Will-Hebert Syndrome

Will-Hebert Syndrome is a genetic disorder resulting from mutations in the 17th chromosome, it is primarly associated with Dyspolia, overweightness and paradoxically, lack of appetite.
==Diagnostic criteria==
Major criteria 	
*Neonatal and				infantile hypertonia
*Feeding				difficulties since early infancy and failure to thrive
*Lack of appetite				(hypophagia or aphagia)
*Hyperactivity
*Multi-System				Deficit (3 domains: abstract thinking, executive functions,				thought organization)
*Restricted				interests
*Hypergonadism
*Epicanthic folds
*Overweight (despite				poor appetite)
*Weight-Limit				between 172 to 180 lbs
Minor criteria 	
*Mild				hypoglycemia
*Sleep disturbance				or insomnia
*High stature for				genetic background
*Hypopigmentation
*Long arms, legs and				fingers
Supportive findings	
*Low pain				threshold
*Very late				adrenarche
*Decreased vomiting
*Unusual verbal				skills
*Occasional anorexia
Scoring: major criteria at 1 point each. Minor criteria are			weighed at 0.5 point. Requirements for diagnostic are:	
*Children 3 years				of age or younger: 5 points (minimum 4 major criteria)
*Children’s older				than 3 years of age: 8 points (minimum 5 major criteria)