Big Three (automobile manufacturers)

There will never be another "Big 3". They were of their time and were, in part, responsible for catapulting anime into the western mainstream (DBZ also takes some the credit for that, but like yu gi oh and pokemon a lot kids back then didn't associate it with being any different from the other Saturday morning cartoons they consumed). Talk to any anime head over the age of 25 and I guarantee you that the vast majority of them fell in love with anime through one of the big 3. The memeifaction and ubiquity of modern day anime means that its simply not possible for any other show to have the cultural impact (from a western perspective) of those early shonen forerunners.