Isaac’s line of sight	
* Entering a new room paralyzes all enemies until they enter Isaac’s line of sight	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat Everything as Guppy 	Defeat Everything as Guppy 	Defeat Everything as Guppy 	Defeat Everything as Guppy 	Defeat Everything as Guppy 	Defeat Everything as Guppy 	Defeat Everything as Guppy 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Excavation Brush 	Excavation Brush 	Excavation Brush 	Excavation Brush 	Excavation Brush 	Excavation Brush 	Excavation Brush 	What’s inside? 	What’s inside? 	What’s inside? 	What’s inside? 	What’s inside? 	What’s inside? 	What’s inside? 	
* Destroying certain grid objects has a higher chance of them dropping pick-ups, and a lower chance of them revealing projectiles or enemies	
* Destroying certain grid objects has a higher chance of them dropping pick-ups, and a lower chance of them revealing projectiles or enemies	
* Destroying certain grid objects has a higher chance of them dropping pick-ups, and a lower chance of them revealing projectiles or enemies	
* Destroying certain grid objects has a higher chance of them dropping pick-ups, and a lower chance of them revealing projectiles or enemies	
* Destroying certain grid objects has a higher chance of them dropping pick-ups, and a lower chance of them revealing projectiles or enemies	
* Destroying certain grid objects has a higher chance of them dropping pick-ups, and a lower chance of them revealing projectiles or enemies	
* Destroying certain grid objects has a higher chance of them dropping pick-ups, and a lower chance of them revealing projectiles or enemies	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Malfunctioning Teleporter	Malfunctioning Teleporter	Malfunctioning Teleporter	Malfunctioning Teleporter	Malfunctioning Teleporter	Malfunctioning Teleporter	Malfunctioning Teleporter	Who knows where you’ll end up! 	Who knows where you’ll end up! 	Who knows where you’ll end up! 	Who knows where you’ll end up! 	Who knows where you’ll end up! 	Who knows where you’ll end up! 	Who knows where you’ll end up! 	
* Entering a new floor spawns Isaac in a random, non hostile room
* This room can be special rooms	
* Entering a new floor spawns Isaac in a random, non hostile room
* This room can be special rooms	
* Entering a new floor spawns Isaac in a random, non hostile room
* This room can be special rooms	
* Entering a new floor spawns Isaac in a random, non hostile room
* This room can be special rooms	
* Entering a new floor spawns Isaac in a random, non hostile room
* This room can be special rooms	
* Entering a new floor spawns Isaac in a random, non hostile room
* This room can be special rooms	
* Entering a new floor spawns Isaac in a random, non hostile room
* This room can be special rooms	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Knuckle Sandwich 	Knuckle Sandwich 	Knuckle Sandwich 	Knuckle Sandwich 	Knuckle Sandwich 	Knuckle Sandwich 	Knuckle Sandwich 	Taste defeat 	Taste defeat 	Taste defeat 	Taste defeat 	Taste defeat 	Taste defeat 	Taste defeat 	
* Challenge rooms can always be entered, regardless of health	
* Challenge rooms can always be entered, regardless of health	
* Challenge rooms can always be entered, regardless of health	
* Challenge rooms can always be entered, regardless of health	
* Challenge rooms can always be entered, regardless of health	
* Challenge rooms can always be entered, regardless of health	
* Challenge rooms can always be entered, regardless of health	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete 10 Challenge rooms 	Complete 10 Challenge rooms 	Complete 10 Challenge rooms 	Complete 10 Challenge rooms 	Complete 10 Challenge rooms 	Complete 10 Challenge rooms 	Complete 10 Challenge rooms 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Smoker’s Lung 	Smoker’s Lung 	Smoker’s Lung 	Smoker’s Lung 	Smoker’s Lung 	Smoker’s Lung 	Smoker’s Lung 	Half rotten 	Half rotten 	Half rotten 	Half rotten 	Half rotten 	Half rotten 	Half rotten 	
* Increases the chance for Rotten Hearts to spawn
* Rotten Hearts take two hits to deplete	
* Increases the chance for Rotten Hearts to spawn
* Rotten Hearts take two hits to deplete	
* Increases the chance for Rotten Hearts to spawn
* Rotten Hearts take two hits to deplete	
* Increases the chance for Rotten Hearts to spawn
* Rotten Hearts take two hits to deplete	
* Increases the chance for Rotten Hearts to spawn
* Rotten Hearts take two hits to deplete	
* Increases the chance for Rotten Hearts to spawn
* Rotten Hearts take two hits to deplete	
* Increases the chance for Rotten Hearts to spawn
* Rotten Hearts take two hits to deplete	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete Greedier Mode as Tainted Guppy’ 	Complete Greedier Mode as Tainted Guppy’ 	Complete Greedier Mode as Tainted Guppy’ 	Complete Greedier Mode as Tainted Guppy’ 	Complete Greedier Mode as Tainted Guppy’ 	Complete Greedier Mode as Tainted Guppy’ 	Complete Greedier Mode as Tainted Guppy’ 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Stalagmite 	Stalagmite 	Stalagmite 	Stalagmite 	Stalagmite 	Stalagmite 	Stalagmite 	The ceiling rumbles 	The ceiling rumbles 	The ceiling rumbles 	The ceiling rumbles 	The ceiling rumbles 	The ceiling rumbles 	The ceiling rumbles 	
* Stalagmites can appear outside of Chapter 2
* Stalagmites fall when Isaac gets near, and can damage both him and enemies	
* Stalagmites can appear outside of Chapter 2
* Stalagmites fall when Isaac gets near, and can damage both him and enemies	
* Stalagmites can appear outside of Chapter 2
* Stalagmites fall when Isaac gets near, and can damage both him and enemies	
* Stalagmites can appear outside of Chapter 2
* Stalagmites fall when Isaac gets near, and can damage both him and enemies	
* Stalagmites can appear outside of Chapter 2
* Stalagmites fall when Isaac gets near, and can damage both him and enemies	
* Stalagmites can appear outside of Chapter 2
* Stalagmites fall when Isaac gets near, and can damage both him and enemies	
* Stalagmites can appear outside of Chapter 2
* Stalagmites fall when Isaac gets near, and can damage both him and enemies	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Complete the Colosseum as The Forgotten 	Complete the Colosseum as The Forgotten 	Complete the Colosseum as The Forgotten 	Complete the Colosseum as The Forgotten 	Complete the Colosseum as The Forgotten 	Complete the Colosseum as The Forgotten 	Complete the Colosseum as The Forgotten 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
thornofthecrown 	thornofthecrown 	thornofthecrown 	thornofthecrown 	thornofthecrown 	thornofthecrown 	thornofthecrown 	Gain from pain 	Gain from pain 	Gain from pain 	Gain from pain 	Gain from pain 	Gain from pain 	Gain from pain 	
* Taking damage has a small chance to activate a random Sacrifice Room effect	
* Taking damage has a small chance to activate a random Sacrifice Room effect	
* Taking damage has a small chance to activate a random Sacrifice Room effect	
* Taking damage has a small chance to activate a random Sacrifice Room effect	
* Taking damage has a small chance to activate a random Sacrifice Room effect	
* Taking damage has a small chance to activate a random Sacrifice Room effect	
* Taking damage has a small chance to activate a random Sacrifice Room effect	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Defeat the Guardian as Tainted Magdalene 	Defeat the Guardian as Tainted Magdalene 	Defeat the Guardian as Tainted Magdalene 	Defeat the Guardian as Tainted Magdalene 	Defeat the Guardian as Tainted Magdalene 	Defeat the Guardian as Tainted Magdalene 	Defeat the Guardian as Tainted Magdalene 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Chewed Gum 	Chewed Gum 	Chewed Gum 	Chewed Gum 	Chewed Gum 	Chewed Gum 	Chewed Gum 	Stuck together 	Stuck together 	Stuck together 	Stuck together 	Stuck together 	Stuck together 	Stuck together 	
* A random enemy in every hostile room has gum stuck to them
* Enemies that touch the gummed enemy become stuck to them
* Enemies stuck in gum take damage at the same time	
* A random enemy in every hostile room has gum stuck to them
* Enemies that touch the gummed enemy become stuck to them
* Enemies stuck in gum take damage at the same time	
* A random enemy in every hostile room has gum stuck to them
* Enemies that touch the gummed enemy become stuck to them
* Enemies stuck in gum take damage at the same time	
* A random enemy in every hostile room has gum stuck to them
* Enemies that touch the gummed enemy become stuck to them
* Enemies stuck in gum take damage at the same time	
* A random enemy in every hostile room has gum stuck to them
* Enemies that touch the gummed enemy become stuck to them
* Enemies stuck in gum take damage at the same time	
* A random enemy in every hostile room has gum stuck to them
* Enemies that touch the gummed enemy become stuck to them
* Enemies stuck in gum take damage at the same time	
* A random enemy in every hostile room has gum stuck to them
* Enemies that touch the gummed enemy become stuck to them
* Enemies stuck in gum take damage at the same time	
* 
* 	
* 
* 	
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* 	
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* 	
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* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Map Piece 	Map Piece 	Map Piece 	Map Piece 	Map Piece 	Map Piece 	Map Piece 	Uncharted territory 	Uncharted territory 	Uncharted territory 	Uncharted territory 	Uncharted territory 	Uncharted territory 	Uncharted territory 	
* 1 - 4 extra rooms are created every floor
* These can be extra special rooms	
* 1 - 4 extra rooms are created every floor
* These can be extra special rooms	
* 1 - 4 extra rooms are created every floor
* These can be extra special rooms	
* 1 - 4 extra rooms are created every floor
* These can be extra special rooms	
* 1 - 4 extra rooms are created every floor
* These can be extra special rooms	
* 1 - 4 extra rooms are created every floor
* These can be extra special rooms	
* 1 - 4 extra rooms are created every floor
* These can be extra special rooms	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Obtain all Completion Marks as Alexandria 	Obtain all Completion Marks as Alexandria 	Obtain all Completion Marks as Alexandria 	Obtain all Completion Marks as Alexandria 	Obtain all Completion Marks as Alexandria 	Obtain all Completion Marks as Alexandria 	Obtain all Completion Marks as Alexandria 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Password Paper 	Password Paper 	Password Paper 	Password Paper 	Password Paper 	Password Paper 	Password Paper 	What’s the password? 	What’s the password? 	What’s the password? 	What’s the password? 	What’s the password? 	What’s the password? 	What’s the password? 	
* Increases the chance for Black Markets to appear
* Black Markets can be entered for free	
* Increases the chance for Black Markets to appear
* Black Markets can be entered for free	
* Increases the chance for Black Markets to appear
* Black Markets can be entered for free	
* Increases the chance for Black Markets to appear
* Black Markets can be entered for free	
* Increases the chance for Black Markets to appear
* Black Markets can be entered for free	
* Increases the chance for Black Markets to appear
* Black Markets can be entered for free	
* Increases the chance for Black Markets to appear
* Black Markets can be entered for free	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Enter a Black Market 10 times 	Enter a Black Market 10 times 	Enter a Black Market 10 times 	Enter a Black Market 10 times 	Enter a Black Market 10 times 	Enter a Black Market 10 times 	Enter a Black Market 10 times 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Forgotten Board 	Forgotten Board 	Forgotten Board 	Forgotten Board 	Forgotten Board 	Forgotten Board 	Forgotten Board 	Your memories burn away 	Your memories burn away 	Your memories burn away 	Your memories burn away 	Your memories burn away 	Your memories burn away 	Your memories burn away 	
* Clearing a room has a chance to unclear it when leaving it, allowing it to be cleared again to farm room clear rewards	
* Clearing a room has a chance to unclear it when leaving it, allowing it to be cleared again to farm room clear rewards	
* Clearing a room has a chance to unclear it when leaving it, allowing it to be cleared again to farm room clear rewards	
* Clearing a room has a chance to unclear it when leaving it, allowing it to be cleared again to farm room clear rewards	
* Clearing a room has a chance to unclear it when leaving it, allowing it to be cleared again to farm room clear rewards	
* Clearing a room has a chance to unclear it when leaving it, allowing it to be cleared again to farm room clear rewards	
* Clearing a room has a chance to unclear it when leaving it, allowing it to be cleared again to farm room clear rewards	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
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* 	
* 
* 	
* 
* 	Complete Greedier Mode as Tainted Forgotten 	Complete Greedier Mode as Tainted Forgotten 	Complete Greedier Mode as Tainted Forgotten 	Complete Greedier Mode as Tainted Forgotten 	Complete Greedier Mode as Tainted Forgotten 	Complete Greedier Mode as Tainted Forgotten 	Complete Greedier Mode as Tainted Forgotten 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Peppermint 	Peppermint 	Peppermint 	Peppermint 	Peppermint 	Peppermint 	Peppermint 	Freezer burn 	Freezer burn 	Freezer burn 	Freezer burn 	Freezer burn 	Freezer burn 	Freezer burn 	
* Luck-based chance to fire a tear that inflicts both Burn and Chill
* 100% chance at 34 Luck	
* Luck-based chance to fire a tear that inflicts both Burn and Chill
* 100% chance at 34 Luck	
* Luck-based chance to fire a tear that inflicts both Burn and Chill
* 100% chance at 34 Luck	
* Luck-based chance to fire a tear that inflicts both Burn and Chill
* 100% chance at 34 Luck	
* Luck-based chance to fire a tear that inflicts both Burn and Chill
* 100% chance at 34 Luck	
* Luck-based chance to fire a tear that inflicts both Burn and Chill
* 100% chance at 34 Luck	
* Luck-based chance to fire a tear that inflicts both Burn and Chill
* 100% chance at 34 Luck	
* 
* 	
* 
* 	
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* 	
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* 	
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* 	
* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Communion Wafer 	Communion Wafer 	Communion Wafer 	Communion Wafer 	Communion Wafer 	Communion Wafer 	Communion Wafer 	Damage resistance… sometimes 	Damage resistance… sometimes 	Damage resistance… sometimes 	Damage resistance… sometimes 	Damage resistance… sometimes 	Damage resistance… sometimes 	Damage resistance… sometimes 	
* Taking damage has a 15% chance to reduce it to half a heart	
* Taking damage has a 15% chance to reduce it to half a heart	
* Taking damage has a 15% chance to reduce it to half a heart	
* Taking damage has a 15% chance to reduce it to half a heart	
* Taking damage has a 15% chance to reduce it to half a heart	
* Taking damage has a 15% chance to reduce it to half a heart	
* Taking damage has a 15% chance to reduce it to half a heart	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
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* 
* 	
* 
* 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Loose Change 	Loose Change 	Loose Change 	Loose Change 	Loose Change 	Loose Change 	Loose Change 	Get yourself something nice 	Get yourself something nice 	Get yourself something nice 	Get yourself something nice 	Get yourself something nice 	Get yourself something nice 	Get yourself something nice 	
* All Shops contain a free Nickel inside of them	
* All Shops contain a free Nickel inside of them	
* All Shops contain a free Nickel inside of them	
* All Shops contain a free Nickel inside of them	
* All Shops contain a free Nickel inside of them	
* All Shops contain a free Nickel inside of them	
* All Shops contain a free Nickel inside of them	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	
* 
* 	Buy 25 items from Shops that cost 5 coins or less 	Buy 25 items from Shops that cost 5 coins or less 	Buy 25 items from Shops that cost 5 coins or less 	Buy 25 items from Shops that cost 5 coins or less 	Buy 25 items from Shops that cost 5 coins or less 	Buy 25 items from Shops that cost 5 coins or less 	Buy 25 items from Shops that cost 5 coins or less 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Dark Key 	Dark Key 	Dark Key 	Dark Key 	Dark Key 	Dark Key 	Dark Key 	Unlocking darkness 	Unlocking darkness 	Unlocking darkness 	Unlocking darkness 	Unlocking darkness 	Unlocking darkness 	Unlocking darkness 	
* Red Chests now require a key to open
* Improves the contents of Red Chests, guaranteeing that they will never contain Spiders or Troll Bombs and increasing the amount of pick-ups or Blue Spiders/Flies they drop	
* Red Chests now require a key to open
* Improves the contents of Red Chests, guaranteeing that they will never contain Spiders or Troll Bombs and increasing the amount of pick-ups or Blue Spiders/Flies they drop	
* Red Chests now require a key to open
* Improves the contents of Red Chests, guaranteeing that they will never contain Spiders or Troll Bombs and increasing the amount of pick-ups or Blue Spiders/Flies they drop	
* Red Chests now require a key to open
* Improves the contents of Red Chests, guaranteeing that they will never contain Spiders or Troll Bombs and increasing the amount of pick-ups or Blue Spiders/Flies they drop	
* Red Chests now require a key to open
* Improves the contents of Red Chests, guaranteeing that they will never contain Spiders or Troll Bombs and increasing the amount of pick-ups or Blue Spiders/Flies they drop	
* Red Chests now require a key to open
* Improves the contents of Red Chests, guaranteeing that they will never contain Spiders or Troll Bombs and increasing the amount of pick-ups or Blue Spiders/Flies they drop	
* Red Chests now require a key to open
* Improves the contents of Red Chests, guaranteeing that they will never contain Spiders or Troll Bombs and increasing the amount of pick-ups or Blue Spiders/Flies they drop	
* 
* 	
* 
* 	
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* 	
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* 	Complete the Colosseum as Tainted Judas 	Complete the Colosseum as Tainted Judas 	Complete the Colosseum as Tainted Judas 	Complete the Colosseum as Tainted Judas 	Complete the Colosseum as Tainted Judas 	Complete the Colosseum as Tainted Judas 	Complete the Colosseum as Tainted Judas 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Lunar Compass 	Lunar Compass 	Lunar Compass 	Lunar Compass 	Lunar Compass 	Lunar Compass 	Lunar Compass 	It points toward lost memories 	It points toward lost memories 	It points toward lost memories 	It points toward lost memories 	It points toward lost memories 	It points toward lost memories 	It points toward lost memories 	
* In hostile rooms, Isaac gains a very slight Tears Up
* The increases in Isaac’s tears scales with how close he is to the Secret Room	
* In hostile rooms, Isaac gains a very slight Tears Up
* The increases in Isaac’s tears scales with how close he is to the Secret Room	
* In hostile rooms, Isaac gains a very slight Tears Up
* The increases in Isaac’s tears scales with how close he is to the Secret Room	
* In hostile rooms, Isaac gains a very slight Tears Up
* The increases in Isaac’s tears scales with how close he is to the Secret Room	
* In hostile rooms, Isaac gains a very slight Tears Up
* The increases in Isaac’s tears scales with how close he is to the Secret Room	
* In hostile rooms, Isaac gains a very slight Tears Up
* The increases in Isaac’s tears scales with how close he is to the Secret Room	
* In hostile rooms, Isaac gains a very slight Tears Up
* The increases in Isaac’s tears scales with how close he is to the Secret Room	
* 
* 	
* 
* 	
* 
* 	
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* 	
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* 	
* 
* 	Defeat the Onlookers as Tainted Leah 	Defeat the Onlookers as Tainted Leah 	Defeat the Onlookers as Tainted Leah 	Defeat the Onlookers as Tainted Leah 	Defeat the Onlookers as Tainted Leah 	Defeat the Onlookers as Tainted Leah 	Defeat the Onlookers as Tainted Leah 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Power Bank 	Power Bank 	Power Bank 	Power Bank 	Power Bank 	Power Bank 	Power Bank 	Hard work doesn’t go to waste 	Hard work doesn’t go to waste 	Hard work doesn’t go to waste 	Hard work doesn’t go to waste 	Hard work doesn’t go to waste 	Hard work doesn’t go to waste 	Hard work doesn’t go to waste 	
* Gaining charges on an already fully charged active item (i.e via batteries or clearing rooms) has a 25% chance to grant a coin for each charge wasted instead	
* Gaining charges on an already fully charged active item (i.e via batteries or clearing rooms) has a 25% chance to grant a coin for each charge wasted instead	
* Gaining charges on an already fully charged active item (i.e via batteries or clearing rooms) has a 25% chance to grant a coin for each charge wasted instead	
* Gaining charges on an already fully charged active item (i.e via batteries or clearing rooms) has a 25% chance to grant a coin for each charge wasted instead	
* Gaining charges on an already fully charged active item (i.e via batteries or clearing rooms) has a 25% chance to grant a coin for each charge wasted instead	
* Gaining charges on an already fully charged active item (i.e via batteries or clearing rooms) has a 25% chance to grant a coin for each charge wasted instead	
* Gaining charges on an already fully charged active item (i.e via batteries or clearing rooms) has a 25% chance to grant a coin for each charge wasted instead	
* 
* 	
* 
* 	
* 
* 	
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* 	
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* 	
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* 	Complete the Colosseum as Ehud 	Complete the Colosseum as Ehud 	Complete the Colosseum as Ehud 	Complete the Colosseum as Ehud 	Complete the Colosseum as Ehud 	Complete the Colosseum as Ehud 	Complete the Colosseum as Ehud 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Mass Card 	Mass Card 	Mass Card 	Mass Card 	Mass Card 	Mass Card 	Mass Card 	A page of the fallen 	A page of the fallen 	A page of the fallen 	A page of the fallen 	A page of the fallen 	A page of the fallen 	A page of the fallen 	
* Using a card grants a random Wisp	
* Using a card grants a random Wisp	
* Using a card grants a random Wisp	
* Using a card grants a random Wisp	
* Using a card grants a random Wisp	
* Using a card grants a random Wisp	
* Using a card grants a random Wisp	
* 
* 	
* 
* 	
* 
* 	
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* 	
* 
* 	
* 
* 	
* 
* 	Die 100 times 	Die 100 times 	Die 100 times 	Die 100 times 	Die 100 times 	Die 100 times 	Die 100 times 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Locust Egg 	Locust Egg 	Locust Egg 	Locust Egg 	Locust Egg 	Locust Egg 	Locust Egg 	Birth of calamity 	Birth of calamity 	Birth of calamity 	Birth of calamity 	Birth of calamity 	Birth of calamity 	Birth of calamity 	
* Every time Isaac takes damage, there is a 15% chance to grant Isaac an Abyss Locust for the current room	
* Every time Isaac takes damage, there is a 15% chance to grant Isaac an Abyss Locust for the current room	
* Every time Isaac takes damage, there is a 15% chance to grant Isaac an Abyss Locust for the current room	
* Every time Isaac takes damage, there is a 15% chance to grant Isaac an Abyss Locust for the current room	
* Every time Isaac takes damage, there is a 15% chance to grant Isaac an Abyss Locust for the current room	
* Every time Isaac takes damage, there is a 15% chance to grant Isaac an Abyss Locust for the current room	
* Every time Isaac takes damage, there is a 15% chance to grant Isaac an Abyss Locust for the current room	
* 
* 	
* 
* 	
* 
* 	
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* 	
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* 	
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* 	
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* 	Complete Greedier Mode as Tainted Apollyon 	Complete Greedier Mode as Tainted Apollyon 	Complete Greedier Mode as Tainted Apollyon 	Complete Greedier Mode as Tainted Apollyon 	Complete Greedier Mode as Tainted Apollyon 	Complete Greedier Mode as Tainted Apollyon 	Complete Greedier Mode as Tainted Apollyon 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
My Soul 	My Soul 	My Soul 	My Soul 	My Soul 	My Soul 	My Soul 	... 	... 	... 	... 	... 	... 	... 	
* Grants a unique effect based on the character holding it:
** Isaac (Decisions, decisions) - Rerolling items with the D6 has a 25% chance to have it cycle between the new item and the item rerolled
** Leah (Shard shot) - Grants Leah a 15% chance to fire a shard projectile with the same properties as Broken Recorder’s projectile.
** Magdalene (Healthier health) - Red Hearts have a higher chance to become Double Red Hearts. Yum Heart heals twice as much health
** Cain (Value in refuse) - Collecting a pick-up has a chance to grant Cain an additional pick-up of that type (i.e, collecting a coin has a chance to grant Cain another coin)
** Judas (Revel in sin) - Taking a Devil Deal or Black Market item that uses up the last of Judas’ Heart Containers grants a Black Heart for each heart container removed
** ??? (Stronger spirit) - HP ups grants double the amount of Soul Hearts
** Eve (Your very own murder) - Eve can summon additional Dead Bird familiars each time she takes damage, for a total of 12 per room
** Samson (Gain from pain) - All types of on-hit effects, such as Bloody Lust, have a chance to activate twice when activated
** Azazel (Fading fury) - Firing a Brimstone beam has a chance for it to have infinite range
** Lazarus (Taking you with me) - Reviving as Lazarus Risen deals 100 damage to all enemies in the room
** Eden (?) - Instantly destroys itself on pick-up and spawns 3 random trinkets. The first trinket picked up is instantly gulped and kept permanently, while the other 2 aren’t gulped but can still be picked up
** The Lost (Panic mode) - When The Lost’s Holy Mantle breaks, he gains +3 Damage and +0.5 Tears until he gets it back
** Lilith (Sharing is caring) - All non-Incubus familiars that Lilith has have a 25% chance to fire a projectile that copies all of her tear effects
** The Keeper (Finders keepers) - If the Shop has an item that The Keeper cannot afford, there is a 25% chance for an extra coin to spawn on room clear alongside any other room clear rewards
** Apollyon (Insatiable appetite) - Active items that are consumed with Void grant stat increases instead of being stored inside of it
** The Forgotten (Push & Shove) - While as The Soul, The Forgotten’s body can be pulled around while moving. Enemies will attempt to target the body when possible, though will target The Soul if it is closer
** Bethany (Faith guides you) - Clearing a room has a 25% chance to grant a basic Wisp
** Jacob & Esau (Stronger than you) - The brother holding a trinket gets 25% of the stat increases the other brother has
** Ehud (Perfect parry) - Parrying an enemy grants Ehud a quickly fading tears, speed, and damage up
** Alexandria (Knowledge is power) - Entering a room that has yet to be visited grants Alexandria a random stat increase for the duration of it
** Guppy (More friends!) - Increases the chance for Guppy to create Blue Flies to 70%
** Tainted Isaac (Options up) - All item pedestals cycle between three items instead of two.
** Tainted Leah (One step ahead) - While in the Escapist Fantasy world, Lovechild is unable to gain any new attacks outside of the ones it has in Chapter 1
** Tainted Magdalene (Heart attack) - Hearts that disappear leave behind a very small puddle of red creep that damages enemies
** Tainted Cain (Repurpose) - Grabbing an pick-up with Bag of Crafting has a 20% chance to drop a copy of the collected item on the ground
** Tainted Judas (Suppressing shadows) - Enemies hit by Dark Arts are temporarily slowed down
** Tainted ??? (Tower defense) - Poops created by Tainted ??? can be targeted and destroyed by enemies
** Tainted Eve (Free bleeding) - Two Blood Clots can be made at once at the cost of draining a full heart of health
** Tainted Samson (Immovable object) - While in Berserk mode, Tainted Samson gains contact damage and invincibility if he is moving fast enough
** Tainted Azazel (Stronger sneeze) - Tainted Azazel’s sneeze is larger and pushes enemies back further
** Tainted Lazarus (A gift from the other side) - The form that holds this trinket gets a random passive item from the other form every room
** Tainted Eden (Force close) - When taking damage, a random passive item held by Tainted Eden is not rerolled
** Tainted Lost (Truly better items?) - Certain defensive items, such as Holy Mantle and Book of Shadows, can now be accessed by Tainted Lost. While held, Holy Cards can no longer appear.
** Tainted Lilith (Mama’s boy) - After launching the Gello, it always stays directly in front of Tainted Lilith, allowing it to be aimed easier
** Tainted Keeper (On the grindset) - All pick-ups outside of Shops are replaced with coins
** Tainted Apollyon (Divided swarms) - Abyss Locusts swarm enemies in groups of up to four instead of individually
** Tainted Forgotten (Boomerang bones) - Tainted Forgotten, when thrown, attempts to boomerang back to The Soul when at peak distance.
** Tainted Bethany (Self defense) - Lemegeton wisps can now fire tears at enemies that deal 3.5 damage each
** Tainted Jacob (Blind rage) - Dark Esau has a 25% to target enemies instead of Tainted Jacob when charging
** Tainted Ehud (Shockwave slam) – Tainted Ehud’s slam attack produces a shockwave that pushes back and slightly damages nearby enemies
** Tainted Alexandria (Monopoly) - Rooms now cost only one type of resource to be built, always being the pick-up type that Tainted Alexandria has most of.
** Tainted Guppy (Infested!) - Tainted Guppy has a chance to produce Blue Spiders instead of Blue Flies	
* Grants a unique effect based on the character holding it:
** Isaac (Decisions, decisions) - Rerolling items with the D6 has a 25% chance to have it cycle between the new item and the item rerolled
** Leah (Shard shot) - Grants Leah a 15% chance to fire a shard projectile with the same properties as Broken Recorder’s projectile.
** Magdalene (Healthier health) - Red Hearts have a higher chance to become Double Red Hearts. Yum Heart heals twice as much health
** Cain (Value in refuse) - Collecting a pick-up has a chance to grant Cain an additional pick-up of that type (i.e, collecting a coin has a chance to grant Cain another coin)
** Judas (Revel in sin) - Taking a Devil Deal or Black Market item that uses up the last of Judas’ Heart Containers grants a Black Heart for each heart container removed
** ??? (Stronger spirit) - HP ups grants double the amount of Soul Hearts
** Eve (Your very own murder) - Eve can summon additional Dead Bird familiars each time she takes damage, for a total of 12 per room
** Samson (Gain from pain) - All types of on-hit effects, such as Bloody Lust, have a chance to activate twice when activated
** Azazel (Fading fury) - Firing a Brimstone beam has a chance for it to have infinite range
** Lazarus (Taking you with me) - Reviving as Lazarus Risen deals 100 damage to all enemies in the room
** Eden (?) - Instantly destroys itself on pick-up and spawns 3 random trinkets. The first trinket picked up is instantly gulped and kept permanently, while the other 2 aren’t gulped but can still be picked up
** The Lost (Panic mode) - When The Lost’s Holy Mantle breaks, he gains +3 Damage and +0.5 Tears until he gets it back
** Lilith (Sharing is caring) - All non-Incubus familiars that Lilith has have a 25% chance to fire a projectile that copies all of her tear effects
** The Keeper (Finders keepers) - If the Shop has an item that The Keeper cannot afford, there is a 25% chance for an extra coin to spawn on room clear alongside any other room clear rewards
** Apollyon (Insatiable appetite) - Active items that are consumed with Void grant stat increases instead of being stored inside of it
** The Forgotten (Push & Shove) - While as The Soul, The Forgotten’s body can be pulled around while moving. Enemies will attempt to target the body when possible, though will target The Soul if it is closer
** Bethany (Faith guides you) - Clearing a room has a 25% chance to grant a basic Wisp
** Jacob & Esau (Stronger than you) - The brother holding a trinket gets 25% of the stat increases the other brother has
** Ehud (Perfect parry) - Parrying an enemy grants Ehud a quickly fading tears, speed, and damage up
** Alexandria (Knowledge is power) - Entering a room that has yet to be visited grants Alexandria a random stat increase for the duration of it
** Guppy (More friends!) - Increases the chance for Guppy to create Blue Flies to 70%
** Tainted Isaac (Options up) - All item pedestals cycle between three items instead of two.
** Tainted Leah (One step ahead) - While in the Escapist Fantasy world, Lovechild is unable to gain any new attacks outside of the ones it has in Chapter 1
** Tainted Magdalene (Heart attack) - Hearts that disappear leave behind a very small puddle of red creep that damages enemies
** Tainted Cain (Repurpose) - Grabbing an pick-up with Bag of Crafting has a 20% chance to drop a copy of the collected item on the ground
** Tainted Judas (Suppressing shadows) - Enemies hit by Dark Arts are temporarily slowed down
** Tainted ??? (Tower defense) - Poops created by Tainted ??? can be targeted and destroyed by enemies
** Tainted Eve (Free bleeding) - Two Blood Clots can be made at once at the cost of draining a full heart of health
** Tainted Samson (Immovable object) - While in Berserk mode, Tainted Samson gains contact damage and invincibility if he is moving fast enough
** Tainted Azazel (Stronger sneeze) - Tainted Azazel’s sneeze is larger and pushes enemies back further
** Tainted Lazarus (A gift from the other side) - The form that holds this trinket gets a random passive item from the other form every room
** Tainted Eden (Force close) - When taking damage, a random passive item held by Tainted Eden is not rerolled
** Tainted Lost (Truly better items?) - Certain defensive items, such as Holy Mantle and Book of Shadows, can now be accessed by Tainted Lost. While held, Holy Cards can no longer appear.
** Tainted Lilith (Mama’s boy) - After launching the Gello, it always stays directly in front of Tainted Lilith, allowing it to be aimed easier
** Tainted Keeper (On the grindset) - All pick-ups outside of Shops are replaced with coins
** Tainted Apollyon (Divided swarms) - Abyss Locusts swarm enemies in groups of up to four instead of individually
** Tainted Forgotten (Boomerang bones) - Tainted Forgotten, when thrown, attempts to boomerang back to The Soul when at peak distance.
** Tainted Bethany (Self defense) - Lemegeton wisps can now fire tears at enemies that deal 3.5 damage each
** Tainted Jacob (Blind rage) - Dark Esau has a 25% to target enemies instead of Tainted Jacob when charging
** Tainted Ehud (Shockwave slam) – Tainted Ehud’s slam attack produces a shockwave that pushes back and slightly damages nearby enemies
** Tainted Alexandria (Monopoly) - Rooms now cost only one type of resource to be built, always being the pick-up type that Tainted Alexandria has most of.
** Tainted Guppy (Infested!) - Tainted Guppy has a chance to produce Blue Spiders instead of Blue Flies	
* Grants a unique effect based on the character holding it:
** Isaac (Decisions, decisions) - Rerolling items with the D6 has a 25% chance to have it cycle between the new item and the item rerolled
** Leah (Shard shot) - Grants Leah a 15% chance to fire a shard projectile with the same properties as Broken Recorder’s projectile.
** Magdalene (Healthier health) - Red Hearts have a higher chance to become Double Red Hearts. Yum Heart heals twice as much health
** Cain (Value in refuse) - Collecting a pick-up has a chance to grant Cain an additional pick-up of that type (i.e, collecting a coin has a chance to grant Cain another coin)
** Judas (Revel in sin) - Taking a Devil Deal or Black Market item that uses up the last of Judas’ Heart Containers grants a Black Heart for each heart container removed
** ??? (Stronger spirit) - HP ups grants double the amount of Soul Hearts
** Eve (Your very own murder) - Eve can summon additional Dead Bird familiars each time she takes damage, for a total of 12 per room
** Samson (Gain from pain) - All types of on-hit effects, such as Bloody Lust, have a chance to activate twice when activated
** Azazel (Fading fury) - Firing a Brimstone beam has a chance for it to have infinite range
** Lazarus (Taking you with me) - Reviving as Lazarus Risen deals 100 damage to all enemies in the room
** Eden (?) - Instantly destroys itself on pick-up and spawns 3 random trinkets. The first trinket picked up is instantly gulped and kept permanently, while the other 2 aren’t gulped but can still be picked up
** The Lost (Panic mode) - When The Lost’s Holy Mantle breaks, he gains +3 Damage and +0.5 Tears until he gets it back
** Lilith (Sharing is caring) - All non-Incubus familiars that Lilith has have a 25% chance to fire a projectile that copies all of her tear effects
** The Keeper (Finders keepers) - If the Shop has an item that The Keeper cannot afford, there is a 25% chance for an extra coin to spawn on room clear alongside any other room clear rewards
** Apollyon (Insatiable appetite) - Active items that are consumed with Void grant stat increases instead of being stored inside of it
** The Forgotten (Push & Shove) - While as The Soul, The Forgotten’s body can be pulled around while moving. Enemies will attempt to target the body when possible, though will target The Soul if it is closer
** Bethany (Faith guides you) - Clearing a room has a 25% chance to grant a basic Wisp
** Jacob & Esau (Stronger than you) - The brother holding a trinket gets 25% of the stat increases the other brother has
** Ehud (Perfect parry) - Parrying an enemy grants Ehud a quickly fading tears, speed, and damage up
** Alexandria (Knowledge is power) - Entering a room that has yet to be visited grants Alexandria a random stat increase for the duration of it
** Guppy (More friends!) - Increases the chance for Guppy to create Blue Flies to 70%
** Tainted Isaac (Options up) - All item pedestals cycle between three items instead of two.
** Tainted Leah (One step ahead) - While in the Escapist Fantasy world, Lovechild is unable to gain any new attacks outside of the ones it has in Chapter 1
** Tainted Magdalene (Heart attack) - Hearts that disappear leave behind a very small puddle of red creep that damages enemies
** Tainted Cain (Repurpose) - Grabbing an pick-up with Bag of Crafting has a 20% chance to drop a copy of the collected item on the ground
** Tainted Judas (Suppressing shadows) - Enemies hit by Dark Arts are temporarily slowed down
** Tainted ??? (Tower defense) - Poops created by Tainted ??? can be targeted and destroyed by enemies
** Tainted Eve (Free bleeding) - Two Blood Clots can be made at once at the cost of draining a full heart of health
** Tainted Samson (Immovable object) - While in Berserk mode, Tainted Samson gains contact damage and invincibility if he is moving fast enough
** Tainted Azazel (Stronger sneeze) - Tainted Azazel’s sneeze is larger and pushes enemies back further
** Tainted Lazarus (A gift from the other side) - The form that holds this trinket gets a random passive item from the other form every room
** Tainted Eden (Force close) - When taking damage, a random passive item held by Tainted Eden is not rerolled
** Tainted Lost (Truly better items?) - Certain defensive items, such as Holy Mantle and Book of Shadows, can now be accessed by Tainted Lost. While held, Holy Cards can no longer appear.
** Tainted Lilith (Mama’s boy) - After launching the Gello, it always stays directly in front of Tainted Lilith, allowing it to be aimed easier
** Tainted Keeper (On the grindset) - All pick-ups outside of Shops are replaced with coins
** Tainted Apollyon (Divided swarms) - Abyss Locusts swarm enemies in groups of up to four instead of individually
** Tainted Forgotten (Boomerang bones) - Tainted Forgotten, when thrown, attempts to boomerang back to The Soul when at peak distance.
** Tainted Bethany (Self defense) - Lemegeton wisps can now fire tears at enemies that deal 3.5 damage each
** Tainted Jacob (Blind rage) - Dark Esau has a 25% to target enemies instead of Tainted Jacob when charging
** Tainted Ehud (Shockwave slam) – Tainted Ehud’s slam attack produces a shockwave that pushes back and slightly damages nearby enemies
** Tainted Alexandria (Monopoly) - Rooms now cost only one type of resource to be built, always being the pick-up type that Tainted Alexandria has most of.
** Tainted Guppy (Infested!) - Tainted Guppy has a chance to produce Blue Spiders instead of Blue Flies	
* Grants a unique effect based on the character holding it:
** Isaac (Decisions, decisions) - Rerolling items with the D6 has a 25% chance to have it cycle between the new item and the item rerolled
** Leah (Shard shot) - Grants Leah a 15% chance to fire a shard projectile with the same properties as Broken Recorder’s projectile.
** Magdalene (Healthier health) - Red Hearts have a higher chance to become Double Red Hearts. Yum Heart heals twice as much health
** Cain (Value in refuse) - Collecting a pick-up has a chance to grant Cain an additional pick-up of that type (i.e, collecting a coin has a chance to grant Cain another coin)
** Judas (Revel in sin) - Taking a Devil Deal or Black Market item that uses up the last of Judas’ Heart Containers grants a Black Heart for each heart container removed
** ??? (Stronger spirit) - HP ups grants double the amount of Soul Hearts
** Eve (Your very own murder) - Eve can summon additional Dead Bird familiars each time she takes damage, for a total of 12 per room
** Samson (Gain from pain) - All types of on-hit effects, such as Bloody Lust, have a chance to activate twice when activated
** Azazel (Fading fury) - Firing a Brimstone beam has a chance for it to have infinite range
** Lazarus (Taking you with me) - Reviving as Lazarus Risen deals 100 damage to all enemies in the room
** Eden (?) - Instantly destroys itself on pick-up and spawns 3 random trinkets. The first trinket picked up is instantly gulped and kept permanently, while the other 2 aren’t gulped but can still be picked up
** The Lost (Panic mode) - When The Lost’s Holy Mantle breaks, he gains +3 Damage and +0.5 Tears until he gets it back
** Lilith (Sharing is caring) - All non-Incubus familiars that Lilith has have a 25% chance to fire a projectile that copies all of her tear effects
** The Keeper (Finders keepers) - If the Shop has an item that The Keeper cannot afford, there is a 25% chance for an extra coin to spawn on room clear alongside any other room clear rewards
** Apollyon (Insatiable appetite) - Active items that are consumed with Void grant stat increases instead of being stored inside of it
** The Forgotten (Push & Shove) - While as The Soul, The Forgotten’s body can be pulled around while moving. Enemies will attempt to target the body when possible, though will target The Soul if it is closer
** Bethany (Faith guides you) - Clearing a room has a 25% chance to grant a basic Wisp
** Jacob & Esau (Stronger than you) - The brother holding a trinket gets 25% of the stat increases the other brother has
** Ehud (Perfect parry) - Parrying an enemy grants Ehud a quickly fading tears, speed, and damage up
** Alexandria (Knowledge is power) - Entering a room that has yet to be visited grants Alexandria a random stat increase for the duration of it
** Guppy (More friends!) - Increases the chance for Guppy to create Blue Flies to 70%
** Tainted Isaac (Options up) - All item pedestals cycle between three items instead of two.
** Tainted Leah (One step ahead) - While in the Escapist Fantasy world, Lovechild is unable to gain any new attacks outside of the ones it has in Chapter 1
** Tainted Magdalene (Heart attack) - Hearts that disappear leave behind a very small puddle of red creep that damages enemies
** Tainted Cain (Repurpose) - Grabbing an pick-up with Bag of Crafting has a 20% chance to drop a copy of the collected item on the ground
** Tainted Judas (Suppressing shadows) - Enemies hit by Dark Arts are temporarily slowed down
** Tainted ??? (Tower defense) - Poops created by Tainted ??? can be targeted and destroyed by enemies
** Tainted Eve (Free bleeding) - Two Blood Clots can be made at once at the cost of draining a full heart of health
** Tainted Samson (Immovable object) - While in Berserk mode, Tainted Samson gains contact damage and invincibility if he is moving fast enough
** Tainted Azazel (Stronger sneeze) - Tainted Azazel’s sneeze is larger and pushes enemies back further
** Tainted Lazarus (A gift from the other side) - The form that holds this trinket gets a random passive item from the other form every room
** Tainted Eden (Force close) - When taking damage, a random passive item held by Tainted Eden is not rerolled
** Tainted Lost (Truly better items?) - Certain defensive items, such as Holy Mantle and Book of Shadows, can now be accessed by Tainted Lost. While held, Holy Cards can no longer appear.
** Tainted Lilith (Mama’s boy) - After launching the Gello, it always stays directly in front of Tainted Lilith, allowing it to be aimed easier
** Tainted Keeper (On the grindset) - All pick-ups outside of Shops are replaced with coins
** Tainted Apollyon (Divided swarms) - Abyss Locusts swarm enemies in groups of up to four instead of individually
** Tainted Forgotten (Boomerang bones) - Tainted Forgotten, when thrown, attempts to boomerang back to The Soul when at peak distance.
** Tainted Bethany (Self defense) - Lemegeton wisps can now fire tears at enemies that deal 3.5 damage each
** Tainted Jacob (Blind rage) - Dark Esau has a 25% to target enemies instead of Tainted Jacob when charging
** Tainted Ehud (Shockwave slam) – Tainted Ehud’s slam attack produces a shockwave that pushes back and slightly damages nearby enemies
** Tainted Alexandria (Monopoly) - Rooms now cost only one type of resource to be built, always being the pick-up type that Tainted Alexandria has most of.
** Tainted Guppy (Infested!) - Tainted Guppy has a chance to produce Blue Spiders instead of Blue Flies	
* Grants a unique effect based on the character holding it:
** Isaac (Decisions, decisions) - Rerolling items with the D6 has a 25% chance to have it cycle between the new item and the item rerolled
** Leah (Shard shot) - Grants Leah a 15% chance to fire a shard projectile with the same properties as Broken Recorder’s projectile.
** Magdalene (Healthier health) - Red Hearts have a higher chance to become Double Red Hearts. Yum Heart heals twice as much health
** Cain (Value in refuse) - Collecting a pick-up has a chance to grant Cain an additional pick-up of that type (i.e, collecting a coin has a chance to grant Cain another coin)
** Judas (Revel in sin) - Taking a Devil Deal or Black Market item that uses up the last of Judas’ Heart Containers grants a Black Heart for each heart container removed
** ??? (Stronger spirit) - HP ups grants double the amount of Soul Hearts
** Eve (Your very own murder) - Eve can summon additional Dead Bird familiars each time she takes damage, for a total of 12 per room
** Samson (Gain from pain) - All types of on-hit effects, such as Bloody Lust, have a chance to activate twice when activated
** Azazel (Fading fury) - Firing a Brimstone beam has a chance for it to have infinite range
** Lazarus (Taking you with me) - Reviving as Lazarus Risen deals 100 damage to all enemies in the room
** Eden (?) - Instantly destroys itself on pick-up and spawns 3 random trinkets. The first trinket picked up is instantly gulped and kept permanently, while the other 2 aren’t gulped but can still be picked up
** The Lost (Panic mode) - When The Lost’s Holy Mantle breaks, he gains +3 Damage and +0.5 Tears until he gets it back
** Lilith (Sharing is caring) - All non-Incubus familiars that Lilith has have a 25% chance to fire a projectile that copies all of her tear effects
** The Keeper (Finders keepers) - If the Shop has an item that The Keeper cannot afford, there is a 25% chance for an extra coin to spawn on room clear alongside any other room clear rewards
** Apollyon (Insatiable appetite) - Active items that are consumed with Void grant stat increases instead of being stored inside of it
** The Forgotten (Push & Shove) - While as The Soul, The Forgotten’s body can be pulled around while moving. Enemies will attempt to target the body when possible, though will target The Soul if it is closer
** Bethany (Faith guides you) - Clearing a room has a 25% chance to grant a basic Wisp
** Jacob & Esau (Stronger than you) - The brother holding a trinket gets 25% of the stat increases the other brother has
** Ehud (Perfect parry) - Parrying an enemy grants Ehud a quickly fading tears, speed, and damage up
** Alexandria (Knowledge is power) - Entering a room that has yet to be visited grants Alexandria a random stat increase for the duration of it
** Guppy (More friends!) - Increases the chance for Guppy to create Blue Flies to 70%
** Tainted Isaac (Options up) - All item pedestals cycle between three items instead of two.
** Tainted Leah (One step ahead) - While in the Escapist Fantasy world, Lovechild is unable to gain any new attacks outside of the ones it has in Chapter 1
** Tainted Magdalene (Heart attack) - Hearts that disappear leave behind a very small puddle of red creep that damages enemies
** Tainted Cain (Repurpose) - Grabbing an pick-up with Bag of Crafting has a 20% chance to drop a copy of the collected item on the ground
** Tainted Judas (Suppressing shadows) - Enemies hit by Dark Arts are temporarily slowed down
** Tainted ??? (Tower defense) - Poops created by Tainted ??? can be targeted and destroyed by enemies
** Tainted Eve (Free bleeding) - Two Blood Clots can be made at once at the cost of draining a full heart of health
** Tainted Samson (Immovable object) - While in Berserk mode, Tainted Samson gains contact damage and invincibility if he is moving fast enough
** Tainted Azazel (Stronger sneeze) - Tainted Azazel’s sneeze is larger and pushes enemies back further
** Tainted Lazarus (A gift from the other side) - The form that holds this trinket gets a random passive item from the other form every room
** Tainted Eden (Force close) - When taking damage, a random passive item held by Tainted Eden is not rerolled
** Tainted Lost (Truly better items?) - Certain defensive items, such as Holy Mantle and Book of Shadows, can now be accessed by Tainted Lost. While held, Holy Cards can no longer appear.
** Tainted Lilith (Mama’s boy) - After launching the Gello, it always stays directly in front of Tainted Lilith, allowing it to be aimed easier
** Tainted Keeper (On the grindset) - All pick-ups outside of Shops are replaced with coins
** Tainted Apollyon (Divided swarms) - Abyss Locusts swarm enemies in groups of up to four instead of individually
** Tainted Forgotten (Boomerang bones) - Tainted Forgotten, when thrown, attempts to boomerang back to The Soul when at peak distance.
** Tainted Bethany (Self defense) - Lemegeton wisps can now fire tears at enemies that deal 3.5 damage each
** Tainted Jacob (Blind rage) - Dark Esau has a 25% to target enemies instead of Tainted Jacob when charging
** Tainted Ehud (Shockwave slam) – Tainted Ehud’s slam attack produces a shockwave that pushes back and slightly damages nearby enemies
** Tainted Alexandria (Monopoly) - Rooms now cost only one type of resource to be built, always being the pick-up type that Tainted Alexandria has most of.
** Tainted Guppy (Infested!) - Tainted Guppy has a chance to produce Blue Spiders instead of Blue Flies	
* Grants a unique effect based on the character holding it:
** Isaac (Decisions, decisions) - Rerolling items with the D6 has a 25% chance to have it cycle between the new item and the item rerolled
** Leah (Shard shot) - Grants Leah a 15% chance to fire a shard projectile with the same properties as Broken Recorder’s projectile.
** Magdalene (Healthier health) - Red Hearts have a higher chance to become Double Red Hearts. Yum Heart heals twice as much health
** Cain (Value in refuse) - Collecting a pick-up has a chance to grant Cain an additional pick-up of that type (i.e, collecting a coin has a chance to grant Cain another coin)
** Judas (Revel in sin) - Taking a Devil Deal or Black Market item that uses up the last of Judas’ Heart Containers grants a Black Heart for each heart container removed
** ??? (Stronger spirit) - HP ups grants double the amount of Soul Hearts
** Eve (Your very own murder) - Eve can summon additional Dead Bird familiars each time she takes damage, for a total of 12 per room
** Samson (Gain from pain) - All types of on-hit effects, such as Bloody Lust, have a chance to activate twice when activated
** Azazel (Fading fury) - Firing a Brimstone beam has a chance for it to have infinite range
** Lazarus (Taking you with me) - Reviving as Lazarus Risen deals 100 damage to all enemies in the room
** Eden (?) - Instantly destroys itself on pick-up and spawns 3 random trinkets. The first trinket picked up is instantly gulped and kept permanently, while the other 2 aren’t gulped but can still be picked up
** The Lost (Panic mode) - When The Lost’s Holy Mantle breaks, he gains +3 Damage and +0.5 Tears until he gets it back
** Lilith (Sharing is caring) - All non-Incubus familiars that Lilith has have a 25% chance to fire a projectile that copies all of her tear effects
** The Keeper (Finders keepers) - If the Shop has an item that The Keeper cannot afford, there is a 25% chance for an extra coin to spawn on room clear alongside any other room clear rewards
** Apollyon (Insatiable appetite) - Active items that are consumed with Void grant stat increases instead of being stored inside of it
** The Forgotten (Push & Shove) - While as The Soul, The Forgotten’s body can be pulled around while moving. Enemies will attempt to target the body when possible, though will target The Soul if it is closer
** Bethany (Faith guides you) - Clearing a room has a 25% chance to grant a basic Wisp
** Jacob & Esau (Stronger than you) - The brother holding a trinket gets 25% of the stat increases the other brother has
** Ehud (Perfect parry) - Parrying an enemy grants Ehud a quickly fading tears, speed, and damage up
** Alexandria (Knowledge is power) - Entering a room that has yet to be visited grants Alexandria a random stat increase for the duration of it
** Guppy (More friends!) - Increases the chance for Guppy to create Blue Flies to 70%
** Tainted Isaac (Options up) - All item pedestals cycle between three items instead of two.
** Tainted Leah (One step ahead) - While in the Escapist Fantasy world, Lovechild is unable to gain any new attacks outside of the ones it has in Chapter 1
** Tainted Magdalene (Heart attack) - Hearts that disappear leave behind a very small puddle of red creep that damages enemies
** Tainted Cain (Repurpose) - Grabbing an pick-up with Bag of Crafting has a 20% chance to drop a copy of the collected item on the ground
** Tainted Judas (Suppressing shadows) - Enemies hit by Dark Arts are temporarily slowed down
** Tainted ??? (Tower defense) - Poops created by Tainted ??? can be targeted and destroyed by enemies
** Tainted Eve (Free bleeding) - Two Blood Clots can be made at once at the cost of draining a full heart of health
** Tainted Samson (Immovable object) - While in Berserk mode, Tainted Samson gains contact damage and invincibility if he is moving fast enough
** Tainted Azazel (Stronger sneeze) - Tainted Azazel’s sneeze is larger and pushes enemies back further
** Tainted Lazarus (A gift from the other side) - The form that holds this trinket gets a random passive item from the other form every room
** Tainted Eden (Force close) - When taking damage, a random passive item held by Tainted Eden is not rerolled
** Tainted Lost (Truly better items?) - Certain defensive items, such as Holy Mantle and Book of Shadows, can now be accessed by Tainted Lost. While held, Holy Cards can no longer appear.
** Tainted Lilith (Mama’s boy) - After launching the Gello, it always stays directly in front of Tainted Lilith, allowing it to be aimed easier
** Tainted Keeper (On the grindset) - All pick-ups outside of Shops are replaced with coins
** Tainted Apollyon (Divided swarms) - Abyss Locusts swarm enemies in groups of up to four instead of individually
** Tainted Forgotten (Boomerang bones) - Tainted Forgotten, when thrown, attempts to boomerang back to The Soul when at peak distance.
** Tainted Bethany (Self defense) - Lemegeton wisps can now fire tears at enemies that deal 3.5 damage each
** Tainted Jacob (Blind rage) - Dark Esau has a 25% to target enemies instead of Tainted Jacob when charging
** Tainted Ehud (Shockwave slam) – Tainted Ehud’s slam attack produces a shockwave that pushes back and slightly damages nearby enemies
** Tainted Alexandria (Monopoly) - Rooms now cost only one type of resource to be built, always being the pick-up type that Tainted Alexandria has most of.
** Tainted Guppy (Infested!) - Tainted Guppy has a chance to produce Blue Spiders instead of Blue Flies	
* Grants a unique effect based on the character holding it:
** Isaac (Decisions, decisions) - Rerolling items with the D6 has a 25% chance to have it cycle between the new item and the item rerolled
** Leah (Shard shot) - Grants Leah a 15% chance to fire a shard projectile with the same properties as Broken Recorder’s projectile.
** Magdalene (Healthier health) - Red Hearts have a higher chance to become Double Red Hearts. Yum Heart heals twice as much health
** Cain (Value in refuse) - Collecting a pick-up has a chance to grant Cain an additional pick-up of that type (i.e, collecting a coin has a chance to grant Cain another coin)
** Judas (Revel in sin) - Taking a Devil Deal or Black Market item that uses up the last of Judas’ Heart Containers grants a Black Heart for each heart container removed
** ??? (Stronger spirit) - HP ups grants double the amount of Soul Hearts
** Eve (Your very own murder) - Eve can summon additional Dead Bird familiars each time she takes damage, for a total of 12 per room
** Samson (Gain from pain) - All types of on-hit effects, such as Bloody Lust, have a chance to activate twice when activated
** Azazel (Fading fury) - Firing a Brimstone beam has a chance for it to have infinite range
** Lazarus (Taking you with me) - Reviving as Lazarus Risen deals 100 damage to all enemies in the room
** Eden (?) - Instantly destroys itself on pick-up and spawns 3 random trinkets. The first trinket picked up is instantly gulped and kept permanently, while the other 2 aren’t gulped but can still be picked up
** The Lost (Panic mode) - When The Lost’s Holy Mantle breaks, he gains +3 Damage and +0.5 Tears until he gets it back
** Lilith (Sharing is caring) - All non-Incubus familiars that Lilith has have a 25% chance to fire a projectile that copies all of her tear effects
** The Keeper (Finders keepers) - If the Shop has an item that The Keeper cannot afford, there is a 25% chance for an extra coin to spawn on room clear alongside any other room clear rewards
** Apollyon (Insatiable appetite) - Active items that are consumed with Void grant stat increases instead of being stored inside of it
** The Forgotten (Push & Shove) - While as The Soul, The Forgotten’s body can be pulled around while moving. Enemies will attempt to target the body when possible, though will target The Soul if it is closer
** Bethany (Faith guides you) - Clearing a room has a 25% chance to grant a basic Wisp
** Jacob & Esau (Stronger than you) - The brother holding a trinket gets 25% of the stat increases the other brother has
** Ehud (Perfect parry) - Parrying an enemy grants Ehud a quickly fading tears, speed, and damage up
** Alexandria (Knowledge is power) - Entering a room that has yet to be visited grants Alexandria a random stat increase for the duration of it
** Guppy (More friends!) - Increases the chance for Guppy to create Blue Flies to 70%
** Tainted Isaac (Options up) - All item pedestals cycle between three items instead of two.
** Tainted Leah (One step ahead) - While in the Escapist Fantasy world, Lovechild is unable to gain any new attacks outside of the ones it has in Chapter 1
** Tainted Magdalene (Heart attack) - Hearts that disappear leave behind a very small puddle of red creep that damages enemies
** Tainted Cain (Repurpose) - Grabbing an pick-up with Bag of Crafting has a 20% chance to drop a copy of the collected item on the ground
** Tainted Judas (Suppressing shadows) - Enemies hit by Dark Arts are temporarily slowed down
** Tainted ??? (Tower defense) - Poops created by Tainted ??? can be targeted and destroyed by enemies
** Tainted Eve (Free bleeding) - Two Blood Clots can be made at once at the cost of draining a full heart of health
** Tainted Samson (Immovable object) - While in Berserk mode, Tainted Samson gains contact damage and invincibility if he is moving fast enough
** Tainted Azazel (Stronger sneeze) - Tainted Azazel’s sneeze is larger and pushes enemies back further
** Tainted Lazarus (A gift from the other side) - The form that holds this trinket gets a random passive item from the other form every room
** Tainted Eden (Force close) - When taking damage, a random passive item held by Tainted Eden is not rerolled
** Tainted Lost (Truly better items?) - Certain defensive items, such as Holy Mantle and Book of Shadows, can now be accessed by Tainted Lost. While held, Holy Cards can no longer appear.
** Tainted Lilith (Mama’s boy) - After launching the Gello, it always stays directly in front of Tainted Lilith, allowing it to be aimed easier
** Tainted Keeper (On the grindset) - All pick-ups outside of Shops are replaced with coins
** Tainted Apollyon (Divided swarms) - Abyss Locusts swarm enemies in groups of up to four instead of individually
** Tainted Forgotten (Boomerang bones) - Tainted Forgotten, when thrown, attempts to boomerang back to The Soul when at peak distance.
** Tainted Bethany (Self defense) - Lemegeton wisps can now fire tears at enemies that deal 3.5 damage each
** Tainted Jacob (Blind rage) - Dark Esau has a 25% to target enemies instead of Tainted Jacob when charging
** Tainted Ehud (Shockwave slam) – Tainted Ehud’s slam attack produces a shockwave that pushes back and slightly damages nearby enemies
** Tainted Alexandria (Monopoly) - Rooms now cost only one type of resource to be built, always being the pick-up type that Tainted Alexandria has most of.
** Tainted Guppy (Infested!) - Tainted Guppy has a chance to produce Blue Spiders instead of Blue Flies	
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* 	Defeat Everything as Tainted Jacob 	Defeat Everything as Tainted Jacob 	Defeat Everything as Tainted Jacob 	Defeat Everything as Tainted Jacob 	Defeat Everything as Tainted Jacob 	Defeat Everything as Tainted Jacob 	Defeat Everything as Tainted Jacob 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Treasure Key 	Treasure Key 	Treasure Key 	Treasure Key 	Treasure Key 	Treasure Key 	Treasure Key 	Treasure awaits! 	Treasure awaits! 	Treasure awaits! 	Treasure awaits! 	Treasure awaits! 	Treasure awaits! 	Treasure awaits! 	
* Treasure Rooms can be opened for free	
* Treasure Rooms can be opened for free	
* Treasure Rooms can be opened for free	
* Treasure Rooms can be opened for free	
* Treasure Rooms can be opened for free	
* Treasure Rooms can be opened for free	
* Treasure Rooms can be opened for free	
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* 	Defeat Mother's Soul as Tainted Ehud 	Defeat Mother's Soul as Tainted Ehud 	Defeat Mother's Soul as Tainted Ehud 	Defeat Mother's Soul as Tainted Ehud 	Defeat Mother's Soul as Tainted Ehud 	Defeat Mother's Soul as Tainted Ehud 	Defeat Mother's Soul as Tainted Ehud 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
mroW Worm 	mroW Worm 	mroW Worm 	mroW Worm 	mroW Worm 	mroW Worm 	mroW Worm 	...ooooW Woooo... 	...ooooW Woooo... 	...ooooW Woooo... 	...ooooW Woooo... 	...ooooW Woooo... 	...ooooW Woooo... 	...ooooW Woooo... 	
* -0.2 Shot Speed
* +2.5 Range
* Isaac's tears appear where they would land and fly towards him, essentially going in reverse	
* -0.2 Shot Speed
* +2.5 Range
* Isaac's tears appear where they would land and fly towards him, essentially going in reverse	
* -0.2 Shot Speed
* +2.5 Range
* Isaac's tears appear where they would land and fly towards him, essentially going in reverse	
* -0.2 Shot Speed
* +2.5 Range
* Isaac's tears appear where they would land and fly towards him, essentially going in reverse	
* -0.2 Shot Speed
* +2.5 Range
* Isaac's tears appear where they would land and fly towards him, essentially going in reverse	
* -0.2 Shot Speed
* +2.5 Range
* Isaac's tears appear where they would land and fly towards him, essentially going in reverse	
* -0.2 Shot Speed
* +2.5 Range
* Isaac's tears appear where they would land and fly towards him, essentially going in reverse	
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*	Defeat the Onlookers as Tainted Lost 	Defeat the Onlookers as Tainted Lost 	Defeat the Onlookers as Tainted Lost 	Defeat the Onlookers as Tainted Lost 	Defeat the Onlookers as Tainted Lost 	Defeat the Onlookers as Tainted Lost 	Defeat the Onlookers as Tainted Lost 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Diced Onion 	Diced Onion 	Diced Onion 	Diced Onion 	Diced Onion 	Diced Onion 	Diced Onion 	Regret for the fallen 	Regret for the fallen 	Regret for the fallen 	Regret for the fallen 	Regret for the fallen 	Regret for the fallen 	Regret for the fallen 	
* Killing an enemy has a luck-based chance to grant Isaac a +0.2 Tears Up for the current room.
* The buffs stack for a total of +1.5 Tears
* 100% chance at 28 Luck	
* Killing an enemy has a luck-based chance to grant Isaac a +0.2 Tears Up for the current room.
* The buffs stack for a total of +1.5 Tears
* 100% chance at 28 Luck	
* Killing an enemy has a luck-based chance to grant Isaac a +0.2 Tears Up for the current room.
* The buffs stack for a total of +1.5 Tears
* 100% chance at 28 Luck	
* Killing an enemy has a luck-based chance to grant Isaac a +0.2 Tears Up for the current room.
* The buffs stack for a total of +1.5 Tears
* 100% chance at 28 Luck	
* Killing an enemy has a luck-based chance to grant Isaac a +0.2 Tears Up for the current room.
* The buffs stack for a total of +1.5 Tears
* 100% chance at 28 Luck	
* Killing an enemy has a luck-based chance to grant Isaac a +0.2 Tears Up for the current room.
* The buffs stack for a total of +1.5 Tears
* 100% chance at 28 Luck	
* Killing an enemy has a luck-based chance to grant Isaac a +0.2 Tears Up for the current room.
* The buffs stack for a total of +1.5 Tears
* 100% chance at 28 Luck	
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Bleeding Rock 	Bleeding Rock 	Bleeding Rock 	Bleeding Rock 	Bleeding Rock 	Bleeding Rock 	Bleeding Rock 	Your sins never back down 	Your sins never back down 	Your sins never back down 	Your sins never back down 	Your sins never back down 	Your sins never back down 	Your sins never back down 	
* While held, Angel Deals can no longer be entered
* While held, Isaac's Devil Deal chance cannot be lower than its highest percentage ever achieved	
* While held, Angel Deals can no longer be entered
* While held, Isaac's Devil Deal chance cannot be lower than its highest percentage ever achieved	
* While held, Angel Deals can no longer be entered
* While held, Isaac's Devil Deal chance cannot be lower than its highest percentage ever achieved	
* While held, Angel Deals can no longer be entered
* While held, Isaac's Devil Deal chance cannot be lower than its highest percentage ever achieved	
* While held, Angel Deals can no longer be entered
* While held, Isaac's Devil Deal chance cannot be lower than its highest percentage ever achieved	
* While held, Angel Deals can no longer be entered
* While held, Isaac's Devil Deal chance cannot be lower than its highest percentage ever achieved	
* While held, Angel Deals can no longer be entered
* While held, Isaac's Devil Deal chance cannot be lower than its highest percentage ever achieved	
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* 	Defeat the Onlookers as Judas 	Defeat the Onlookers as Judas 	Defeat the Onlookers as Judas 	Defeat the Onlookers as Judas 	Defeat the Onlookers as Judas 	Defeat the Onlookers as Judas 	Defeat the Onlookers as Judas 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Snake Eyes 	Snake Eyes 	Snake Eyes 	Snake Eyes 	Snake Eyes 	Snake Eyes 	Snake Eyes 	She sees 	She sees 	She sees 	She sees 	She sees 	She sees 	She sees 	
* Replaces all Curses with random Waiver effects	
* Replaces all Curses with random Waiver effects	
* Replaces all Curses with random Waiver effects	
* Replaces all Curses with random Waiver effects	
* Replaces all Curses with random Waiver effects	
* Replaces all Curses with random Waiver effects	
* Replaces all Curses with random Waiver effects	
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* 	Complete the challenge 'Serpette's Offering' 	Complete the challenge 'Serpette's Offering' 	Complete the challenge 'Serpette's Offering' 	Complete the challenge 'Serpette's Offering' 	Complete the challenge 'Serpette's Offering' 	Complete the challenge 'Serpette's Offering' 	Complete the challenge 'Serpette's Offering' 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Baby Shoes 	Baby Shoes 	Baby Shoes 	Baby Shoes 	Baby Shoes 	Baby Shoes 	Baby Shoes 	Never worn 	Never worn 	Never worn 	Never worn 	Never worn 	Never worn 	Never worn 	
* When Isaac clears all rooms in a floor, he becomes The Lost	
* When Isaac clears all rooms in a floor, he becomes The Lost	
* When Isaac clears all rooms in a floor, he becomes The Lost	
* When Isaac clears all rooms in a floor, he becomes The Lost	
* When Isaac clears all rooms in a floor, he becomes The Lost	
* When Isaac clears all rooms in a floor, he becomes The Lost	
* When Isaac clears all rooms in a floor, he becomes The Lost	
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* 	Complete the challenge 'Close for Comfort' 	Complete the challenge 'Close for Comfort' 	Complete the challenge 'Close for Comfort' 	Complete the challenge 'Close for Comfort' 	Complete the challenge 'Close for Comfort' 	Complete the challenge 'Close for Comfort' 	Complete the challenge 'Close for Comfort' 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Defiled Priestess 	Defiled Priestess 	Defiled Priestess 	Defiled Priestess 	Defiled Priestess 	Defiled Priestess 	Defiled Priestess 	You can run, but you can't hide 	You can run, but you can't hide 	You can run, but you can't hide 	You can run, but you can't hide 	You can run, but you can't hide 	You can run, but you can't hide 	You can run, but you can't hide 	
* Isaac's tears have a 2% chance to cause Mom's foot to strike down on the enemy when they hit them.	
* Isaac's tears have a 2% chance to cause Mom's foot to strike down on the enemy when they hit them.	
* Isaac's tears have a 2% chance to cause Mom's foot to strike down on the enemy when they hit them.	
* Isaac's tears have a 2% chance to cause Mom's foot to strike down on the enemy when they hit them.	
* Isaac's tears have a 2% chance to cause Mom's foot to strike down on the enemy when they hit them.	
* Isaac's tears have a 2% chance to cause Mom's foot to strike down on the enemy when they hit them.	
* Isaac's tears have a 2% chance to cause Mom's foot to strike down on the enemy when they hit them.	
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* 	Complete the challenge 'Bad Boy' 	Complete the challenge 'Bad Boy' 	Complete the challenge 'Bad Boy' 	Complete the challenge 'Bad Boy' 	Complete the challenge 'Bad Boy' 	Complete the challenge 'Bad Boy' 	Complete the challenge 'Bad Boy' 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Placenta Penny 	Placenta Penny 	Placenta Penny 	Placenta Penny 	Placenta Penny 	Placenta Penny 	Placenta Penny 	Wealth of children 	Wealth of children 	Wealth of children 	Wealth of children 	Wealth of children 	Wealth of children 	Wealth of children 	
* Collecting coins has a chance to create a random temporary familiar, including Blue Spiders, Blue Flies, Dips, Wisps, and Blood Clots, and a rarer chance to create a random familiar for the current floor.
* The chance is based on the coins worth	
* Collecting coins has a chance to create a random temporary familiar, including Blue Spiders, Blue Flies, Dips, Wisps, and Blood Clots, and a rarer chance to create a random familiar for the current floor.
* The chance is based on the coins worth	
* Collecting coins has a chance to create a random temporary familiar, including Blue Spiders, Blue Flies, Dips, Wisps, and Blood Clots, and a rarer chance to create a random familiar for the current floor.
* The chance is based on the coins worth	
* Collecting coins has a chance to create a random temporary familiar, including Blue Spiders, Blue Flies, Dips, Wisps, and Blood Clots, and a rarer chance to create a random familiar for the current floor.
* The chance is based on the coins worth	
* Collecting coins has a chance to create a random temporary familiar, including Blue Spiders, Blue Flies, Dips, Wisps, and Blood Clots, and a rarer chance to create a random familiar for the current floor.
* The chance is based on the coins worth	
* Collecting coins has a chance to create a random temporary familiar, including Blue Spiders, Blue Flies, Dips, Wisps, and Blood Clots, and a rarer chance to create a random familiar for the current floor.
* The chance is based on the coins worth	
* Collecting coins has a chance to create a random temporary familiar, including Blue Spiders, Blue Flies, Dips, Wisps, and Blood Clots, and a rarer chance to create a random familiar for the current floor.
* The chance is based on the coins worth	
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* 	Complete the challenge 'Hypotension' 	Complete the challenge 'Hypotension' 	Complete the challenge 'Hypotension' 	Complete the challenge 'Hypotension' 	Complete the challenge 'Hypotension' 	Complete the challenge 'Hypotension' 	Complete the challenge 'Hypotension' 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Green Bandana 	Green Bandana 	Green Bandana 	Green Bandana 	Green Bandana 	Green Bandana 	Green Bandana 	Knocked out 	Knocked out 	Knocked out 	Knocked out 	Knocked out 	Knocked out 	Knocked out 	
* Taking damage pushes Isaac away from enemies.
* The lower Isaac's health, the further he is pushed.	
* Taking damage pushes Isaac away from enemies.
* The lower Isaac's health, the further he is pushed.	
* Taking damage pushes Isaac away from enemies.
* The lower Isaac's health, the further he is pushed.	
* Taking damage pushes Isaac away from enemies.
* The lower Isaac's health, the further he is pushed.	
* Taking damage pushes Isaac away from enemies.
* The lower Isaac's health, the further he is pushed.	
* Taking damage pushes Isaac away from enemies.
* The lower Isaac's health, the further he is pushed.	
* Taking damage pushes Isaac away from enemies.
* The lower Isaac's health, the further he is pushed.	
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* 	Complete the challenge 'Getting Smashed' 	Complete the challenge 'Getting Smashed' 	Complete the challenge 'Getting Smashed' 	Complete the challenge 'Getting Smashed' 	Complete the challenge 'Getting Smashed' 	Complete the challenge 'Getting Smashed' 	Complete the challenge 'Getting Smashed'