Shadowrun

Shadowrun, p.n. a cyberpunk RPG with fantasy elements, originally published by FASA; has spawned novels, video games, a CCG, and a action-figure based wargame. [GJ1]
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Addendum: Entering its twentieth year in 2009 and 4th Edition in 2005, Shadowrun remains a popular alternative to Dungeons & Dragons, ranked in a number of polls in the top 5 RPGs due largely in part to its intricate background supported by a large number of sourcebooks and a continuous metaplot that has advanced close to real-time in conjunction with the release of subsequent manuals and sourcebooks. Originally produced by FASA, when the company folded in 2001, the Shadowrun property was picked up by WizKids, and subsequently licensed to Fantasy Productions (usually shortened to “FanPro”) and later the fan-created Catalyst Game Labs, the current publisher. Though keeping the metaplot fairly consistent, the 4th Edition presented a fundamental shift in the rules system, much like 3rd Edition (and the subsequent 3.5 revision) did for Dungeons & Dragons.
Addendum #2: As of last printing: there are a total of 44 novels, 4 video games (though many Shadowrun gamers summarily reject the 2007 FPS), a defunct CCG with two editions and one expansion (produced by FASA itself in 1997), a defunct “Action Figure Game” (a sort of large clicky-game) called Shadowrun Duels produced by WizKids in 2003, and well over 100 game manuals and sourcebooks for the game. Not bad for 20 years, eh?