Great Western Railway

Great Western Railway or Great Western Railroad may refer to:
;Australia
*Great Western Railway (Tasmania)
;Canada
*Great Western Railway (Ontario)
*Great Western Railway (Saskatchewan)
;Great Britain
*Great Western Railway (UK) (1833–1948)
**Great Western Main Line main line formerly operated by the GWR
**First Great Western company currently operating the main line
;Ireland
*Midland Great Western Railway
*Great Southern and Western Railway
;South America
*Argentine Great Western Railway
*Great Western Railway of Brazil
;United States
*Atlantic and Great Western Railroad (1853–1880) predecessor of the New York, Pennsylvania and Ohio Railroad
*Chicago Great Western Railway (1885–1968)
*Great Western Railway of Colorado
*Great Western Railroad (Illinois) (1853-1865) predecessor of the Wabash Railroad
*Great Western Railroad (Ohio)