Pestilence (Arrowverse)

Pestilence is one of the three secondary antagonists of the third season of Supergirl. 
She was a genetically engineered Worldkiller created on Krypton by the Children of Juru, an ancient sect of Kryptonians who worshipped the Old Gods.
In the 31st Century, Pestilence is the Blight that killed Imra Ardeen's sister. 
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