Spiritual Death

Spiritual Death (あきらめる) is a process and a state of being, when one has "given up the ghost." It is the epitome of surrender, and may come about in various ways, such as rejecting the notion of a caring or loving God or losing all hope during a harrowing trial. The very spirit within one's soul begins to fade and flicker out of existence as the thing anchoring them to the plane or whatever other raison d'etre they have dies.
Brandon has been believed to have fallen into a state of Spiritual Death several times in his reincarnations and WeskerPawnch too has brushed with this phenomenon. Even though Spiritual Death is clearly a condition of absolute defeat, it can be subverted through Paradox into the release state of Ego Death, which is the first enlighted step towards Nirvana, the Inverse Gnosis.