Methylation

Creatine is related to methionine / choline metabolism. Perhaps your depression is partly because of a methylation problem and the creatine is acting as a band-aid, sparing other resources? Betaine, sarcosine, methyl-B vitamins, CDP choline, NAC etc might help.reddit.comIn the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.English Wikipedia. "Methylation is a simple biochemical process – it is the transfer of four atoms - one carbon atom and three hydrogen atoms (CH3) – from one substance to another. When optimal methylation occurs, it has a significant positive impact on many biochemical reactions in the body that regulate the activity of the cardiovascular, neurological, reproductive, and detoxification systems."thorne.com
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