MTOR

mTOR is a nutrient signal pathway in inter-cellular signalling networks activated by nutrient and growth factors to stimulate growth, hypertrophy and robustness. Provided that nutrients (fuel) are readily available, MTOR is active "or, metaphorically, MoTOR is running". [ Blagosklonny 13 ] 
Previously known as the mammalian target of rapamycin, mTOR stands for ‘the mechanistic target of rapamycin’. Nutrient signal mTOR -- the target of rapamycin -- has been tied to epigenetic changes in the genome. [Puigserver 12] 
The TOR pathway is involved in yeast and organismal aging from worm to mammals [ Blago. 12 ] Prominent links between TOR signaling and aging in invertebrates. In mouse models dampening the TOR pathway leads to widespread protection from an array of age-related diseases. [Ken. 9] The PIK3CA–AKT–mTOR pathway is one of the most commonly activated pathways in human cancers, which has led to the development of small-molecule inhibitors that target various nodes in the pathway. [ Shokat 17 ]
See: A-influences
MTOR gene products (62): 3'UTR GoClone (1), Antibodies (21), Custom CRISPR Plasmid (1), Proteins (3), Related Products (12), SYBR Green Primers (2), Zinc Finger Nucleases (8), , shRNA Products (6), siRNA Products (8)
Synonyms FRAP, FRAP1, FRAP2, RAFT1, RAPT1 This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]