The Omega Squad

=== Members ===
* VHS (voiced by Greg Holgate)
* Yo-Yo (voiced by Ethan Nestor)
* Inferno (voiced by Anna Brisbin)
* Lady Liquid (voiced by Elsie Lovelock)
* Monkey King (voiced by Diamondbolt)
=== Antagonists ===
* The Virtuoso (voiced by Aaron Bishop) - an eccentric yet dangerous god-like entity who believes humanity to be beneath him as he is obsessed with being a god, having several loyal disciples to his cause.
* Susan Wyndham (voiced by Maggie Mae Fish) - the corrupt CEO of MarvelCo who was both responsible for Inferno and Lady Liquid's powers and is also one of Virtuoso's disciples, wanting to help him enslave the world.
* Mr. Roboto (voiced by Ian Bonds) - Susan's cyborg bodyguard who is extremely loyal to her, no matter what.
* The Inventor (voiced by John Enter) - an enigmatic scientist who worships the Virtuoso as he had previously clashed with VHS several times, often being seen in the shadows.
*Queen Marcella (voiced by Anna Brisbin) - the bloodthirsty queen of an island of warrior women who believe that men are worthless and that the mainland belong to women.