UNSC Ether-à-go-go

The UNSC Ether-à-go-go is a vessel of the UNSC Office of Naval Intelligence.
==Behind the Scenes==
It is named after ether-a-go-go, a murine gene that encodes a protein formally known as "potassium voltage-gated channel, subfamily H (eag-related), member 1" (KCNH1). In humans, the homologue is known as "potassium voltage-gated channel, subfamily H (eag-related), member 1" (KCNH2), and is otherwise known as human ether-a-go-go related gene (hERG). hERG is an important target for discovery toxicology in pharmaceutical development of lead and hit small-molecule chemical compounds for drug discovery because its blockade is a common non-specific side effect of many pharmacological agents, and its blockade induces prolongation of the QT cardiac arrhythmia and may induce fatal cardiac tachyarrythmia (Torsades de Pointe)Kramer et. al (2007). The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nature Reviews Drug Discovery (6): 636-649..
==References==